TWI461435B - 纖維母細胞生長因子２１變體 - Google Patents

纖維母細胞生長因子２１變體 Download PDF

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Publication number: TWI461435B
Authority: TW; Taiwan
Prior art keywords: fgf21; variant; seq; amino acid; fgf21 variant
Prior art date: 2011-10-04

Application number

TW101134800A

Other languages

English (en)

Chinese (zh)

Other versions

TW201326198A (zh

Inventor

Ryan James Darling

Craig Duane Dickinson

David Albert Driver

Malgorzata Donata Gonciarz

Radmila Micanovic

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-10-04

Filing date

2012-09-21

Publication date

2014-11-21

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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46964112&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI461435(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-09-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2013-07-01 Publication of TW201326198A publication Critical patent/TW201326198A/zh

2014-11-21 Application granted granted Critical

2014-11-21 Publication of TWI461435B publication Critical patent/TWI461435B/zh

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238000007410 oral glucose tolerance test Methods 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
239000008020 pharmaceutical preservative Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
230000000291 postprandial effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
210000001236 prokaryotic cell Anatomy 0.000 description 1
239000003531 protein hydrolysate Substances 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000003259 recombinant expression Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000004627 regenerated cellulose Substances 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
238000011808 rodent model Methods 0.000 description 1
239000012723 sample buffer Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
239000012679 serum free medium Substances 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
210000004003 subcutaneous fat Anatomy 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
125000005555 sulfoximide group Chemical group 0.000 description 1
238000004114 suspension culture Methods 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000001890 transfection Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
239000013598 vector Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
239000003643 water by type Substances 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
210000005253 yeast cell Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Obesity (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

TW101134800A 2011-10-04 2012-09-21 纖維母細胞生長因子２１變體 TWI461435B (zh)

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US201161542906P	2011-10-04	2011-10-04

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TW201326198A TW201326198A (zh)	2013-07-01
TWI461435B true TWI461435B (zh)	2014-11-21

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TW101134800A TWI461435B (zh)	2011-10-04	2012-09-21	纖維母細胞生長因子２１變體

Country Status (28)

Country	Link
US (2)	US8541369B2 (2)
EP (1)	EP2763689B1 (2)
JP (1)	JP6060167B2 (2)
KR (1)	KR20140059271A (2)
CN (1)	CN103906530B (2)
AP (1)	AP2014007532A0 (2)
AR (1)	AR087973A1 (2)
AU (1)	AU2012318956A1 (2)
BR (1)	BR112014007532A2 (2)
CA (1)	CA2843520A1 (2)
CL (1)	CL2014000801A1 (2)
CO (1)	CO6910165A2 (2)
CR (1)	CR20140142A (2)
DO (1)	DOP2014000050A (2)
EA (1)	EA201490521A1 (2)
EC (1)	ECSP14013285A (2)
ES (1)	ES2548214T3 (2)
IL (1)	IL230754A0 (2)
IN (1)	IN2014CN00782A (2)
MA (1)	MA35458B1 (2)
MX (1)	MX2014004159A (2)
PE (1)	PE20142044A1 (2)
PH (1)	PH12014500740A1 (2)
SG (1)	SG11201401792UA (2)
TN (1)	TN2014000096A1 (2)
TW (1)	TWI461435B (2)
WO (1)	WO2013052311A1 (2)
ZA (1)	ZA201400882B (2)

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JP6728352B2 (ja)	2015-11-09	2020-07-22	エヌジーエムバイオファーマシューティカルス，インコーポレーテッド	胆汁酸に関係した障害の治療方法
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EP3503882A4 (en)	2016-08-26	2020-07-29	NGM Biopharmaceuticals, Inc.	METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS
CN106220724B (zh) *	2016-09-13	2019-10-11	河南师范大学	人成纤维细胞生长因子21重组蛋白及其制备方法和应用
CN106397607A (zh) *	2016-09-13	2017-02-15	河南师范大学	重组人成纤维细胞生长因子21融合蛋白及其在制备治疗代谢疾病药物中的应用
CN106432509B (zh) *	2016-09-13	2019-05-21	河南师范大学	一种治疗代谢疾病的重组人成纤维细胞生长因子21融合蛋白及其制备方法和应用
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MX2020002206A (es)	2017-09-08	2020-07-20	Bristol Myers Squibb Co	Factor de crecimiento de fibroblastos 21 (fgf-21) modificado para usarse en metodos para tratar la esteatohepatitis no alcoholica (nash).
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AU2019218147B2 (en) *	2018-02-08	2023-06-08	Sunshine Lake Pharma Co., Ltd.	FGF21 variant, fusion protein and application thereof
CA3104686A1 (en) *	2018-07-03	2020-01-09	Bristol-Myers Squibb Company	Fgf-21 formulations
CN109836486B (zh) *	2019-01-30	2020-09-08	北京双因生物科技有限公司	成纤维生长因子21变体、其融合蛋白及其用途
CN111662373B (zh) *	2019-03-05	2024-05-14	广东东阳光药业股份有限公司	一种多肽分子及其应用
CN114853908B (zh)	2019-05-16	2024-06-07	浙江道尔生物科技有限公司	一种治疗代谢疾病的融合蛋白
IL294534A (en)	2020-01-08	2022-09-01	Bristol Myers Squibb Co	Fgf-21 conjugate formulations
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2012
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Publication number	Publication date
CA2843520A1 (en)	2013-04-11
EP2763689B1 (en)	2015-08-12
DOP2014000050A (es)	2014-04-15
AR087973A1 (es)	2014-04-30
ECSP14013285A (es)	2014-05-31
US8883726B2 (en)	2014-11-11
EP2763689A1 (en)	2014-08-13
SG11201401792UA (en)	2014-08-28
PH12014500740A1 (en)	2020-10-19
WO2013052311A1 (en)	2013-04-11
AP2014007532A0 (en)	2014-03-31
MA35458B1 (fr)	2014-09-01
US8541369B2 (en)	2013-09-24
BR112014007532A2 (pt)	2017-04-04
EA201490521A1 (ru)	2014-07-30
US20130324460A1 (en)	2013-12-05
IN2014CN00782A (2)	2015-04-03
ZA201400882B (en)	2016-02-24
AU2012318956A1 (en)	2014-02-06
KR20140059271A (ko)	2014-05-15
IL230754A0 (en)	2014-03-31
JP6060167B2 (ja)	2017-01-11
TN2014000096A1 (en)	2015-07-01
CL2014000801A1 (es)	2014-09-12
CR20140142A (es)	2014-05-02
JP2014530220A (ja)	2014-11-17
TW201326198A (zh)	2013-07-01
ES2548214T3 (es)	2015-10-14
CN103906530A (zh)	2014-07-02
MX2014004159A (es)	2015-02-12
CN103906530B (zh)	2016-01-20
CO6910165A2 (es)	2014-03-31
PE20142044A1 (es)	2014-12-06
US20130085098A1 (en)	2013-04-04

Legal Events

Date	Code	Title	Description
2016-08-21	MM4A	Annulment or lapse of patent due to non-payment of fees

Publication	Publication Date	Title
TWI461435B (zh)	2014-11-21	纖維母細胞生長因子２１變體
TWI513705B (zh)	2015-12-21	纖維母細胞生長因子２１蛋白質
EP2859014B1 (en)	2017-04-26	Fibroblast growth factor 21 variants
WO2014149699A1 (en)	2014-09-25	Bifunctional protein
KR20070050454A (ko)	2007-05-15	섬유아세포 성장 인자 21의 뮤테인
KR102427426B1 (ko)	2022-08-01	신규한 인슐린 유사체 및 이의 용도
US20170334971A1 (en)	2017-11-23	Alpha-1-Antitrypsin (A1AT) Fusion Proteins and Uses Thereof
JP2009544325A (ja)	2009-12-17	Ｂｍｐ−７変異体組成物、方法および使用