TW201733580A - Ｔｒｋ抑制劑抵抗性的癌治療劑 - Google Patents

Ｔｒｋ抑制劑抵抗性的癌治療劑 Download PDF

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Publication number: TW201733580A
Authority: TW; Taiwan
Prior art keywords: trifluoromethyl; urea; phenoxy; phenyl; amino
Prior art date: 2016-03-11

Application number

TW106107769A

Other languages

English (en)

Chinese (zh)

Inventor

小崎龍平

本光希

江頭啓

竹内淳

Original Assignee

小野藥品工業股份有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-03-11

Filing date

2017-03-09

Publication date

2017-10-01

2017-03-09 Application filed by 小野藥品工業股份有限公司 filed Critical 小野藥品工業股份有限公司

2017-10-01 Publication of TW201733580A publication Critical patent/TW201733580A/zh

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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

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TW106107769A 2016-03-11 2017-03-09 Ｔｒｋ抑制劑抵抗性的癌治療劑 TW201733580A (zh)

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PT3106463T (pt)	2008-10-22	2018-05-18	Array Biopharma Inc	Compostos de pirazolo[1,5-]pirimidina substituídos como inibidores de cinase trk
AR077468A1 (es)	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
RU2735545C2 (ru)	2010-05-20	2020-11-03	Эррэй Биофарма Инк.	Макроциклические соединения в качестве ингибиторов киназы trk
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TN2019000271A1 (en)	2015-10-26	2021-01-07	Univ Colorado Regents	Point mutations in trk inhibitor-resistant cancer and methods relating to the same
IL304018A (en)	2016-04-04	2023-08-01	Loxo Oncology Inc	Liquid formulations of (S)-N-(5-((R)-2-(5,2-difluorophenyl)-pyrrolidine-1-yl)-pyrazolo[5,1-A]pyrimidin-3-yl)-3 -hydroxypyrrolidine-1-carboxamide
US10045991B2 (en)	2016-04-04	2018-08-14	Loxo Oncology, Inc.	Methods of treating pediatric cancers
ES2952056T3 (es)	2016-05-18	2023-10-26	Loxo Oncology Inc	Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
JOP20190092A1 (ar)	2016-10-26	2019-04-25	Array Biopharma Inc	عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar)	2017-03-16	2019-09-16	Array Biopharma Inc	مركبات حلقية ضخمة كمثبطات لكيناز ros1
CN110305138B (zh) *	2018-03-27	2021-04-23	海创药业股份有限公司	一种治疗癌症的化合物及其用途

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HUE042591T2 (hu) *	2013-02-19	2019-07-29	Ono Pharmaceutical Co	TRK-gátló vegyület
BR122017020365A2 (pt) *	2014-08-18	2019-09-10	Ono Pharmaceutical Co	sal de adição de ácido do composto inibidor de trk

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WO2017155018A1 (fr)	2017-09-14

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TW201733580A (zh)	2017-10-01	Ｔｒｋ抑制劑抵抗性的癌治療劑
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US20140357636A1 (en)	2014-12-04	Treatment of Skeletal-Related Disorders
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JP2018109013A (ja)	2018-07-12	キナーゼ調節のための化合物および方法、ならびにその適応
TW202108572A (zh)	2021-03-01	Ｃｄｋ抑制劑
JP2019048899A (ja)	2019-03-28	化合物及び使用方法
US20160272635A1 (en)	2016-09-22	Substituted dihydropyrido[3,4-b]pyrazinones as dual inhibitors of bet proteins and polo-like kinases
EP3868757A1 (fr)	2021-08-25	Dérivés de la pyridone ayant le groupe tétrahydropyranylmethyl
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US20210000830A1 (en)	2021-01-07	CANCER TREATMENT METHOD USING Trk INHIBITOR AND KINASE INHIBITOR IN COMBINATION
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KR20260004307A (ko)	2026-01-08	다환성 irak 및 flt3 억제 화합물 및 이의 용도
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HK40057478B (zh)	2024-01-19	Hpk1抑制剂及其使用方法
HK1238630A1 (en)	2018-05-04	Pyridone derivative having tetrahydropyranyl methyl group
HK1238630B (en)	2022-01-14	Pyridone derivative having tetrahydropyranyl methyl group
BR112017000242B1 (pt)	2024-06-04	Composto, cristal, inibidor de axl, medicamento, composição farmacêutica, e, uso de um composto