TWI364289B - Antitussive agent and manufacture thereof - Google Patents

Antitussive agent and manufacture thereof Download PDF

Info

Publication number: TWI364289B
Authority: TW; Taiwan
Prior art keywords: extract; reverse phase; ethanol; phase chromatography; chromatography column
Prior art date: 2008-12-24

Application number

TW097150373A

Other languages

English (en)

Chinese (zh)

Other versions

TW201023869A (en

Inventor

Yuan Ling Ku

Chien Jen Shih

Hsiao Chu Huang

Chun Hung Kuo

Yi Chen Lin

Yueh Chu Chen

Original Assignee

Medical & Pharm Ind Tech & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-24

Filing date

2008-12-24

Publication date

2012-05-21

2008-12-24 Application filed by Medical & Pharm Ind Tech & Dev filed Critical Medical & Pharm Ind Tech & Dev

2008-12-24 Priority to TW097150373A priority Critical patent/TWI364289B/zh

2009-01-19 Priority to DE102009005059A priority patent/DE102009005059B4/de

2009-02-02 Priority to GBGB0901628.8A priority patent/GB0901628D0/en

2009-02-05 Priority to FR0900498A priority patent/FR2940088B1/fr

2009-04-06 Priority to GB0905971A priority patent/GB2466525B/en

2009-08-13 Priority to JP2009187754A priority patent/JP5174760B2/ja

2010-07-01 Publication of TW201023869A publication Critical patent/TW201023869A/zh

2012-05-21 Application granted granted Critical

2012-05-21 Publication of TWI364289B publication Critical patent/TWI364289B/zh

Links

229940124584 antitussives Drugs 0.000 title claims description 21
239000003434 antitussive agent Substances 0.000 title claims description 13
238000004519 manufacturing process Methods 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 57
239000000284 extract Substances 0.000 claims description 41
235000008708 Morus alba Nutrition 0.000 claims description 29
240000000249 Morus alba Species 0.000 claims description 28
206010011224 Cough Diseases 0.000 claims description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
238000004366 reverse phase liquid chromatography Methods 0.000 claims description 17
239000000706 filtrate Substances 0.000 claims description 16
239000000843 powder Substances 0.000 claims description 16
230000000954 anitussive effect Effects 0.000 claims description 14
238000000034 method Methods 0.000 claims description 14
239000011347 resin Substances 0.000 claims description 13
229920005989 resin Polymers 0.000 claims description 13
239000000469 ethanolic extract Substances 0.000 claims description 11
239000007788 liquid Substances 0.000 claims description 11
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 9
238000000605 extraction Methods 0.000 claims description 9
239000000203 mixture Substances 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 9
239000003937 drug carrier Substances 0.000 claims description 8
239000000546 pharmaceutical excipient Substances 0.000 claims description 8
239000000287 crude extract Substances 0.000 claims description 7
238000004587 chromatography analysis Methods 0.000 claims description 4
239000003814 drug Substances 0.000 claims description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 4
238000001179 sorption measurement Methods 0.000 claims description 4
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 3
239000003456 ion exchange resin Substances 0.000 claims description 3
229920003303 ion-exchange polymer Polymers 0.000 claims description 3
239000012528 membrane Substances 0.000 claims description 3
239000004793 Polystyrene Substances 0.000 claims description 2
229920002223 polystyrene Polymers 0.000 claims description 2
239000000243 solution Substances 0.000 claims 4
238000011049 filling Methods 0.000 claims 3
239000003795 chemical substances by application Substances 0.000 claims 2
238000011068 loading method Methods 0.000 claims 2
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
239000005977 Ethylene Substances 0.000 claims 1
238000011010 flushing procedure Methods 0.000 claims 1
238000003306 harvesting Methods 0.000 claims 1
238000002347 injection Methods 0.000 claims 1
239000007924 injection Substances 0.000 claims 1
238000002156 mixing Methods 0.000 claims 1
229920005990 polystyrene resin Polymers 0.000 claims 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
238000011156 evaluation Methods 0.000 description 9
239000012141 concentrate Substances 0.000 description 7
230000000694 effects Effects 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
230000005764 inhibitory process Effects 0.000 description 5
238000001914 filtration Methods 0.000 description 4
238000000926 separation method Methods 0.000 description 4
241000700198 Cavia Species 0.000 description 3
241000700199 Cavia porcellus Species 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
238000002481 ethanol extraction Methods 0.000 description 3
238000010992 reflux Methods 0.000 description 3
241000218213 Morus <angiosperm> Species 0.000 description 2
206010036790 Productive cough Diseases 0.000 description 2
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
241000555745 Sciuridae Species 0.000 description 2
239000000084 colloidal system Substances 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000006199 nebulizer Substances 0.000 description 2
241000894007 species Species 0.000 description 2
208000024794 sputum Diseases 0.000 description 2
210000003802 sputum Anatomy 0.000 description 2
101100313763 Arabidopsis thaliana TIM22-2 gene Proteins 0.000 description 1
241000218231 Moraceae Species 0.000 description 1
241000772415 Neovison vison Species 0.000 description 1
241000270666 Testudines Species 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
239000006286 aqueous extract Substances 0.000 description 1
239000011324 bead Substances 0.000 description 1
229920001429 chelating resin Polymers 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
235000009508 confectionery Nutrition 0.000 description 1
239000007799 cork Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000002934 diuretic Substances 0.000 description 1
230000001882 diuretic effect Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000002024 ethyl acetate extract Substances 0.000 description 1
238000003810 ethyl acetate extraction Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000005360 mashing Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
239000001294 propane Substances 0.000 description 1
239000002893 slag Substances 0.000 description 1
239000002689 soil Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000003809 water extraction Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Biotechnology (AREA)
Botany (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Medical Informatics (AREA)
Alternative & Traditional Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW097150373A 2008-12-24 2008-12-24 Antitussive agent and manufacture thereof TWI364289B (en)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
TW097150373A TWI364289B (en)	2008-12-24	2008-12-24	Antitussive agent and manufacture thereof
DE102009005059A DE102009005059B4 (de)	2008-12-24	2009-01-19	Hustenmittelzusammensetzung und Verfahren zur Herstellung derselben
GBGB0901628.8A GB0901628D0 (en)	2008-12-24	2009-02-02	Antitussive composition and method for making the same
FR0900498A FR2940088B1 (fr)	2008-12-24	2009-02-05	Composition antitussive et son procede de fabrication
GB0905971A GB2466525B (en)	2008-12-24	2009-04-06	Antitussive composition comprising a root-bark extract of Morus australis Poir and method for making the same
JP2009187754A JP5174760B2 (ja)	2008-12-24	2009-08-13	鎮咳組成物およびその作製方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
TW097150373A TWI364289B (en)	2008-12-24	2008-12-24	Antitussive agent and manufacture thereof

Publications (2)

Publication Number	Publication Date
TW201023869A TW201023869A (en)	2010-07-01
TWI364289B true TWI364289B (en)	2012-05-21

Family

ID=40469406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW097150373A TWI364289B (en)	2008-12-24	2008-12-24	Antitussive agent and manufacture thereof

Country Status (5)

Country	Link
JP (1)	JP5174760B2 (fr)
DE (1)	DE102009005059B4 (fr)
FR (1)	FR2940088B1 (fr)
GB (2)	GB0901628D0 (fr)
TW (1)	TWI364289B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102688309A (zh) *	2012-06-14	2012-09-26	李良	治疗咳嗽的龙舌叶中药汤剂及制备方法
CN104800271A (zh) *	2015-04-14	2015-07-29	南京多宝生物科技有限公司	一种大青叶提取物的制备方法
CN104971081A (zh) *	2015-06-16	2015-10-14	陕西师范大学	一种超声辅助提取大青叶中靛蓝和靛玉红的方法
CN105030869A (zh) *	2015-06-29	2015-11-11	安徽瑞思威尔科技有限公司	一种基于响应面优化的亳菊总黄酮提取液的制备方法
CN105031178A (zh) *	2015-08-03	2015-11-11	南京中医药大学	一种高效利用知母的提取精制方法
CN105106263B (zh) *	2015-09-24	2018-11-30	海南医学院	海南眼树莲醇提取物抗炎活性成分及应用
CN105055479B (zh) *	2015-09-24	2018-11-30	海南医学院	海南眼树莲水提取物抗炎活性成分及应用
JP2021122255A (ja) *	2020-02-07	2021-08-30	株式会社モレラ	水耕栽培により作られた桑の根、およびその抽出物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH1067769A (ja) *	1996-06-17	1998-03-10	Oji Paper Co Ltd	天然抗菌剤
JP3796340B2 (ja) *	1997-11-18	2006-07-12	株式会社ノエビア	セリンプロテアーゼ阻害剤
CN1166384C (zh) *	2000-12-26	2004-09-15	高守荣	止咳平喘药剂
JP2003321362A (ja) *	2002-05-08	2003-11-11	Toyo Shinyaku:Kk	食品組成物および医薬品組成物
JP2004189609A (ja) *	2002-12-06	2004-07-08	Kao Corp	アロマターゼ活性化剤
CN101224240A (zh) *	2007-01-17	2008-07-23	周应军	一种具有降血糖作用的提取物、制备方法及其用途
CN101164601A (zh) *	2007-09-24	2008-04-23	黄春祥	一种养阴润肺、利痰止咳的润肺汤

2008
- 2008-12-24 TW TW097150373A patent/TWI364289B/zh not_active IP Right Cessation
2009
- 2009-01-19 DE DE102009005059A patent/DE102009005059B4/de active Active
- 2009-02-02 GB GBGB0901628.8A patent/GB0901628D0/en active Pending
- 2009-02-05 FR FR0900498A patent/FR2940088B1/fr active Active
- 2009-04-06 GB GB0905971A patent/GB2466525B/en active Active
- 2009-08-13 JP JP2009187754A patent/JP5174760B2/ja active Active

Also Published As

Publication number	Publication date
JP2010150231A (ja)	2010-07-08
TW201023869A (en)	2010-07-01
FR2940088B1 (fr)	2017-01-13
GB2466525A (en)	2010-06-30
GB0905971D0 (en)	2009-05-20
DE102009005059B4 (de)	2013-12-12
GB0901628D0 (en)	2009-03-11
JP5174760B2 (ja)	2013-04-03
GB2466525B (en)	2011-11-23
DE102009005059A1 (de)	2010-07-01
FR2940088A1 (fr)	2010-06-25

Legal Events

Date	Code	Title	Description
2019-02-21	MM4A	Annulment or lapse of patent due to non-payment of fees

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