TW201625658A - 經取代之核苷、核苷酸及其類似物 - Google Patents

經取代之核苷、核苷酸及其類似物 Download PDF

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Publication number
TW201625658A
TW201625658A TW104142822A TW104142822A TW201625658A TW 201625658 A TW201625658 A TW 201625658A TW 104142822 A TW104142822 A TW 104142822A TW 104142822 A TW104142822 A TW 104142822A TW 201625658 A TW201625658 A TW 201625658A
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TW
Taiwan
Prior art keywords
optionally substituted
compound
group
alkyl
echovirus
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TW104142822A
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English (en)
Chinese (zh)
Inventor
廣義 王
大衛 柏娜德 史密斯
里歐尼德 畢吉爾曼
克莉絲汀安 安卓斯 傑可爾
Original Assignee
艾洛斯生物製藥公司
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Publication of TW201625658A publication Critical patent/TW201625658A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
TW104142822A 2014-12-19 2015-12-18 經取代之核苷、核苷酸及其類似物 TW201625658A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462094418P 2014-12-19 2014-12-19

Publications (1)

Publication Number Publication Date
TW201625658A true TW201625658A (zh) 2016-07-16

Family

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Family Applications (1)

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TW104142822A TW201625658A (zh) 2014-12-19 2015-12-18 經取代之核苷、核苷酸及其類似物

Country Status (12)

Country Link
US (2) US9890188B2 (2)
EP (1) EP3233879A4 (2)
JP (1) JP2017538722A (2)
CN (1) CN107250145A (2)
AU (1) AU2015364630A1 (2)
CA (1) CA2970936A1 (2)
HK (1) HK1245800A1 (2)
MA (1) MA41213A (2)
MX (1) MX2017008184A (2)
TW (1) TW201625658A (2)
WO (1) WO2016100569A1 (2)
ZA (1) ZA201704876B (2)

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TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
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Also Published As

Publication number Publication date
MA41213A (fr) 2017-10-24
US20160176910A1 (en) 2016-06-23
AU2015364630A1 (en) 2017-07-06
US9890188B2 (en) 2018-02-13
CN107250145A (zh) 2017-10-13
HK1245800A1 (zh) 2018-08-31
US20180155384A1 (en) 2018-06-07
EP3233879A4 (en) 2018-09-19
WO2016100569A1 (en) 2016-06-23
JP2017538722A (ja) 2017-12-28
MX2017008184A (es) 2018-03-06
ZA201704876B (en) 2020-01-29
CA2970936A1 (en) 2016-06-23
EP3233879A1 (en) 2017-10-25

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