TW200626565A - Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition - Google Patents
Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibitionInfo
- Publication number
- TW200626565A TW200626565A TW094142936A TW94142936A TW200626565A TW 200626565 A TW200626565 A TW 200626565A TW 094142936 A TW094142936 A TW 094142936A TW 94142936 A TW94142936 A TW 94142936A TW 200626565 A TW200626565 A TW 200626565A
- Authority
- TW
- Taiwan
- Prior art keywords
- serotonin reuptake
- combination
- reuptake inhibition
- phenylpiperazine derivatives
- receptor agonism
- Prior art date
Links
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title abstract 2
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title abstract 2
- 230000008484 agonism Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000697 serotonin reuptake Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification. And tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106394 | 2004-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200626565A true TW200626565A (en) | 2006-08-01 |
Family
ID=34930019
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094142937A TW200634008A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142941A TW200634009A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142936A TW200626565A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142952A TW200628457A (en) | 2004-12-08 | 2005-12-06 | Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094142937A TW200634008A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142941A TW200634009A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094142952A TW200628457A (en) | 2004-12-08 | 2005-12-06 | Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
Country Status (7)
| Country | Link |
|---|---|
| CN (4) | CN101072559A (en) |
| AR (4) | AR052147A1 (en) |
| BR (3) | BRPI0518621A2 (en) |
| MX (4) | MX2007006817A (en) |
| SA (2) | SA05260391B1 (en) |
| TW (4) | TW200634008A (en) |
| ZA (2) | ZA200704219B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103360342B (en) * | 2012-04-09 | 2015-12-16 | 江苏恩华药业股份有限公司 | 3-cyano-aniline alkylaryl bridged piperazine derivatives and preparing the application in medicine |
| CN103073524B (en) * | 2013-01-25 | 2015-06-10 | 宁波市微循环与莨菪类药研究所 | 4-[4-(substituted phenyl) piperazine piperazinyl-1]-butylcarbamic acid substituted aromatic ester derivative and preparation method thereof |
-
2005
- 2005-12-06 AR ARP050105094A patent/AR052147A1/en not_active Application Discontinuation
- 2005-12-06 BR BRPI0518621-8A patent/BRPI0518621A2/en not_active IP Right Cessation
- 2005-12-06 SA SA05260391A patent/SA05260391B1/en unknown
- 2005-12-06 MX MX2007006817A patent/MX2007006817A/en active IP Right Grant
- 2005-12-06 TW TW094142937A patent/TW200634008A/en unknown
- 2005-12-06 MX MX2007006818A patent/MX2007006818A/en not_active Application Discontinuation
- 2005-12-06 AR ARP050105093A patent/AR052261A1/en not_active Application Discontinuation
- 2005-12-06 CN CNA2005800422159A patent/CN101072559A/en active Pending
- 2005-12-06 TW TW094142941A patent/TW200634009A/en unknown
- 2005-12-06 TW TW094142936A patent/TW200626565A/en unknown
- 2005-12-06 CN CNA2005800422214A patent/CN101072560A/en active Pending
- 2005-12-06 MX MX2007006816A patent/MX2007006816A/en not_active Application Discontinuation
- 2005-12-06 AR ARP050105092A patent/AR052260A1/en not_active Application Discontinuation
- 2005-12-06 BR BRPI0518620-0A patent/BRPI0518620A2/en not_active IP Right Cessation
- 2005-12-06 CN CNA2005800421758A patent/CN101072558A/en active Pending
- 2005-12-06 SA SA05260387A patent/SA05260387B1/en unknown
- 2005-12-06 BR BRPI0518862-8A patent/BRPI0518862A2/en not_active IP Right Cessation
- 2005-12-06 AR ARP050105091A patent/AR052259A1/en not_active Application Discontinuation
- 2005-12-06 TW TW094142952A patent/TW200628457A/en unknown
- 2005-12-06 MX MX2007006815A patent/MX2007006815A/en active IP Right Grant
- 2005-12-06 CN CNA2005800422248A patent/CN101119722A/en active Pending
-
2007
- 2007-05-23 ZA ZA200704219A patent/ZA200704219B/en unknown
- 2007-05-23 ZA ZA200704217A patent/ZA200704217B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR052259A1 (en) | 2007-03-07 |
| CN101072558A (en) | 2007-11-14 |
| ZA200704219B (en) | 2008-05-28 |
| CN101119722A (en) | 2008-02-06 |
| BRPI0518620A2 (en) | 2008-12-02 |
| SA05260387B1 (en) | 2009-07-29 |
| SA05260391B1 (en) | 2009-04-01 |
| BRPI0518862A2 (en) | 2008-12-09 |
| CN101072559A (en) | 2007-11-14 |
| MX2007006818A (en) | 2007-11-09 |
| MX2007006815A (en) | 2007-11-09 |
| BRPI0518621A2 (en) | 2008-12-02 |
| AR052260A1 (en) | 2007-03-07 |
| CN101072560A (en) | 2007-11-14 |
| AR052261A1 (en) | 2007-03-07 |
| ZA200704217B (en) | 2008-12-31 |
| TW200628457A (en) | 2006-08-16 |
| MX2007006816A (en) | 2007-07-24 |
| TW200634009A (en) | 2006-10-01 |
| TW200634008A (en) | 2006-10-01 |
| AR052147A1 (en) | 2007-03-07 |
| MX2007006817A (en) | 2007-07-24 |
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