TW317502B - - Google Patents

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Publication number: TW317502B
Authority: TW; Taiwan
Prior art keywords: vitamin; acid; oil; ministry; weight
Prior art date: 1992-07-13

Application number

TW85115876A

Other languages

English (en)

Chinese (zh)

Original Assignee

Shiseido Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-13

Filing date

1993-07-13

Publication date

1997-10-11

1992-07-13 Priority claimed from JP22773092A external-priority patent/JPH0632712A/ja

1992-07-13 Priority claimed from JP4227725A external-priority patent/JP2794252B2/ja

1992-07-13 Priority claimed from JP22772892A external-priority patent/JP3545429B2/ja

1992-07-13 Priority claimed from JP22772992A external-priority patent/JP3455553B2/ja

1992-07-13 Priority claimed from JP22772792A external-priority patent/JPH0632729A/ja

1993-07-13 Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd

1997-10-11 Application granted granted Critical

1997-10-11 Publication of TW317502B publication Critical patent/TW317502B/zh

Links

FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 199
239000011719 vitamin A Substances 0.000 claims description 194
229940045997 vitamin a Drugs 0.000 claims description 194
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 191
235000019155 vitamin A Nutrition 0.000 claims description 191
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 190
-1 benzophenone compound Chemical class 0.000 claims description 103
239000000203 mixture Substances 0.000 claims description 92
239000003921 oil Substances 0.000 claims description 85
235000019198 oils Nutrition 0.000 claims description 85
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 59
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 52
239000002253 acid Substances 0.000 claims description 36
150000001875 compounds Chemical class 0.000 claims description 28
239000011732 tocopherol Substances 0.000 claims description 26
239000003963 antioxidant agent Substances 0.000 claims description 25
235000006708 antioxidants Nutrition 0.000 claims description 25
229960001295 tocopherol Drugs 0.000 claims description 24
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 19
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 18
239000004006 olive oil Substances 0.000 claims description 18
235000010199 sorbic acid Nutrition 0.000 claims description 18
239000004334 sorbic acid Substances 0.000 claims description 18
229940075582 sorbic acid Drugs 0.000 claims description 18
235000008390 olive oil Nutrition 0.000 claims description 17
239000003381 stabilizer Substances 0.000 claims description 16
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 15
229920000858 Cyclodextrin Polymers 0.000 claims description 15
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 15
229940055577 oleyl alcohol Drugs 0.000 claims description 15
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 15
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 12
CIWBSHSKHKDKBQ-DUZGATOHSA-N D-araboascorbic acid Natural products OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 claims description 11
235000010323 ascorbic acid Nutrition 0.000 claims description 11
239000011668 ascorbic acid Substances 0.000 claims description 11
239000012965 benzophenone Substances 0.000 claims description 11
235000010350 erythorbic acid Nutrition 0.000 claims description 10
229940026239 isoascorbic acid Drugs 0.000 claims description 10
RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 7
235000010389 delta-tocopherol Nutrition 0.000 claims description 7
239000004318 erythorbic acid Substances 0.000 claims description 7
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 6
229940071106 ethylenediaminetetraacetate Drugs 0.000 claims description 6
239000011630 iodine Substances 0.000 claims description 6
229910052740 iodine Inorganic materials 0.000 claims description 6
KJCLYACXIWMFCC-UHFFFAOYSA-M sodium;5-benzoyl-4-hydroxy-2-methoxybenzenesulfonate Chemical compound [Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 KJCLYACXIWMFCC-UHFFFAOYSA-M 0.000 claims description 5
239000006097 ultraviolet radiation absorber Substances 0.000 claims description 5
WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 4
WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 4
235000019485 Safflower oil Nutrition 0.000 claims description 4
CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 4
229930016911 cinnamic acid Natural products 0.000 claims description 4
235000013985 cinnamic acid Nutrition 0.000 claims description 4
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 4
235000005713 safflower oil Nutrition 0.000 claims description 4
239000003813 safflower oil Substances 0.000 claims description 4
CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 claims description 4
229960000368 sulisobenzone Drugs 0.000 claims description 4
229940072107 ascorbate Drugs 0.000 claims description 3
239000003795 chemical substances by application Substances 0.000 claims description 3
238000011049 filling Methods 0.000 claims description 3
229920000742 Cotton Polymers 0.000 claims description 2
241000237502 Ostreidae Species 0.000 claims description 2
229940079894 benzophenone-9 Drugs 0.000 claims description 2
235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
QDCHWIWENYCPIL-UHFFFAOYSA-L disodium;4-hydroxy-5-(2-hydroxy-4-methoxy-5-sulfonatobenzoyl)-2-methoxybenzenesulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC(S([O-])(=O)=O)=C(OC)C=C1O QDCHWIWENYCPIL-UHFFFAOYSA-L 0.000 claims description 2
235000020636 oyster Nutrition 0.000 claims description 2
150000003789 δ-tocopherols Chemical class 0.000 claims description 2
238000002309 gasification Methods 0.000 claims 2
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
WURBFLDFSFBTLW-UHFFFAOYSA-N benzil Chemical group C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 WURBFLDFSFBTLW-UHFFFAOYSA-N 0.000 claims 1
239000008280 blood Substances 0.000 claims 1
210000004369 blood Anatomy 0.000 claims 1
239000012320 chlorinating reagent Substances 0.000 claims 1
210000002700 urine Anatomy 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 111
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 108
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 105
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 94
238000000034 method Methods 0.000 description 72
230000000052 comparative effect Effects 0.000 description 66
230000000694 effects Effects 0.000 description 62
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 54
235000011187 glycerol Nutrition 0.000 description 47
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 44
229940032094 squalane Drugs 0.000 description 43
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 41
235000019441 ethanol Nutrition 0.000 description 39
KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Inorganic materials [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 35
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 34
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 33
150000003839 salts Chemical class 0.000 description 32
239000008159 sesame oil Substances 0.000 description 28
235000011803 sesame oil Nutrition 0.000 description 28
229940099259 vaseline Drugs 0.000 description 27
235000014113 dietary fatty acids Nutrition 0.000 description 25
239000000194 fatty acid Substances 0.000 description 25
229930195729 fatty acid Natural products 0.000 description 25
239000008213 purified water Substances 0.000 description 24
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 24
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 22
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 22
229960002216 methylparaben Drugs 0.000 description 22
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 21
239000000839 emulsion Substances 0.000 description 21
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 20
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 20
239000006071 cream Substances 0.000 description 20
238000002835 absorbance Methods 0.000 description 19
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 18
229920002125 Sokalan® Polymers 0.000 description 18
DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 description 17
229940024606 amino acid Drugs 0.000 description 17
235000001014 amino acid Nutrition 0.000 description 17
229960000541 cetyl alcohol Drugs 0.000 description 17
150000008163 sugars Chemical class 0.000 description 17
238000010521 absorption reaction Methods 0.000 description 16
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 15
229930003268 Vitamin C Natural products 0.000 description 15
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
239000013078 crystal Substances 0.000 description 15
AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 15
229960000984 tocofersolan Drugs 0.000 description 15
235000019154 vitamin C Nutrition 0.000 description 15
239000011718 vitamin C Substances 0.000 description 15
229940087168 alpha tocopherol Drugs 0.000 description 14
150000001413 amino acids Chemical class 0.000 description 14
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 14
HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 14
239000011734 sodium Substances 0.000 description 14
229910052708 sodium Inorganic materials 0.000 description 14
229940083542 sodium Drugs 0.000 description 14
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239000002076 α-tocopherol Substances 0.000 description 14
238000002156 mixing Methods 0.000 description 13
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 13
238000001556 precipitation Methods 0.000 description 13
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 12
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 12
238000011481 absorbance measurement Methods 0.000 description 12
230000003078 antioxidant effect Effects 0.000 description 12
235000019271 petrolatum Nutrition 0.000 description 12
229940031439 squalene Drugs 0.000 description 12
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 12
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 11
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 11
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 11
230000033228 biological regulation Effects 0.000 description 11
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 11
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 11
238000009472 formulation Methods 0.000 description 11
QUAMTGJKVDWJEQ-UHFFFAOYSA-N octabenzone Chemical compound OC1=CC(OCCCCCCCC)=CC=C1C(=O)C1=CC=CC=C1 QUAMTGJKVDWJEQ-UHFFFAOYSA-N 0.000 description 11
JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 11
235000011118 potassium hydroxide Nutrition 0.000 description 11
235000015424 sodium Nutrition 0.000 description 11
230000002079 cooperative effect Effects 0.000 description 10
ATUOYWHBWRKTHZ-UHFFFAOYSA-N dimethylmethane Natural products CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 10
239000011521 glass Substances 0.000 description 10
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235000010384 tocopherol Nutrition 0.000 description 10
GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 10
QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 9
239000004264 Petrolatum Substances 0.000 description 9
IYNWNKYVHCVUCJ-UHFFFAOYSA-N bismuth Chemical compound [Bi].[Bi] IYNWNKYVHCVUCJ-UHFFFAOYSA-N 0.000 description 9
229940066842 petrolatum Drugs 0.000 description 9
238000007639 printing Methods 0.000 description 9
235000010388 propyl gallate Nutrition 0.000 description 9
239000000473 propyl gallate Substances 0.000 description 9
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238000011002 quantification Methods 0.000 description 9
235000021419 vinegar Nutrition 0.000 description 9
239000000052 vinegar Substances 0.000 description 9
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 8
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
230000002378 acidificating effect Effects 0.000 description 8
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BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 8
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229910052751 metal Inorganic materials 0.000 description 8
239000002184 metal Substances 0.000 description 8
DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 8
239000000843 powder Substances 0.000 description 8
238000002360 preparation method Methods 0.000 description 8
RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 7
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240000004808 Saccharomyces cerevisiae Species 0.000 description 7
HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 7
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239000004310 lactic acid Substances 0.000 description 7
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239000001788 mono and diglycerides of fatty acids Substances 0.000 description 7
RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 7
239000001702 nutmeg Substances 0.000 description 7
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239000004575 stone Substances 0.000 description 7
MMMPXNOKIZOWHM-UHFFFAOYSA-N 1-octoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCC MMMPXNOKIZOWHM-UHFFFAOYSA-N 0.000 description 6
241000251730 Chondrichthyes Species 0.000 description 6
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 6
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OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 6
239000002585 base Substances 0.000 description 6
WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 6
238000013329 compounding Methods 0.000 description 6
238000005336 cracking Methods 0.000 description 6
238000011161 development Methods 0.000 description 6
230000018109 developmental process Effects 0.000 description 6
150000002148 esters Chemical class 0.000 description 6
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
239000011591 potassium Substances 0.000 description 6
229910052700 potassium Inorganic materials 0.000 description 6
239000001294 propane Substances 0.000 description 6
239000002904 solvent Substances 0.000 description 6
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 6
229940088594 vitamin Drugs 0.000 description 6
229930003231 vitamin Natural products 0.000 description 6
235000013343 vitamin Nutrition 0.000 description 6
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Landscapes

Cosmetics (AREA)

TW85115876A 1992-07-13 1993-07-13 TW317502B (2)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP22773092A JPH0632712A (ja)	1992-07-13	1992-07-13	皮膚外用剤
JP4227725A JP2794252B2 (ja)	1992-07-13	1992-07-13	皮膚外用剤
JP22772892A JP3545429B2 (ja)	1992-07-13	1992-07-13	レチノール安定配合皮膚外用剤
JP22772992A JP3455553B2 (ja)	1992-07-13	1992-07-13	皮膚外用剤
JP22772792A JPH0632729A (ja)	1992-07-13	1992-07-13	皮膚外用剤

Publications (1)

Publication Number	Publication Date
TW317502B true TW317502B (2)	1997-10-11

Family

ID=51565742

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
TW82105572A TW302284B (2)	1992-07-13	1993-07-13
TW85115876A TW317502B (2)	1992-07-13	1993-07-13

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
TW82105572A TW302284B (2)	1992-07-13	1993-07-13

Country Status (1)

Country	Link
TW (2)	TW302284B (2)

1993
- 1993-07-13 TW TW82105572A patent/TW302284B/zh not_active IP Right Cessation
- 1993-07-13 TW TW85115876A patent/TW317502B/zh active

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TW302284B (2)	1997-04-11

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