TW201632513A - 前列腺素ｅｐ３受體之拮抗劑 - Google Patents

前列腺素ｅｐ３受體之拮抗劑 Download PDF

Info

Publication number: TW201632513A
Authority: TW; Taiwan
Prior art keywords: compound; salt; pharmaceutically acceptable; solvate; acceptable salt
Prior art date: 2014-12-22

Application number

TW104142513A

Other languages

English (en)

Chinese (zh)

Inventor

凱文班克

丹尼爾坎特布瑞

大衛艾德蒙

二木建太郎

伊特成盈李

厄納茲曼哈傑克洛茲

加納波利科瓦

羅伯特史坦登

Original Assignee

輝瑞股份有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-22

Filing date

2015-12-17

Publication date

2016-09-16

2015-12-17 Application filed by 輝瑞股份有限公司 filed Critical 輝瑞股份有限公司

2016-09-16 Publication of TW201632513A publication Critical patent/TW201632513A/zh

Links

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229960004559 theobromine Drugs 0.000 description 1
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229960002277 tolazamide Drugs 0.000 description 1
OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
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WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW104142513A 2014-12-22 2015-12-17 前列腺素ｅｐ３受體之拮抗劑 TW201632513A (zh)

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US201462095337P	2014-12-22	2014-12-22
US201562259528P	2015-11-24	2015-11-24

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US (1)	US9738626B2 (2)
EP (1)	EP3237401B1 (2)
JP (1)	JP2017538769A (2)
CA (1)	CA2915470A1 (2)
TW (1)	TW201632513A (2)
UY (1)	UY36455A (2)
WO (1)	WO2016103097A1 (2)

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2015
- 2015-12-11 EP EP15821169.8A patent/EP3237401B1/en not_active Not-in-force
- 2015-12-11 WO PCT/IB2015/059548 patent/WO2016103097A1/en not_active Ceased
- 2015-12-11 JP JP2017533416A patent/JP2017538769A/ja not_active Withdrawn
- 2015-12-16 US US14/970,930 patent/US9738626B2/en not_active Expired - Fee Related
- 2015-12-17 CA CA2915470A patent/CA2915470A1/en not_active Abandoned
- 2015-12-17 TW TW104142513A patent/TW201632513A/zh unknown
- 2015-12-18 UY UY0001036455A patent/UY36455A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2016103097A1 (en)	2016-06-30
US20160176851A1 (en)	2016-06-23
UY36455A (es)	2016-07-29
EP3237401A1 (en)	2017-11-01
CA2915470A1 (en)	2016-06-22
US9738626B2 (en)	2017-08-22
JP2017538769A (ja)	2017-12-28
EP3237401B1 (en)	2019-03-06

Publication	Publication Date	Title
TW201632513A (zh)	2016-09-16	前列腺素ｅｐ３受體之拮抗劑
US20240140937A1 (en)	2024-05-02	Diacylglycerol Acyl Transferase 2 Inhibitors
TWI551596B (zh)	2016-10-01	二醯甘油醯基轉移酶２抑制劑
JP2019085427A (ja)	2019-06-06	ＴｒｋＡキナーゼ阻害剤としての１−（（３Ｓ，４Ｒ）−４−（３−フルオロフェニル）−１−（２−メトキシエチル）ピロリジン−３−イル）−３−（４−メチル−３−（２−メチルピリミジン−５−イル）−１−フェニル−１Ｈ−ピラゾール−５−イル）尿素
CA2926568C (en)	2017-09-05	Antagonists of prostaglandin ep3 receptor
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