TW200740807A - Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein - Google Patents
Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced thereinInfo
- Publication number
- TW200740807A TW200740807A TW095122521A TW95122521A TW200740807A TW 200740807 A TW200740807 A TW 200740807A TW 095122521 A TW095122521 A TW 095122521A TW 95122521 A TW95122521 A TW 95122521A TW 200740807 A TW200740807 A TW 200740807A
- Authority
- TW
- Taiwan
- Prior art keywords
- piperazine derivatives
- triazole substituted
- salt forms
- novel salt
- forms produced
- Prior art date
Links
- 150000004885 piperazines Chemical class 0.000 title abstract 3
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 125000001425 triazolyl group Chemical group 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical group 0.000 title 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69300405P | 2005-06-22 | 2005-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200740807A true TW200740807A (en) | 2007-11-01 |
Family
ID=37460063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095122521A TW200740807A (en) | 2005-06-22 | 2006-06-22 | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7601715B2 (zh) |
| EP (1) | EP1907389B1 (zh) |
| JP (1) | JP5010593B2 (zh) |
| CN (1) | CN101243085A (zh) |
| AR (1) | AR055801A1 (zh) |
| AT (1) | ATE517898T1 (zh) |
| ES (1) | ES2368788T3 (zh) |
| NO (1) | NO341136B1 (zh) |
| PE (1) | PE20070122A1 (zh) |
| TW (1) | TW200740807A (zh) |
| WO (1) | WO2007002308A2 (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601715B2 (en) * | 2005-06-22 | 2009-10-13 | Bristol-Myers Squibb Company | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
| US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
| JP2011527689A (ja) * | 2008-07-08 | 2011-11-04 | リヒター ゲデオン エヌワイアールティー． | ２−［４−（４−フルオロ−ベンジル）−ピペリジン−１−イル］−２−オキソ−ｎ−（２−オキソ−２，３−ジヒドロ−ベンゾオキサゾール−６−イル）−アセトアミドの結晶形態 |
| EP2323633B1 (en) * | 2008-09-04 | 2012-03-21 | Bristol-Myers Squibb Company | Stable pharmaceutical composition for optimized delivery of an hiv attachment inhibitor |
| EP2552893B1 (en) | 2010-03-31 | 2014-10-29 | Actelion Pharmaceuticals Ltd. | Antibacterial isoquinolin-3-ylurea derivatives |
| WO2011130500A1 (en) * | 2010-04-16 | 2011-10-20 | Novartis Ag | Formulations of a pyridazine bipyrazinyl |
| US20110263701A1 (en) * | 2010-04-21 | 2011-10-27 | Sigal Blau | Gabapentin enacarbil compositions |
| CN102372707B (zh) * | 2010-08-16 | 2015-08-19 | 上海药明康德新药开发有限公司 | 6-甲基-4-溴-1,6-二氢吡咯[2,3-c]吡啶-7-酮的合成方法 |
| CN103339130B (zh) | 2011-01-31 | 2015-05-06 | 百时美施贵宝公司 | 制备hiv附着抑制剂前药化合物的方法及中间体 |
| CN102993109A (zh) * | 2012-12-03 | 2013-03-27 | 浙江工业大学 | 一种脒化合物的制备方法 |
| CN105793263B (zh) | 2013-12-05 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 一种苯并[e]薁化合物及其晶型的合成 |
| AR099677A1 (es) | 2014-03-07 | 2016-08-10 | Sumitomo Chemical Co | Compuesto heterocíclico fusionado y su uso para el control de plagas |
| CN108863917A (zh) * | 2017-05-16 | 2018-11-23 | 穆云 | 一种2,5-二甲氧基吡啶的制备方法 |
| EP3911651B1 (en) | 2019-01-17 | 2024-01-10 | ViiV Healthcare UK (No.4) Limited | Process for preparing fostemsavir |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3545461B2 (ja) | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | 二環式ヘテロ環含有スルホンアミド誘導体 |
| ZA949293B (en) | 1993-12-08 | 1995-08-17 | Nihon Nohyaku Co Ltd | Hydrazine derivatives and uses thereof |
| US20020061892A1 (en) | 2000-02-22 | 2002-05-23 | Tao Wang | Antiviral azaindole derivatives |
| US6476034B2 (en) | 2000-02-22 | 2002-11-05 | Bristol-Myers Squibb Company | Antiviral azaindole derivatives |
| RU2303038C2 (ru) | 2001-02-02 | 2007-07-20 | Бристол-Маерс Сквибб Компани | Азаиндолоксоуксусные производные пиперазины и фармацевтическая композиция на их основе |
| US20030207910A1 (en) | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20040063744A1 (en) | 2002-05-28 | 2004-04-01 | Tao Wang | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
| US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| US20060100432A1 (en) | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US7601715B2 (en) | 2005-06-22 | 2009-10-13 | Bristol-Myers Squibb Company | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
-
2006
- 2006-06-19 US US11/455,338 patent/US7601715B2/en active Active
- 2006-06-21 EP EP06785355A patent/EP1907389B1/en active Active
- 2006-06-21 ES ES06785355T patent/ES2368788T3/es active Active
- 2006-06-21 JP JP2008518395A patent/JP5010593B2/ja active Active
- 2006-06-21 CN CNA2006800304477A patent/CN101243085A/zh active Pending
- 2006-06-21 AR ARP060102666A patent/AR055801A1/es unknown
- 2006-06-21 WO PCT/US2006/024335 patent/WO2007002308A2/en not_active Ceased
- 2006-06-21 AT AT06785355T patent/ATE517898T1/de not_active IP Right Cessation
- 2006-06-22 PE PE2006000714A patent/PE20070122A1/es not_active Application Discontinuation
- 2006-06-22 TW TW095122521A patent/TW200740807A/zh unknown
-
2007
- 2007-12-20 NO NO20076575A patent/NO341136B1/no not_active IP Right Cessation
-
2009
- 2009-08-27 US US12/548,809 patent/US7968718B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE517898T1 (de) | 2011-08-15 |
| JP2008546795A (ja) | 2008-12-25 |
| JP5010593B2 (ja) | 2012-08-29 |
| NO341136B1 (no) | 2017-08-28 |
| AR055801A1 (es) | 2007-09-05 |
| US20060293304A1 (en) | 2006-12-28 |
| WO2007002308A2 (en) | 2007-01-04 |
| PE20070122A1 (es) | 2007-03-11 |
| EP1907389A2 (en) | 2008-04-09 |
| US20100076191A1 (en) | 2010-03-25 |
| CN101243085A (zh) | 2008-08-13 |
| US7601715B2 (en) | 2009-10-13 |
| ES2368788T3 (es) | 2011-11-22 |
| WO2007002308A3 (en) | 2007-07-12 |
| WO2007002308A9 (en) | 2007-03-01 |
| NO20076575L (no) | 2008-03-18 |
| US7968718B2 (en) | 2011-06-28 |
| EP1907389B1 (en) | 2011-07-27 |
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