TR201905687T4 - Travoprost hazırlanışına yönelik proses. - Google Patents

Travoprost hazırlanışına yönelik proses. Download PDF

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Publication number
TR201905687T4
TR201905687T4 TR2019/05687T TR201905687T TR201905687T4 TR 201905687 T4 TR201905687 T4 TR 201905687T4 TR 2019/05687 T TR2019/05687 T TR 2019/05687T TR 201905687 T TR201905687 T TR 201905687T TR 201905687 T4 TR201905687 T4 TR 201905687T4
Authority
TR
Turkey
Prior art keywords
formula
compound
travoprost
crystallization
iii
Prior art date
Application number
TR2019/05687T
Other languages
English (en)
Inventor
Kardos Zsuzsanna
Kiss Tibor
Lászlofi István
Hortobágyi Irén
Bischof Zoltán
Bódis Ádám
Havasi Gábor
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt
Publication of TR201905687T4 publication Critical patent/TR201905687T4/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Buluş formüle (I) ait travoprostun hazırlanışına yönelik, formül (II) bileşiğinin stereoselektif bir şekilde indirgenmesini, ortaya çıkan formül (III) bileşiğinin istenmesi halinde kristalize edilmesini, formül (III) bileşiğinin lakton grubunun indirgenmesini, böylece elde edilen formül (IV) bileşiğinin p-fenil-benzoil koruma grubunun uzaklaştırılmasını, ortaya çıkan formül (V) triolünün, kristalizasyondan sonra istenmesi halinde, Wittig reaksiyonu aracılığıyla, akabinde esterleştirilecek olan, formül (VI) asidine dönüştürülmesini içeren bir proses ile ilgilidir.
TR2019/05687T 2011-12-21 2012-12-10 Travoprost hazırlanışına yönelik proses. TR201905687T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1100701A HU231203B1 (hu) 2011-12-21 2011-12-21 Új eljárás travoprost előállítására

Publications (1)

Publication Number Publication Date
TR201905687T4 true TR201905687T4 (tr) 2019-05-21

Family

ID=89990547

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/05687T TR201905687T4 (tr) 2011-12-21 2012-12-10 Travoprost hazırlanışına yönelik proses.

Country Status (18)

Country Link
US (2) US9212125B2 (tr)
EP (1) EP2802562B1 (tr)
JP (1) JP6174040B2 (tr)
KR (1) KR102027889B1 (tr)
CN (1) CN103998423B (tr)
BR (1) BR112014014060A2 (tr)
CA (1) CA2859923C (tr)
ES (1) ES2721662T3 (tr)
HU (1) HU231203B1 (tr)
IL (1) IL232625B (tr)
IN (1) IN2014CN03482A (tr)
MX (1) MX2014007684A (tr)
PL (1) PL2802562T3 (tr)
RU (1) RU2631316C2 (tr)
TR (1) TR201905687T4 (tr)
TW (1) TWI640500B (tr)
WO (1) WO2013093528A1 (tr)
ZA (1) ZA201404440B (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9238621B2 (en) * 2011-06-02 2016-01-19 Chinoin Zrt Processes for the preparation of prostaglandin amides
US9115109B2 (en) 2013-08-15 2015-08-25 Chirogate International Inc. Processes and intermediates for the preparations of isomer free prostaglandins
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
CN113557227A (zh) * 2019-03-27 2021-10-26 协和医药化工股份有限公司 前列腺素的制造方法
HU231350B1 (hu) * 2019-12-18 2023-01-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt Eljárás királis prosztaglandin-enol intermedier előállítására, és az eljárásban hasznos köztitermék vegyületek
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
WO2021222117A1 (en) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Methods of treating allergic conjunctivitis
CN116583500B (zh) * 2020-12-23 2025-11-18 协和医药化工股份有限公司 几何异构体的分离方法
CN114671906B (zh) * 2020-12-24 2024-03-15 武汉武药制药有限公司 制备曲伏前列素中间体的方法
CN116947725B (zh) * 2022-04-14 2026-03-27 广州楷石医药有限公司 曲伏前列素的合成方法
CN115806517A (zh) * 2022-12-21 2023-03-17 上海彩迩文生化科技有限公司 一种高纯度地诺前列腺素的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2328131C3 (de) * 1973-05-30 1986-11-13 Schering AG, 1000 Berlin und 4709 Bergkamen Neues Verfahren zur Herstellung von Prostaglandin-F↓2↓↓α↓ und seinen Analogen
HU184948B (en) * 1981-04-14 1984-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 5-substituted 4-oxo-pgi down 1 derivatives
HU190007B (en) 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
CS239696B1 (cs) * 1984-05-03 1986-01-16 Jiri Hajek Způsob dělení 15S-a 15R-isomerů 4-/4-/substituovaných X-fenoxy/-3-hydroxy-1butenyí/hexahydro-5-hydroxy- -2H-cyklopenta[b]furan-2-onů
HU212570B (en) 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
GB0112699D0 (en) * 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
GB0329379D0 (en) * 2003-12-19 2004-01-21 Johnson Matthey Plc Prostaglandin synthesis
MXPA06007678A (es) * 2004-01-05 2006-09-01 Nicox Sa Nitroxiderivados de prostaglandinas.
EP2143712A1 (en) * 2008-07-10 2010-01-13 Sandoz AG Improved Process for the Production of Prostaglandins and Prostaglandin Analogs
IT1393112B1 (it) * 2009-02-27 2012-04-11 Sifavitor S R L Procedimento per la preparazione di derivati di prostaglandine
KR101561171B1 (ko) 2009-10-16 2015-10-19 카이맨 케미칼 컴파니 인코포레이티드 Ｆ-계열 프로스타글란딘의 제조 방법
EP2496553A4 (en) * 2009-11-05 2013-03-06 Biocon Ltd NEW METHOD FOR THE PRODUCTION OF PROSTAGLANDINES AND INTERMEDIATE PRODUCTS THEREOF
EP2495235B1 (en) 2011-03-04 2015-08-05 Newchem S.p.A. Process for the synthesis of prostaglandins and intermediates thereof
US9238621B2 (en) 2011-06-02 2016-01-19 Chinoin Zrt Processes for the preparation of prostaglandin amides

Also Published As

Publication number Publication date
KR102027889B1 (ko) 2019-10-04
PL2802562T3 (pl) 2019-08-30
EP2802562B1 (en) 2019-01-23
HU231203B1 (hu) 2021-10-28
KR20140107541A (ko) 2014-09-04
CN103998423A (zh) 2014-08-20
BR112014014060A2 (pt) 2017-06-13
EP2802562A1 (en) 2014-11-19
US20160137621A1 (en) 2016-05-19
IL232625A0 (en) 2014-06-30
HUP1100701A2 (en) 2013-07-29
CA2859923C (en) 2020-11-24
US20140343299A1 (en) 2014-11-20
IN2014CN03482A (tr) 2015-07-03
ES2721662T3 (es) 2019-08-02
CN103998423B (zh) 2018-04-27
RU2631316C2 (ru) 2017-09-21
TW201336816A (zh) 2013-09-16
JP6174040B2 (ja) 2017-08-02
ZA201404440B (en) 2015-12-23
IL232625B (en) 2019-03-31
RU2014129492A (ru) 2016-02-10
CA2859923A1 (en) 2013-06-27
TWI640500B (zh) 2018-11-11
HK1198584A1 (en) 2015-04-30
US9212125B2 (en) 2015-12-15
WO2013093528A1 (en) 2013-06-27
MX2014007684A (es) 2014-07-28
JP2015506343A (ja) 2015-03-02

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