ATE517898T1 - Verfahren zur herstellung von triazolsubstituierten azaindoloxoessigsäurepiperazinderivaten und dabei hergestellte neue salzformen - Google Patents
Verfahren zur herstellung von triazolsubstituierten azaindoloxoessigsäurepiperazinderivaten und dabei hergestellte neue salzformenInfo
- Publication number
- ATE517898T1 ATE517898T1 AT06785355T AT06785355T ATE517898T1 AT E517898 T1 ATE517898 T1 AT E517898T1 AT 06785355 T AT06785355 T AT 06785355T AT 06785355 T AT06785355 T AT 06785355T AT E517898 T1 ATE517898 T1 AT E517898T1
- Authority
- AT
- Austria
- Prior art keywords
- azaindoloxoacetic
- substituted
- salt forms
- produced therefrom
- piperazine derivatives
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical group 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69300405P | 2005-06-22 | 2005-06-22 | |
| PCT/US2006/024335 WO2007002308A2 (en) | 2005-06-22 | 2006-06-21 | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517898T1 true ATE517898T1 (de) | 2011-08-15 |
Family
ID=37460063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06785355T ATE517898T1 (de) | 2005-06-22 | 2006-06-21 | Verfahren zur herstellung von triazolsubstituierten azaindoloxoessigsäurepiperazinderivaten und dabei hergestellte neue salzformen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7601715B2 (de) |
| EP (1) | EP1907389B1 (de) |
| JP (1) | JP5010593B2 (de) |
| CN (1) | CN101243085A (de) |
| AR (1) | AR055801A1 (de) |
| AT (1) | ATE517898T1 (de) |
| ES (1) | ES2368788T3 (de) |
| NO (1) | NO341136B1 (de) |
| PE (1) | PE20070122A1 (de) |
| TW (1) | TW200740807A (de) |
| WO (1) | WO2007002308A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601715B2 (en) * | 2005-06-22 | 2009-10-13 | Bristol-Myers Squibb Company | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
| US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
| EA201170007A1 (ru) * | 2008-07-08 | 2011-08-30 | Рихтер Гедеон Нирт. | Новая кристаллическая форма 2-[4-(4-фторбензил)пиперидин-1-ил]-2-оксо-n-(2-оксо-2,3-дигидробензоксазол-6-ил)ацетамида |
| CN102143739B (zh) * | 2008-09-04 | 2014-12-17 | 百时美施贵宝公司 | 用于最优化传递hiv附着抑制剂的稳定的药用组合物 |
| EP2552893B1 (de) | 2010-03-31 | 2014-10-29 | Actelion Pharmaceuticals Ltd. | Antibakterielle isochinolin-3-ylurea-derivate |
| AR080908A1 (es) * | 2010-04-16 | 2012-05-16 | Novartis Ag | Formulaciones de un piridazin -bipirazinilo |
| US20110263701A1 (en) * | 2010-04-21 | 2011-10-27 | Sigal Blau | Gabapentin enacarbil compositions |
| CN102372707B (zh) * | 2010-08-16 | 2015-08-19 | 上海药明康德新药开发有限公司 | 6-甲基-4-溴-1,6-二氢吡咯[2,3-c]吡啶-7-酮的合成方法 |
| PT2670751E (pt) | 2011-01-31 | 2015-07-29 | Bristol Myers Squibb Co | Métodos de fabrico de um composto profármaco inibidor da fixação do vih e intermediários |
| CN102993109A (zh) * | 2012-12-03 | 2013-03-27 | 浙江工业大学 | 一种脒化合物的制备方法 |
| HRP20210966T1 (hr) * | 2013-12-05 | 2021-09-17 | F. Hoffmann - La Roche Ag | Sinteza trans-8-kloro-5-metil-1-[4-(piridin-2-iloksi)-cikloheksil]-5,6-dihidro-4h-2,3,5,10b-tetraazabenzo[e]azulena i njegovih kristalnih oblika |
| AR099677A1 (es) | 2014-03-07 | 2016-08-10 | Sumitomo Chemical Co | Compuesto heterocíclico fusionado y su uso para el control de plagas |
| CN108863917A (zh) * | 2017-05-16 | 2018-11-23 | 穆云 | 一种2,5-二甲氧基吡啶的制备方法 |
| EP3911651B1 (de) | 2019-01-17 | 2024-01-10 | ViiV Healthcare UK (No.4) Limited | Verfahren zur herstellung von fostemsavir |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3545461B2 (ja) | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | 二環式ヘテロ環含有スルホンアミド誘導体 |
| ZA949293B (en) | 1993-12-08 | 1995-08-17 | Nihon Nohyaku Co Ltd | Hydrazine derivatives and uses thereof |
| US20020061892A1 (en) | 2000-02-22 | 2002-05-23 | Tao Wang | Antiviral azaindole derivatives |
| US6476034B2 (en) | 2000-02-22 | 2002-11-05 | Bristol-Myers Squibb Company | Antiviral azaindole derivatives |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| PL364279A1 (en) | 2001-02-02 | 2004-12-13 | Bristol-Myers Squibb Company | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20030207910A1 (en) | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20040063744A1 (en) | 2002-05-28 | 2004-04-01 | Tao Wang | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
| US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| US20060100432A1 (en) | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US7601715B2 (en) | 2005-06-22 | 2009-10-13 | Bristol-Myers Squibb Company | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
-
2006
- 2006-06-19 US US11/455,338 patent/US7601715B2/en active Active
- 2006-06-21 AT AT06785355T patent/ATE517898T1/de not_active IP Right Cessation
- 2006-06-21 ES ES06785355T patent/ES2368788T3/es not_active Expired - Lifetime
- 2006-06-21 CN CNA2006800304477A patent/CN101243085A/zh active Pending
- 2006-06-21 WO PCT/US2006/024335 patent/WO2007002308A2/en not_active Ceased
- 2006-06-21 JP JP2008518395A patent/JP5010593B2/ja not_active Expired - Lifetime
- 2006-06-21 EP EP06785355A patent/EP1907389B1/de not_active Expired - Lifetime
- 2006-06-21 AR ARP060102666A patent/AR055801A1/es unknown
- 2006-06-22 TW TW095122521A patent/TW200740807A/zh unknown
- 2006-06-22 PE PE2006000714A patent/PE20070122A1/es not_active Application Discontinuation
-
2007
- 2007-12-20 NO NO20076575A patent/NO341136B1/no not_active IP Right Cessation
-
2009
- 2009-08-27 US US12/548,809 patent/US7968718B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007002308A2 (en) | 2007-01-04 |
| NO341136B1 (no) | 2017-08-28 |
| EP1907389A2 (de) | 2008-04-09 |
| US20060293304A1 (en) | 2006-12-28 |
| AR055801A1 (es) | 2007-09-05 |
| US7968718B2 (en) | 2011-06-28 |
| WO2007002308A9 (en) | 2007-03-01 |
| ES2368788T3 (es) | 2011-11-22 |
| WO2007002308A3 (en) | 2007-07-12 |
| EP1907389B1 (de) | 2011-07-27 |
| TW200740807A (en) | 2007-11-01 |
| PE20070122A1 (es) | 2007-03-11 |
| CN101243085A (zh) | 2008-08-13 |
| JP5010593B2 (ja) | 2012-08-29 |
| US7601715B2 (en) | 2009-10-13 |
| JP2008546795A (ja) | 2008-12-25 |
| US20100076191A1 (en) | 2010-03-25 |
| NO20076575L (no) | 2008-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |