TWI650316B - Ｍｅｋ抑制劑之製備及包含ｍｅｋ抑制劑之調配物 - Google Patents

Ｍｅｋ抑制劑之製備及包含ｍｅｋ抑制劑之調配物 Download PDF

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Publication number: TWI650316B
Authority: TW; Taiwan
Prior art keywords: compound; formula; cancer; pharmaceutical composition; crystalline
Prior art date: 2012-10-19

Application number

TW102137813A

Other languages

English (en)

Chinese (zh)

Other versions

TW201427956A (zh

Inventor

克里斯多弗馬克思卡爾

瑪瑞恩謬孫

丹尼爾安卓尼德爾

華納漢茲帕奇格

瑪瑞克里斯汀沃夫

丹尼爾茲瑪曼

劉衛東

彼得Ｊ史丹格

保羅尼可斯

Original Assignee

諾華公司

亞雷生物製藥股份有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-10-19

Filing date

2013-10-18

Publication date

2019-02-11

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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50488781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI650316(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-10-18 Application filed by 諾華公司, 亞雷生物製藥股份有限公司 filed Critical 諾華公司

2014-07-16 Publication of TW201427956A publication Critical patent/TW201427956A/zh

2019-02-11 Application granted granted Critical

2019-02-11 Publication of TWI650316B publication Critical patent/TWI650316B/zh

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- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
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TW102137813A 2012-10-19 2013-10-18 Ｍｅｋ抑制劑之製備及包含ｍｅｋ抑制劑之調配物 TWI650316B (zh)

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US20170231963A1 (en)	2017-08-17
TW201427956A (zh)	2014-07-16
FI3702351T3 (fi)	2024-01-24
DK2909182T3 (da)	2020-02-17
LT3702351T (lt)	2024-01-10
EP2909182A4 (en)	2016-07-06
US9562016B2 (en)	2017-02-07
RU2018127873A (ru)	2019-03-14
US9382212B1 (en)	2016-07-05
AR099630A1 (es)	2016-08-10
JOP20130304B1 (ar)	2021-08-17
SI2909182T1 (sl)	2020-03-31
US20160168103A1 (en)	2016-06-16
EP4306171A2 (en)	2024-01-17
CA3079071C (en)	2022-06-07
BR112015008623B1 (pt)	2022-10-25
CA2888474C (en)	2021-03-02
CN104870427B (zh)	2018-10-23
PL3702351T3 (pl)	2024-04-02
DK3702351T3 (da)	2024-01-29
HK1214254A1 (en)	2016-07-22
HUE065433T2 (hu)	2024-05-28
US20160168102A1 (en)	2016-06-16
PL2909182T3 (pl)	2020-06-01
CN104870427A (zh)	2015-08-26
CA3079071A1 (en)	2014-04-24
ES2971077T3 (es)	2024-06-03
SMT202400044T1 (it)	2024-03-13
US20180296533A1 (en)	2018-10-18
WO2014063024A1 (en)	2014-04-24
RU2669391C2 (ru)	2018-10-11
SI3702351T1 (sl)	2024-03-29
EP4306171A3 (en)	2024-04-03
JP2016503391A (ja)	2016-02-04
RU2015118572A (ru)	2016-12-20
BR112015008623A2 (pt)	2017-07-04
US9598376B2 (en)	2017-03-21
US9980944B2 (en)	2018-05-29
EP3702351B1 (en)	2023-11-22
ES2772498T3 (es)	2020-07-07
HUE047708T2 (hu)	2020-05-28
CA2888474A1 (en)	2014-04-24
RS65117B1 (sr)	2024-02-29
US10398683B2 (en)	2019-09-03
CN109336824A (zh)	2019-02-15
US9238627B2 (en)	2016-01-19
EP2909182B1 (en)	2019-12-04
EP2909182A1 (en)	2015-08-26
JP2019194272A (ja)	2019-11-07
HRP20240033T1 (hr)	2024-03-29
JP6385939B2 (ja)	2018-09-05
EP3702351A1 (en)	2020-09-02
US20140128442A1 (en)	2014-05-08
PT3702351T (pt)	2024-01-17
CN109336824B (zh)	2022-11-11
JP6737838B2 (ja)	2020-08-12
PT2909182T (pt)	2020-03-02
US10729678B2 (en)	2020-08-04
CN109456272A (zh)	2019-03-12
CY1122670T1 (el)	2021-03-12
US20200171002A1 (en)	2020-06-04
JP2018135399A (ja)	2018-08-30
US20160168104A1 (en)	2016-06-16

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TWI650316B (zh)	2019-02-11	Ｍｅｋ抑制劑之製備及包含ｍｅｋ抑制劑之調配物
CN103298819B (zh)	2015-07-08	6,7-不饱和-7-氨基甲酰基吗啡喃衍生物的晶体及其制备方法
WO2018184185A1 (zh)	2018-10-11	奥扎莫德加成盐晶型、制备方法及药物组合物和用途
CN104379581B (zh)	2017-04-12	达拉菲尼的晶型及其制备方法和用途
HK40108420A (en)	2024-11-15	Formulation comprising a mek inhibitor
CN115463133A (zh)	2022-12-13	一种药物组合物、制剂及其制备方法和应用
HK40005916A (en)	2020-05-15	Preparation of and formulation comprising a mek inhibitor
HK1214254B (en)	2021-01-15	Preparation of and formulation comprising a mek inhibitor
WO2022144042A1 (zh)	2022-07-07	Tas-116的晶型及其制备方法、药物组合物和用途