TWI747178B - 單鏈trail-受體激動劑蛋白質 - Google Patents

單鏈trail-受體激動劑蛋白質 Download PDF

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Publication number: TWI747178B
Authority: TW; Taiwan
Prior art keywords: trail; receptor agonist; seq; domain; protein
Prior art date: 2014-04-23

Application number

TW109106778A

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English (en)

Chinese (zh)

Other versions

TW202024123A (zh

Inventor

奧利維希爾

克利斯汀安吉佛司

曼諾夫希爾曼

福瑞茲Ｇ布恰南

戴倫Ｃ菲利浦

蘇珊 E 萊普

Original Assignee

德商阿波吉尼克斯公司

美商艾伯維有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-04-23

Filing date

2015-04-23

Publication date

2021-11-21

2015-04-23 Application filed by 德商阿波吉尼克斯公司, 美商艾伯維有限公司 filed Critical 德商阿波吉尼克斯公司

2020-07-01 Publication of TW202024123A publication Critical patent/TW202024123A/zh

2021-11-21 Application granted granted Critical

2021-11-21 Publication of TWI747178B publication Critical patent/TWI747178B/zh

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Cell Biology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)

TW109106778A 2014-04-23 2015-04-23 單鏈trail-受體激動劑蛋白質 TWI747178B (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461983152P	2014-04-23	2014-04-23
US61/983,152		2014-04-23

Publications (2)

Publication Number	Publication Date
TW202024123A TW202024123A (zh)	2020-07-01
TWI747178B true TWI747178B (zh)	2021-11-21

Family

ID=53055121

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
TW109106778A TWI747178B (zh)	2014-04-23	2015-04-23	單鏈trail-受體激動劑蛋白質
TW104113087A TWI683825B (zh)	2014-04-23	2015-04-23	單鏈ｔｒａｉｌ-受體激動劑蛋白質

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
TW104113087A TWI683825B (zh)	2014-04-23	2015-04-23	單鏈ｔｒａｉｌ-受體激動劑蛋白質

Country Status (38)

Country	Link
US (5)	US9908927B2 (2)
EP (2)	EP3366699A1 (2)
JP (2)	JP6523331B2 (2)
KR (2)	KR20190135546A (2)
CN (2)	CN106459221B (2)
AR (1)	AR100168A1 (2)
AU (3)	AU2015249649B2 (2)
BR (1)	BR112016024515B1 (2)
CA (2)	CA2946402C (2)
CL (1)	CL2016002683A1 (2)
CR (1)	CR20160516A (2)
CY (1)	CY1120281T1 (2)
DK (1)	DK3134430T3 (2)
DO (1)	DOP2016000284A (2)
EC (1)	ECSP16089579A (2)
ES (1)	ES2672368T3 (2)
HR (1)	HRP20180950T1 (2)
HU (1)	HUE038914T2 (2)
IL (2)	IL248244B (2)
LT (1)	LT3134430T (2)
MA (2)	MA39770A (2)
MX (2)	MX2016013858A (2)
MY (1)	MY181986A (2)
NO (1)	NO2776305T3 (2)
PE (1)	PE20170299A1 (2)
PH (2)	PH12020500377A1 (2)
PL (1)	PL3134430T3 (2)
PT (1)	PT3134430T (2)
RS (1)	RS57153B1 (2)
RU (1)	RU2699285C2 (2)
SG (3)	SG10202111785VA (2)
SI (1)	SI3134430T1 (2)
SM (1)	SMT201800286T1 (2)
TR (1)	TR201806912T4 (2)
TW (2)	TWI747178B (2)
UA (1)	UA118286C2 (2)
UY (1)	UY36095A (2)
WO (1)	WO2015164588A1 (2)

Families Citing this family (18)

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ES2754432T3 (es) *	2015-05-04	2020-04-17	Apogenix Ag	Proteínas agonistas de receptor CD40 de cadena sencilla
CA3002741A1 (en) *	2015-10-23	2017-04-27	Apogenix Ag	Single-chain gitr-receptor agonist proteins
CA3002587A1 (en) *	2015-10-23	2017-04-27	Apogenix Ag	Single-chain light receptor agonist proteins
EP3364995B1 (en)	2015-10-23	2021-08-04	Apogenix AG	Single-chain cd27-receptor agonist proteins
WO2017102010A1 (en) *	2015-12-17	2017-06-22	Biontech Rna Pharmaceuticals Gmbh	Novel cytokine fusion proteins
CA3054286A1 (en)	2016-03-01	2017-09-08	The Board Of Trustees Of The University Of Illinois	L-asparaginase variants and fusion proteins with reduced l-glutaminase activity and enhanced stability
AU2017234679A1 (en) *	2016-03-16	2018-08-30	Merrimack Pharmaceuticals, Inc.	Engineered trail for cancer therapy
US10501744B2 (en)	2016-05-04	2019-12-10	Indiana University Research And Technology Corporation	Presentation of bioactive proteins
TWI794171B (zh)	2016-05-11	2023-03-01	美商滬亞生物國際有限公司	Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh)	2016-05-11	2023-07-11	美商滬亞生物國際有限公司	Hdac 抑制劑與 pd-1 抑制劑之組合治療
JP2019517570A (ja) *	2016-06-13	2019-06-24	メリマックファーマシューティカルズインコーポレーティッド	Ｔｒａｉｌベースの治療剤または細胞死受容体アゴニストを用いて患者を選択および治療する方法
EP3360898A1 (en)	2017-02-14	2018-08-15	Boehringer Ingelheim International GmbH	Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
JP7744621B2 (ja) *	2017-08-11	2025-09-26	ザボードオブトラスティーズオブザユニヴァーシティオブイリノイ	切断されたモルモットｌ－アスパラギナーゼバリアントおよび使用の方法
TW202002952A (zh)	2018-03-15	2020-01-16	美商艾伯維有限公司	用於治療胰臟癌之abbv-621與抗癌劑之組合
WO2019178438A1 (en)	2018-03-15	2019-09-19	Abbvie Inc.	Abbv-621 in combination with anti-cancer agents for the treatment of cancer
EP4149964A2 (en)	2020-05-15	2023-03-22	Apogenix AG	Multi-specific immune modulators
AU2022281108A1 (en)	2021-05-28	2023-12-14	Julius-Maximilians-Universität Würzburg	Recombinant proteinaceous binding molecules
WO2023088876A1 (en)	2021-11-16	2023-05-25	Apogenix Ag	Multi-specific immune modulators

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2012
- 2012-11-06 NO NO12790406A patent/NO2776305T3/no unknown
2015
- 2015-04-23 SG SG10202111785VA patent/SG10202111785VA/en unknown
- 2015-04-23 MX MX2016013858A patent/MX2016013858A/es active IP Right Grant
- 2015-04-23 HR HRP20180950TT patent/HRP20180950T1/hr unknown
- 2015-04-23 EP EP18155146.6A patent/EP3366699A1/en not_active Withdrawn
- 2015-04-23 DK DK15721089.9T patent/DK3134430T3/en active
- 2015-04-23 PH PH1/2020/500377A patent/PH12020500377A1/en unknown
- 2015-04-23 TW TW109106778A patent/TWI747178B/zh not_active IP Right Cessation
- 2015-04-23 PT PT157210899T patent/PT3134430T/pt unknown
- 2015-04-23 MA MA039770A patent/MA39770A/fr unknown
- 2015-04-23 EP EP15721089.9A patent/EP3134430B1/en active Active
- 2015-04-23 RS RS20180450A patent/RS57153B1/sr unknown
- 2015-04-23 LT LTEP15721089.9T patent/LT3134430T/lt unknown
- 2015-04-23 TR TR2018/06912T patent/TR201806912T4/tr unknown
- 2015-04-23 RU RU2016145608A patent/RU2699285C2/ru active
- 2015-04-23 SM SM20180286T patent/SMT201800286T1/it unknown
- 2015-04-23 AU AU2015249649A patent/AU2015249649B2/en not_active Ceased
- 2015-04-23 SI SI201530223T patent/SI3134430T1/en unknown
- 2015-04-23 CA CA2946402A patent/CA2946402C/en active Active
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- 2015-04-23 CN CN201580031858.7A patent/CN106459221B/zh not_active Expired - Fee Related
- 2015-04-23 UA UAA201611802A patent/UA118286C2/uk unknown
- 2015-04-23 TW TW104113087A patent/TWI683825B/zh not_active IP Right Cessation
- 2015-04-23 SG SG11201608767XA patent/SG11201608767XA/en unknown
- 2015-04-23 BR BR112016024515-6A patent/BR112016024515B1/pt not_active IP Right Cessation
- 2015-04-23 MY MYPI2016703814A patent/MY181986A/en unknown
- 2015-04-23 CR CR20160516A patent/CR20160516A/es unknown
- 2015-04-23 KR KR1020197035100A patent/KR20190135546A/ko not_active Ceased
- 2015-04-23 PL PL15721089T patent/PL3134430T3/pl unknown
- 2015-04-23 SG SG10201806465TA patent/SG10201806465TA/en unknown
- 2015-04-23 MA MA045069A patent/MA45069A/fr unknown
- 2015-04-23 AR ARP150101224A patent/AR100168A1/es active IP Right Grant
- 2015-04-23 CA CA3184067A patent/CA3184067A1/en active Pending
- 2015-04-23 ES ES15721089.9T patent/ES2672368T3/es active Active
- 2015-04-23 KR KR1020167032819A patent/KR102079919B1/ko not_active Expired - Fee Related
- 2015-04-23 JP JP2016564068A patent/JP6523331B2/ja not_active Expired - Fee Related
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- 2015-04-23 HU HUE15721089A patent/HUE038914T2/hu unknown
- 2015-04-23 PE PE2016002016A patent/PE20170299A1/es unknown
- 2015-04-23 CN CN202010767219.XA patent/CN111718424A/zh active Pending
2016
- 2016-10-07 IL IL248244A patent/IL248244B/en active IP Right Grant
- 2016-10-19 PH PH12016502079A patent/PH12016502079B1/en unknown
- 2016-10-19 DO DO2016000284A patent/DOP2016000284A/es unknown
- 2016-10-21 MX MX2019013587A patent/MX2019013587A/es unknown
- 2016-10-21 CL CL2016002683A patent/CL2016002683A1/es unknown
- 2016-11-23 EC ECIEPI201689579A patent/ECSP16089579A/es unknown
2018
- 2018-02-02 US US15/887,509 patent/US20180222962A1/en not_active Abandoned
- 2018-05-25 CY CY20181100568T patent/CY1120281T1/el unknown
- 2018-11-30 AU AU2018271369A patent/AU2018271369B2/en not_active Ceased
2019
- 2019-04-24 JP JP2019082671A patent/JP6714751B2/ja not_active Expired - Fee Related
2020
- 2020-02-11 IL IL272612A patent/IL272612A/en unknown
- 2020-03-30 AU AU2020202247A patent/AU2020202247A1/en not_active Abandoned
- 2020-08-14 US US16/993,569 patent/US20210040178A1/en not_active Abandoned
2023
- 2023-07-14 US US18/352,769 patent/US20240174731A1/en not_active Abandoned
2024
- 2024-09-23 US US18/892,964 patent/US20250145688A1/en active Pending

Patent Citations (1)

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Publication number	Priority date	Publication date	Assignee	Title
WO2010010051A1 (en) *	2008-07-21	2010-01-28	Apogenix Gmbh	Tnfsf single chain molecules

Also Published As

Publication number	Publication date
US20150337027A1 (en)	2015-11-26
US9908927B2 (en)	2018-03-06
US20180222962A1 (en)	2018-08-09
PH12016502079A1 (en)	2016-12-19
ECSP16089579A (es)	2018-05-31
KR20170012257A (ko)	2017-02-02
TWI683825B (zh)	2020-02-01
SMT201800286T1 (it)	2018-07-17
BR112016024515A2 (pt)	2017-10-10
CA3184067A1 (en)	2015-10-29
CN106459221A (zh)	2017-02-22
TR201806912T4 (tr)	2018-06-21
CR20160516A (es)	2017-05-10
EP3134430B1 (en)	2018-03-21
IL248244A0 (en)	2016-11-30
SG10201806465TA (en)	2018-08-30
CY1120281T1 (el)	2019-07-10
KR20190135546A (ko)	2019-12-06
JP6714751B2 (ja)	2020-06-24
EP3366699A1 (en)	2018-08-29
HRP20180950T1 (hr)	2018-08-10
CA2946402C (en)	2023-02-28
SG10202111785VA (en)	2021-12-30
MX2016013858A (es)	2017-08-02
MA39770A (fr)	2015-10-29
NO2776305T3 (2)	2018-01-27
PH12020500377A1 (en)	2022-11-14
MA45069A (fr)	2019-04-03
LT3134430T (lt)	2018-05-10
SI3134430T1 (en)	2018-05-31
IL248244B (en)	2020-03-31
AU2015249649B2 (en)	2018-10-04
WO2015164588A1 (en)	2015-10-29
PH12016502079B1 (en)	2016-12-19
PT3134430T (pt)	2018-04-20
DOP2016000284A (es)	2017-02-15
AU2018271369A1 (en)	2018-12-20
BR112016024515B1 (pt)	2020-03-31
RU2016145608A3 (2)	2018-12-26
AU2015249649A1 (en)	2016-11-10
SG11201608767XA (en)	2016-11-29
PE20170299A1 (es)	2017-05-06
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