TW201218948A - Microbicidal composition - Google Patents
Microbicidal composition Download PDFInfo
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- TW201218948A TW201218948A TW100149813A TW100149813A TW201218948A TW 201218948 A TW201218948 A TW 201218948A TW 100149813 A TW100149813 A TW 100149813A TW 100149813 A TW100149813 A TW 100149813A TW 201218948 A TW201218948 A TW 201218948A
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- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 230000003641 microbiacidal effect Effects 0.000 title abstract 2
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- KUQCZABKHLILRI-UHFFFAOYSA-M sodium;2,2-dihydroxyacetate Chemical compound [Na+].OC(O)C([O-])=O KUQCZABKHLILRI-UHFFFAOYSA-M 0.000 description 1
- IUEMQUIQAPPJDL-UHFFFAOYSA-M sodium;2,3-dihydroxypropanoate Chemical compound [Na+].OCC(O)C([O-])=O IUEMQUIQAPPJDL-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 description 1
- 238000003971 tillage Methods 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
201218948 六、發明說明： 【發明所屬之技術領域】 本發明係關於一種經選 有之活性比在個別殺菌劍 杈菌劑的協同組合，其具 【先前技術】 ^所觀察到之活性更大。 在某些情況中，即使是在* 菌劑對抗某些類型的微生 μ使用》農度下’由於商用殺 性之微生物）之活性弱，戋由例如’對於某些殺菌劑具有抗 商用殺菌劑無法提供有^於知略性環境條件，而使該等 目的使用環境中使用不物控制。有時候，在特定 生物控制。例如，美國專利之組合，以提供全面的微 號揭示Ν-甲基-i 2_笼、，|請公開案第2007/0078118 生物劑之協同組合。4異：唑啉I，⑽T)與其他殺 於具有抗各種微生物菌株之==微生物控制，· :所需求，，為了環境 殺菌劑組合而解需未。本發明係提供此等額外的 【發明内容】 、本發明係有關-種殺g組成物（τ文中有稱為「抗菌組 成物」之情形），其包含：（a) Ν一甲基_!，2_苯并異嗔峻琳一3一 酮，及（b)至少一種殺菌劑，其係選自下列各者所組成之群 組：六氫-1，3,5-參（2-羥基乙基）對稱三哄（hexahydr〇_ 1’3,5-1：1^3(2-117(11*〇又>^1:1^1)-5-玄1^3211^);4,4-二甲基 噚唑啶；羥基甲基甘胺酸鈉；肉豆蔻醯胺丙基丙二醇_氣化 94379D05 3 201218948 二甲基銨磷酸酯（myristamidopropyl PG-dimonium chloride phosphate);辛酸；2-乙基己基甘油；單辛酸甘 油酯；單癸酸甘油酯；7α-乙基二氫-1H, 3H，5H-卩萼唑并 (3, 4-C)卩等唑；及2-(硫基氰基甲基硫基）苯并噻唑（2-(thiocyanomethylthio)benzothiazole)。 【實施方式】 如本文中所使用，除非文中另有明確指示，否則下列 術語具有指定的定義。“MBIT”係N-曱基-1,2-苯并異噻 唾琳-3-酮。術語“殺菌劑”意指能夠於一位置（1〇cus)殺 死微生物、抑制微生物生長或控制微生物生長的化合物； 殺菌劑包括殺細菌劑、殺真菌劑及殺藻劑。術語“微生物” 包括例如真菌（例如酵母菌及黴菌）、細菌及藻類。術語‘‘位 置意指受到微生物污染之工業系統或産品。下列縮寫係 用於說明書全文中：ppm=以重量計之每百萬份之份數（重量 /重量），mL=毫升’ ATCC=美國菌種保藏中心（American Type
Culture Collection)，MBC=最低殺菌濃度，及 MIC=最低 抑制濃度。除非另外指明，否則溫度係以攝氏度rc)計， 且百分比（％ )之參考基準係以重量計。有機殺菌劑的量係由 以PPm (重量/重量）計之活性成分基質呈現。 思外地發現本發明之組成物能在組合的活性成分含 ，低於個別殺菌劑的活性成分含量之情況下，提供增強的 才又菌效力。超出巾請專利II圍所列殺菌劑範嘴之其他殺菌 劑亦可存在於該組成物中。 於本發明的一具體例中，該抗菌組成物包含N-曱基 4 94379D05 201218948 1，2本并異。塞唾琳―^—酮及六氫_1，g，參（2_經基乙基） 對稱二哄。六氫_丨，3, 5_參（2_羥基乙基）對稱三哄對N一甲 基-1，2-苯并異噻唑啉_3_酮之重量比較佳為丨：〇. 〇〇14至 1 : 150 ’ 更佳為 1 : 〇 〇12 至 1 : 15〇。 於本發明的一具體例中，該抗菌組成物包含N_曱基 一1，2_苯并異噻唑啉-3-酮及4, 4-二曱基噚唑啶。4, 4-二甲 基噚唑啶對N-曱基-1,2-苯并異噻唑啉-3-酮之重量比較 佳為 1 : 0011 至 1 : 3. 5。 於本發明的一具體例中，該抗菌組成物包含N_甲基 -1，2-苯并異噻唑啉_3_酮及羥基曱基甘胺酸鈉。羥基曱基 甘胺酸納對N-曱基-1，2-苯并異噻唑啉-3-酮之重量比較 佳為 1 : 0.0005 至 1 : 2. 3,更佳為 1 : 0.14至 1 : 2.3，又 更佳為1 : 〇·29至1 : 2.3。 於本發明的一具體例中，該抗菌組成物包含Ν_甲基 -1，2-苯并異噻唑啉_3_酮及肉豆蔻醯胺丙基丙二醇-氯化 二甲基銨碟酸酯。肉豆蔻醯胺丙基丙二醇-氯化二曱基銨碟 酸酉1對Ν'曱基-1，2-苯并異噻唑啉-3-酮之重量比較佳為 1 : 0.0011 至 1 : 15〇 。 於本發明的一具體例中，該抗菌組成物包含Ν-甲基 _1，2—苯并異噻唑啉-3-酮及辛酸。辛酸對Ν-曱基-1，2-笨 并異嗟唾琳-3-_之重量比較佳為1 : 〇. 〇〇46至1 : 〇. 68， 更佳為 1 : 029 至 1 : 68。 於本發明的一具體例中，該抗菌組成物包含Ν-甲基 一1，2—苯并異噻唑啉-3-酮及2-乙基己基甘油。2-乙基己基 5 94379D05 201218948 甘'由對N甲基-1，2-苯并異嗟嗅琳-3-酮之重量比較佳為 1 : 0.017至 i : 2 3。 ‘ ;發月的一具體例中，該抗菌組成物包含N-甲基 -1’2-苯并異噻唑啉_3_酮及單辛酸甘油酯。單辛酸甘油酯 對N曱基-ι’2__苯并異噻唑啉_3_酮之重量比較佳為1: 〇. 0004 至 1 : 75，更佳為 1 : 0. 012 至 1 : 75。 於本發明的一具體例中，該抗菌組成物包含甲基 -1，2-笨并異噻唑啉_3—酮及單癸酸甘油酯。單癸酸甘油酯 對N-甲基-u—苯并異噻唑啉_3_酮之重量比較佳 0.0031 至 1 : 8·8，更佳為 i : 〇 〇17 至工：8 8。 於本發明的-具體例中，該抗菌組成物包含n一甲基 1，2-苯并異噻唑啉_3_酮及乙基二氫丨噚 ㈣U4-唾。7α—乙基二氫-1Η，3Η，5Η—嗜唾并 (3,4~〇卩§销m-u-苯并異嗟峻淋 -3-酮之重量比 較佳為 1 : 〇· 〇〇〇3 至 1 : 7. 1。 於本發明的一具體例中’該抗菌組成物包含N_甲基 -1,2-苯并異嗟㈣_3，及2_(硫基氰基甲基硫基）苯二 噻唑。2-(硫基氰基甲基硫基）苯并噻唑對N_甲基—1 2一笨 并異。純琳-3-酮之重量比較佳為i : g.G63至2 :⑷。 可使用本發明組成物中之殺菌劑“本身，，或可先 該殺菌劑與溶劑或固體载劑調製。適當的溶劑包括例如 水；二醇，例如乙二醇、丙二醇、二乙二醇、二丙二醇 聚乙二醇及聚丙二醇；二醇醚；醇，例如〒醇、乙醇、丨 醇、苯乙醇及苯氧基丙醇；_，例如_及甲基乙基^ 94379D05 6 201218948 酯’例如醋酸乙酯、醋酸丁酯、擰檬酸三乙醯酯及三醋酸 甘油酯；碳酸酯，例如碳酸丙二酯及碳酸二甲酯；及其混 合物。該溶劑較佳係選自水、二醇、二醇醚、酯及其混合 物。適當的固體載劑包括例如：環糊精、氧化矽、矽藻土、 虫鼠、纖維質材料、驗金屬及驗土金屬（例如，鈉、鎂、鉀） 鹽（例如’氯化物、硝酸鹽、溴化物、硫酸鹽）及木炭。 將殺菌劑組分調製於溶劑中時，該調配物可視需要含 有界面活性劑。當此等調配物含有界面活性劑時，其通常 呈乳化濃縮物、乳液、微乳化濃縮物、或微乳液形式。乳 化濃縮物在添加足量水之後，會形成乳液。微乳化濃縮物 在添加足量水之後，會形成微乳液。此等乳化及微乳化濃 縮物於本技術領域中普遍為人所熟知；此等調配物較佳不 含界面活性劑。可查閱美國專利第5, 444, 078號，以進一 步獲取製備各種微乳液及微乳化濃縮物之一般及具體細 節。 亦可將殺菌劑組分調製成分散液形式。分散液之溶劑 組刀可為有機溶劑或水，較佳為水。此等分散液可含有佐 劑，例如共溶劑、增稠劑、防凍劑、分散劑、填充劑、顏 料、界面活性劑、生物分散劑、磺酸基琥珀酸酯、萜烯、 夫喃S同、多價陽離子、安定劑、防垢劑及防腐蝕添加劑。 當將兩種殺菌劑各自首先與溶劑調製時，用於第一種 杈菌劑之溶劑可與用於調製另一種商用殺菌劑之溶劑相同 或不同，但對於大部分工業殺菌應用而言，水為較佳者。 該兩種溶劑較佳為可混溶者。 7 94379D05 201218948 熟悉此項技術者將暸解，可相繼或同時添加本發明之 殺菌劑組分至一位置，或可在添加至該位置之前，先組合 該等殺菌劑組分。較佳為同時或相繼添加第一種殺菌劑及 第二種殺菌劑組分至一位置。當同時或相繼添加該等殺菌 劑時，個別組分可各自含有佐劑，舉例而言，例如溶劑、 增稠劑、防凍劑、著色劑、螯合劑（例如乙二胺四醋酸、乙 二胺二琥珀酸、亞胺基二琥珀酸及其鹽）、分散劑、界面活 性劑、生物分散劑、續酸基琥拍酸s旨、萜稀、吱喃s同、多 價陽離子、安定劑、防垢劑及防腐蝕添加劑。 可藉由將殺菌有效量之本發明殺菌組成物引至受微生 物侵襲的位置上、位置内或位置處，而將本發明殺菌組成 物用於抑制微生物或較高等水生生物種類（例如原生動物、 無脊椎動物、苔蘚蟲類、雙鞭毛藻類、甲殼動物、軟體動 物等）的生長。適當的位置包括例如：工業處理水；電塗沉 積系統；冷卻塔；空氣清洗器；氣體洗滌器；礦物漿料； 廢水處理；裝飾用喷泉；逆滲透過濾；超過濾；壓艙水； 蒸發冷凝器；熱交換器；紙漿及紙張加工流體與添加劑； 澱粉；塑膠；乳液；分散液；油漆；乳膠；塗料，例如清 漆；建築產品，例如膠黏劑（mastics)、填隙劑及密封劑； 建築黏著劑，例如陶瓷黏著劑、地毯背襯黏著劑及層合黏 著劑；工業或消費性黏著劑；照相化學品；印刷流體；家 用產品，例如浴室及廚房清潔劑與清潔濕巾；美容用品； 化妝品；洗髮精；肥t;去汙劑；工業清潔劑；地板光亮 劑；洗衣用洗濯水；金屬加工流體；輸送機潤滑劑；液壓 8 94379D05 201218948 流體，皮革及皮革產品；織物；織造產品；木材及木材產 品，例如合板、碎木片板、牆板、刨花板、層合樑、定向 刨花板、硬板及粒片板；石油加工流體；燃料；油田流體， 例如喷射水、裂隙流體及鑽井泥漿；農業佐劑保存；界面 活性劑保存；醫學裝置；診斷試劑保存；食物保存 ，例如 塑膠或紙製食品包裝；食品、飲料及工業處理殺菌器；便 盆；娛樂用水；水池；以及礦泉。 較佳地，本發明殺菌組成物係用於抑制在選自下列一 或多個位置處的微生物之生長：礦物漿料；紙漿及紙張加 工流體與添加劑；澱粉；乳液；分散液；油漆；乳膠；塗 料，建築黏著劑，例如陶瓷黏著劑、地毯背襯黏著劑；照 相化學品；印刷流體；家用產品，例如浴室及廚房清潔劑 與π潔濕巾，美容用品；化妝品；洗髮精；肥皀；去汙劑； 工業清潔劑；地板光亮劑；洗衣用洗濯水；金屬加工流體； 、哉埯產品；木材及木材產品；農業佐劑保存；界面活性劑 保存·’診斷試劑保存；食物保存；以及食品、飲料及工業 處理殺菌器。 抑制或控制一位置之微生物及較高等水生生物種類 的生長所需之本發明組成物的具體量係取決於欲保護之特 疋位置。典型地，在一位置控制微生物生長的本發明組成 物若忐於該位置提供〇· 1至1，〇〇〇 ppm的該組成物之異噻 唑啉_成分’則其量為足夠。在該位置，該組成物之異噻 唑啉酮成分較佳以至少〇. 5 ppm，更佳以至少4 ppm，最佳 以至少10 ppm的量存在。在該位置，該組成物之異噻唑啉 9 94379D05 201218948 酮成分較佳以不超過1000 ppm，更佳以不超過5〇〇 ppm， 最佳以不超過200 ppm的量存在。 實施例 材料及方法 本發明之組合的協同作用係藉由測試廣泛濃度及比 率車ιΐ圍的該等化合物而予以證實。 協同作用之一種量測法係Kull，F.C· ; Eisman, P. C.;
Sylwestrowicz，H. D·及 Mayer, R. L.在 Applied
Microbiology 9:538-541 (1961)中所述之工業上接受的方 法，其係使用下述公式所測定之比率：
Qa/QA+ Qb/QB=協同指數（“SI”） 其中： QA=以ppm計的單獨作用之化合物A(第一種組分）的濃度， 其產生一終點（化合物A之MIC)。
Qa=以ppm計的混合物中之化合物a的濃度，其產生一終點。 QB=以ppm計的單獨作用之化合物b(第二種組分）的濃度， 其產生一終點（化合物B之MIC)。
Qb=以ppm計的混合物中之化合物b的濃度，其產生一終點。 當Qa/QA及Qb/QB之總和大於1時，表示拮抗作用。當 該總和等於1時，表示相加性；而當該總和小於1時，則 說明為協同作用。SI值愈低，則該特定混合物所展現的協 同性愈高。殺菌劑之最低抑制濃度（MIC)為在阻止所添加微 生物之生長的一組特別條件下所測得之最低濃度。 使用標準微量滴定盤分析，以設計成使測試微生物達 10 94379D05 201218948 到最佳生長之培養基來進行協同性測試。補充有〇. 2%葡萄 糖及0. 1%酵母萃取物的基本鹽類培養*(M9GY培養基）係 用於測試細菌；馬鈐薯葡萄糖培養液（？])]8培養基〉係用於
測試酵母g及黴I在此方法巾，#由在各種濃度的MBIT 之存在下進行高解析度MIC分析來測試廣範圍的殺菌劑袓 合。藉由對微量滴定盤的其中一欄添加不同量的殺菌劑、， 並使用自動液體處理系統進行十倍連續稀釋，以獲得活性 成分自2 ppm至10, 000 ppm變化的一系列終點，來測定高 解析度MIC。 山本發明之組合的協同性係以對抗如下表中所迷之數種 微生物而予以測定。所使用的細g之濃度約為每毫升5χΐ〇6 個細菌，而酶母菌及黴菌之濃度為每毫升5x1q5個真菌。 此等微生物代表許多消費性及卫業性應时的自缺污毕 物。經過於251 (酶母菌及黴菌）或阶（細菌）培養不同時 間後，_定盤進行微生物生長（混濁度）之視覺評估，以 測定MIC。 用於證實本發日狀ΜΒΠ組合之關性㈣域 =於下表丨至10中。於各測試中，第二組分⑻為。瞻， =第-組分⑴為其他商用殺菌劑。各表係顯示：随斑 =組分之特定組合；以各培養時_試之對抗微生物的 =;藉由單獨的隱⑽、單獨的其他組分⑻、混人 中的MBIT (Qb)及混合物中的其他組分⑽之㈣所量測 的以ppm計之終點活性；所計算之ST枯 組合（其他組分/MBIT或A/B)的協同比率範圍。所測试之各 94379D05
II 201218948 表1
Ca : BIOBAN GK(六氫-1，3, 5-參（2-羥基乙基）對稱三畊）之 ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑麴菌（A. niger) 3天 425 - - • ATCC # 16404 37.5 * 110 18.8 0.76 1:0.1709 200 18.8 0.97 1:0.0940 300 18.8 1.21 1:0.0627 300 9.4 0.96 1:0.0313 425 9.4 1.25 1:0.0221 300 4.7 0.83 1:0.0157 425 4.7 1.13 1:0.0111 300 2.4 0.77 1:0.0080 425 2.4 1.06 1:0.0056 300 1.2 0.74 1:0.0040 425 1.2 1.03 1:0.0028 7天 650 - - - - 150 * - 42.5 75 0.57 1:1.7647 65 75 0.60 1:1.1538 110 75 0.67 1:0.6818 200 75 0.81 1:0.3750 300 75 0.96 1:0.2500 400 75 1.12 1:0.1875 425 18.8 0.78 1:0.0442 525 18.8 0.93 1:0.0358 650 9.4 1.06 1:0·0145 525 4.7 0.84 1:0.0090 650 4.7 1.03 1:0.0072 525 2.4 0.82 1:0-0046 650 2.4 1.02 1:0.0037 650 1.2 1.01 1:0.0018 白色念珠菌 48小時 875 - - - (C. albicans) • 30 • ATCC# 10231 87.5 15 0.60 1:0.1714 110 15 0.63 1:0.1364 200 15 0.73 1:0.0750 300 15 0.84 1:0.0500 425 15 0.99 1:0.0353 110 7.5 0.38 1:0.0682 200 7.5 0.48 1:0.0375 300 7.5 0.59 1:0.0250 425 7.5 0.74 1:0.0176 525 7.5 0.85 1:0.0143 650 7.5 0.99 1:0.0115 425 3.75 0.61 1:0.0088 525 3.75 0.73 1:0.0071 650 3.75 0.87 1:0.0058 12 94379D05 201218948 875 3.75 1.13 1:0.0043 650 1.86 0.80 1:0.0029 875 1.86 1.06 1:0.0021 650 0.94 0.77 1:0.0014 875 0.94 1.03 1:0.0011 72小時 875 - • - 30 • 87.5 15 0.60 1:0.1714 110 15 0.63 1:0.1364 200 15 0.73 1:0.0750 300 15 0.84 1:0.0500 425 15 0.99 1:0.0353 425 7.5 0.74 1:0.0176 525 7.5 0.85 1:0.0143 650 7.5 0.99 1:0.0115 875 1.86 1.06 1:0.0021 875 0.94 1.03 1:0.0011 綠膿桿菌 24小時 55 - - - (Ps. aeruginosa) • 75 • * ATCC#9027 32.5 37.5 1.09 1:1.1538 43.75 18.75 1.05 1:0.4286 43.75 9.4 0.92 1:0.2149 43.75 4.6 0.86 1:0.1051 48小時 55 - -* - 125 - - 26.25 75 1.08 1:2.8571 32.5 37.5 0.89 1:1.1538 43.75 37.5 1.10 1:0.8571 55 4.6 1.04 1:0.0836 金黃色葡萄球菌 24小時 55 - - - (S. aureus) - 15 • • ATCC#6538 15 7.5 0.77 1：0.5000 32.5 3.8 0.84 1:0.1169 43.75 3.8 1.05 1:0.0869 32.5 1.8 0.71 1:0.0554 43.75 1.8 0.92 1:0.0411 55 1.8 1.12 1:0.0327 55 0.94 1.06 1:0.0171 48小時 55 - - - - 30 - - 0.1 15 0.50 1:150.0000 1.5 15 0.53 1:10.0000 2.625 15 0.55 1:5.7143 4.375 15 0.58 1:3.4286 5.5 15 0.60 1:2.7273 10 15 0.68 1:1.5000 15 15 0.77 1:1,0000 21.25 15 0.89 1:0.7059 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 21.25 7,5 0.64 1:0.3529 26.25 7,5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 32.5 3.8 0.72 1:0.1169 43.75 3：8 0.92 1:0.0869 55 3.8 1.13 1:0.0691 32.5 1.8 0.65 1:0.0554 55 1.8 1.06 1:0.0327 43.75 0.94 0.83 1:0.0215 55 0.94 1.03 1:0.0171 13 94379D05 s 201218948 表2
Ca : BIOBAN 1135(4, 4-二曱基噚唑啶）之ppm(活性成分） Cb:MBIT(N-甲基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑魏菌（A. niger) 3天 525 - - - ATCC# 16404 - 37.5 • • 200 18.8 0.88 1:0.0940 300 18.8 1.07 1:0.0627 300 9.4 0.82 1:0.0313 425 9.4 1.06 1:0.0221 425 4.7 0.93 1:0.0111 525 4.7 1.13 1:0.0090 425 2.4 0.87 1:0.0056 525 2.4 1.06 1:0.0046 425 1.2 0.84 1:0.0028 525 1.2 1.03 1:0.0023 7天 875 - • - - 150 - - 525 75 LI 1:0.1429 650 37.5 0.99 1:0.0577 875 9,4 1.06 1:0.0107 650 4·7 0,77 1:0.0072 875 4.7 1.03 1:0.0054 650 2.4 0.76 1:0.0037 875 2.4 1.02 1:0.0027 875 1.2 1.01 1:0.0014 白色念珠菌 48小時 1100 • - - (C.albicans) - 30 - - ATCC# 10231 425 15 0.89 1:0.0353 525 15 0.98 1:0.0286 650 15 1.09 10.0231 650 7.5 0.84 1:0.0115 875 7.5 1.05 1:0.0086 875 3.75 0.92 1:0.0043 1100 3.75 1.13 1:0.0034 875 1.86 0.86 1:0.0021 1100 1.86 1.06 1:0.0017 875 0.94 0.83 1:0.0011 14 94379D05 201218948 1100 .0.94 1.03 1:0.0009 72小時 1100 - - - - 30 - * 425 16 0.89 1:0.0353 525 15 0.98 1:0.0286 650 15 1.09 1:0.0231 875 7.5 1.05 1Ό.0086 875 3.75 0.92 1:0.0043 1100 3.75 1.13 1:0.0034 875 1.86 0.86 Γ0.0021 1100 1.86 1.06 1:0.0017 875 0.94 0.83 1:0.0011 1100 0.94 1.03 1:0.0009 綠膿桿菌 24小時 100 - - - (Ps. aeruginosa) - 75 - - ATCC#9027 55 37.5 1.05 1:0.6818 55 9.4 0.68 1:0.1709 100 9.4 1.13 1:0.0940 55 4.6 0.61 1:0.0836 100 4.6 1.06 1:0.0460 48小時 100 - - - - 125 - 21.25 75 0.81 1:3.5294 26.25 75 0.86 1:2.8571 32.5 75 0.93 1:2.3077 43.75 75 1.04 1:1.7143 55 37.5 0.85 1:0.6818 100 9.4 1.08 1:0.0940 100 4.6 1.04 1:0.0460 金黃色葡萄球菌 24小時 55 - - • (S. aureus) 30 - ATCC#6538 21.25 15 0.89 1:0.7059 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 10.1714 43.75 3.8 0.92 1:0.0869 55 3.8 1.13 1:0.0691 55 1.8 1.06 1：0.0327 55 0.94 1.03 1:0.0171 48小時 55 - - - - 30 - - 21.25 15 0.89 1:0.7059 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 43.75 3.8 0.92 1:0.0869 55 3.8 1.13 1-0.0691 55 1.8 1.06 1:0.0327 55 0.94 1.03 1:0.0171 15 94379D05 201218948 表3
Ca : SUTTOCIDE A(羥基甲基甘胺酸鈉）之ppm(活性成分） Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca:Cb 黑麵菌（A.niger) 3天 875 - - - ATCC # 16404 - 75 425 18.8 0.74 1:0.0442 525 18.8 0.85 1:0.0358 650 18.8 0.99 1:0.0289 425 9.4 0,61 1:0.0221 525 9.4 0.73 1:0.0179 650 9.4 0.87 1:0.0145 875 9.4 1.13 1:0.0107 650 4.7 0.81 1:0.0072 875 4.7 1.06 1:0.0054 525 2.4 0.63 1:0.0046 650 2.4 0.77 1:0.0037 875 2.4 1.03 1:0.0027 650 1.2 0.76 1:0.0018 875 1.2 1.02 1:0.0014 7天 1100 - - - - 150 - - 110 75 0.60 1:0.6818 200 75 0.68 1:0.3750 300 75 0.77 1:0.2500 425 75 0.89 1:0.1765 525 75 0.98 1:0.1429 650 75 1.09 1:0.1154 425 37.5 0.64 1:0.0882 525 37.5 0.73 1:0.0714 650 37.5 0.84 1:0.0577 875 37.5 1.05 1:0.0429 525 18.8 0.6 1:0.0358 650 18.8 0.72 1:0.0289 875 18.8 0.92 1:0.0215 1100 18.8 1.13 1:0.0171 525 9.4 0.54 1:0.0179 650 9.4 0.65 1:0.0145 875 9.4 0.86 1:0.0107 1100 9.4 1.06 1:0.0085 650 4.7 0.62 1:0.0072 875 4.7 0.83 1:0.0054 1100 4.7 1.03 1:0.0043 650 2.4 0.61 1:0.0037 875 2.4 0.81 1:0,0027 16 94379D05 201218948 1100 650 875 1100 2.4 1.2 1.2 1.2 1.02 0.60 0.80 1.01 1:0.0022 1:0.0018 1:0.0014 Γ0.0011 白色念珠菌 48小時 3000 - - - (C. albicans) - 30 - - ATCC# 10231 525 15 0.68 1:0.0286 650 15 0.72 1:0.0231 875 15 0.79 1:0.0171 1100 15 0.87 1:0.0136 2000 15 1.17 1:0.0075 525 7.5 0.43 1:0.0143 650 7.5 0.47 1:0.0115 875 7.5 0.54 1:0.0086 1100 7.5 0.62 1-0.0068 2000 7.5 0.92 1:0.0038 3000 7.5 1.25 1:0.0025 875 3.75 0.42 1:0.0043 1100 3.75 0.49 1-0.0034 2000 3.75 0.79 1:0.0019 3000 3.75 1.13 1:0.0013 2000 1.86 0.73 1:0.0009 3000 1.86 1.06 1:0.0006 2000 0.94 0.70 1:0.0005 3000 0.94 1.03 1:0.0003 72小時 3000 - - - - 30 - - 525 15 0.68 1:0.0286 650 15 0.72 1:0.0231 875 15 0.79 1:0.0171 1100 15 0.87 1:0.0136 2000 15 1.17 1:0.0075 3000 15 1.5 1:0.0050 525 7.5 0.43 1-0.0143 650 7.5 0.47 1:0.0115 875 7.5 0.54 1:0.0086 1100 7.5 0.62 1:0.0068 2000 7.5 0.92 1:0.0038 3000 7.5 1.25 1:0.0025 875 3.75 0.42 1:0.0043 1100 3.75 0.49 1:0.0034 2000 3.75 0.79 1:0.0019 3000 3.75 1.13 1:0.0013 2000 1.86 0.73 1:0.0009 3000 1.86 1.06 1:0.0006 2000 0.94 0.70 1:0.0005 3000 0.94 1.03 1:0.0003 綠膿桿菌 24小時 87.5 - - - (Ps.aeruginosa) - 75 - • ATCC#9027 65 9.4 0.87 1:0.1446 87.5 9.4 1.13 1:0.1074 48小時 110 - - - 17 94379D05 201218948 87.5 110 110 125 9.4 9.4 4.6 0.87 1.08 1.04 1:0.1074 1:0.0855 1:0.0418 金黃色葡萄球菌 24小時 110 - • - (S.aureus) - 15 - ATCC#6538 30 7.5 0.77 1:0.2500 42.5 7.5 89 1:0.1765 52.5 7.5 98 1:0.1429 65 7.5 1.09 1:0.1154 52.5 3.8 0.73 1:0.0724 65 3.8 0.84 1:0.0585 87.5 3.8 1.05 1:0.0434 110 0.94 1.06 1:0.0085 48小時 110 - - - 30 • - 6.5 15 0.56 1:2.3077 8.75 15 0.58 1:1.7143 11 15 0.6 1:1.3636 20 15 0.68 1:0.7500 30 15 0.77 1:0.5000 42.5 15 0.89 1:0.3529 52.5 15 0.98 1:0.2857 65 15 1.09 1:0.2308 42.5 7.5 0.64 1:0.1765 52.5 7.5 0.73 1:0.1429 65 7.5 0.84 1:0.1154 87.5 7.5 1.05 1:0.0857 65 3.8 0.72 1:0.0585 110 1.8 1.06 1:0.0164 110 0.94 1.03 1:0.0085 18 94379D05 201218948 表4
Ca : Phosphol ipid PTM(肉豆蔻蕴胺丙基丙二醇-氯化二甲 基銨麟酸S旨）之ppm(活性成分）
Cb:MBIT(N-甲基-1，2-苯并異11 塞唾琳-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑麴菌（A. niger) 3天 1100 - - ATCC # 16404 - 37.5 * - 425 18.8 0.89 1:0.0442 525 18.8 0.98 1:0.0358 650 18.8 1.09 10.0289 525 9.4 0.73 1:0.0179 650 9.4 0.84 1:0.0145 875 9.4 1.05 1:0.0107 1100 2.4 1.06 1:0.0022 1100 1.2 1.03 1:0.0011 7天 1100 - - - 19 94379D05 201218948 - 150 - - 2 75 0.50 1:37.5000 20 75 0.52 1:3.7500 200 75 0.68 1:0.3750 525 75 0.98 1:0.1429 650 75 1.09 10.1154 20 37.5 0.27 1:1.8750 52.5 37.5 0.3 1:0.7143 87.5 37.5 0.33 1:0.4286 200 37.5 0.43 1:0.1875 425 37.5 0.64 1:0.0882 650 37.5 0.84 1:0.0577 875 37.5 1.05 1:0.0429 650 18.8 0.72 1:0.0289 875 18.8 0.92 1:0.0215 1100 18.8 1.13 1:0.0171 650 9.4 0.65 1:0.0145 875 9.4 0.86 1:0.0107 1100 9.4 1.06 1:0.0085 1100 4.7 1.03 1:0.0043 1100 2.4 1.02 1:0.0022 1100 1.2 1.01 1:0.0011 白色念珠菌 48小時 1100 垂 - (C. albicans) - 30 - -· ATCC# 10231 525 15 0.98 1:0.0286 650 15 1.09 1:0.0231 525 7.5 0.73 1:0.0143 650 7.5 0.84 1:0.0115 875 7.5 1.05 1:0.0086 650 3.75 0.72 1:0.0058 875 3.75 0.92 1:0.0043 1100 3.75 1.13 1:0.0034 875 1.86 0.86 1:0.0021 身 1100 1.86 1.06 1:0.0017 875 0.94 0.83 1:0.0011 1100 0.94 1.03 1:0.0009 72小時 1100 - - - 60 - - 2 30 0.50 1:15.0000 20 30 0.52 1： 1.5000 110 30 0.60 1:0.2727 200 30 0.68 1:0.1500 300 30 0.77 1:0.1000 425 30 0.89 1:0.0706 525 30 0.98 1:0.0571 650 30 1.09 1:0.0462 525 15 0.73 1:0.0286 650 15 0.84 1:0.0231 525 7.5 0.6 1:0.0143 650 7.5 0.72 1:0.0115 875 7.5 0.92 1:0.0086 650 3.75 0.65 1:0.0058 20 94379D05 201218948 875 1100 875 1100 875 1100 3.75 3.75 1.86 1.86 0.94 0.94 0.86 1.06 0.83 1.03 0,81 1.02 1:0.0043 1:0,0034 1:0.0021 1:0·0017 1:0,0011 1:0.0009 綠膿桿菌 24小時 425 - - - (Ps. aeruginosa) - 75 - - ATCC#9027 425 4.6 1.06 1:0.0108 48小時 525 舉 - - - 125 - • 525 4.6 1.04 1:0.0088 金黃色葡萄球菌 24小時 10 - - - (S. aureus) - 15 - - ATCC#6538 2.625 7.5 0.76 1:2.8571 3.25 7.5 0.83 1:2.3077 4.375 7.5 0.94 1:1.7143 5.5 7.5 1.05 1:1,3636 4.375 3.8 0.69 1:0.8686 5.5 3.8 0.80 1:0.6909 10 3.8 1.25 1:0.3800 4.375 1.8 0.56 1:0.4114 5.5 1.8 0.67 1:0.3273 10 1.8 1.12 1：0.18Θ0 10 0.94 1.06 1:0.0940 48小時 10 - - - 30 - • 0.1 15 0.51 1： 150.0000 0.5 15 0.55 1:30.0000 1 15 0.6 1:15-0000 1.5 15 0.65 1:10.0000 2.125 15 0.71 1:7.0588 2.625 15 0.76 1:5.7143 3.25 15 0.83 1:4.6154 4.375 15 0.94 1:3.4286 5.5 15 1.05 1:2.7273 4.375 7.5 0.69 1:1.7143 5.5 7.5 0.80 1:1.3636 10 7.5 1.25 1:0.7500 4.375 3.8 0.56 1:0.8686 5.5 3.8 0.68 1:0.6909 10 3.8 1.13 1:0.3800 5.5 1.8 0.61 1:0.3273 10 1.8 1.06 1:0.1800 10 0.94 1.03 1:0.0940 21 94379D05 201218948 表5
Ca : Caprylic acid(辛酸）之 ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ce*Cb 黑鲍菌（A. niger) 3天 650 - - ATCC# 16404 - 75 麵 425 18.8 0.9 1:0.0442 525 18.8 1.06 1:0.0358 525 9.4 0.93 1:0.0179 650 9.4 1.13 1:0.0145 525 4.7 0.87 1:0.0090 525 2.4 0.84 1:0.0046 650 2.4 1.03 1:0.0037 650 1.2 1.02 1:0.0018 7天 875 - - - 150 * - 110 75 0.63 1:0.6818 200 75 0.73 1:0.3750 300 75 0.84 1:0.2500 425 75 0.99 1:0.1765 650 37.5 0.99 1Ό.0577 425 18.8 0.61 1:0.0442 650 18.8 0.87 1:0.0289 875 18.8 1.13 1:0.0215 875 9.4 1.06 1:0.0107 875 4.7 1.03 1:0.0054 875 2.4 1.02 1：0.0027 875 1.2 1.01 1:0.0014 白色念珠菌 48小時 65 - • • (C. albicans) - 30 - * ATCC# 10231 42.5 7.5 0.9 1:0.1765 52.5 7.5 1.06 1:0.1429 65 1.86 1.06 1:0.0286 65 0.94 1.03 1:0.0145 72小時 87.5 - • • - 30 • - 42.5 15 0.99 1:0.3529 42.5 7.5 0.74 1:0.1765 52.5 7.5 0.85 1:0.1429 65 7.5 0.99 1:0.1154 65 3.75 0.87 1:0.0577 87.5 3.75 1.13 1:0.0429 87.5 1.86 1.06 1:0.0213 87.5 0.94 1.03 1:0.0107 綠膿桿菌 48小時 >11000 • * - (Ps. aeruginosa) • 125 - * ATCC#9027 8750 75 1.4 1:0.0086 11000 37.5 1.3 1:0·0034 11000 18.75 1.15 1:0.0017 11000 9.4 1.08 1:0.0009 11000 4.6 1.04 1:0.0004 金黃色砝病球菌 24小時 425 - • - (S. aureus) - 15 • - ATCC#6538 425 0.94 1.06 1:0.0022 48小時 425 - - - - 30 - 425 1.8 1.06 1:0.0042 425 0.94 1.03 1:0·0022 22 94379D05 201218948 表6
Ca: SENSIVASC 50 (3[(2-乙基己基）氧基]1，2-丙二醇）（2-乙基己基甘油）之ppm(活性成分）
Cb:MBIT(N-甲基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. C&*Cb 黑鉋菌（A. niger) 3天 875 - - - ATCC # 16404 - 37.5 - • 650 9.4 0.99 1:0.0145 650 4.7 0.87 1:0.0072 875 4.7 1.13 1:0.0054 875 2.4 1.06 1:0.0027 875 1.2 1.03 1:0.0014 7天 1100 - - - - 150 - 87.5 75 0.58 1:0.8571 110 75 0.60 1:0.6818 200 75 0.68 1:0.3750 300 75 0.77 1:0.2500 425 75 0.89 1:0.1765 525 75 0.98 1:0.1429 650 75 1.09 1:0.1154 650 37.5 0.84 1:0.0577 1100 9.4 1.06 1:0.0085 1100 4.7 1.03 1:0.0043 1100 2.4 1.02 1:0.0022 1100 1.2 1.01 1:0.0011 白色念珠菌 48小時 2000 - - (C.albicans) . 30 - - ATCC# 10231 6.5 15 0.50 1--2.3077 11 15 0.51 1:1.3636 110 15 0.56 1:0.1364 200 15 0.60 1:0.0750 300 15 0.65 1:0.0500 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.86 1.06 1:0.0009 23 94379D05 201218948 2000 0.94 1.03 1 ：0.0005 72小時 2000 - - - - 30 - - 425 15 0.71 1:0.0353 525 15 0.76 1:0.0286 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.86 1.06 1：0.0009 2000 0.94 1.03 1:0.0005 綠膿桿菌 24小時 11000 - - (Ps. aeruginosa) - 75 - ATCC#9027 8750 37.5 1.3 1:0.0043 48小時 11000 • - * 125 - - 4250 75 0.99 1:0.0176 金黃色葡萄球菌 24小時 2000 - - - (S. aureus) • 30 - - ATCC#6538 8.75 15 0.5 1:1.7143 20 15 0.51 1:0.7500 42.5 15 0.52 1:0.3529 65 15 0.53 1:0.2308 110 15 0.56 1:0.1364 200 15 0.6 1:0.0750 425 15 0.71 1:0.0353 525 15 0.76 1:0.0286 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.8 1.06 1:0.0009 2000 0.94 1.03 1:0.0005 48小時 2000 - • - - 30 - - 8.75 15 0.50 1:1.7143 20 15 0.51 1:0.7500 42.5 15 0.52 1:0.3529 65 15 0.53 1:0.2308 110 15 0.56 1:0.1364 200 15 0.60 1:0.0750 425 15 0.71 1:0.0353 525 15 0.76 1:0.0286 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.8 1.06 1:0.0009 2000 0.94 1.03 1:0.0005 24 94379D05 201218948 表7
Ca : CAPMUL MCM C8(單辛酸甘油酯）之ppm(活性成分） Cb:MBIT(N-甲基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca:Cb 黑麴菌（A. niger) 3天 4250 - - - ATCC# 16404 75 - * 2000 37.5 0.97 1:0.0188 3000 37.5 1.21 1:0.0125 2000 18.8 0.72 1:0.0094 3000 18.8 0.96 1:0.0063 4250 18.8 1.25 1:0.0044 2000 9.4 0.60 1:0.0047 3000 9.4 0.83 1:0:0031 4250 9.4 1.13 1:0.0022 2000 4.7 0.53 1:0.0024 3000 4.7 0.77 1Ό.0016 4250 4.7 1.06 1:0.0011 2000 2.4 0.5 1Ό.0012 3000 2.4 0.74 1:0.0008 4250 2.4 1.03 1：0.0006 3000 1.2 0.72 1:0.0004 4250 1.2 1.02 1：0.0003 7天 4250 - - - 150 - 1100 75 0.76 1:0.0682 2000 75 0.97 1:0.0375 3000 75 1.21 1:0.0250 2000 37.5 0.72 1:0.0188 3000 37.5 0.96 1Ό.0125 4250 37.5 1.25 1:0.0088 2000 18.8 0.60 1:0.0094 3000 18.8 0.83 1:0.0063 4250 18.8 1.13 1:0.0044 2000 9.4 0.53 1:0.0047 3000 9.4 0.77 1:0.0031 4250 9.4 1.06 1:0.0022 2000 4.7 0.50 1:0.0024 3000 4.7 0.74 1:0.0016 4250 4.7 1.03 1:0.0011 2000 2.4 0.49 1:0.0012 3000 2.4 0.72 1:0.0008 4250 2.4 1.02 1:0.0006 白色念珠菌 48小時 200 - - - (C. albicans) - 30 - - ATCC# 10231 0.2 15 0.50 1:75.0000 2 15 0,51 1:7.5000 20 15 0.60 1:0.7500 42.5 15 0.71 1:0.3529 65 15 0.83 1:0.2308 25 94379D05 201218948 87.5 15 0.94 1:0.1714 110 15 1.05 1:0.1364 200 1.86 1.06 1:0.0093 200 0.94 1.03 1:0.0047 72小時 200 - - - - 30 - • 0.2 15 0.50 1:75.0000 2 15 0.51 1:7.5000 20 15 0.6 1:0.7500 42.5 15 0.71 1:0.3529 65 15 0.83 1:0.2308 87.5 15 0.94 1:0.1714 110 15 1.05 1:0.1364 200 1.86 1.06 1:0.0093 200 0.94 1.03 1:0.0047 綠膿桿菌 48小時 >11000 - (Ps.aeruginosa) - 125 - - ATCC#9027 2000 75 0.78 1:0.0375 3000 75 0.87 1-Ό.0250 4250 75 0.99 1:0.0176 金黃色葡萄球菌 24小時 650 - - - (S. aureus) • 30 - ATCC#6538 0.2 15 0.50 1:75.0000 2 15 0.50 1:7.5000 6.5 15 0,51 1:2.3077 11 15 0.52 1:1.3636 20 15 0.53 1:0.7500 30 15 0.55 1:0.5000 42.5 15 0.57 1:0.3529 52.5 15 0.58 1:0.2857 65 15 0.60 1:0.2308 87.5 15 0.63 1:0.1714 110 15 0.67 1:0.1364 200 15 0.81 1:0.0750 300 15 0.96 1:0.0500 425 15 1.15 1:0.0353 425 7.5 0.9 1:0.0176 525 7.5 1.06 1Ό.0143 48小時 875 - - - - 30 - - 0.2 15 0.50 1:75.0000 2 15 0.50 1:7.5000 6.5 15 0.51 1:2.3077 11 15 0.51 1:1.3636 20 15 0.52 1:0.7500 30 15 0.53 1:0.5000 42.5 15 0.55 1:0-3529 52.5 15 0.56 1:0.2857 65 15 0.57 1:0.2308 87.5 15 0.60 1:0.1714 110 15 0.63 1:0.1364 200 15 0.73 1:0.0750 300 15 0.84 1Ό.0500 425 15 0,99 1:0.0353 660 7.5 0.99 1:0.0115 875 1.8 1.06 10.0021 875 0.94 1.03 1:0.0011 26 94379D05 201218948 表8
Ca : CapmulMCMCIO (癸酸之單/二甘油酯（單癸酸甘油酯）） 之ppm(活性成分）
Cb:MBIT(N-甲基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑錄菌（A. niger) 3天 2000 - - - ATCC# 16404 - 75 • - 4.25 37.5 0.50 1:8.8235 6.5 37.5 0.50 1:5.7692 11 37.5 0.51 1:3.4091 30 37.5 0.52 1:1.2500 65 37.5 0.53 1:0.5769 110 37.5 0.56 1:0.3409 200 37.5 0.60 1:0.1875 300 37.5 0.65 1:0.1250 425 37.5 0.71 1:0.0882 525 37.5 0.76 1:0.0714 650 37.5 0.83 1:0.0577 875 37.5 0.94 1:0.0429 1100 37.5 1.05 1:0.0341 1100 18.8 0.8 1：0.0171 2000 4.7 1.06 1:0.0024 2000 2.4 1.03 10.0012 2000 1.2 1.02 1:0.0006 7天 2000 - - * 150 - - 525 75 0.76 1:0.1429 650 75 0.83 1:0.1154 . 875 75 0.94 1:0.0857 1100 75 1.05 1:0.0682 1100 37.5 0.8 1:0.0341 1100 18.8 0.68 1:0.0171 2000 9.4 1.06 1:0.0047 2000 4.7 1.03 1:0.0024 2000 2,4 1.02 1:0.0012 2000 1.2 1.01 1:0.0006 白色念珠菌 48小時 425 - • - (C· albicans) - 30 - - ATCC# 10231 87.5 15 0.71 1:0.1714 110 15 0.76 1:0.1364 200 15 0.97 1:0.0750 300 15 1.21 1:0.0500 27 94379D05 201218948 200 7.5 0.72 1:0.0375 300 7.5 0.96 1:0.0250 425 7.5 1.25 1:0.0176 200 3.75 0.60 1:0.0188 300 3.75 0.83 1:0.0125 425 3.75 1.13 1:0.0088 200 1.86 0.53 1:0.0093 300 1.86 0.77 1:0,0062 425 1.86 1.06 1:0.0044 200 0.94 0.50 1:0.0047 300 0.94 0.74 1:0.0031 425 0.94 1.03 1:0.0022 72小時 425 - - - - 30 - - 87.5 15 0.71 1:0.1714 110 15 0.76 1:0.1364 200 15 0.97 1:0.0750 300 15 1.21 1:0.0500 200 7.5 0.72 1:0.0375 300 7.5 0.96 1:0.0250 425 7.5 1.25 10.0176 200 3.75 0.60 1:0.0188 300 3.75 0.83 1：0.0125 425 3.75 1.13 1:0.0088 200 1.86 0.53 1:0.0093 300 1.86 0.77 1:0.0062 425 1.86 1.06 1:0.0044 200 0.94 0.50 1:0.0047 300 0.94 0.74 1:0.0031 425 0.94 1.03 1:0.0022 綠膿桿菌 24小時 11000 - - - (Ps. aeruginosa) - 75 - - ATCC#9027 - 37.5 - - - 18.75 - - - 9.4 - - 4.6 - - 48小時 11000 - - - - 125 • • - 75 - - - 37.5 - - - 18.75 - - 9.4 - - - 4.6 - - 金黃色葡萄球菌 24小時 200 > - - (S. aureus) - 30 - _ ATCC#6538 5.25 15 0.53 1:2.8571 11 15 0.56 1 1.3636 20 15 0.60 1:0.7500 30 15 0.65 1Ό.5000 42.5 15 0.71 1:0.3529 52.5 15 0.76 1:0.2857 65 15 0.83 1:0.2308 87.5 15 0.94 1:0.1714 110 15 1.05 1:0.1364 48小時 200 - - - - 30 - - 65 15 0.83 1:0.2308 87.5 15 0.94 1:0.1714 110 15 1.05 1:0.1364 28 94379D05 201218948 表9
Ca:BI0BAN1246(7 a-乙基二氫-1H，3H，5H-噚唑并（3,4-C) 曙。坐）之ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca:Cb 黑麴菌（A. niger) 3天 650 - - - ATCC# 16404 - 37.5 • • 200 18.8 0.81 1:0.0940 300 18.8 0.96 1:0.0627 425 18.8 1.16 1:0.0442 425 9.4 0.90 1:0.0221 525 9.4 1.06 1:0.0179 425 4.7 0.78 1:0.0111 525 4.7 0.93 1:0.0090 650 4.7 1.13 1:0.0072 425 2.4 0.72 1:0.0056 525 2.4 0.87 1:0.0046 650 2.4 1.06 1:0.0037 425 1.2 0.69 1:0.0028 525 1.2 0.84 1:0.0023 650 1.2 1.03 1:0.0018 7天 875 - - • • 150 - - 425 75 0.99 1:0.1765 650 37.5 0.99 1:0.0577 525 18.8 0.73 10.0358 650 18.8 0.87 1:0.0289 875 18.8 1.13 1:0.0215 875 9.4 1.06 1:0.0107 875 4.7 1.03 1:0.0054 875 2.5 1.02 1-0.0029 875 1.2 1.01 1:0.0014 白色念珠菌 48小時 3000 - - • (C. albicans) - 30 - • ATCC# 10231 875 15 0.79 1Ό.0171 1100 15 0.87 1:0.0136 2000 15 1.17 1:0.0075 875 7.5 0.54 1:0.0086 1100 7.5 0.62 1:0.0068 2000 7.5 0.92 1:0.0038 29 94379D05 201218948 3000 7.5 1.25 1:0.0025 2000 3.75 0.79 1:0.0019 3000 3.75 1.13 1：0.0013 2000 1.86 0.73 1：0.0009 3000 1.86 1.06 1:0.0006 3000 0.94 1.03 1:0.0003 72小時 4250 - - - - 30 • 875 15 0.71 1:0.0171 1100 15 0.76 1:0.0136 2000 15 0.97 1:0.0075 3000 15 1.21 1:0.0050 875 7.5 0.46 1:0.0086 1100 7.5 0.51 1:0.0068 2000 7.5 0.72 1:0.0038 3000 7.5 0.96 1:0.0025 4250 7.5 1.25 1:0.0018 2000 3.75 0.6 1:0.0019 3000 3.75 0.83 1：0.0013 4250 3.75 1.13 1:0.0009 2000 1.86 0.53 1:0.0009 3000 0.94 0.74 1:0.0003 4250 0.94 1.03 1:0.0002 綠膿桿菌 24小時 100 - - • · (Ps. aeruginosa) • 75 * - ATCC#9027 26.25 75 1.26 1:2.8571 43.75 37.5 0.94 1:0.8571 55 37.5 1.05 1:0.6818 55 18.75 0,80 10.3409 100 18.75 1.25 1:0.1875 55 9.4 0.68 1Ό.1709 100 9.4 1.13 1:0.0940 100 4.6 1.06 1:0.0460 48小時 150 - * - - 125 - - 26.25 75 0.78 1:2.8571 32.5 75 0.82 1:2.3077 43.75 75 0.89 11.7143 55 75 0.97 1:1.3636 100 75 1.27 1Ό.7500 55 37.5 0.67 1:0.6818 100 37.5 0.97 1:0.3750 150 37.5 1.3 1:0.2500 100 18.75 0.82 1:0.1875 150 18.75 1.15 1:0.1250 150 9.4 1.08 1:0.0627 150 4.6 1.04 1:0.0307 金黃色葡萄球菌 24小時 55 - - - (S. aureus) - 30 - - ATCC#6538 2.125 15 0.54 1:7.0588 5.5 15 0.60 1:2.7273 10 15 0.68 1:1.5000 30 94379D05 201218948 48小時 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 21.25 7.5 0.64 1:0.3529 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 32.5 3.8 0.72 1:0.1169 43.75 3.8 0.92 1:0.0869 55 3.8 1.13 1:0.0691 55 1.8 1.06 1:0.0327 55 0.94 1.03 1:0.0171 55 - - - 30 - 2.125 15 0.54 1:7.0588 5.5 15 0.60 1:2.7273 10 15 0.68 1:1.5000 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0,4615 21.25 7.5 0.64 1:0.3529 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 32.5 3.8 0.72 1:0.1169 43.75 3.8 0.92 1:0.0869 55 3.8 1.13 1:0.0691 55 1.8 1.06 1:0.0327 55 0.94 1,03 1Ό.0171 31 94379D05 201218948 表ίο
Ca:TCMTB(2-(硫基氰基甲基硫基）苯并噻唑）之PPm(活性成分） Cb: MBIT (N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分) 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.L Ca-Cb 黑麵菌（A.niger) 3天 3 • - ATCC# 16404 37.5 - 3 2.4 1.06 1:0.8000 3 1.2 1.03 1:0.4000 7天 8.75 - - 150 * 0.525 75 0.56 1:142.8571 0.65 75 0.57 1:115.3846 0.875 75 0.60 1:85.7143 1.1 75 0.63 1:68.1818 2 75 0.73 1:37.5000 3 75 0.84 1:25.0000 4.25 75 0.99 1:17.6471 8.75 9.4 1.06 1:1.0743 6.5 2.4 0.76 1··0·3692 8.75 2.4 1.02 1:0.2743 8.75 1.2 1.01 1:0.1371 白色念珠菌 48小時 4.25 - • (C. albicans) - 30 * ATCC# 10231 4,25 1.86 1.06 1:0.4376 4.25 0.94 1.03 1:0.2212 72小時 5.25 - * -. 60 - - 1.1 30 0.71 1:27.2727 2 30 0.88 1:15.0000 3 30 1.07 1:10.0000 4.25 15 1.06 1:3.5294 4.25 7·5 0.93 1:1.7647 5.25 3.75 1.06 1:0.7143 4.25 1.86 0.84 1:0.4376 5.25 1.86 1.03 1:0.3543 4.25 0.94 0.83 1:0.2212 5.25 0.94 1.02 1:0.1790 綠膿桿菌 48小時 212.5 - - - (Ps.aeruginosa) - 125 - ATCC#9027 21.25 75 0.70 1:3.5294 26.25 75 0.72 1:2.8571 43.75 75 0.81 1:1-7143 55 75 0.86 1:1.3636 100 75 1.07 1:0.7500 150 37.5 1.01 1:0.2500 150 18.75 0.86 1:0.1250 212.5 18.75 1.15 1:0.0882 150 9.4 0.78 1:0.0627 212.5 9.4 1.08 1:0.0442 212.5 4.6 1.04 1:0.0216 金黃色葡萄球菌 24小時 26.25 - - - (S. aureus) - 15 - - ATCC#6538 26.25 0.94 1.06 1:0.0358 32 94379D05 201218948 • 【圖式簡單說明】 無 【主要元件符號說明】
Claims (1)
- 201218948 七、申請專利範圍： 1. 一種殺菌組成物，包含： (a)(b) N-甲基-1，2-苯并異噻唑啉—3-顯I 至少-種殺菌劑，其係選自單辛酸甘油輯及單癸酸 及 甘油酉旨 2. 3. 4.如申請專利範圍第1項之殺菌組成物，其中，該至，丨、一 種殺菌劑為單辛酸甘油目旨，且單辛酸— -1，2-苯并異嗟唾琳_3_酮之比率為1:〇.〇_至 如申請專利範圍第2項之殺Ϊ組成物，其中 酉〜 甲基-u-苯并異嗟终夂 1 · 0.012 至 1 : 75。 如申請專利範圍第1項之殺菌組成物，其中，a | ，殺菌劑為單癸酸甘㈣，且單魏甘至甲\ 二，2-苯并異噻唑啉_3_酮之比率為1:〇 〇〇3ι 土 申請專利範圍第4項之殺菌組成物，复 . μ⑽甲基-u2-苯并異麵琳—3,二”酸甘 1 ： π η,.. . 玄比率為 94379D05 1 201218948 四、指定代表圖： (一) 本案指定代表圖為：第（）圖。（本案無圖式) (二) 本代表圖之元件符號簡單說明：（無） 五、本案若有化學式時，請揭示最能顯示發明特徵的化學式： 本案無化學式 94379D05
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| TW100149807A TWI377020B (en) | 2007-07-18 | 2008-07-08 | Microbicidal composition |
| TW100149815A TWI377022B (en) | 2007-07-18 | 2008-07-08 | Microbicidal composition |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8188127B2 (zh) |
| EP (8) | EP2119355B1 (zh) |
| JP (9) | JP4944843B2 (zh) |
| KR (8) | KR101090155B1 (zh) |
| CN (8) | CN102308848B (zh) |
| AU (1) | AU2008203011B2 (zh) |
| CA (8) | CA2722123C (zh) |
| MX (1) | MX2008009225A (zh) |
| PL (2) | PL2119359T3 (zh) |
| TW (8) | TWI377017B (zh) |
| ZA (1) | ZA200806096B (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP4944844B2 (ja) * | 2007-07-18 | 2012-06-06 | ローム アンド ハース カンパニー | 殺微生物組成物 |
| JP2009149610A (ja) * | 2007-12-20 | 2009-07-09 | Rohm & Haas Co | 相乗的殺微生物性組成物 |
| AU2013266432B2 (en) * | 2012-05-24 | 2016-05-19 | Dow Global Technologies Llc | Microbicidal composition |
| WO2014191097A2 (en) * | 2013-05-28 | 2014-12-04 | Thor Specialities (Uk) Limited | Microbicidal composition comprising an isothiazolone and an amineoxide |
| RU2654625C2 (ru) * | 2013-10-03 | 2018-05-21 | Дау Глоубл Текнолоджиз Ллк | Микробицидная композиция |
| WO2015102832A1 (en) * | 2013-12-30 | 2015-07-09 | Dow Global Technologies Llc | Microbicidal composition |
| US9642367B2 (en) | 2013-12-30 | 2017-05-09 | Dow Global Technologie Sllc | Microbicidal composition |
| JP6551650B2 (ja) * | 2015-03-04 | 2019-07-31 | セイコーエプソン株式会社 | インクジェット記録用水系インク組成物 |
| WO2017003772A1 (en) * | 2015-06-29 | 2017-01-05 | Rohm And Haas Company | Microbicidal composition |
| EP3439473B1 (de) * | 2016-04-05 | 2024-08-07 | THOR GmbH | Synergistische biozidzusammensetzungen enthaltend 5-chlor-2-methylisothiazolin-3-on |
| CN112136820A (zh) * | 2020-09-21 | 2020-12-29 | 西安三业新材料股份有限公司 | 一种强化型金属加工液防腐杀菌剂及其制备方法和应用 |
| KR102841670B1 (ko) | 2024-08-20 | 2025-08-01 | 주식회사 유스타터 | 경영 시뮬레이션을 위한 교육 시스템, 서버 및 그 동작 방법 |
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