TW201200022A - Pesticidal composition - Google Patents

Abstract

An agrochemical composition is provided, the composition comprising a C2-C4 dialkylene glycol di-/mono- C1-C4 alkyl ether, at least one benzoylphenyl urea active ingredient and optionally at least one member selected from the group consisting of a surface-active agent, an organic polar solvent and a low temperature stabilizer. The presence of the C2-C4 dialkylene glycol di-/mono-C1-C4 alkyl ether reduces the irritancy of the composition, in particular the benzoylphenyl urea active ingredient, to the eyes. The composition is preferably a liquid concentrate, in particular an emulsion concentrate. A method of controlling pests at a locus using the composition and the use of a C2-C4 dialkylene glycol di-/mono- C1-C4 alkyl ether in reducing the eye irritancy of benzoylphenyl urea active ingredients are also provided.

Description

201200022 VI. Description of the Invention: [Technical Field of the Invention] The present invention relates to a pesticidal composition. The invention particularly relates to compositions comprising one or more phenylnonylphenylurea compounds as active ingredients of insecticides. The invention also relates to a process for the preparation of the aforementioned compositions and to the use of crop protection. More particularly, the present invention relates to compositions which reduce irritation to the eye when a liquid concentrate based on a benzamidine phenylurea insecticide compound is used, and which exhibits reduced eye irritation. [Prior Art] An insect growth regulator comprising one or more phenylf-phenylphenyl urea (BPU) compounds is known in the art for inhibiting insects. Examples of such preparations include active ingredients from the following: diphenylguan gland, wind sputum gland, fluorobell gland, chlorinated gland, de-fine, complex. Urea urea 'Fluididin, Novoflumuron and fluorophenylurea. Benzoylphenyl gland compounds are generally commercially available in the form of emulsions (EC). However, the formulation requires the use of a large amount of an organic solvent such as an aromatic hydrocarbon, a chlorinated hydrocarbon or the like to effectively formulate the active ingredient. However, the organic solvent is known to have toxicological and ecotoxicological properties, which causes toxicological and ecotoxicological problems. Therefore, in addition to the active ingredients present, the US Environmental Protection Agency also reviewed the ingredients in the insecticide formulations. In Europe, the European Community Commission (EEC c〇undl) is in the final stages of the use of volatile organic compounds (VqC) by legislative supervisors, and short-term requirements will be required to contain the VOC. In addition, Canada and the system have also bribed the ecotoxicity system. In order to address the need to use the aromatic hydrocarbons or chlorinated hydrocarbons, alternative solvents have been used in commercial formulations to reduce the toxic effects of the solvent components of the formulation. Examples of the alternative solvent are fatty oil hydrocarbons, alcohols, glycols, polyethylene glycols, lysines and ketones, and polar solvents having high solubility, such as gamma-butyric acid, and methyl groups. Tetrazolium is more than steel and so on. 201200022 The fat oil type is generally low in the solubility of solid insecticides, so it is difficult to produce when it is effective and stable. The above other solvents are suitable for dissolving the insecticide, but at the same time are themselves soluble in water. The solubility in water is a problem when the EC formulation is diluted to prepare a spray for the final application. Water solubility leads to the phenomenon of crystallization of insecticidal active ingredients. The crystallization makes the formulation unsuitable for spraying, in particular causing clogging of the spray equipment, in particular the tubules and nozzles of the apparatus. People have been trying to solve the above problems. For example, W002/45507 describes microemulsions of hydrophobic insecticide compounds in which the active ingredient and at least one surfactant are dissolved in a solvent system comprising water-insoluble hydrophobic butyrate ethyl vinegar (as a - a solvent) and a polyol or a condensate thereof (as a second solvent). It has been reported that the formulation exhibits reduced eye irritation. PCT/EP2GG5/G7256 discloses improved non-aqueous, micro-killing compound formulations with improved storage and dilution stability. The formulation comprises at least one pesticide compound, at least one organic solvent having a water solubility of at least 1 g/l, and at least one nonionic block copolymer (package 3 at least one polyoxyethylene moiety and at least one hydrophobicity) Convergence part). This file does not discuss the problem of eye irritation, and the file does not address the issue. The solvent mixtures and surfactants disclosed in prior art publication A do not provide a solution for all needs. a benzhydrylphenylurea (Bpu) compound (for example selected from the group consisting of bis-fluorofluorourea, guanidine urea, hexaflumuron, triflumuron, diflubenzuron, fluridazine, flubenzuron, polyfluorourea, and fluorine Both benzene and urea are strong fabrics of the eye. Commercial benzhydrylphenylureas are strong eye irritations of the eye, which are caused not only by the solvents and surfactants present in the formulation, but also by the active ingredients present. Therefore, even if the solvent and surfactant used do not irritate the eye, the formulation always exhibits strong irritation due to the characteristics of the active ingredient. - Straight need to find safe (preferably substantially inert) ingredients for concentrate preparations, which not only do not irritate the eyes themselves, but also preferably reduce the active ingredients present (especially benzepyl phenylureas (BPU) ) Compound) irritation to the eye. Unexpectedly, it was found that 'some CrQ bis-alkylene glycol bis/mono_C|_C4 alkyl ether not only does not stab 201200022 ocular eye' and can reduce the benzoylphenylurea compound from the final formulation. Causes irritation to the eyes. SUMMARY OF THE INVENTION The present invention relates to the use of certain CrCt bisalkylene glycol bis/mono-crC4 alkyl ethers for reducing ocular irritation of insecticidal preparations, especially for reducing the active ingredient as an agrochemical preparation. Use of a benzamidine-based urea compound to cause eye irritation. Accordingly, in a first aspect, the present invention provides a pesticidal composition comprising benzamidine phenylurea as an active ingredient and CrC4 bisalkylene glycol bis/mono-crC4 alkyl ether. Studies have found that the presence of one or more CrC» bis-alkylene glycol bis/mono-QC:4 alkyl ethers in formulations containing one or more of the compounds of the genus-based sulfhydryl-based ureas can significantly reduce the formulation. Toxicity, especially to reduce the irritation of the preparation to the eye. It is believed that (^(di-alkylene glycol bis/monoalkyl ether reduces or significantly reduces the irritation of the benzamidine-based urea to the eye. More preferably, in a first aspect, the invention provides a a pesticide composition comprising a QQ bis-alkylene glycol bis/mono-CrQ alkyl ether selected from the group consisting of diethylene glycol dimethyl ether, diethylene glycol f riddle, dipropylene glycol dimethyl mystery, dipropylene glycol (IV) , dibutyl glycol dimethic acid, dibutyl glycol methyl bond, diethylene glycol diethylene (tetra), diethylene glycol ethyl acetate, dipropylene glycol diethylene light, dipropylene glycol, ethylene diacetate, dibutyl glycol diethylene glycol, Dibutylene glycol acetamidine, diethylene glycol dipropyl ether, diethylene glycol propylene bond, dipropylene glycol dipropyl ether, dipropylene glycol propyl ether, dibutylene glycol dipropyl ether, dibutyl glycol propyl ether, diethyl Diol dibutyl ether, - ethyl alcohol butyl hydrazine, dipropylene glycol dibutyl bond, dipropylene glycol butyl sulphate, dibutyl diol dibutyl sulphate, dibutyl succinate, and mixtures thereof. As described above, 'the invention The composition further comprises at least a benzhydryl phenyl gland active ingredient. Suitable phenyl f-phenyl phenyl urea compounds are well known in the art and are commercially available. Optionally, the composition comprises at least one selected from the group consisting of: diphenyl fluorogland, secret gland, fluorobell gland, killing ship, mites, gas, fluoride, polyfluoro and fluorophenylurea. The composition may comprise other components known in the art. Preferably, the composition may comprise 201200022 to J - a component selected from the group consisting of surfactants, organic polar solvents, and low temperature agents. Suitable surfactants Organic polar solvents and stabilizers are well known in the art and are commercially available. In another aspect, the present invention also provides a method of preparing an agriculturally acceptable stable concentrate formulation which comprises one or A plurality of benzoylphenyl dirty active ingredients are combined with a solvent of one or more CrC4 bis-decylene glycol bis/mono-CVC4 alkyl ether. Further, the present invention also provides a CrC4 double subfield base. The use of diol double pools to reduce irritation to the eye, especially when used as an active ingredient in insecticidal formulations. In yet another aspect, the present invention also provides The aforementioned composition is controlling pests (especially In another aspect, the invention also provides a method of controlling a pest (especially an insect) at a location, the method comprising applying to the site a composition as described in the text. Benzoyl phenyl glands are water-insoluble compounds, which are highly irritating to the eyes. Each type of compound is sold in the market in the county. It is irritating to the eyes. The main problem with the preparation of condensed concentrates is that these preparations can cause irritation to the eyes. - The present invention unexpectedly finds that "some CrC4 bis-alkylene diols double/single" The ether is not only non-irritating to the eye' but also reduces the thorns of certain active ingredients, which is the stimulation of the eye by the benzepidine phenylurea in the final preparation. The C2_c4 bisalkylene glycol double / Single_c "The c4 hospital base is present in the composition in an amount that is strong in the foot of the Nagasaki low-grade benzene county. It has been found that CrC4 double-substrate diol bis/mono-CrC4 oxime ether can effectively reduce eye irritation of benzoquinone-based phenyl-based compound. Therefore, in the condensed secret contains one or more kinds 201200022

CrC4 disalkylene glycol bis/mono-Ci-Ct alkyl ether reduces the irritation of the formulation to the eye. In addition, it has been found that CrC4 bisalkylene glycol bis/mono-CK metholane used in the insecticide concentrate is environmentally friendly. i

CrQ bisalkylene glycol bis/mono-CrQ alkyl ether is suitable for the preparation of water-dilutable concentrates of poorly soluble in water or even water-insoluble organic insecticide compounds such as phenyl hydrazino The formulation, in particular, is used to reduce ocular irritation caused by the insecticidal liquid preparation of the insecticide compound. The one or more Q-C4 bis-thylene glycol bis/early-CrC4 hospital bases are present in an amount sufficient to reduce ocular irritation caused by the benzhydryl phenyl urea compound. The amount of (^-(^bis-alkylene glycol bis/mono-C1-C4 ** 趟) required will depend on the concentration of the active ingredient of the phenylhydrinylphenylurea and the particular benzene used in the formulation. Methyl phenylurea. The amount of CrC4 bis-alkylene diol bis/mono-CI-C4 oxime ether used to reduce or eliminate ocular irritation of the formulation can be determined by the skilled person without undue experimentation (eg trial and error). .

The CrQ bisalkylene glycol bis/mono_crC4 alkyl ether is preferably present in an amount such that the benzoylphenyl urea active ingredient pair (: 2_(:4 bisalkylene glycol bis/mono-crc4) The weight ratio of alkyl ether is at least 1: more preferably at least 1:1.5, still more preferably at least 1:2, especially at least 1: 3. In particular, CrC4 bisalkylene glycol bis/single succinimide The alkyl ether is preferably present in an amount such that the weight ratio of the benzepidine phenylurea active ingredient to the CrC4 bisalkylene glycol bis/mono-Ci-C4 alkyl ether is from 1:1 to 1:30. Preferably, it is from 1:2 to 1:2, still more preferably from 1:3 to 1:15. The composition may contain a single CrC4 bisalkylene glycol bis/mono-CrC4 alkyl ether, or two More or more (: combination of a broad-spectrum bis-alkylene glycol bis/mono-CVCt alkyl ether. According to a preferred embodiment of the invention, the CrCj bis-alkylene glycol bis/mono-CrQ alkyl group The ether is at least one member selected from the group consisting of diethylene glycol dimethyl ether, diethylene glycol methyl ether, dipropylene glycol dimethyl ether, dipropylene glycol methyl ether, dibutyl glycol dimethyl ether, dibutyl glycol methyl ether , diethylene glycol diethyl bond, diethylene glycol ether Dipropylene glycol di 2> ether, dipropylene glycol diethyl ether, dibutyl glycol diethyl ether, dibutyl glycol diethyl ether, diethylene glycol dipropyl ether, diethylene glycol propyl ether, dipropylene glycol dipropyl ether, monopropanol Key, dibutylene glycol dipropylene bond, dibutyl glycol propylene scale, diethylene glycol, monobutyl bond, monoethylene glycol butyl ether, dipropylene glycol dibutyl ether, dipropylene glycol butyl ether, dibutyl glycol dibutyl Ether, dibutyl glycol 201200022 butyl ether and mixtures thereof. The composition of the present invention can be mixed. The composition of the present invention is usually a concentrate, especially an emulsion (EC). The amount of bis-alkylene glycol bis/mono-c-alkyl ether will depend on the amount, number and nature of the other ingredients of the composition towel. In particular, the one or more C2_C4 bis-alkylene groups The alcohol bis/mono-CK:4 alkyl group-amount may be present in an amount of 1% by weight, preferably at least 2% by weight, more preferably at least, especially at least 35% by weight of the leaf. CrC4 bis-base diol material - The OQ filament break weight is present in the composition in an amount of 2 to 5, more preferably 10 to 75%. It has been found that in many embodiments, the C2_C4 double sub-base II The double/single "4:^ fine amount is 35 to 75% is suitable. As mentioned above, it has been found that crC4 double sub-based diol bis/mono-CrQ alkyl ether can effectively reduce some of the active agricultural use. The benzoquinone-based compound of the compound (especially an insecticide) is irritating to the eye. The composition may comprise a combination of two or more benzhydrylphenyl urea derivatives as an active ingredient. In a real financial case, the ship's surface is activated from the following benzene and benzene fine petals. Diphenylfluorourea, scorpion, hexaflumuron, chlorpyrifos, mites, fluorosis, gas Insect glands, polyfluoroureas, fluorobenzamides, and mixtures thereof. The sulfhydryl groups and the pharmaceutically acceptable components may be present in any suitable amount. Preferably, the benzyl myristyl urea is present in an amount of at least 2%, more preferably at least 3%, still more preferably at least % by weight. The amount of the benzoyl phenylurea may be 2 to 5 % by weight, preferably 3 to, more preferably most, 4 to 40% by weight. It has been found that in many embodiments, the amount of benzammonose is from 5 to 35% by weight is particularly preferred. The composition of the present invention may further comprise other groups well known in the art, in addition to the active ingredient of the crc4 double-silk diol double KrC4 alkyl ether and one or more phenyl phenyl phenyl urea derivatives. Minute. Such fractions may include, for example, thief-country heterogeneous solvents and emulsions, which are well known in the art and are commercially available. A suitable organic polar agent comprises one or more alcohols such as benzyl alcohol, one or more leucoindene ketones such as [Sf-methyl 吼 鲷 鲷, N _ 辛 咖 各 或者 或者 或者 或者 or one or more Vinegar such as Ding 201200022 acid vinegar. Other suitable solvents The beta solvents well known to those skilled in the art may be present in any suitable amount. In particular, the amount of the solvent may range from 90% by weight of the composition, preferably from μ to 75%, more preferably from 2 to 6〇0/〇. In order for the present invention to be ecologically acceptable, it is preferred that the composition comprise one or more surfactants. Preferably, the lipophilic portion of the surfactant is derived from a safe natural product. Such surface active pros are often found in food and cosmetic needles. Combinations of the Invention: Preferred surfactants are those having a Η丄.Β between 7 and 17. Suitable surface-active compounds are nonionic, cationic and/or anionic surfactants, or mixtures of said surfactants, depending on the nature of the compound to be formulated, said surfactant or surfactant mixture having Good emulsification, dispersion and wetting ability. Preferred nonionic surfaces are difficult to formulate polyoxyethylene lining oil, polymer and polyoxyethylene addition polymers, tributyl fine ethoxylate, polyethylene glycol, and octyl benzoyl oxyethylene. Fatty acid vinegar of polyoxyethylene sorbitan (Pdy〇xye_eneSGrbitan) (e.g., polyoxyethylene sorbitan trioleate) is also a suitable nonionic surfactant. The U.S. surface active carrier of the composition cap of the present invention includes a quarter-salt salt having at least one CrC22 yard base as a substitute base, and an unsubstituted or toothed lower-grade yard base or a base or other substituent. Jingji-low-level courtyard. The salt is preferably in the form of a amide, dimethyl sulphate or diacetic sulphate. Examples of the cationic surfactant include stearyltrimethyl gasification and phenylbis(2-vaporethyl)ethylammonium bromide. Suitable anionic surfactants for use in the compositions include water soluble fatty acid salts and water soluble synthetic surface active compounds, aryl aryl rhodamine. A typical example of a aryl aryl acid salt is a sodium, about or triethanol salt of a decyl benzoic acid, a dibutyl phthalate or a condensate of a naphthene and a hydrazine. Correspondingly, the acid salt (e.g., a salt of a phosphate ester of an alkylene benzene of 4 to 14 moles of an epoxy compound) is also suitable. The surface active surface-active conjugate can be present in the composition in any suitable amount. Preferably, the surfactant is present in an amount of from 5 to 4% by weight, more preferably from 5 to 35%, still more preferably from 1 to 30% by weight. It has been found that in many embodiments, a surfactant concentration of from 2% to 3% by weight of the 201200022 agent is particularly suitable. The other components included in the composition are "\", which is well known in the art and includes, for example, stabilizers and sputums, which are known and understood by the skilled artisans. "r-μ tree The wolf is supplied - the species contains phenyl silk gland and CrQ bis-alkylene glycol bis/mono-CrC4 alkyl ether. The ruthenium component of 匕3 in the * condensed liquid is as described above. The liquid group is given in the foregoing. In another aspect, the present invention provides a double-silk diol double #«4 ndyl ether (excellent, CrC4 double-silk diol double/single wire (6) as described in the month j is used for Use of ocular eye to reduce insecticidal activity. The composition of the present invention can be prepared using techniques known in the art of the field. A particularly preferred method for preparing the composition is as follows: Add each component according to the required 4 parts of the final composition. First, add the required solvent and one or more kinds of CrQ bis-substrate diol bis/single Ci_c4 decyl ether to a suitable mixing container. (for example, a mixing tank) a mixture obtained by adding Na- or a plurality of phenyl-based derivatives to the mixture, The benzophenanthene-based benzene derivative is completely soluble in the glutamics. The _ is usually about 3G minutes. Thereafter, other ingredients such as emulsifiers (if any) are added, and the compound is stirred again to ensure uniformity. The agitation time is usually about 1 hour. In another aspect, the present invention provides a method for reducing ocular irritation of a pesticidal liquid preparation containing a benzepidine phenylurea derivative, the method comprising An amount sufficient to reduce the amount of ocular irritation caused by the abbreviated phenylurea derivative (^(^)bisalkylene glycol bis/mono_Cl_C4 趟 趟 (preferably C2-C4 bis Alkyl glycol bis/mono-Q-C4 alkyl ether) is added to the formulation. Examples of the invention will be described in more detail by way of example. In each of the following examples, the compositions are formulated according to the following general methods: For the formulation of the preparation, each component is added to the container in the following manner. First, a solvent and a C2-C4 disalkylene glycol bis/mono-CrC4 alkyl ether are added to the mixing tank 20120022. The mixture is stirred. Add one or more of the mixture in the tank The benzepidine phenylurea active ingredient is stirred for a further 30 minutes until the benzhydrylphenyl urea active ingredient is completely dissolved in the solvent. The emulsifier is added to the mixture in the tank and stirring is continued for one hour until the mixture It has been uniform. Stirring is stopped and the resulting composition is poured out of the mixing tank. The possibility of the preparation causing eye irritation according to NPLuepke: Hen's Egg Chorio

Allantoic Membrane Test for Irritation Potential, Fd. Chem. Toxic. 23 (1985) The method described on pages 287 to 291 (hereinafter referred to as "het-cam test") determines that this method is based on the method of H. Spielmann (H) Spielmann: Methods in Molecular Biology 43 (1995) pp. 199-204 and η. Spielmann et al. ATLA 24 (1996) pp. 741-858) make adjustments. The allantoic chorion membrane was treated with the test sample in the HET-CAM test. The researchers observed the urinary choriocapilla for five minutes' observations of coagulation, coagulation, and vascular dissolution. Depending on the time of onset and the severity of the symptoms, the test samples are classified into the following categories: Terpenoids: Severe irritant Class I: Irritant Class II: Slightly irritating Class III: Non-irritating, compositions of the invention ( The composition and ocular behavior of the preparation and test as described above are described in the comparison results given in the following examples and tables. EXAMPLES The liquid preparations described in Table 1 were prepared, which contained the indicated double-combined __ __ about 1:13. The cis to the eye and the second liquid a first liquid preparation were prepared in the same manner using the same fraction 12 201200022, but did not contain any CVC4 disalkylene glycol as an eye irritation slowing agent. Bi/single_C|_c4 alkyl bond. The formulation of Example 1 contained 65% by weight of CrC4 bisalkylene glycol bis/monochatty ether. Table 1 describes the liquid formulation of Comparative Example 1 and a comparative formulation (Comparative A). Table 1 Example 1. Urea-urea ritual (including eye irritation; comparison A: bismuth urea emulsion (excluding 备 remarking mitigator) g stimulator) 4 component rT HF? Pt composition 1 component composition脉原乐 5〇kg (as pure product) 1 虱螨 urea original drug νί Λ ί J 5〇 kg (as pure product) active ingredient 12-alkyl benzoic acid sodium-L, , Tian / ΊΓΛΧ / ΈΈΧΤ, 〇 λ 100 kg — ---- ^ j -------- j dodecapine benzoic acid sodium J 100 kg agent qt/mv 1 WritiN ) 80 ethoxylated water loss Yamanashi ΐ〇ϋ kg丨Tween 80] Ethoxylated sorbitan Γϊοο^^ Emulsifier alcohol monooleate i monooleate γ-butyric acid 酉 100 kg 1--1—--- 〗 γ-butyric acid Lactone 750 kg solvent diethylene glycol dimethyl hydrazine 650 kg Ί---- 1 eye irritation slowing agent total 1000 kg-----^r~r-------- 3 total 1 1000 kg implementation Example 2 - cc liquid preparation 'which contains the indicated group of di-weig diol bis / single-cp mixed age a urea, its towel bis- _ and CrC4 bis-alkane mei yin double / early «4 burn Based on the 4 spells, the base preparations were compared. = The formulation of the two stimuli eye and a second liquid St. Any crc4 diweityl glycol bis/single & base 201200022 The formulation of Example 2 contained 6% by weight of the indicated (^(^)bisalkylene glycol bis/mono-C1-C4 alkyl ether. Table 2 describes the liquid formulation of Comparative Example 2 and the comparative formulation (Comparative B). Table 2 Example 2: Diphenylfluorourea emulsion (with eye comparison B: bis-fluorofluorourea emulsion (without eye-stimulation stimulator) Agent) Component composition Diphenyl fluorourea original drug 100 kg bis-fluorofluorourea original drug 100 kg active (as pure) (as pure) Didecyl benzoic acid sodium 100 kg dodecyl Sodium benzenesulfonate 100 kg emulsifier i temperature 80 100 kg Tween 80 100 kg emulsifier ethoxylated water loss sorbate ethoxylated sorbitol monooleate monooleic acid S γ-butyric acid s Ι Ι Κ 公斤 ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) The C2_Cj subhotrient diol bis/mono CrC4 alkyl group is shown as a ringing agent as an active ingredient Gland, in which the ratio of the defeated gland to the team's double-substrate double/single-c "c4" is about 1:7·25. This preparation is compared with the second preparation of the eye. The second liquid system is _ the same component is the same as the same = but does not contain the granules _ any CrC4 bis-diyl bis-light 7 single. smoldering base The formulation of Example 3 contains up to 58% by weight of CrC4 bis Table 3 describes the liquid preparation of Comparative Example 3 and the comparative preparation (Comparative c). 疋201200022 Table 3 Remarks Component composition Component Fluoroquinone original drug 80 kg (as Pure) i 12-based benzene- 1 〇〇-hyun-based sodium sulphate composition 8 〇 kg (as pure) 100 kg active ingredient emulsion Tween 80 ethoxylated sorbitan monooleate γ - Butyrolactone---------- Dipropylene glycol dimethyl ether 100 kg 2^1^80 — ; ethoxy ethoxylated sorbitan j-alcohol monooleate 100 kg 620 kg! 1000 Kg< Total 100 kg 720 kg 1000 kg emulsion solvent eye irritation slowing agent Example 4 The liquid preparation described in Table 4 was prepared, which contained an alkylene ether and an active ingredient chlorpyrifos. Trace _ / 4 double-alkylene diol double / single into the _ _ _ _ w two kinds of liquid preparations against the comparison, the second liquid preparation is the 帛 体 体 body is not included as ____ what crQ The formulation prepared in the same manner, but the preparation of Example 4 contained 6 % by weight of mono-C,-C4 alkyl ether. Shouting the ground. Table 4 describes the liquid formulation of Example 4 and the ratio of 4 doses (Abbie = Lai single ^ Table 4 15 201200022 Example 4: Triflumuron emulsion (including a stimulating agent) Comparison D: Triflumuron emulsion (excluding Eye irritation mitigator) --- - Remarks component composition ^ Component composition of chlorfenapyr original drug 50 gong is pure 丨 丨 腺 腺 腺 腺 〇 〇 〇 〇 作为 作为 作为 作为 作为 作为 作为 作为 作为 作为 作为Sodium sodium dodecyl benzene sulfonate 100 kg emulsifier EL360 Ethoxylated sesame oil 100 gong ^^ EL360 ethoxylated lotus oil 100 kg emulsifier N-methylpyrrolidone oxime - methyl 0 than ketone ketone 750 Kilogram of solvent-propylene glycol dimethyl _ 650 eye irritation slowing agent total L----- 1000 kg total 1000 kg Example 5 The liquid listener described in Table 5 was prepared, which contained the CrC4 double-silk diol shown. Bis/monoalkyl ether and active ingredient diflubenzuron, wherein the ratio of diflubenzuron to C2_q disalkylene glycol bis/single Ci, C4 alkyl ether is about 1:6. The irritancy is compared to a second liquid formulation which uses the same components in the same manner Prepared, but without eye irritation slowing agent CrC4 bisalkylene glycol bis / single _C | _C4 ^ base shout. The formulation of Example 5 contains 60% by weight of bisalkylene glycol bis / single _ C "C4 alkyl ether. Table 5 describes the liquid formulation of Comparative Example 5 and a comparative formulation (Comparative E). Table 5 teaches a slowing agent) Diflubenzuron emulsion (containing eye thorns. 除 除 除 脲 urea emulsion (without eyes)箣 注 激 减缓 ) 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 Ethylene dehydrated sorbitol monooleic acid brewed polyoxyethylene oxime water loss Yamanashi: alcohol monooleate γ-butyrolactone 100 jin ~ ~ Dipropylene glycol A shout 600 kg ~ Ί ---.. \ Total 1000 kg [ ^j: ~~-一~- ----___ Example 6 100 kg (as pure product) Active ingredient 100 kg emulsifier emulsifier 100 kg 700 kg ^ Solvent eye irritation reducer 1000 kg Table 6 , its Qiqiu CrQ double Weijidiol bis/single & c hospital fine and active ingredient fluoride collar, wherein a Wei and CrQ double base two material single V burning base _ ratio丨^. Compare the ocular eye _ stimuli with the purchase price of the second residual body preparation, the second general body (four) is the _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ CVCA Weiji II light/single_Crc4 burnt. The formulation of Example 6 contained 4% by weight of CrC4 bis-silylene glycol bis/mono (A silk ether). Table 6 describes the liquid formulation of Comparative Example 6 and the comparative formulation (Comparative F). Table 6 Example 6: Fluriazine emulsion (containing (without eye "reagent mitigation agent": stimulating agent) Component composition 〖Component·/ Λ Composition of chlorfluazuril original drug 200 kg of guanidinium 200 kg of activity (as pure y (as pure product) Ingredients eleven-burning stupid acid sodium e 1 〇〇 kg sodium dodecyl sulfonate 100 kg emulsifier 17 201200022 Tween 80 ^ Ethoxylation 100 kg of sorbitan monooleate - Tween 80 ethoxylated sorbitan monooleate γ-butyrolactone ' 1 200 kg γ-butyrolactone dibutylene glycol dioxime 400 Kilograms'~ total dose of 1000 kg total slowing agent ~^. Example 7 -^. The liquid preparation described in Table 7 was prepared, which contained the CrC4 double sub-house (VQ alkyl ether and active ingredient fluorine) as shown. In the case of worm urea, the light ratio of flubendiamide to hydrazine* bis-bis-alcohol bis/mono-CrC4 sulphur is about i: u. The irritancy of this preparation on the eye is compared with the third alcohol bis/single. 'The second liquid preparation is the same component according to the same side = liquid preparation does not contain eye thorns "supplement agent () 2- (: 4 double hetero base two light / single "way fine : Injured, but the formulation of Example 7 contained 4% by weight of CrC^alkylene glycol bis, a single heptapeptide. Table 7 describes the liquid formulation of Comparative Example 7 and a comparative formulation (Comparative (7). Early lC4 Table 7 Example 7: Flunifluridon emulsion (including eye irritation slowing agent) Comparison G: Fluoridinodusol emulsion (non-irritating slowing agent) Remarks - Component composition of flubendiamide 250 kg (as pure Product) Flumazenil original drug 250 kg (as pure product) Active ingredient sodium dodecyl benzene sulfonate --------- sodium dodecyl benzene sulfonate 100 kg emulsifier σ soil temperature 80 100 Tween 80 100 kg emulsifier ethoxylated water-deficient mountain ethoxylated water-free sorbus 201200022 sorbitol monooleate monooleic acid S γ-butyrolactone 150 Γ / Γ :: γ- Butyrolactone - Λ .. _, -------- 550 kg solvent diethylene glycol ether 400 kg - - ί. :: —— — 1 eye irritation slowing agent total 1000 kg 丨 total - 1000 kg - Example 8 The liquid formulation described in Table 8 was prepared containing the oxime* bis-alkylene glycol bis/mono-CrC4 alkyl ether shown and the active ingredient _, wherein the ratio of polyfluorogland to 仏^ 亚 院 diol diol bis/single _ «4 炫 base is about 1: 12. This preparation is compared with ocular stimuli and the second liquid preparation' The second liquid formulation is prepared in the same manner using the same components, but does not contain any CVQ bisalkylene glycol bis/monoalkyl ether as an eye irritation slowing agent. The formulation of Example 8 contained 6% by weight of Cr (: 4 bis-denylene diol bis/mono_c "C4 alkyl ether. Table 8 describes the liquid formulation and comparative formulation of Example 8 (Comparative H) Table 8 实关8. New ruthless agent (including eye thorn j than positive H: more sloppy injection slowing agent) 1 stimulating slowing agent) -· Component composition 丨 component one--5 composition > mouse urea Original music) υ kg (for 1 polyfluorourea original drug 50 kg (for activity to become pure) 1 is pure) Distillation - Yue basic continuous acid sodium _ kg! Dodecyl benzene sulfonate 100 kg emulsifier Tween 80 Β 0 kg 丨 Tween 8 〇 150 kg emulsifier ethoxylated water loss Yamanashi! Ethoxylated sorbitan monooleate m λ containing alcohol monooleic vinegar sterol - kg 丨Benzyl alcohol 1---- 4 7 〇〇 kg solvent one-in-one alcohol- hex scale--- (> υυ kg eye irritation 201200022 slowing agent total 1000 kg total 1000 kg Example 9 prepared the liquid described in Table 9 a formulation comprising the CrC4 bisalkylene glycol bis/mono-CrC4 alkyl ether and the active ingredient fluorophenylurea, wherein the fluorophenylurea and the CrQ bisalkylene group The ratio of bis/mono-CrC4 alkyl ether is about 1: 15. The irritancy of the formulation to the eye is compared to the second liquid formulation. The second liquid formulation is the same in the same manner. Prepared, but not containing any C2-C4 bisalkylene glycol bis/mono-CrC4 alkyl ether as an eye irritation slowing agent. The formulation of Example 9 contains 60% by weight of crC4 bisalkylene glycol Bi/mono-CrC» alkyl ether. Table 9 describes the liquid formulation of Comparative Example 9 and a comparative formulation (Comparative I). Table 9 Example 9: Fluorobenzene emulsion (Compared with eye irritation): Fluorobenzaldehyde emulsion (No Including the stimulator of the eye sputum) The stimulating agent) The composition of the components constitutes 40 kg of the original fluorophenylurea (as the original fluorophenylurea 4 〇 kg (as the activity is pure) is pure) Ingredients 10 - basic ^^1 酸 kg: sodium dodecyl benzene sulfonate 100 kg emulsifier Tween 80 160 kg Tween 80 A '-160 kg emulsifier ethoxylated water loss sorbate ethoxylated sorbitol Monooleic acid monooleate monooleate γ-butyric acid·inner 100kg γ-butyrolactone~~ 700kg solvent-inside&q Uot; one fermented b 600 kg eye thorn i mitigator ---- 1000 kg total 1000 kg Example 10 20 201200022 Prepared the liquid preparation of the table, which contains the indicated. - Bialkylene II Alcohol bis/mono-CrC4 alkyl hydrazine and the active ingredient combination of bis-phenyl fluorogland and sputum sulphate urea, wherein bisphenol gas gland plus wind worm urea to CrC4 bis alkylene glycol bis/mono (paraffin The ratio is about i: 6. This formulation was compared to the second stencil preparation of the eye, which was prepared in the same manner using the same components, but without any C2_C4 doubles as an eye irritation slowing agent. Affiliated to - diol bis / single - C | - C4 alkyl hydrazine. The formulation of Example 10 contained 6% by weight of CrC4 bis-alkylene glycol bis/mono-c々 alkyl ether. Table 10 describes the liquid formulation and comparative formulation of Example 10 (Comparative J). Table 10 Example 10 Emulsion (including eye irritation slowing agent) U does not contain eye irritation slowing agent) Component diphenylfluoro urea original drug guanidine urea drug sodium dodecyl benzene sulfonate Tween 80 ethoxylation loss Water sorbitol monooleate stupid methanol dibutyl glycol diethyl ether total remarks composition

50 kg of fluorourea culvert (as pure $

(as pure product) 50 kg (as pure product ^

100 kg 100 kg Ethoxylated dehydrated sorbitol! Alcohol monooleate 5 〇 kg (as pure product) 100 kg 600 kg

Emulsifier emulsifier solvent 1000 kg eye irritation slowing agent Example 11 201200022 The liquid preparation described in Table 11 was prepared, which contained the indicated % bis-alkylene glycol-CrQ yard scale and active ingredient killer gland domain bell. The combination of exhibiting hormones, wherein the ratio of the killing urea plus the gas parotid gland to the crc4 bis-diol bis / single _CrC4 green ether is about t: 25. This preparation? The irritancy of the portion is compared to a second liquid formulation which is prepared in the same manner as the components of the Chichi, but does not contain any CrC4 dual sub-compartment diol as an eye irritation slowing agent. Bis/single-crc4 alkyl ether. Further alumina Example 11 w Formulation contains 5% by weight of CrC4 bis-alkylene glycol bis/mono"4 alkyl ether. Table 11 describes the liquid preparations and comparative preparations of Example 11 (Comparative^ Table 11 Example 11: Triflumuron + Fluoroquinone Urea Milk Comparison κ: Killing gland + Fluorine Meal - Reagent (including eye irritation reducing agent) (without eye irritation mitigator) Component composition: component chlorpyrifos original drug 100 tablets of chlorfluazuril original drug iuo kg active (as pure) Ϊ (as pure;) fluorinated glandular drug 100 Kilogram of hexaflumuron original drug 100 kg active (as pure product (as pure;)) Dodecylbenzenesulfonate 100 kg dodecylbenzenesulfonate 100 kg emulsifier Tween 80 100 kg Tween 80 100 kg emulsifier ethoxylated water loss mountain ethoxylated water loss sorbitol monooleate monooleate γ-butyrolactone 100 kg γ-butyrolactone 600 kg solvent dibutyl Alcohol diethyl ether 500 kg eye irritation slowing agent total 1000 kg total 1000 kg Example 12 22 201200022 The liquid preparation described in Table 12 was prepared, which contained the C2_C4 double sub-formyl diol bis/mono-CA alkyl ether shown and The combination of active ingredient diflubenzuron and fluoride-modified urea, in which de-wormed urea plus _ The ratio of CrQ bisalkylene glycol bis/mono-CrC4 alkyl ether is about i: 2·75 ^ The irritancy of the formulation against the eye is compared to a second liquid formulation, the second The liquid preparation was prepared in the same manner using the same components, but did not contain any bis-sinter-alcoholic-alcoholic/alcoholic-C丨·〇4 hospital mystery as an eye irritation slowing agent. ^ Formulation of Example 12 Containing 55% by weight of CrC4 dual-library diol bis/monoalkyl ether. Table 12 describes the liquid formulation and comparative formulation of Example 12. (Comparative ^ 1 Table 12 Remarks Example 12: Diflubenzuron Insecticide (including eye irritation slowing agent) i contains eye irritation slowing agent) component diflubenzuron original drug fluorine biting urea original drug sodium dodecylbenzenesulfonate Tween 80 ethoxylated sorbitan mono oil Acidate γ-butyrolactone•ethylene glycol dipropyl ether total Example 13 Composition 1〇〇kg i of diflubenzuron (as pure product | component

50 kg of urea original ^ (as pure product) 100 kg pf dialkyl Tween 80! Ethoxylated water loss Yamanashi | alcohol monooleate γ-butyric acid inner watt - active ingredient emulsifier (as pure product) (as pure) 100 kg Ιΰ^ί

Eye irritation slowing agent 1〇〇〇kg

23 201200022 The liquid preparation described in Table 13 contains the combination of CrC4 bis-alkylene glycol bis/mono-CrC4 sinter thief into money _ _ _ _ _ _ _ _ _ _ _ _ _ The ratio of the leuco-alcohol bis/mono-CrC4 alkyl ether is ❸1:14. The irritating nature of this system is suspected and the first kind of _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Alkaloid bis/mono-rcc4 alkyl ether. The formulation of Example η contained 35% by weight of CrC4 bis-alkylene glycol diol·Ci_Q alkyl ether. Table 13 describes the liquid formulation and comparative formulation of Example 13 (Comparative. Table 13 1 Example agent (including eye irritation mitigator) ί (without eye irritation mitigator) Component Wind 1 worm original Levo-fluorourea original drug Sodium dodecyl benzene sulfonate Tween 80 ethoxylated sorbitan monooleate B, • Alcohol propylene brewing 100 kg: Twelve: 3⁄43⁄43⁄43⁄4 100 kg; Tween 80 Ethoxylated water loss Yamanashi Alcohol monooleic acid West 350 kg total 〖Component 2 〇〇 kg j flu worm 13⁄43⁄4 (as pure) 丨 50 kg polyfluoro-gland (as pure) 丨 1000 kg. Total

Example 14 24 201200022 The liquid preparation described in Table 14 was prepared, rr 3 of which 有所2<:4 double alkylene glycol bis/mono-CVQ silk 敝 成分 成分 _ _ _ urea urea group urea For the c2-c4 double-silk diol double/single seven, r sedative plus the ratio of the first 12 topographic scale is about 1: 〖3. The stimulating property of the BP portion of the fasting and the second liquid preparation is applied to the rod. The agent is prepared in the same manner as the eye-same component, but does not contain the objective sputum agent, the phase diol double and the W trace. 3 As a reel of any team, the double sub-base implementation ^ coffee contains Wei called q double-position diol fresh ^ alkyl ether by weight. Table 14 describes the liquid preparations and comparative preparations of Example 14 (Comparative n 4 doses (including eye irritation reducing agents) i contain eye irritation slowing agents) Component Urea prodrugs Fluorophenyl urea. Burning benzoic acid Natto 80 Ethoxylated sorbitan monooleate γ-butyrolactone dipropylene glycol dipropylene ether Total Example 15 Composition ϋ ϋ ___i 100 kg fTSSS'S' (as pure product) 200 kg I (as pure product) i - —.^ 100 kg 丨 eleven burning base sodium sulphate 100 kg \ I ethoxylated water loss sorbitol i alcohol monooleic acid g purpose ^ ^ · | γ-butyric acid inside fif 4 〇〇 kg! 1___j ^ ^斤;总Λ 组成 Composition 100 kg (as pure product) 2 〇〇 kg (as pure product) 100 kg 500 kg 1 〇〇〇 kg cents "iuhjip' slowing agent 25 201200022 Prepared the liquid preparations described in the table, It contains the combination of diols from Shuangyayuan diols (the combination of Λ 嶋雑 嶋雑 与 与 与 与 与 与 与 与 与 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 组合 Q Q Q Q Q It is about i: 6. This preparation is compared to the thorny fresh eye of the eye, which is prepared in the same manner using the same component. Contains no (d) bis-alkylene alcohol bis/early-C1.C4 yard-based bond as an eye irritation slowing agent. The formulation of Example I5 contains 65% by weight of C2_Q bis-alkylene diol bis/single 4 Demonstration of the hospital. Table 15 describes the liquid preparation and the comparative preparation of Example 15 (Comparative 〇). Table 15 Pages of the spores of the fluorourea + fluoroquinone urea comparison 0: bisphenyl fluoride gland + hexaflumuron emulsion ( Including eye irritation minus 1 dose) Agent (without eye irritation mitigator) Component composition ΓΤ'--- Component composition double qipeng ^ original music 50 kg (as pure product) diphenyl fluorourea original drug Sichuan kg (as pure product) active ingredient gas age 1 original Le 12 sylvestre sodium sodium sulphate 80 ethoxylated sorbitan monooleate 50 ^: (as pure) fluorobell gland original drug 50 kg (as pure product) Active ingredient 12 yards of benzoic acid sodium 100 kg emulsifier 100 kg Tween 80 ethoxylated sorbitan monooleate 100 kg emulsifier γ--] acid S 曰 100 ^ — γ-butyrolactone solvent dipropylene glycol propyl ether ~600^—^7---- Eye irritation slowing agent total 1000 kg: total - Example 16 26 201200022 The liquid preparation described in Table 16 was prepared, which contained the combination of C2_Q bisalkylene glycol bis/single-QQ sinter _ and live thief sputum 43⁄4 sylvestre urea. The ratio of urea to CrC:4 disalkylene glycol bis/mono-QQ alkyl ether is about 〖: 29. The irritancy of the formulation to the eye is compared to a second liquid formulation which is prepared in the same manner using the same components but does not contain any C2_C4 bimodal as an eye irritation slowing agent. Alkyl-·diol bis/mono-qQ alkyl ether. The formulation of Example 16 contained 52 by weight. /. C2_C4 Bialkylene Glycol Double/Single_CrC4 Terephthalyl Ether. Table 16 describes the liquid formulation of Comparative Example 16 and the comparative formulation (Comparative p). Table 16 Example 16. Parotid gland + acaricidal gland milk 〖Compared r mouse cochlear gland + salivary gland emulsion (not dose (including eye irritation slowing agent) 1 containing eye irritation slowing agent) -- i Remarks component composition丨Component /. /. Composition of carbendazim original drug 80 kg of guanidine urea original drug (as pure product I 80 kg (as pure product) active ingredient carnitine original drug 100 kg killing chlorpyrifos original drug (as pure Product i % 100kg (as pure product) Active ingredient 12-alkyl benzoate sodium 100 kg 丨 sodium dodecyl benzene sulfonate 100 kg emulsifier spit > Benefit 80 ethoxylated sorbitan oil Acid S is 100 kg 丨Tween 80 i ethoxylated water loss sorbitol 1 alcohol monooleic acid vinegar 100 emulsifier γ-butyric acid 酉 酉 ------- 100 kg 1γ-butyrolactone' ί 620 公^- Solvent dibutylene glycol dipropanol---- @公斤§ ϋ Κ h --- Eye irritation slowing agent total 1000 kg 彳 total Λ 1000 kg"--- Example 17 27 201200022 Prepared The liquid preparation described in Table 17, which contains the indicated c2_c4 bis-succinyl diol bis/mono-Ci-Q alkyl ether and a combination of the active ingredient guanidine urea and sterilized urea, wherein 虱螨The ratio of the addition of diflubenzuron to CrCt double sub-based diol bis/mono-c, _C4 alkyl ether was about 1: 1.8. The irritancy of this preparation on the eye was compared with the second liquid preparation. The second liquid formulation is prepared in the same manner using the same components, but does not contain any alkylene glycol bis/mono-crc4 alkyl ether as an eye irritation slowing agent. The formulation of Example 17 contains 45% by weight of CVC4 bisalkylene glycol bis/mono-crc4 alkyl ether. Table 17 describes the liquid formulation of Comparative Example 17 and the comparative formulation (Comparative q). Table 17 Example 17. Urea urea + deworming Urea milk ratio 衩Q: guanidinium + chlorpyrifos emulsion (including eye irritation mitigator) (without eye irritation mitigator) Remarks The components of the composition of the wind sac of the original drug 100 kg of guanidine urea ( As pure product): 100 kg (as pure product) Active ingredient, worm gland 150 kg of diflubenzuron (as pure product): 150 kg (as pure product) Active ingredient t" -k base table continued acid Natto 80 B Oxylated sorbitan monooleic acid vinegar 10 〇 kg: sodium dodecyl benzene sulfonate —— — — — ιοο^τ- emulsifier (10) kg Tween 80: Ethoxylated water-deficient mountain: Phenol monooleate 100 kg emulsifier γ-butyric acid Nishi 100 kg _γ-butyric acid S 550 kg solvent dibutyl glycol "450^-: One eye stimulator mitigator 1000^---- 28 201200022 Example 18 The liquid formulation described in Table 18 was prepared which contained the crc4 bis-alkylene glycol bis/mono-CrC4 burned as shown. The combination of a hydrazine and an active ingredient guanidinium and fluoropyridine urea, wherein the ratio of guanidine urea plus chlorfluazuron to CrQ bisalkylene glycol bis/mono-CrQ alkyl ether is about 丨: 丨4. The irritancy of the formulation to the eye was compared to a second liquid formulation prepared in the same manner using the same components, but without any CrC4 as an eye irritation slowing agent. Dialkylene glycol bis/mono-CrC4 alkyl ether. The formulation of Example 18 contained 65% by weight of CrC4 bisalkylene glycol bis/mono-C "C4 alkyl ether. Table 18 describes the liquid formulation of Comparative Example 18 and the comparative formulation (Comparative R). Table 18 Implementation Example 18. Comparison of guanidinium + flubenzuron chylomicron urinary urea + fluridazine emulsion (no dose (including eye irritation slowing agent) 1 containing eye irritation mitigator) —~r~------- -- Remarks Component composition ^ --- A component composition 虱螨 urea original drug 50 kg f (as pure product $ --- ^ 虱 虱 腺 original drug 50 kg (as pure) active ingredient chlorfluazuridine original drug 200 kg 5 (as pure product $ fluazim original drug 200 kg (as pure product) sodium dodecyl benzene sulfonate 1 〇〇 kg complex ____3 sodium dodecyl benzene sulfonate " ΐ〇 ο ^ - Emulsifier Tween 80 Ethoxylated sorbitan monooleate 100 kg ii ί \ ;- ~~^TZ~~----- -. Tween 80 ethoxylated sorbitan oil Acid ester 100 kg emulsifier N-methyl pirone ketone 200 kg \ one _ _ interest. '------ N-mercaptopyrrolidone 550 kg solvent diethylene glycol dibutyl ether 35 〇 kg containing \ Eye irritation t mitigator total - total 1000 Jin

29 S 201200022 Example 19 The liquid preparations described in Table 19 were prepared, which contained the indicated % Shuangyayuan bis-QQ alkyl (10) and the live reduction of the cisplatin urea ridge, the shot·urea plus lining double Weiji diol material ·CrC4^_tt is the irritant of this system = the second liquid preparation is prepared in the same way as the same component, but Contains no bis-j-diol bis/mono-CrC4 alkyl ethers as scales. & The formulation of Example 19 contained 70% by weight of CrC4 bisalkylene glycol bis/single "a alkyl ether. Table 9 describes the liquid formulation and comparative formulation of Example 19 (Comparative 'Table 19 Example 19: guanidinium + 3⁄43⁄4⁄4 a comparison S: guanidine urea + fluoroagent (including eye irritation mitigator) (without eye irritation) Ingredients: 组成 原 原 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 〇 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 () as a product) sodium dodecyl benzene sulfonate 5 〇 kg dodecyl benzene sulfonate 1 5 〇 ^ gT ^ ~ ~ ~ ~ emulsifier Tween 80 5 〇 kg Tween 80 emulsified Ethoxylated water-deficient mountain ethoxylated sorbitan monooleate monooleate-------- ----- --- γ-butyric acid vinegar 100 kg Γ-butyrolactone solvent diethylene glycol butyl shouting 700 kg ~ - one eye stimulator slowing agent total 1000 kg total 201200022 Example 20 -C urea pair, G reliance bribe _ 'age core (four) C2_C4 diweiyl diol double / Single 4 two shouts and the combination of the active component wind end gland and multi-gas urea, wherein urea plus 24 4 bis-alkylene alcohol double / single (a ratio of burnt is about ^ ^). The sensitivity of the part is compared with a second liquid preparation which is prepared in the same manner and which is not prepared as an eye irritation slowing agent. /Single-Crc4 alkyl ether. The formulation of Example 2 is containing 35% by weight of CrC4 bis-alkylene glycol bis/monoheptaether. Table 20 describes the liquid formulation of Example 20 and Comparison of preparations (compare τ). 1<:4 Table 20 ~?^ Example 20: anti-+ polyfluorourethane milk|^匕T: mourning, 1/input u, upper*, y』a, d . . ... component composition 彳 component 虱螨 原 urea drug --- 100 kg 丨虱 脲 脲 房 房 房 房 ─ ─ (as a pure product i polyfluoro urea original drug 250 kg fluorourea original drug '^ - S. (As pure product | ??? sodium dodecyl benzene sulfonate - - 100 kg! Sodium dodecyl benzoate Tween 80 ethoxylated sorbitan monooleate 100 kg ΐ Tween 80 ~ ~ \ I ethoxylated dehydrated sorbitol I alcohol monooleic acid vinegar γ-butyrolactone 100 kg ξ γ-butyrolactone ~ dipropylene glycol dibutyl ether Ί 350 kg 5 total 1000 kg 丨 s - 100 kg ( As pure product) 250^: (as pure product) 100 kg 100 kg 450 kg

^0003⁄47 mitigator 201200022 Example 21 The liquid preparation described in Table 21 was prepared, which contained the lyophilized granules, and the urinary uranium was added to the crc: 4 The ratio of the sub-diol diol double kq is about i: 6. This irritancy to the eye is compared with a second liquid formulation which uses the same components in the same manner Prepared, but not containing any 2 alkyl diol bis/mono-CrC4 alkyl ether as an eye irritation slowing agent. 2 4 bis-'C4 The formulation of Example 21 contains 6 〇 % by weight of CrC4 bis-alkylene Base diol bis/mono c alkyl ether. Table 21 describes the liquid formulation and comparative formulation of Example 21. (Comparative. Table 21 Example 21: guanidinium + fluorobenzamide guanidine + fluorobenzene. 3⁄43⁄4 agent (including Eye irritation mitigator) j (without eye irritation mitigator) component guanidine urea drug fluorophenylurea drug sodium dodecyl benzene sulfonate Tween 80 ethoxylated sorbitan monooleate γ - Butyrolactone dipropylene dibutyl ether. Propylene glycol II · 'Μ Composition: Component 5 〇 kg hurricane and original drug - (as pure product) > 5 〇 kg (as pure product > 100 gong斤|Sodium dodecyl benzene sulfonate 100 kg 100 kg ioo kg 300 kg γ-butyric acid 酉 吐 Tween 80 ethoxylated water loss sorbitol alcohol monooleate 50 kg (as pure product)

50 kg (as pure product) 32 201200022 Total Example 22 The body (4) described in Table 22 was prepared, which contained face-filled CrC4 double sharp diol bis/mono-CrQ burned _ and female silk bribes turned to German, Wei secret f and i benzophenone C2-C4 bis-alkylene diol bis / single "4 base bond ratio of about i: 2, this preparation for eye irritation compared with the second liquid ship, the The second liquid formulation is prepared in the same manner using the same components 'but without any CrC4 bisalkylene glycol bis/mono-CrC4 alkyl ether as an eye irritation slowing agent. The formulation of Example 22 contained 40% by weight of Q-Q bisalkylene glycol bis/single succinimide. Alkyl ether. Table 22 depicts the liquid formulation of Comparative Example 22 and the comparative formulation (Comparative V). Table 22 Greedy Example 21 Killing gland + fluorobenzaldehyde emulsion (including eye irritation slowing agent) ! Compare V: Killing gland + fluorobenzaldehyde emulsion (not | with eye irritation reducing agent) Remarks Component composition | Composition ~~ 100 mg of the original drug of chlorfluazuron! 100 kg of the original drug of chlorfluazuron (for active (as pure product;)! pure product) 100 gram of ibuprofen original drug 100 kg ( For (as pure) \ pure product) sodium dodecyl benzene sulfonate 100 kg sodium dodecyl benzene sulfonate 100 kg emulsifier Tween 80 乙 ethoxylated sorbitan monooleic acid Ester 100 kg! Tween 80 ί | Ethoxylated dehydrated sorbitol 1 alcohol monooleic acid Ϊ J__ 100 kg emulsifier γ-butyrolactone 200 kg butyrolactone Λ 600 kg solvent dibutyl diol dibutyl Ether 200 kg \ i eye thorn i mitigator 33 201200022 Dipropylene glycol butyl engraving 200 kg eye irritation slowing agent total 1000 kg total 1000 kg Example 23 A - The liquid preparation described in Table 23 was prepared, which contains the indicated (: 2<:4 bis-alkylene glycol bis/mono-C1-C4 leucoether and active ingredient carbofuramide and polyfluoro urea Wherein the ratio of the killing urea plus the polyfluorourea to the CrC4 disalkylene glycol bis/mono-CrC4 alkyl ether is about 1:3 3. The irritating effect of the preparation on the eye and the second liquid The formulations were compared, the second liquid formulation being prepared in the same manner using the same components, but without any C2_C4 bis-alkylene glycol bis/mono-C1-C4 alkyl ether as an eye irritation slowing agent The formulation of Example 23 contained 50% by weight of CrC4 bisalkylene glycol bis/monoalkyl ether. Table 23 describes the liquid formulation of Comparative Example 23 and the comparative formulation (Comparative w) ^ Table 23 Example 23 : Killing gland + polyfluorourea emulsion comparison w: chlorpyrifos remarks (including eye irritation mitigator) (without irritating and soothing components) Component composition of the composition of Shuling glandular music υυ υυ kg: chlorpyrifos (as pure product); —-----. (as pure product) divided into polyfluoro Urea original drug 50 kg 丨 polyfluoro urea original drug activity into sodium dodecyl benzoate (as pure): plant 100 kg of 12 yards of benzoic acid sodium (as a product) ΙΟ γ Π Γ — — — — — 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 80 Υυ kg Tween 80 ethoxylated water-depleted sorbey [emulsifier alcohol monooleate alcohol monooleic acid vinegar γ-butyrolactone 15 〇 kg γ-butyrolactone dibutyl butyl ether butyl ether "500^ : —· ---------------... Solvent eye irritation --- | — 34 201200022 Total amount of slowing agent 1000 kg total 1000 kg Example 24 Probability of eye irritation caused by preparation According to Ν · ρ· LuePke: Hen's Egg chorio Allantoic Membrane Test for Irritation Potential, Fd. Chem. Toxic. 23 (1985) The method described on pages 287 to 291 (HET-CAM test) determines that this method is based on H. Spielmann's Methods (H. Spielmann: Methods in Molecular Biology 43 (1995) pp. 199 to 2〇4 and H. Spielmann et al. ATLA 24 (19%) pages 741 to 858) make adjustments. In the HET-CAM test, samples were processed to treat the chorioallantoic membrane. The researchers observed the chorioallantoic membrane five exercises ', gambling and vascular miscellaneous. The correction and the severity of the symptoms' s test samples are divided into the following categories: Category 0: severe irritant class I: stimulation Sexual dioxins: mildly irritating in class: non-irritating

35 201200022 Comparison E Class 0 Example 6 Class II Comparison F Class 0 Example 7 Class II Comparison G Class 0 Example 8 Class III Comparison Η Class 0 Example 9 Class III Comparison I Number 0 Class Example 10 Class III Comparison J Class 0 Example 11 Class III Comparison Κ Class 0 Example 12 Class III Comparison L Class 0 Example 13 Class II Comparison Μ Class 0 Example 14 Section II Class Comparison Ν Class 0 Example 15 Class III Comparison 0 Class 0 Example 16 Class III Comparison Ρ Class 0 Example 17 Class II Comparison Q Class 0 Example 18 Class II 36 201200022 Comparison R Class 0 Example 19 Class III Comparison S Class 0 Example 20 Class II Comparison T Class 0 Example 21 Class III Comparison U Class 0 Example 22 Class II Comparison V Class 0 Example 23 Class III Comparison W Class 0 It can be seen from the above experimental data that the above C2-C4 bisalkylene glycol bis/mono-Q-C4 alkyl ether exhibits a significant reduction in insecticidal activity of phenylhydrinylphenylurea. The performance of derivatives on eye irritation. [Simple description of the diagram] None [Key component symbol description] None 37 h

Claims (1)

201200022 VII. Patent application scope: 1. A pesticide composition comprising: at least one CrC4 alkylene glycol bis/herbocene ether, at least one kind of arachidyl phenylurea active ingredient, and optionally At least one selected from the group consisting of a surfactant, an organic polar solvent, and a low temperature stabilizer is selected. 2. The agrochemical composition according to claim 1, wherein the ratio of the phenyl lysine active ingredient to the C2-CA leucodiol bis/single_Ci_c4 alkyl group is between 1:1 and 1:1. 1:3 〇, preferably 1:3 to 1:15. 3. 4. 5. 6. The money composition of claim 1 to 2, wherein there are more than two types of the CVQ bisalkylene glycol bis/mono_C|_C4 alkyl ether. . The money composition according to any one of claims 1 to 3, wherein the towel has two or more of the clumpy phenylurea active ingredients. The agrochemical composition according to any one of claims 1 to 4, wherein the C2_c4 bis-alkylene glycol bis/mono-CVQ alkyl ether is selected from the group consisting of diethylene glycol dioxime ether and diethylene glycol methyl ester. Ether, dipropylene glycol, dipropylene glycol, dibutyl glycol, dibutyl glycol, diethylene glycol diethyl ether, diethylene glycol diethyl ether, dipropylene glycol diethyl ether, dipropylene glycol ether , dibutyl glycol-diethyl ether-butanol-ethyl ketone, diethylene glycol dipropylene oxime diethylene glycol propyl ether, dipropylene glycol dipropyl ether, dipropylene di-, dibutylene glycol dipropyl ether, dibutyl a group consisting of glycol propylene ether, diethylene glycol di-, diethylene glycol, dipropylene glycol dibutyl ether, dipropylene glycol, dibutylene glycol dibutyl ether, di-tdiol TST and mixtures thereof At least one of them. The agrochemical composition according to any one of claims 1 to 5, wherein the C2_C4 bisalkylene glycol bis/mono is shouted at 5 〇/ by weight. It is present in an amount of up to 8〇%. The invention relates to the money composition of the item 1 to 6, wherein the benzene duck phenylurea street organism is selected from the group consisting of double stupid, secret urea, fluoropterin, killing, and mitochondria. At least one of the group of the group of the gasbiting gland, the fluorine fine, the poly-, and the fluorobenzene. The benzene(tetra)benzene phthalate 38 201200022 is present in an amount of 2 to 50% by weight, as described in the claims 1 to 7. 9. The pesticide composition according to any one of the preceding claims, further comprising a polar solvent. The pesticide composition according to claim 9, wherein the polar solvent is selected from the group consisting of stupid methanol, leutropyrrolidone such as N-methylpyrrolidone, N-octyl scale, or internal vinegar butyric acid-lactone At least one of the group consisting of. The agrochemical composition according to claim 9 or 10, wherein the polar solvent is present in an amount of from 1 90 to 90% by weight. The agrochemical composition according to any one of the preceding claims, further comprising: an emulsifier. 13. The agrochemical composition according to claim 12, wherein the emulsifier is present in an amount of from 5 to 4% by weight, and the pesticide composition according to any one of the preceding claims, wherein For concentrates, especially emulsions (EC) » 15. -CrQ bis-alkylene glycol bis / single "4 yards for reducing eye irritation of insecticide benzoyl phenylurea derivatives . The use according to claim 15, wherein the CrC4 bisalkylene glycol bis/mono"4 alkyl ether is combined with the phenyl phenyl phenyl urea derivative in the pesticidal composition. 17. A method of reducing the irritation of a tetanus containing a pesticidal liquid comprising a parabenylphenylglycine derivative, comprising using a G sufficient to reduce the amount of the benzamidine-based urea derivative for eye irritation -C4 bis-alkylene-alcoholic double/early-C1-C4 hospital based preparation. A method of treating pests at a site, comprising applying a pesticidal composition according to any one of claims 14 to 14 at the site. A method of treating pests at a location as claimed in claim 18, wherein the pesticidal composition is an emulsion, and the pesticidal composition is dispersed in water nails before being applied to the site. The use of the pesticidal composition according to any one of claims 1 to 3 for controlling pests. 39 201200022 IV. Designated representative map. (1) The representative representative of the case is: ( ). (2) A brief description of the symbol of the representative figure: None 5. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: