TW200612918A - Lonidamine analogs - Google Patents
Lonidamine analogsInfo
- Publication number
- TW200612918A TW200612918A TW094126067A TW94126067A TW200612918A TW 200612918 A TW200612918 A TW 200612918A TW 094126067 A TW094126067 A TW 094126067A TW 94126067 A TW94126067 A TW 94126067A TW 200612918 A TW200612918 A TW 200612918A
- Authority
- TW
- Taiwan
- Prior art keywords
- lonidamine analogs
- lonidamine
- analogs
- bph
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59272304P | 2004-07-29 | 2004-07-29 | |
| US59283304P | 2004-07-29 | 2004-07-29 | |
| US59966604P | 2004-08-05 | 2004-08-05 | |
| US64618805P | 2005-01-21 | 2005-01-21 | |
| US65170505P | 2005-02-09 | 2005-02-09 | |
| US66106705P | 2005-03-11 | 2005-03-11 | |
| US68308705P | 2005-05-19 | 2005-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200612918A true TW200612918A (en) | 2006-05-01 |
Family
ID=35787877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094126067A TW200612918A (en) | 2004-07-29 | 2005-07-29 | Lonidamine analogs |
Country Status (2)
| Country | Link |
|---|---|
| TW (1) | TW200612918A (fr) |
| WO (1) | WO2006015263A2 (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514463B2 (en) * | 2004-08-20 | 2009-04-07 | University Of Kansas | Lonidamine analogues and their use in male contraception and cancer treatment |
| MX2007012082A (es) | 2005-03-31 | 2007-11-20 | Pfizer Prod Inc | Derivados de ciclopentapiridina y tetrahidroquinolina. |
| US8003625B2 (en) | 2005-06-29 | 2011-08-23 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| JP2009528989A (ja) | 2006-02-17 | 2009-08-13 | ファイザー・リミテッド | Ｔｌｒ７変調剤としての３−デアザプリン誘導体 |
| WO2008005908A2 (fr) | 2006-07-07 | 2008-01-10 | Forest Laboratories Holdings Limited | Dérivés de pyridoïmidazole |
| EP2049520A4 (fr) | 2006-08-07 | 2011-01-05 | Ironwood Pharmaceuticals Inc | Composés d'indole |
| DK2065388T3 (da) | 2006-09-19 | 2012-01-09 | Daiichi Sankyo Co Ltd | Pyrazolopyrimidinderivat |
| US7858645B2 (en) * | 2006-11-01 | 2010-12-28 | Hoffmann-La Roche Inc. | Indazole derivatives |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| WO2009106982A1 (fr) * | 2008-02-29 | 2009-09-03 | Pfizer Inc. | Dérivés d'indazole |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| MX2011006682A (es) | 2008-12-22 | 2011-07-13 | Merck Patent Gmbh | Nuevas formas polimorficas de dihidrogeno-fosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirim idin-2-il]-bencil}-2h-piridazin-3-ona y procesos para su preparacion. |
| RU2520966C2 (ru) | 2009-02-25 | 2014-06-27 | Дайити Санкио Компани, Лимитед | Производное трициклического пиразолопиримидина |
| CA2809120C (fr) | 2010-08-23 | 2015-10-13 | Daiichi Sankyo Company, Limited | Derive pyrazolopyrimidine tricyclique sous forme cristalline |
| JPWO2012026433A1 (ja) | 2010-08-23 | 2013-10-28 | 第一三共株式会社 | 三環性ピラゾロピリミジン誘導体のフリー体結晶 |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| DK2888010T3 (da) | 2012-08-22 | 2021-06-28 | Univ Cornell | Fremgangsmåder til at hæmme fascin |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| NZ723203A (en) | 2014-02-13 | 2020-08-28 | Incyte Corp | Cyclopropylamines as lsd1 inhibitors |
| EP3392244A1 (fr) | 2014-02-13 | 2018-10-24 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
| KR102421235B1 (ko) | 2014-02-13 | 2022-07-15 | 인사이트 코포레이션 | Lsd1 저해제로서 사이클로프로필아민 |
| WO2015127125A1 (fr) | 2014-02-20 | 2015-08-27 | Cornell University | Composés et procédés d'inhibition de la fascine |
| WO2016007731A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines et imidazopyrazines à utiliser en tant qu'inhibiteurs de lsd1 |
| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| WO2016007722A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1 |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| UA122688C2 (uk) | 2015-04-03 | 2020-12-28 | Інсайт Корпорейшн | Гетероциклічні сполуки як інгібітори lsd1 |
| JP7427363B2 (ja) | 2015-08-12 | 2024-02-05 | インサイト・ホールディングス・コーポレイション | Ｌｓｄ１阻害剤の塩 |
| CA3010615C (fr) * | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Modulateurs de mastocytes et leurs utilisations |
| WO2017121693A1 (fr) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | Thiazolamides et thiadiazolamides substitués et leur utilisation |
| US10166221B2 (en) | 2016-04-22 | 2019-01-01 | Incyte Corporation | Formulations of an LSD1 inhibitor |
| EP3564214B1 (fr) | 2018-05-04 | 2024-07-03 | Universita' Degli Studi G. D'annunzio Chieti - Pescara | Dérivés d'indazole en tant que modulateurs du système de cannabinoïdes |
| WO2020047198A1 (fr) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Sels d'un inhibiteur de lsd1 et leurs procédés de préparation |
| EP3856194A4 (fr) | 2018-09-28 | 2022-05-04 | Acucela Inc. | Inhibiteurs de vap-1 |
| AU2019351122A1 (en) | 2018-09-28 | 2021-05-20 | Acucela Inc. | Inhibitors of VAP-1 |
| KR102241064B1 (ko) * | 2019-07-30 | 2021-04-16 | 부산대학교 산학협력단 | 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물 |
| CN116438162A (zh) * | 2020-09-17 | 2023-07-14 | 伊赛恩特制药公司 | Mas相关g蛋白受体x4的调节剂及相关产物和方法 |
| WO2024109642A1 (fr) * | 2023-07-28 | 2024-05-30 | 常州大学 | UTILISATION D'UN COMPOSÉ BENZOAZACYCLIQUE EN TANT QUE MODULATEUR ALLOSTÉRIQUE D'UN β2-ADRÉNORÉCEPTEUR |
-
2005
- 2005-07-29 TW TW094126067A patent/TW200612918A/zh unknown
- 2005-07-29 WO PCT/US2005/027092 patent/WO2006015263A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006015263A3 (fr) | 2006-07-27 |
| WO2006015263A2 (fr) | 2006-02-09 |
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