WO2006015263A3 - Analogues de lonidamine - Google Patents

Analogues de lonidamine Download PDF

Info

Publication number
WO2006015263A3
WO2006015263A3 PCT/US2005/027092 US2005027092W WO2006015263A3 WO 2006015263 A3 WO2006015263 A3 WO 2006015263A3 US 2005027092 W US2005027092 W US 2005027092W WO 2006015263 A3 WO2006015263 A3 WO 2006015263A3
Authority
WO
WIPO (PCT)
Prior art keywords
lonidamine analogs
lonidamine
analogs
bph
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/027092
Other languages
English (en)
Other versions
WO2006015263A2 (fr
Inventor
Mark Matteucci
Photon Rao
Jian-Xin Duan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Templates Inc
Original Assignee
Threshold Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Threshold Pharmaceuticals Inc filed Critical Threshold Pharmaceuticals Inc
Priority to US11/346,632 priority Critical patent/US20070043057A1/en
Priority to US11/351,347 priority patent/US20070015771A1/en
Publication of WO2006015263A2 publication Critical patent/WO2006015263A2/fr
Publication of WO2006015263A3 publication Critical patent/WO2006015263A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention a trait à des analogues de lonidamine utiles dans le traitement du cancer et de l'hypertrophie bénigne de la prostate.
PCT/US2005/027092 2004-07-29 2005-07-29 Analogues de lonidamine Ceased WO2006015263A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/346,632 US20070043057A1 (en) 2005-02-09 2006-02-01 Lonidamine analogs
US11/351,347 US20070015771A1 (en) 2004-07-29 2006-02-08 Lonidamine analogs

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US59283304P 2004-07-29 2004-07-29
US59272304P 2004-07-29 2004-07-29
US60/592,723 2004-07-29
US60/592,833 2004-07-29
US59966604P 2004-08-05 2004-08-05
US60/599,666 2004-08-05
US64618805P 2005-01-21 2005-01-21
US60/646,188 2005-01-21
US65170505P 2005-02-09 2005-02-09
US60/651,705 2005-02-09
US66106705P 2005-03-11 2005-03-11
US60/661,067 2005-03-11
US68308705P 2005-05-19 2005-05-19
US60/683,087 2005-05-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/346,632 Continuation-In-Part US20070043057A1 (en) 2004-07-29 2006-02-01 Lonidamine analogs

Publications (2)

Publication Number Publication Date
WO2006015263A2 WO2006015263A2 (fr) 2006-02-09
WO2006015263A3 true WO2006015263A3 (fr) 2006-07-27

Family

ID=35787877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/027092 Ceased WO2006015263A2 (fr) 2004-07-29 2005-07-29 Analogues de lonidamine

Country Status (2)

Country Link
TW (1) TW200612918A (fr)
WO (1) WO2006015263A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493450B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7514463B2 (en) * 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
JP4318744B2 (ja) 2005-03-31 2009-08-26 ファイザー・プロダクツ・インク シクロペンタピリジンおよびテトラヒドロキノリン誘導体
CN102746336B (zh) 2005-06-29 2015-08-19 施瑞修德制药公司 氨基磷酸酯烷化剂前体药物
JP2009528989A (ja) 2006-02-17 2009-08-13 ファイザー・リミテッド Ｔｌｒ７変調剤としての３−デアザプリン誘導体
US7501438B2 (en) 2006-07-07 2009-03-10 Forest Laboratories Holdings Limited Pyridoimidazole derivatives
EP2049520A4 (fr) 2006-08-07 2011-01-05 Ironwood Pharmaceuticals Inc Composés d'indole
KR20140127367A (ko) 2006-09-19 2014-11-03 다이이찌 산쿄 가부시키가이샤 피라졸로피리미딘 유도체
US7858645B2 (en) * 2006-11-01 2010-12-28 Hoffmann-La Roche Inc. Indazole derivatives
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
MX2010009462A (es) * 2008-02-29 2010-09-24 Pfizer Derivados de indazol.
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
US8586599B2 (en) 2008-12-22 2013-11-19 Merck Patent Gmbh Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
NZ595233A (en) 2009-02-25 2013-01-25 Daiichi Sankyo Co Ltd Tricyclic pyrazolopyrimidine derivatives
JP5701884B2 (ja) 2010-08-23 2015-04-15 第一三共株式会社 三環性ピラゾロピリミジン誘導体の結晶
KR20130099006A (ko) 2010-08-23 2013-09-05 다이이찌 산쿄 가부시키가이샤 3 고리성 피라졸로피리미딘 유도체의 프리체 결정
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
CN113679717A (zh) 2012-08-22 2021-11-23 康奈尔大学 用于抑制肌成束蛋白的方法
PE20161573A1 (es) 2014-02-13 2017-01-19 Incyte Corp Ciclopropilamina como inhibidor de la lsd1
CA2940144C (fr) 2014-02-20 2023-06-13 Cornell University Derives d'indazol-3-yl substitues et compositions pharmaceutiques connexes utiles comme inhibiteurs de la fascine
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007722A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1
WO2016007727A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
PE20180455A1 (es) 2015-04-03 2018-03-05 Incyte Corp Compuestos heterociclicos como inhibidores de lsd1
SG10202001219UA (en) 2015-08-12 2020-03-30 Incyte Corp Salts of an lsd1 inhibitor
US20190016680A1 (en) * 2016-01-14 2019-01-17 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof
WO2017121693A1 (fr) 2016-01-15 2017-07-20 Bayer Pharma Aktiengesellschaft Thiazolamides et thiadiazolamides substitués et leur utilisation
CN109414410B (zh) 2016-04-22 2022-08-12 因赛特公司 Lsd1抑制剂的制剂
EP3564214B1 (fr) 2018-05-04 2024-07-03 Universita' Degli Studi G. D'annunzio Chieti - Pescara Dérivés d'indazole en tant que modulateurs du système de cannabinoïdes
WO2020047198A1 (fr) 2018-08-31 2020-03-05 Incyte Corporation Sels d'un inhibiteur de lsd1 et leurs procédés de préparation
CA3114166A1 (fr) 2018-09-28 2020-04-02 Acucela Inc. Inhibiteurs de vap-1
CN113164454A (zh) 2018-09-28 2021-07-23 奥克塞拉有限公司 Vap-1的抑制剂
KR102241064B1 (ko) * 2019-07-30 2021-04-16 부산대학교 산학협력단 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물
CN116438162A (zh) * 2020-09-17 2023-07-14 伊赛恩特制药公司 Mas相关g蛋白受体x4的调节剂及相关产物和方法
WO2024109642A1 (fr) * 2023-07-28 2024-05-30 常州大学 UTILISATION D'UN COMPOSÉ BENZOAZACYCLIQUE EN TANT QUE MODULATEUR ALLOSTÉRIQUE D'UN β2-ADRÉNORÉCEPTEUR

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHENG C.Y. ET AL.: "Indazole carboxylic acids in male contraception", CONTRACEPTION, vol. 65, no. 4, 2002, pages 265 - 268, XP003001053 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493450B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors

Also Published As

Publication number Publication date
WO2006015263A2 (fr) 2006-02-09
TW200612918A (en) 2006-05-01

Similar Documents

Publication Publication Date Title
WO2006015263A3 (fr) Analogues de lonidamine
EP1835929B8 (fr) Procédés et traitements combinés anti-kir
EP1587837A3 (fr) Diagnostic et traitement du cancer de la prostate
AU2003213144A1 (en) Alkylating agent combinations in the treatment of cancer
EP1571968A3 (fr) Compositions et methodes permettant de diagnostiquer et de traiter une tumeur
IL178012A0 (en) Diphenyl-indol-2-on compounds and their use in the treatment of cancer
EP1572091A3 (fr) Compositions et methodes de diagnostic et de traitement de tumeurs
ZA200409492B (en) Compositions and methods for the diagnosis and treatment of tumor.
AU2003300368A1 (en) Methods and compositions for the diagnosis, prognosis, and treatment of cancer
AU2003212634A1 (en) Compounds useful in the treatment of cancer
WO2006113483A3 (fr) Methodes et compositions pour le traitement ou la prevention du cancer
WO2005003154A8 (fr) Compositions et methodes de diagnostic et de traitement de tumeur
AP2005003362A0 (en) Formulation and methods for the treatment of thrombocythemia.
AU2003237792A1 (en) Compositions and methods for the diagnosis and treatment of tumor
AU2003219160A1 (en) Methods and compositions for the treatment of cancer
ZA200709542B (en) Combination therapy in the treatment of cancer
AU2003223538A1 (en) Methods for the treatment of cancer
AU2006251169A8 (en) Tetrahydropyridothiophenes for use in the treatment of cancer
AU2006251167A8 (en) Tetrahydropyridothiophenes for use in the treatment of cancer
WO2006015191A3 (fr) Analogues de lonidamine multicycliques
WO2007076320A3 (fr) Composes
EG24959A (en) Indoles useful in the treatment of androgenreceptor related diseases.
AU2004281077A1 (en) Methods and agents for the treatment of cancer
AU2003231803A1 (en) Treatment of cancer with mefloquire
WO2005052191A8 (fr) Compositions et methodes de diagnostic et de traitement d'une tumeur

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 11346632

Country of ref document: US

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: 11346632

Country of ref document: US

122 Ep: pct application non-entry in european phase