TWI347319B - Process for the manufacture of tocopheryl acylates - Google Patents
Process for the manufacture of tocopheryl acylatesInfo
- Publication number
- TWI347319B TWI347319B TW094112728A TW94112728A TWI347319B TW I347319 B TWI347319 B TW I347319B TW 094112728 A TW094112728 A TW 094112728A TW 94112728 A TW94112728 A TW 94112728A TW I347319 B TWI347319 B TW I347319B
- Authority
- TW
- Taiwan
- Prior art keywords
- manufacture
- tocopheryl
- acylates
- tocopheryl acylates
- tocopherols
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G13/00—Vitamins of unknown constitution
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04009816 | 2004-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200538448A TW200538448A (en) | 2005-12-01 |
| TWI347319B true TWI347319B (en) | 2011-08-21 |
Family
ID=34965832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094112728A TWI347319B (en) | 2004-04-26 | 2005-04-21 | Process for the manufacture of tocopheryl acylates |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7435836B2 (zh) |
| EP (1) | EP1740567B1 (zh) |
| JP (1) | JP4874236B2 (zh) |
| KR (1) | KR101174174B1 (zh) |
| CN (1) | CN1946706B (zh) |
| AT (1) | ATE370939T1 (zh) |
| DE (1) | DE602005002136T2 (zh) |
| TW (1) | TWI347319B (zh) |
| WO (1) | WO2005103026A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE112007003075T5 (de) | 2006-12-27 | 2009-12-17 | Dsm Ip Assets B.V. | Verfahren zur Acylierung organischer Hydroxyverbindungen |
| US8796809B2 (en) | 2008-09-08 | 2014-08-05 | Cree, Inc. | Varactor diode with doped voltage blocking layer |
| CA3102404A1 (en) | 2018-06-05 | 2019-12-12 | Flagship Pioneering Innovations V, Inc. | Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease |
| CN116440889A (zh) * | 2018-07-02 | 2023-07-18 | 帝斯曼知识产权资产管理有限公司 | 在仲羟基及其催化剂的存在下选择性酰化伯羟基的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4955633A (zh) | 1972-10-12 | 1974-05-30 | ||
| DE4243464A1 (de) | 1992-12-22 | 1994-06-23 | Basf Ag | Verfahren zur Herstellung von alpha-Tocopherol und alpha-Tocopherylacetat in flüssigem oder überkritischem Kohlendioxid |
| JP2002502360A (ja) * | 1996-01-29 | 2002-01-22 | ビーエーエスエフ アクチェンゲゼルシャフト | dlα―トコフェロールまたは酢酸dl―α―トコフェリルの製造方法 |
| DE19603142A1 (de) | 1996-01-29 | 1997-07-31 | Basf Ag | Verfahren zur Herstellung von dl-alpha-Tocopherol oder dl-alpha-Tocopherylacetat |
| DE10011402A1 (de) * | 2000-03-09 | 2001-09-13 | Degussa | Verfahren zur Herstellung von alpha-Tocopherolestern |
| CN1205200C (zh) * | 2000-11-22 | 2005-06-08 | 巴斯福股份公司 | 色原烷醇酯衍生物的连续酰化方法 |
-
2005
- 2005-04-18 JP JP2007509922A patent/JP4874236B2/ja not_active Expired - Lifetime
- 2005-04-18 DE DE602005002136T patent/DE602005002136T2/de not_active Expired - Lifetime
- 2005-04-18 EP EP05736077A patent/EP1740567B1/en not_active Expired - Lifetime
- 2005-04-18 WO PCT/EP2005/004068 patent/WO2005103026A1/en not_active Ceased
- 2005-04-18 AT AT05736077T patent/ATE370939T1/de not_active IP Right Cessation
- 2005-04-18 US US11/578,549 patent/US7435836B2/en not_active Expired - Lifetime
- 2005-04-18 KR KR1020067022225A patent/KR101174174B1/ko not_active Expired - Lifetime
- 2005-04-18 CN CN200580013095XA patent/CN1946706B/zh not_active Expired - Lifetime
- 2005-04-21 TW TW094112728A patent/TWI347319B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR101174174B1 (ko) | 2012-08-14 |
| US7435836B2 (en) | 2008-10-14 |
| JP2007534713A (ja) | 2007-11-29 |
| TW200538448A (en) | 2005-12-01 |
| CN1946706B (zh) | 2012-03-21 |
| EP1740567A1 (en) | 2007-01-10 |
| ATE370939T1 (de) | 2007-09-15 |
| JP4874236B2 (ja) | 2012-02-15 |
| DE602005002136D1 (de) | 2007-10-04 |
| DE602005002136T2 (de) | 2008-05-21 |
| WO2005103026A1 (en) | 2005-11-03 |
| US20070225509A1 (en) | 2007-09-27 |
| CN1946706A (zh) | 2007-04-11 |
| EP1740567B1 (en) | 2007-08-22 |
| KR20070015550A (ko) | 2007-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |