TW302284B - - Google Patents

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Publication number: TW302284B
Authority: TW; Taiwan
Prior art keywords: acid; vitamin; weight; composition; oil
Prior art date: 1992-07-13

Application number

TW82105572A

Other languages

English (en)

Chinese (zh)

Original Assignee

Shiseido Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-13

Filing date

1993-07-13

Publication date

1997-04-11

1992-07-13 Priority claimed from JP22773092A external-priority patent/JPH0632712A/ja

1992-07-13 Priority claimed from JP22772992A external-priority patent/JP3455553B2/ja

1992-07-13 Priority claimed from JP22772792A external-priority patent/JPH0632729A/ja

1992-07-13 Priority claimed from JP4227725A external-priority patent/JP2794252B2/ja

1992-07-13 Priority claimed from JP22772892A external-priority patent/JP3545429B2/ja

1993-07-13 Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd

1997-04-11 Application granted granted Critical

1997-04-11 Publication of TW302284B publication Critical patent/TW302284B/zh

Links

FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 192
239000011719 vitamin A Substances 0.000 claims description 192
229940045997 vitamin a Drugs 0.000 claims description 192
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 189
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 188
235000019155 vitamin A Nutrition 0.000 claims description 188
239000000203 mixture Substances 0.000 claims description 114
-1 2-ethylhexyl Chemical group 0.000 claims description 101
239000003921 oil Substances 0.000 claims description 91
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 55
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 39
239000002253 acid Substances 0.000 claims description 37
150000003839 salts Chemical class 0.000 claims description 30
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
235000001014 amino acid Nutrition 0.000 claims description 25
239000003963 antioxidant agent Substances 0.000 claims description 24
235000006708 antioxidants Nutrition 0.000 claims description 24
150000001413 amino acids Chemical class 0.000 claims description 23
239000011732 tocopherol Substances 0.000 claims description 21
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 18
239000003381 stabilizer Substances 0.000 claims description 16
150000002148 esters Chemical class 0.000 claims description 12
230000003078 antioxidant effect Effects 0.000 claims description 11
230000002079 cooperative effect Effects 0.000 claims description 11
229930003799 tocopherol Natural products 0.000 claims description 11
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 10
230000002378 acidificating effect Effects 0.000 claims description 9
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical group O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 9
235000014655 lactic acid Nutrition 0.000 claims description 9
239000004310 lactic acid Substances 0.000 claims description 9
229920001223 polyethylene glycol Polymers 0.000 claims description 8
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 7
150000004676 glycans Chemical class 0.000 claims description 7
229920001451 polypropylene glycol Polymers 0.000 claims description 7
229920001282 polysaccharide Polymers 0.000 claims description 7
239000005017 polysaccharide Substances 0.000 claims description 7
239000004475 Arginine Substances 0.000 claims description 6
239000002202 Polyethylene glycol Substances 0.000 claims description 6
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
239000002734 clay mineral Substances 0.000 claims description 6
229920002674 hyaluronan Polymers 0.000 claims description 6
229960003160 hyaluronic acid Drugs 0.000 claims description 6
238000012360 testing method Methods 0.000 claims description 6
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
239000004471 Glycine Substances 0.000 claims description 5
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 5
239000002738 chelating agent Substances 0.000 claims description 5
229910052802 copper Inorganic materials 0.000 claims description 5
239000010949 copper Substances 0.000 claims description 5
229910001389 inorganic alkali salt Inorganic materials 0.000 claims description 5
230000007935 neutral effect Effects 0.000 claims description 5
229920000045 Dermatan sulfate Polymers 0.000 claims description 4
229920000084 Gum arabic Polymers 0.000 claims description 4
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 4
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 4
235000010489 acacia gum Nutrition 0.000 claims description 4
239000000205 acacia gum Substances 0.000 claims description 4
235000004279 alanine Nutrition 0.000 claims description 4
235000003704 aspartic acid Nutrition 0.000 claims description 4
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 4
229940051593 dermatan sulfate Drugs 0.000 claims description 4
238000011049 filling Methods 0.000 claims description 4
PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims description 4
AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical compound [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 claims description 4
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 3
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical group O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 3
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 3
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 3
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 3
239000003098 androgen Substances 0.000 claims description 3
239000010931 gold Substances 0.000 claims description 3
229910052737 gold Inorganic materials 0.000 claims description 3
229960003104 ornithine Drugs 0.000 claims description 3
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 3
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
239000004472 Lysine Substances 0.000 claims description 2
MXNODNKXIIQMMI-UHFFFAOYSA-N [3-decanoyloxy-2,2-bis(decanoyloxymethyl)propyl] decanoate Chemical compound CCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCC)(COC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC MXNODNKXIIQMMI-UHFFFAOYSA-N 0.000 claims description 2
150000007513 acids Chemical class 0.000 claims description 2
125000003277 amino group Chemical group 0.000 claims description 2
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims description 2
229910000271 hectorite Inorganic materials 0.000 claims description 2
229920000642 polymer Polymers 0.000 claims description 2
238000004321 preservation Methods 0.000 claims description 2
229940063675 spermine Drugs 0.000 claims description 2
235000019149 tocopherols Nutrition 0.000 claims description 2
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
229920001287 Chondroitin sulfate Polymers 0.000 claims 2
235000017788 Cydonia oblonga Nutrition 0.000 claims 2
241000978776 Senegalia senegal Species 0.000 claims 2
AVJBPWGFOQAPRH-FWMKGIEWSA-N alpha-L-IdopA-(1->3)-beta-D-GalpNAc4S Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS(O)(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C(O)=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-N 0.000 claims 2
229940059329 chondroitin sulfate Drugs 0.000 claims 2
WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims 2
KFSJYZYQSZKRRQ-BYPYZUCNSA-N (2s)-2-(hydroxyamino)-4-methylsulfanylbutanoic acid Chemical compound CSCC[C@H](NO)C(O)=O KFSJYZYQSZKRRQ-BYPYZUCNSA-N 0.000 claims 1
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
ODHCTXKNWHHXJC-VKHMYHEASA-M 5-oxo-L-prolinate Chemical compound [O-]C(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-M 0.000 claims 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
239000005977 Ethylene Substances 0.000 claims 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
WTHXTWHYLIZJBH-UHFFFAOYSA-N acetic acid;azane Chemical compound N.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O WTHXTWHYLIZJBH-UHFFFAOYSA-N 0.000 claims 1
230000032683 aging Effects 0.000 claims 1
125000003368 amide group Chemical group 0.000 claims 1
239000001913 cellulose Substances 0.000 claims 1
229920002678 cellulose Polymers 0.000 claims 1
150000002334 glycols Chemical class 0.000 claims 1
150000003840 hydrochlorides Chemical class 0.000 claims 1
238000012856 packing Methods 0.000 claims 1
229940071139 pyrrolidone carboxylate Drugs 0.000 claims 1
229910000275 saponite Inorganic materials 0.000 claims 1
238000005406 washing Methods 0.000 claims 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 claims 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 111
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 109
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 108
235000019198 oils Nutrition 0.000 description 89
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 78
230000000052 comparative effect Effects 0.000 description 74
230000000694 effects Effects 0.000 description 63
229940032094 squalane Drugs 0.000 description 56
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 54
238000000034 method Methods 0.000 description 51
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 49
235000019441 ethanol Nutrition 0.000 description 43
239000008213 purified water Substances 0.000 description 43
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 42
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 38
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 37
229960004756 ethanol Drugs 0.000 description 36
235000011187 glycerol Nutrition 0.000 description 35
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 33
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 28
239000008159 sesame oil Substances 0.000 description 26
235000011803 sesame oil Nutrition 0.000 description 26
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 25
239000012071 phase Substances 0.000 description 24
235000014113 dietary fatty acids Nutrition 0.000 description 23
239000000194 fatty acid Substances 0.000 description 23
229930195729 fatty acid Natural products 0.000 description 23
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 23
DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 description 22
229920002125 Sokalan® Polymers 0.000 description 22
229940099259 vaseline Drugs 0.000 description 22
239000006071 cream Substances 0.000 description 21
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 21
229960002216 methylparaben Drugs 0.000 description 21
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 20
238000002360 preparation method Methods 0.000 description 20
AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 20
229960000984 tocofersolan Drugs 0.000 description 20
229940087168 alpha tocopherol Drugs 0.000 description 19
229940024606 amino acid Drugs 0.000 description 19
229960000541 cetyl alcohol Drugs 0.000 description 19
239000000839 emulsion Substances 0.000 description 19
239000011734 sodium Substances 0.000 description 19
235000004835 α-tocopherol Nutrition 0.000 description 19
239000002076 α-tocopherol Substances 0.000 description 19
238000002835 absorbance Methods 0.000 description 18
HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 18
239000004006 olive oil Substances 0.000 description 18
235000008390 olive oil Nutrition 0.000 description 18
229910052708 sodium Inorganic materials 0.000 description 17
229940083542 sodium Drugs 0.000 description 17
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 16
238000010521 absorption reaction Methods 0.000 description 16
239000012965 benzophenone Substances 0.000 description 16
239000013078 crystal Substances 0.000 description 16
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 16
235000010199 sorbic acid Nutrition 0.000 description 16
239000004334 sorbic acid Substances 0.000 description 16
229940075582 sorbic acid Drugs 0.000 description 16
229960001295 tocopherol Drugs 0.000 description 16
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 15
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 15
150000001875 compounds Chemical class 0.000 description 15
229940075507 glyceryl monostearate Drugs 0.000 description 15
238000002156 mixing Methods 0.000 description 15
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 15
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 15
235000019271 petrolatum Nutrition 0.000 description 15
235000015424 sodium Nutrition 0.000 description 15
229920000858 Cyclodextrin Polymers 0.000 description 14
IYNWNKYVHCVUCJ-UHFFFAOYSA-N bismuth Chemical compound [Bi].[Bi] IYNWNKYVHCVUCJ-UHFFFAOYSA-N 0.000 description 14
229910052797 bismuth Inorganic materials 0.000 description 14
238000011002 quantification Methods 0.000 description 14
GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 14
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 13
239000004264 Petrolatum Substances 0.000 description 13
229930003268 Vitamin C Natural products 0.000 description 13
238000011481 absorbance measurement Methods 0.000 description 13
229940066842 petrolatum Drugs 0.000 description 13
235000019154 vitamin C Nutrition 0.000 description 13
239000011718 vitamin C Substances 0.000 description 13
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 12
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TW82105572A 1992-07-13 1993-07-13 TW302284B (th)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP22773092A JPH0632712A (ja)	1992-07-13	1992-07-13	皮膚外用剤
JP22772992A JP3455553B2 (ja)	1992-07-13	1992-07-13	皮膚外用剤
JP22772792A JPH0632729A (ja)	1992-07-13	1992-07-13	皮膚外用剤
JP4227725A JP2794252B2 (ja)	1992-07-13	1992-07-13	皮膚外用剤
JP22772892A JP3545429B2 (ja)	1992-07-13	1992-07-13	レチノール安定配合皮膚外用剤

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TW82105572A TW302284B (th)	1992-07-13	1993-07-13

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