TW499435B - Pregnane glucuronides - Google Patents

Pregnane glucuronides Download PDF

Info

Publication number: TW499435B
Authority: TW; Taiwan
Prior art keywords: pregnane; compound; salt; scope; carbon atoms
Prior art date: 1998-10-13

Application number

TW088117305A

Other languages

English (en)

Chinese (zh)

Inventor

Christopher P Miller

Bach D Tran

Michael D Collini

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-13

Filing date

1999-10-07

Publication date

2002-08-21

1999-10-07 Application filed by Wyeth Corp filed Critical Wyeth Corp

2002-08-21 Application granted granted Critical

2002-08-21 Publication of TW499435B publication Critical patent/TW499435B/zh

Links

-1 Pregnane glucuronides Chemical class 0.000 title claims description 13
229930182480 glucuronide Natural products 0.000 title description 3
150000003839 salts Chemical class 0.000 claims abstract description 11
150000001875 compounds Chemical class 0.000 claims description 25
229940097043 glucuronic acid Drugs 0.000 claims description 12
125000000217 alkyl group Chemical group 0.000 claims description 6
229910052783 alkali metal Inorganic materials 0.000 claims description 4
IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims description 3
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 3
125000005210 alkyl ammonium group Chemical group 0.000 claims description 3
150000003863 ammonium salts Chemical class 0.000 claims description 3
125000005131 dialkylammonium group Chemical group 0.000 claims description 3
125000005208 trialkylammonium group Chemical group 0.000 claims description 3
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims 6
JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 claims 1
239000000583 progesterone congener Substances 0.000 abstract description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
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IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 12
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 11
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XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 7
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GWTNLHGTLIBHHZ-SVNGYHJRSA-N methyl (2s,3s,4s,5r,6r)-3,4,5-triacetyloxy-6-bromooxane-2-carboxylate Chemical compound COC(=O)[C@H]1O[C@H](Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O GWTNLHGTLIBHHZ-SVNGYHJRSA-N 0.000 description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW088117305A 1998-10-13 1999-10-07 Pregnane glucuronides TW499435B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17034298A	1998-10-13	1998-10-13

Publications (1)

Publication Number	Publication Date
TW499435B true TW499435B (en)	2002-08-21

Family

ID=22619512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW088117305A TW499435B (en)	1998-10-13	1999-10-07	Pregnane glucuronides

Country Status (17)

Country	Link
EP (1)	EP1121376A1 (ko)
JP (1)	JP2002527448A (ko)
KR (1)	KR20010080102A (ko)
CN (1)	CN1330659A (ko)
AR (1)	AR020778A1 (ko)
AU (1)	AU751708B2 (ko)
BR (1)	BR9914521A (ko)
CA (1)	CA2346693A1 (ko)
CZ (1)	CZ20011343A3 (ko)
EA (1)	EA200100437A1 (ko)
HU (1)	HUP0103992A3 (ko)
IL (1)	IL142441A0 (ko)
NO (1)	NO20011825L (ko)
PL (1)	PL347270A1 (ko)
TW (1)	TW499435B (ko)
WO (1)	WO2000021977A1 (ko)
ZA (1)	ZA200103012B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0104423D0 (sv)	2001-12-27	2001-12-27	Umecrine Ab	Pregnane steroids and their use in the treatment of CNS disorders
KR100440607B1 (ko) *	2001-12-28	2004-07-15	주식회사 엘컴사이언스	프레그난 배당체 화합물 및 이를 유효성분으로 함유하는퇴행성 뇌신경계 질환의 예방 및 치료제

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2029011B (en) *	1978-09-01	1983-02-02	Coulson W	Use of a synthetic bifunctional ligand for the immunimetric determination of the concentration ratio of two solutes

1999
- 1999-10-07 CZ CZ20011343A patent/CZ20011343A3/cs unknown
- 1999-10-07 AU AU65115/99A patent/AU751708B2/en not_active Ceased
- 1999-10-07 HU HU0103992A patent/HUP0103992A3/hu unknown
- 1999-10-07 JP JP2000575882A patent/JP2002527448A/ja active Pending
- 1999-10-07 TW TW088117305A patent/TW499435B/zh active
- 1999-10-07 EA EA200100437A patent/EA200100437A1/ru unknown
- 1999-10-07 WO PCT/US1999/023467 patent/WO2000021977A1/en not_active Ceased
- 1999-10-07 CA CA002346693A patent/CA2346693A1/en not_active Abandoned
- 1999-10-07 PL PL99347270A patent/PL347270A1/xx not_active Application Discontinuation
- 1999-10-07 CN CN99814413A patent/CN1330659A/zh active Pending
- 1999-10-07 KR KR1020017004572A patent/KR20010080102A/ko not_active Withdrawn
- 1999-10-07 EP EP99953101A patent/EP1121376A1/en not_active Withdrawn
- 1999-10-07 IL IL14244199A patent/IL142441A0/xx unknown
- 1999-10-07 BR BR9914521-9A patent/BR9914521A/pt not_active IP Right Cessation
- 1999-10-12 AR ARP990105144A patent/AR020778A1/es unknown
2001
- 2001-04-10 NO NO20011825A patent/NO20011825L/no not_active Application Discontinuation
- 2001-04-11 ZA ZA200103012A patent/ZA200103012B/en unknown

Also Published As

Publication number	Publication date
CN1330659A (zh)	2002-01-09
HUP0103992A2 (hu)	2002-04-29
JP2002527448A (ja)	2002-08-27
AR020778A1 (es)	2002-05-29
PL347270A1 (en)	2002-03-25
HUP0103992A3 (en)	2002-12-28
BR9914521A (pt)	2001-06-26
EA200100437A1 (ru)	2001-10-22
EP1121376A1 (en)	2001-08-08
NO20011825L (no)	2001-06-05
CZ20011343A3 (cs)	2002-04-17
NO20011825D0 (no)	2001-04-10
KR20010080102A (ko)	2001-08-22
AU751708B2 (en)	2002-08-22
WO2000021977A1 (en)	2000-04-20
ZA200103012B (en)	2002-07-11
CA2346693A1 (en)	2000-04-20
AU6511599A (en)	2000-05-01
IL142441A0 (en)	2002-03-10

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