TW200727902A - Amorphous solid dispersions - Google Patents

Amorphous solid dispersions

Info

Publication number: TW200727902A
Authority: TW; Taiwan
Prior art keywords: amorphous solid; solid dispersions; pyridazino; acetamide; indole
Prior art date: 2005-08-29

Application number

TW095131682A

Other languages

English (en)

Other versions

TWI398250B (zh

Inventor

Irwin C Jacobs

John D Higgins

Micael Guillot

Nancy M Franson

William L Rocco

Khawla Abdullah Abu-Izza

Original Assignee

Sanofi Aventis Us Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-29

Filing date

2006-08-29

Publication date

2007-08-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37499538&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200727902(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-08-29 Application filed by Sanofi Aventis Us Llc filed Critical Sanofi Aventis Us Llc

2007-08-01 Publication of TW200727902A publication Critical patent/TW200727902A/zh

2013-06-11 Application granted granted Critical

2013-06-11 Publication of TWI398250B publication Critical patent/TWI398250B/zh

Links

239000007962 solid dispersion Substances 0.000 title abstract 2
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
HJSQVJOROCIILI-UHFFFAOYSA-N ssr-180,575 Chemical compound O=C1C=2N(C)C3=CC(Cl)=CC=C3C=2C(CC(=O)N(C)C)=NN1C1=CC=CC=C1 HJSQVJOROCIILI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Cardiology (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

TW095131682A 2005-08-29 2006-08-29 非晶形固態分散體 TWI398250B (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71215005P	2005-08-29	2005-08-29

Publications (2)

Publication Number	Publication Date
TW200727902A true TW200727902A (en)	2007-08-01
TWI398250B TWI398250B (zh)	2013-06-11

Family

ID=37499538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095131682A TWI398250B (zh)	2005-08-29	2006-08-29	非晶形固態分散體

Country Status (30)

Country	Link
US (1)	US7713548B2 (zh)
EP (1)	EP1926476B1 (zh)
JP (1)	JP5026426B2 (zh)
KR (1)	KR20080061354A (zh)
CN (1)	CN101272767B (zh)
AR (1)	AR055615A1 (zh)
AU (1)	AU2006285111B8 (zh)
BR (1)	BRPI0615609A2 (zh)
CA (1)	CA2619438A1 (zh)
CR (1)	CR9750A (zh)
DK (1)	DK1926476T3 (zh)
EA (1)	EA015715B1 (zh)
EC (1)	ECSP088203A (zh)
ES (1)	ES2414434T3 (zh)
HN (1)	HN2008000360A (zh)
HR (1)	HRP20130533T1 (zh)
IL (1)	IL189587A (zh)
MA (1)	MA29783B1 (zh)
ME (1)	ME01560B (zh)
NO (1)	NO20081364L (zh)
NZ (1)	NZ566313A (zh)
PL (1)	PL1926476T3 (zh)
PT (1)	PT1926476E (zh)
RS (1)	RS52914B (zh)
SI (1)	SI1926476T1 (zh)
TN (1)	TNSN08069A1 (zh)
TW (1)	TWI398250B (zh)
UA (1)	UA93517C2 (zh)
WO (1)	WO2007027494A2 (zh)
ZA (1)	ZA200801893B (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ571803A (en)	2006-04-07	2011-12-22	Vertex Pharma	Amide indole derivatives as modulators of ATP-binding cassette transporters
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
JP2010526848A (ja) *	2007-05-11	2010-08-05	エフ．ホフマン−ラロシュアーゲー	難溶性薬物用の医薬組成物
AU2009223014A1 (en) *	2008-03-11	2009-09-17	Dr. Reddy's Laboratories Ltd.	Preparation of lenalidomide
CA2734448A1 (en) *	2008-08-18	2010-02-25	Sanofi-Aventis U.S. Llc	Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
US20110251253A1 (en) *	2010-03-25	2011-10-13	Vertex Pharmaceuticals Incorporated	Solid forms of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
WO2013132457A2 (en)	2012-03-07	2013-09-12	National Institute Of Pharmaceutical Education And Research (Niper)	Nanocrystalline solid dispersion compositions and process of preparation thereof
KR101986683B1 (ko) *	2012-12-13	2019-06-10	한미약품 주식회사	테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
US9965611B2 (en) *	2013-08-30	2018-05-08	Entit Software Llc	Comparing real-time movements to pattern profile background
CN106232144B (zh) *	2014-03-18	2019-12-06	武田药品工业株式会社	固体分散体
ES2885181T3 (es)	2014-04-15	2021-12-13	Vertex Pharma	Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
WO2017148837A1 (en)	2016-02-29	2017-09-08	F. Hoffmann-La Roche Ag	Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase
RU2767872C2 (ru) *	2017-07-04	2022-03-22	Цзянсу Хэнжуй Медсин Ко., Лтд.	Фармацевтическая композиция и способ ее получения
JP2025008679A (ja) *	2023-07-05	2025-01-20	学校法人名城大学	非晶質性化有機化合物を含む複合粒子の製造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5091381A (en) *	1991-04-12	1992-02-25	Biomeasure, Inc.	2H-1,3,4-benzotriazepin-2-ones
TW487582B (en) *	1995-08-11	2002-05-21	Nissan Chemical Ind Ltd	Method for converting sparingly water-soluble medical substance to amorphous state
FR2766823B1 (fr)	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
ES2287971T3 (es) *	1997-08-11	2007-12-16	Pfizer Products Inc.	Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
AUPP278498A0 (en) *	1998-04-03	1998-04-30	Australian Nuclear Science & Technology Organisation	Peripheral benzodiazepine receptor binding agents
FR2788696B1 (fr) *	1999-01-26	2004-03-05	Synthelabo	Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
ATE400251T1 (de)	1999-02-09	2008-07-15	Pfizer Prod Inc	Zusammensetzungen basischer arzneistoffe mit verbesserter bioverfügbarkeit
ATE400252T1 (de)	1999-02-10	2008-07-15	Pfizer Prod Inc	Pharmazeutische feste dispersionen
ATE404178T1 (de) *	1999-02-10	2008-08-15	Pfizer Prod Inc	Vorrichtung mit matrixgesteuerter wirkstofffreisetzung
EP1120109A3 (en) *	2000-01-24	2002-07-10	Pfizer Products Inc.	Rapidly disintegrating and fast dissolving solid dosage form
FR2829939B3 (fr) *	2001-09-21	2003-11-28	Sanofi Synthelabo	Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide
CL2004001884A1 (es)	2003-08-04	2005-06-03	Pfizer Prod Inc	Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
US20050220881A1 (en) *	2003-10-10	2005-10-06	Bvm Holding Co.	Pharmaceutical composition

2006
- 2006-08-24 CN CN2006800317142A patent/CN101272767B/zh not_active Expired - Fee Related
- 2006-08-24 HR HRP20130533TT patent/HRP20130533T1/hr unknown
- 2006-08-24 PT PT68022151T patent/PT1926476E/pt unknown
- 2006-08-24 SI SI200631605T patent/SI1926476T1/sl unknown
- 2006-08-24 BR BRPI0615609-6A patent/BRPI0615609A2/pt not_active IP Right Cessation
- 2006-08-24 JP JP2008529117A patent/JP5026426B2/ja not_active Expired - Fee Related
- 2006-08-24 PL PL06802215T patent/PL1926476T3/pl unknown
- 2006-08-24 KR KR1020087004952A patent/KR20080061354A/ko not_active Abandoned
- 2006-08-24 CA CA002619438A patent/CA2619438A1/en not_active Abandoned
- 2006-08-24 AU AU2006285111A patent/AU2006285111B8/en not_active Ceased
- 2006-08-24 ME MEP-2013-80A patent/ME01560B/me unknown
- 2006-08-24 UA UAA200803944A patent/UA93517C2/ru unknown
- 2006-08-24 ES ES06802215T patent/ES2414434T3/es active Active
- 2006-08-24 EA EA200800713A patent/EA015715B1/ru not_active IP Right Cessation
- 2006-08-24 WO PCT/US2006/033022 patent/WO2007027494A2/en not_active Ceased
- 2006-08-24 ZA ZA200801893A patent/ZA200801893B/xx unknown
- 2006-08-24 NZ NZ566313A patent/NZ566313A/en not_active IP Right Cessation
- 2006-08-24 EP EP06802215.1A patent/EP1926476B1/en active Active
- 2006-08-24 RS RS20130288A patent/RS52914B/sr unknown
- 2006-08-24 DK DK06802215.1T patent/DK1926476T3/da active
- 2006-08-28 AR ARP060103739A patent/AR055615A1/es not_active Application Discontinuation
- 2006-08-29 TW TW095131682A patent/TWI398250B/zh not_active IP Right Cessation
2008
- 2008-02-12 US US12/029,691 patent/US7713548B2/en not_active Expired - Fee Related
- 2008-02-13 TN TNP2008000069A patent/TNSN08069A1/en unknown
- 2008-02-18 IL IL189587A patent/IL189587A/en not_active IP Right Cessation
- 2008-02-19 EC EC2008008203A patent/ECSP088203A/es unknown
- 2008-02-21 CR CR9750A patent/CR9750A/es unknown
- 2008-02-28 HN HN2008000360A patent/HN2008000360A/es unknown
- 2008-03-14 NO NO20081364A patent/NO20081364L/no not_active Application Discontinuation
- 2008-03-17 MA MA30752A patent/MA29783B1/fr unknown

Also Published As

Publication number	Publication date
RS52914B (sr)	2014-02-28
MA29783B1 (fr)	2008-09-01
WO2007027494A3 (en)	2007-08-02
ES2414434T3 (es)	2013-07-19
EA200800713A1 (ru)	2008-10-30
HN2008000360A (es)	2011-05-31
TNSN08069A1 (en)	2009-07-14
CR9750A (es)	2008-06-18
CA2619438A1 (en)	2007-03-08
WO2007027494A2 (en)	2007-03-08
EP1926476A2 (en)	2008-06-04
EP1926476B1 (en)	2013-04-10
EA015715B1 (ru)	2011-10-31
IL189587A0 (en)	2008-08-07
AR055615A1 (es)	2007-08-29
SI1926476T1 (sl)	2013-07-31
ZA200801893B (en)	2009-08-26
US7713548B2 (en)	2010-05-11
BRPI0615609A2 (pt)	2011-05-24
IL189587A (en)	2012-12-31
AU2006285111B2 (en)	2012-04-26
PL1926476T3 (pl)	2013-08-30
TWI398250B (zh)	2013-06-11
JP5026426B2 (ja)	2012-09-12
DK1926476T3 (da)	2013-07-01
HK1124785A1 (zh)	2009-07-24
HRP20130533T1 (en)	2013-07-31
UA93517C2 (en)	2011-02-25
CN101272767B (zh)	2012-08-29
NO20081364L (no)	2008-04-03
NZ566313A (en)	2011-04-29
PT1926476E (pt)	2013-07-10
CN101272767A (zh)	2008-09-24
KR20080061354A (ko)	2008-07-02
AU2006285111B8 (en)	2012-05-17
ECSP088203A (es)	2008-06-30
ME01560B (me)	2014-04-20
AU2006285111A1 (en)	2007-03-08
JP2009506114A (ja)	2009-02-12
US20080160080A1 (en)	2008-07-03

Legal Events

Date	Code	Title	Description
2016-03-11	MM4A	Annulment or lapse of patent due to non-payment of fees

Publication	Publication Date	Title
TNSN08069A1 (en)	2009-07-14	Amorphous solid dispersions of 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5,-dihydro-4h-pyridazino[4,5 b] indole -1- acetamide
WO2008066630A3 (en)	2008-11-06	Methods for reprogramming adult somatic cells and uses thereof
WO2007067315A3 (en)	2007-12-06	Ion sources, systems and methods
EP2223921B8 (en)	2013-02-20	2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents
SG153834A1 (en)	2009-07-29	1-aza-bicyclo[3.3.1]nonanes
WO2008027600A3 (en)	2008-04-24	Imatinib compositions
WO2007011741A3 (en)	2008-01-17	Stable organic devices
WO2007073554A3 (en)	2007-11-08	Block copolymer particles
WO2005099754A3 (en)	2006-03-09	Maytansinoid analogs as antitumor agents
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