ATE250622T1 - 4'-c-ethynyl-pyrimidine nukleoside - Google Patents

4'-c-ethynyl-pyrimidine nukleoside

Info

Publication number
ATE250622T1
ATE250622T1 AT00925624T AT00925624T ATE250622T1 AT E250622 T1 ATE250622 T1 AT E250622T1 AT 00925624 T AT00925624 T AT 00925624T AT 00925624 T AT00925624 T AT 00925624T AT E250622 T1 ATE250622 T1 AT E250622T1
Authority
AT
Austria
Prior art keywords
ethynyl
hydrogen atom
nucleosides
pyrimidine
pyrimidines
Prior art date
Application number
AT00925624T
Other languages
English (en)
Inventor
Hiroshi Ohrui
Shiro Shigeta
Eiichi Kodama
Haruhiko Machida
Satoru Kohgo
Hiroaki Mitsuya
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE250622T1 publication Critical patent/ATE250622T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT00925624T 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside ATE250622T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP17492099 1999-06-22
JP31824699 1999-11-09
JP2000081117 2000-03-23
PCT/JP2000/003024 WO2000069876A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl pyrimidine nucleosides

Publications (1)

Publication Number Publication Date
ATE250622T1 true ATE250622T1 (de) 2003-10-15

Family

ID=27471622

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00925625T ATE250623T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside
AT00925624T ATE250622T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00925625T ATE250623T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Country Status (10)

Country Link
US (3) US6333315B1 (de)
EP (2) EP1177202B1 (de)
AT (2) ATE250623T1 (de)
AU (2) AU4431300A (de)
BR (1) BR0011521B8 (de)
CA (2) CA2308677C (de)
DE (2) DE60005502T2 (de)
ES (1) ES2207504T3 (de)
MX (1) MXPA01011517A (de)
WO (2) WO2000069876A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250623T1 (de) * 1999-05-12 2003-10-15 Yamasa Corp 4'-c-ethynyl-purin-nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
WO2003068796A1 (en) * 2002-02-15 2003-08-21 Yamasa Corporation 4’-c-cyano-2’-deoxypurine nucleosides
EA012844B1 (ru) 2003-02-19 2009-12-30 Йельский Университет Аналоги противовирусных нуклеозидов и способы лечения вирусных инфекций, в частности вич-инфекций
CA2502109C (en) 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
DE602005015466D1 (de) 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
NZ567272A (en) 2005-09-26 2012-02-24 Pharmasset Inc Modified 4'-nucleosides as antiviral agents
WO2008043704A1 (en) 2006-10-10 2008-04-17 Medivir Ab Hcv nucleoside inhibitor
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
UA117095C2 (uk) 2011-12-22 2018-06-25 Аліос Біофарма, Інк. Нуклеозидна сполука або її фармацевтично прийнятна сіль
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP3055319A4 (de) 2013-10-11 2018-01-10 Alios Biopharma, Inc. Substituierte nukleoside, nukleotide und analoga davon
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
CN108289931B (zh) 2015-09-23 2022-10-11 默沙东公司 4’-取代的核苷逆转录酶抑制剂及其制备
US10933067B2 (en) 2016-11-16 2021-03-02 National Center For Global Health And Medicine Nucleoside derivative having physiological activity such as antiviral activity
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
MX2020006864A (es) * 2017-12-27 2020-11-11 Univ Emory Modalidades combinadas para inhibidores de nucleosidos y/o nadph oxidasa (nox) como agentes antivirales especificos de mieloides.
KR102868585B1 (ko) 2018-07-09 2025-10-13 머크 샤프 앤드 돔 엘엘씨 4'-에티닐 뉴클레오시드 유사체의 효소적 합성
JP2021536444A (ja) * 2018-08-30 2021-12-27 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited Ｈｉｖ療法に有用な化合物
JP7530899B2 (ja) 2018-12-20 2024-08-08 メルク・シャープ・アンド・ドーム・エルエルシー Ｎｒｔｔｉ化合物の新規結晶形態
SG11202107145SA (en) 2019-01-25 2021-08-30 Univ Brown Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
AU2020231934B2 (en) 2019-03-06 2023-04-20 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in HIV therapy
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
PE20221037A1 (es) 2019-09-11 2022-06-17 Scripps Research Inst Profarmacos antivirales y composiciones farmaceuticas de los mismos
US11718637B2 (en) 2020-03-20 2023-08-08 Gilead Sciences, Inc. Prodrugs of 4′-C-substituted-2-halo-2′- deoxyadenosine nucleosides and methods of making and using the same
TW202400134A (zh) 2022-03-15 2024-01-01 美商羅米醫療公司 用於治療疾病之化合物及方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250623T1 (de) * 1999-05-12 2003-10-15 Yamasa Corp 4'-c-ethynyl-purin-nukleoside

Also Published As

Publication number Publication date
MXPA01011517A (es) 2003-08-20
BR0011521B8 (pt) 2021-05-25
WO2000069876A1 (en) 2000-11-23
US6291670B1 (en) 2001-09-18
CA2308677C (en) 2007-09-18
AU4431200A (en) 2000-12-05
DE60005502D1 (de) 2003-10-30
CA2308677A1 (en) 2000-11-12
AU4431300A (en) 2000-12-05
ES2207504T3 (es) 2004-06-01
DE60005502T2 (de) 2004-06-24
US6403568B1 (en) 2002-06-11
BR0011521A (pt) 2002-03-26
EP1177201A1 (de) 2002-02-06
BR0011521B1 (pt) 2013-12-24
CA2308192A1 (en) 2000-11-12
DE60005501T2 (de) 2004-06-24
WO2000069877A1 (en) 2000-11-23
CA2308192C (en) 2007-09-18
US6333315B1 (en) 2001-12-25
DE60005501D1 (de) 2003-10-30
EP1177201B1 (de) 2003-09-24
EP1177202A1 (de) 2002-02-06
US20020022722A1 (en) 2002-02-21
EP1177202B1 (de) 2003-09-24
ATE250623T1 (de) 2003-10-15

Similar Documents

Publication Publication Date Title
ATE250622T1 (de) 4'-c-ethynyl-pyrimidine nukleoside
WO1997030677A3 (en) Pentafluorobenzenesulfonamides and analogs
AU4264396A (en) Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
TR200103395T2 (tr) 13-metil eritromisin türevleri.
NO996108L (no) 9-oksinerytromycinderivater
GEP20084284B (en) Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
CA2336412A1 (en) Medicament for treatment of diabetes
NO20020282L (no) Nytt difenyl-piperidinderivat
CA2238875A1 (en) Tri-aryl ethane derivatives as pde iv inhibitors
CA2406685A1 (en) Oxadiazole derivatives having anticancer effects
MD1560F2 (en) Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses.
MX9805023A (es) Derivados de 1-metilcarbapenem.
GB9426090D0 (en) Pharmaceutical compounds
DE69911785D1 (de) Triazolo[4,5-d]pyrimidin-verbindungen
ATE285771T1 (de) Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung
DE69007356D1 (de) Zyklisches Tetrapeptid und Verfahren zu dessen Herstellung.
IL147307A0 (en) Indolocarbazole alkaloid derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
WO2000024389A3 (en) Benzoquinoline derivatives useful as antibacterial agents
CA2245484A1 (en) Novel urea derivatives
EA200001157A2 (ru) Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции
FR2823749B1 (fr) Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
TW360630B (en) A secoaporphine compounds on arrhythmia
MX9604072A (es) Derivados de oxazolidinona y composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties