TR201910497T4 - S-asetil glutatyonun kristal formları, bunların hazırlanması ve farmasötik ve nutrasötik formülasyonlarda kullanımları. - Google Patents
S-asetil glutatyonun kristal formları, bunların hazırlanması ve farmasötik ve nutrasötik formülasyonlarda kullanımları. Download PDFInfo
- Publication number
- TR201910497T4 TR201910497T4 TR2019/10497T TR201910497T TR201910497T4 TR 201910497 T4 TR201910497 T4 TR 201910497T4 TR 2019/10497 T TR2019/10497 T TR 2019/10497T TR 201910497 T TR201910497 T TR 201910497T TR 201910497 T4 TR201910497 T4 TR 201910497T4
- Authority
- TR
- Turkey
- Prior art keywords
- pharmaceutical
- crystal forms
- preparation
- nutraceutical formulations
- water
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Abstract
Kontrollü koşullar altında su-aseton, su-etanol veya su-metanol karışımlarından, tercihen asetondan SAG'nin kristallendirilmesi ile elde edilen, S-asetil glutatyonun (SAG) Form A ve Form B adı verilen iki kristal formu açıklanmaktadır. Bu kristal formların karakterize edici özelliği, X-ışını toz kırınımı, IR spektrumu ve DSC'sidir. Formlar A ve B, farmasötik veya nutrasötik formülasyonların içerik maddeleri olarak avantajlı bir şekilde kullanılabilir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001856A ITMI20131856A1 (it) | 2013-11-08 | 2013-11-08 | Processo per la preparazione di differenti forme cristalline del s-acetil glutatione e loro utilizzi in formulazioni farmaceutiche e nutraceutiche |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201910497T4 true TR201910497T4 (tr) | 2019-08-21 |
Family
ID=49683911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/10497T TR201910497T4 (tr) | 2013-11-08 | 2014-11-06 | S-asetil glutatyonun kristal formları, bunların hazırlanması ve farmasötik ve nutrasötik formülasyonlarda kullanımları. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9834579B2 (tr) |
| EP (1) | EP3066111B1 (tr) |
| JP (1) | JP6534394B2 (tr) |
| KR (1) | KR20160070782A (tr) |
| CN (1) | CN105705512B (tr) |
| AU (1) | AU2014345562B2 (tr) |
| CA (1) | CA2929707C (tr) |
| CY (1) | CY1121811T1 (tr) |
| DK (1) | DK3066111T3 (tr) |
| EA (1) | EA029886B1 (tr) |
| ES (1) | ES2738858T3 (tr) |
| GE (2) | GEP20196957B (tr) |
| HR (1) | HRP20191522T1 (tr) |
| HU (1) | HUE045975T2 (tr) |
| IL (1) | IL245487A0 (tr) |
| IT (1) | ITMI20131856A1 (tr) |
| LT (1) | LT3066111T (tr) |
| MX (1) | MX368816B (tr) |
| PH (1) | PH12016500832A1 (tr) |
| PL (1) | PL3066111T3 (tr) |
| RS (1) | RS59101B1 (tr) |
| SI (1) | SI3066111T1 (tr) |
| TR (1) | TR201910497T4 (tr) |
| UA (1) | UA120257C2 (tr) |
| WO (1) | WO2015067708A1 (tr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107227220A (zh) * | 2016-03-23 | 2017-10-03 | 百瑞全球有限公司 | 制备含有s-乙酰基谷胱甘肽的发酵酒的方法 |
| EP3560947B1 (en) | 2016-12-20 | 2022-08-24 | Kyowa Hakko Bio Co., Ltd. | Crystal of glutathione trisulfide dihydrate and method for producing same |
| CN114605491B (zh) * | 2022-03-24 | 2024-02-06 | 安庆辰泰生物科技有限公司 | S-乙酰-l-谷胱甘肽的制备方法以及混合溶剂的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB761093A (en) * | 1954-03-31 | 1956-11-07 | Distillers Co Yeast Ltd | Production of s-acetyl glutathione |
| DE3722647A1 (de) * | 1987-07-09 | 1989-01-19 | Gerhard Ohlenschlaeger | Galenische verwendung eines tripeptids als arzneimittel |
| IT1248994B (it) * | 1990-06-26 | 1995-02-11 | Co Ri T S A S Di Buoso Maria & | Processo per la preparazione di s-acil derivati di glutatione composti ottenuti da detto processo e intermedio utile per la loro preparazione |
| EP1874948B1 (en) * | 2005-03-31 | 2013-03-20 | NewSouth Innovations Pty Limited | Process for the production of y-glutamylcysteine |
| WO2008144675A1 (en) * | 2007-05-17 | 2008-11-27 | Neopro Labs, Llc | Crystalline and amorphous forms of peptide |
| NZ605526A (en) * | 2010-07-12 | 2015-04-24 | Celgene Corp | Romidepsin solid forms and uses thereof |
| CN103058922B (zh) * | 2012-09-06 | 2014-07-16 | 湖南有色凯铂生物药业有限公司 | 用于抗肿瘤药物的芳香脲的晶型及其制备方法 |
| CN104193800B (zh) * | 2014-09-25 | 2017-01-18 | 北京德默高科医药技术有限公司 | S‑乙酰‑l‑谷胱甘肽的i、ii型晶体 |
-
2013
- 2013-11-08 IT IT001856A patent/ITMI20131856A1/it unknown
-
2014
- 2014-11-06 RS RS20191020A patent/RS59101B1/sr unknown
- 2014-11-06 JP JP2016551047A patent/JP6534394B2/ja active Active
- 2014-11-06 HR HRP20191522 patent/HRP20191522T1/hr unknown
- 2014-11-06 MX MX2016005881A patent/MX368816B/es active IP Right Grant
- 2014-11-06 DK DK14803064.6T patent/DK3066111T3/da active
- 2014-11-06 HU HUE14803064A patent/HUE045975T2/hu unknown
- 2014-11-06 GE GEAP201414134A patent/GEP20196957B/en unknown
- 2014-11-06 US US15/034,806 patent/US9834579B2/en active Active
- 2014-11-06 EA EA201690735A patent/EA029886B1/ru not_active IP Right Cessation
- 2014-11-06 EP EP14803064.6A patent/EP3066111B1/en active Active
- 2014-11-06 PL PL14803064T patent/PL3066111T3/pl unknown
- 2014-11-06 ES ES14803064T patent/ES2738858T3/es active Active
- 2014-11-06 CN CN201480060573.1A patent/CN105705512B/zh active Active
- 2014-11-06 GE GEAP201814134A patent/GEAP201814134A/en unknown
- 2014-11-06 LT LT14803064T patent/LT3066111T/lt unknown
- 2014-11-06 AU AU2014345562A patent/AU2014345562B2/en active Active
- 2014-11-06 TR TR2019/10497T patent/TR201910497T4/tr unknown
- 2014-11-06 KR KR1020167012015A patent/KR20160070782A/ko not_active Ceased
- 2014-11-06 SI SI201431306T patent/SI3066111T1/sl unknown
- 2014-11-06 CA CA2929707A patent/CA2929707C/en active Active
- 2014-11-06 UA UAA201605006A patent/UA120257C2/uk unknown
- 2014-11-06 WO PCT/EP2014/073957 patent/WO2015067708A1/en not_active Ceased
-
2016
- 2016-05-05 IL IL245487A patent/IL245487A0/en active IP Right Grant
- 2016-05-05 PH PH12016500832A patent/PH12016500832A1/en unknown
-
2019
- 2019-07-10 CY CY20191100725T patent/CY1121811T1/el unknown
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