TW201102372A - Indane analogs and use as pharmaceutical agents and process of making - Google Patents

Indane analogs and use as pharmaceutical agents and process of making Download PDF

Info

Publication number: TW201102372A
Authority: TW; Taiwan
Prior art keywords: group; compound; alkyl; doc; disease
Prior art date: 2009-06-04

Application number

TW099118309A

Other languages

English (en)

Chinese (zh)

Inventor

Kenneth James Ingold

Mary Katherine Delmedico

Original Assignee

Dara Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-04

Filing date

2010-06-04

Publication date

2011-01-16

2010-06-04 Application filed by Dara Biosciences Inc filed Critical Dara Biosciences Inc

2011-01-16 Publication of TW201102372A publication Critical patent/TW201102372A/zh

Links

238000000034 method Methods 0.000 title claims abstract description 92
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125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 title 1
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238000011282 treatment Methods 0.000 claims abstract description 43
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 16
238000002360 preparation method Methods 0.000 claims abstract description 15
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OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
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BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
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GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

TW099118309A 2009-06-04 2010-06-04 Indane analogs and use as pharmaceutical agents and process of making TW201102372A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18414909P	2009-06-04	2009-06-04

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TW201102372A true TW201102372A (en)	2011-01-16

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TW (1)	TW201102372A (fr)
WO (1)	WO2010141690A2 (fr)

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EP3378472A1 (fr) *	2012-08-09	2018-09-26	Dynamis Therapeutics, Inc.	Combinaisons avec de la méglumine
WO2025054309A1 (fr) *	2023-09-07	2025-03-13	T3D Therapeutics, Inc.	Procédés d'identification et de traitement de patients atteints d'une maladie neurodégénérative sur la base de niveaux de biomarqueurs plasmatiques

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JP4590158B2 (ja) *	2001-04-04	2010-12-01	オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド	グルコース再吸収阻害剤およびレチノイド−ｘ受容体モジュレーターを含んで成る併用療法
AR036237A1 (es) *	2001-07-27	2004-08-25	Bayer Corp	Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento
CA2529036A1 (fr) *	2003-07-03	2005-02-03	Eli Lilly And Company	Derives d'indane utilises comme agonistes du recepteur muscarinique

2010
- 2010-06-03 WO PCT/US2010/037216 patent/WO2010141690A2/fr not_active Ceased
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WO2010141690A2 (fr)	2010-12-09
WO2010141690A3 (fr)	2011-01-27

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