TW200730518A - Crystalline forms of docetaxel and processes for their preparation - Google Patents
Crystalline forms of docetaxel and processes for their preparationInfo
- Publication number
- TW200730518A TW200730518A TW095137557A TW95137557A TW200730518A TW 200730518 A TW200730518 A TW 200730518A TW 095137557 A TW095137557 A TW 095137557A TW 95137557 A TW95137557 A TW 95137557A TW 200730518 A TW200730518 A TW 200730518A
- Authority
- TW
- Taiwan
- Prior art keywords
- docetaxel
- processes
- preparation
- crystalline forms
- crystalline docetaxel
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 3
- 229960003668 docetaxel Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72532105P | 2005-10-12 | 2005-10-12 | |
| US72664705P | 2005-10-17 | 2005-10-17 | |
| US73687005P | 2005-11-16 | 2005-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200730518A true TW200730518A (en) | 2007-08-16 |
Family
ID=37907299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095137557A TW200730518A (en) | 2005-10-12 | 2006-10-12 | Crystalline forms of docetaxel and processes for their preparation |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20070142457A1 (zh) |
| EP (1) | EP1819688A2 (zh) |
| JP (1) | JP2008523111A (zh) |
| KR (1) | KR20070088784A (zh) |
| BR (1) | BRPI0606132A2 (zh) |
| CA (1) | CA2620308A1 (zh) |
| TW (1) | TW200730518A (zh) |
| WO (1) | WO2007044950A2 (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0615265A8 (pt) | 2005-08-31 | 2018-03-06 | Abraxis Bioscience Llc | composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos |
| US8034765B2 (en) * | 2005-08-31 | 2011-10-11 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
| KR100995390B1 (ko) | 2006-01-02 | 2010-11-19 | 주식회사 삼양제넥스 | 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법 |
| AU2007226937A1 (en) | 2006-03-21 | 2007-09-27 | Dr. Reddy's Laboratories Ltd. | Docetaxel polymorphs and processes |
| JP2010506932A (ja) * | 2006-10-20 | 2010-03-04 | シノファーム シンガポール ピーティーイー，リミテッド | 結晶性の無水ドセタキセルの製造方法 |
| KR100878455B1 (ko) * | 2007-04-10 | 2009-01-13 | 한미약품 주식회사 | 안정한 무수결정형 도세탁셀 및 이의 제조방법 |
| WO2009006590A2 (en) * | 2007-07-04 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Docetaxel process and polymorphs |
| CN101337951B (zh) * | 2007-07-06 | 2011-09-14 | 江苏恒瑞医药股份有限公司 | 一种多烯紫杉醇无水结晶物的制备方法 |
| FR2926551A1 (fr) * | 2008-01-17 | 2009-07-24 | Aventis Pharma Sa | Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation |
| KR101068230B1 (ko) * | 2009-03-03 | 2011-09-28 | 정규능 | 도세탁셀의 제조방법, 그 중간체 및 이의 제조방법 |
| JP5824511B2 (ja) | 2010-05-03 | 2015-11-25 | テイコク ファーマ ユーエスエー インコーポレーテッド | 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法 |
| KR20120096200A (ko) * | 2011-02-22 | 2012-08-30 | 동아제약주식회사 | 결정형 도세탁셀 및 이의 제조방법 |
| CN103764637A (zh) * | 2011-04-12 | 2014-04-30 | 普拉斯化学品有限公司 | 卡巴他赛的固态形式及其制备方法 |
| TWI526437B (zh) * | 2011-09-09 | 2016-03-21 | 台灣神隆股份有限公司 | 卡巴他賽之結晶型 |
| US8633240B2 (en) | 2012-06-01 | 2014-01-21 | The University Of Utah Research Foundation | Paclitaxel trihydrates and methods of making thereof |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| US10500285B2 (en) | 2015-05-15 | 2019-12-10 | Zhuhai Beihai Biotech Co., Ltd. | Docetaxel and human serum albumin complexes |
| CN115487312B (zh) | 2016-10-27 | 2025-02-07 | 珠海贝海生物技术有限公司 | 多西他赛和人血清白蛋白的中性pH组合物 |
| CN108822062B (zh) * | 2018-09-07 | 2020-08-28 | 无锡紫杉药业有限公司 | 一种多西他赛的精制方法 |
| US20230190699A1 (en) | 2020-02-04 | 2023-06-22 | Zhuhai Beihai Biotech Co., Ltd. | Formulations of docetaxel |
| US20250152551A1 (en) | 2022-02-25 | 2025-05-15 | Zhuhai Beihai Biotech Co., Ltd. | Docetaxel compositions and methods |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2703049B1 (fr) * | 1993-03-22 | 1995-04-21 | Rhone Poulenc Rorer Sa | Procédé de purification des taxoïdes. |
| FR2722191B1 (fr) * | 1994-07-08 | 1996-08-23 | Rhone Poulenc Rorer Sa | Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle |
| US5681846A (en) * | 1995-03-17 | 1997-10-28 | Board Of Regents, The University Of Texas System | Extended stability formulations for paclitaxel |
| DE19518082A1 (de) * | 1995-05-17 | 1996-11-21 | Merck Patent Gmbh | 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one |
| US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| CU22723A1 (es) * | 1997-04-02 | 2002-02-28 | Dalmer Lab Sa | Mezcla de ácidos grasos primarios de alto peso molecular obtenidos de la cera de cana de azúcar y sus usos farmacéuticos |
| EP1451168A4 (en) * | 2001-11-30 | 2005-08-24 | Bristol Myers Squibb Co | PACLITAXELSOLVATE |
| US6838569B2 (en) * | 2002-12-16 | 2005-01-04 | Dabur India Limited | Process for preparation of paclitaxel trihydrate and docetaxel trihydrate |
| CN1805968A (zh) * | 2003-06-18 | 2006-07-19 | 明治制果株式会社 | 结晶卡巴培南中间体 |
-
2006
- 2006-10-12 TW TW095137557A patent/TW200730518A/zh unknown
- 2006-10-12 EP EP06826004A patent/EP1819688A2/en not_active Withdrawn
- 2006-10-12 CA CA002620308A patent/CA2620308A1/en not_active Abandoned
- 2006-10-12 KR KR1020077015857A patent/KR20070088784A/ko not_active Ceased
- 2006-10-12 BR BRPI0606132-0A patent/BRPI0606132A2/pt not_active IP Right Cessation
- 2006-10-12 JP JP2007545751A patent/JP2008523111A/ja active Pending
- 2006-10-12 WO PCT/US2006/040308 patent/WO2007044950A2/en not_active Ceased
- 2006-10-12 US US11/580,626 patent/US20070142457A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070142457A1 (en) | 2007-06-21 |
| JP2008523111A (ja) | 2008-07-03 |
| EP1819688A2 (en) | 2007-08-22 |
| WO2007044950A3 (en) | 2007-06-14 |
| KR20070088784A (ko) | 2007-08-29 |
| CA2620308A1 (en) | 2007-04-19 |
| BRPI0606132A2 (pt) | 2009-06-02 |
| WO2007044950A2 (en) | 2007-04-19 |
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