BR112012017164A2 - proteína de fusão de região constante de anticorpo-cd47 tetravalente - Google Patents
proteína de fusão de região constante de anticorpo-cd47 tetravalenteInfo
- Publication number
- BR112012017164A2 BR112012017164A2 BR112012017164A BR112012017164A BR112012017164A2 BR 112012017164 A2 BR112012017164 A2 BR 112012017164A2 BR 112012017164 A BR112012017164 A BR 112012017164A BR 112012017164 A BR112012017164 A BR 112012017164A BR 112012017164 A2 BR112012017164 A2 BR 112012017164A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- sirp
- binding
- soluble
- fusion protein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
proteína de fusão de região constante de anticorpo-cd47 tetravalente. a presente invenção se refere a proteínas de ligação sirp<244> solúveis, para uso como um medicamento, em particular para a prevenção ou tratamento de distúrbios autoimunes e inflamatórios, por exemplo, asma alérgica e doenças inflamatórias do intestino. a invenção mais especificamente se refere a uma proteína de ligação sirp<244> solúvel que compreende um complexo de dois heterodímeros, em que cada heterodímero consiste essencialmente em: (i) um primeiro polipeptídeo de cadeia simples monovalente compreendendo um primeiro domínio de ligação de sirp<244> fundido na parte n-terminal de uma região constante da cadeia passada de um anticorpo, e (ii) um segundo polipeptídeo de cadeia simples monovalente compreendendo um segundo domínio de ligação de sirp<244> fundido na parte n-terminal de uma região da cadeia leve cl de um anticorpo. a invenção também se refere à proteína semelhante a anticorpo de ligação a sirp<244> solúvel como mostrada na figura 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28900709P | 2009-12-22 | 2009-12-22 | |
| PCT/EP2010/070355 WO2011076781A1 (en) | 2009-12-22 | 2010-12-21 | Tetravalent cd47-antibody constant region fusion protein for use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012017164A2 true BR112012017164A2 (pt) | 2019-09-24 |
Family
ID=43706449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012017164A BR112012017164A2 (pt) | 2009-12-22 | 2010-12-21 | proteína de fusão de região constante de anticorpo-cd47 tetravalente |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20130011401A1 (pt) |
| EP (1) | EP2516458A1 (pt) |
| JP (1) | JP2013514795A (pt) |
| KR (1) | KR20120107122A (pt) |
| CN (1) | CN102939303A (pt) |
| AR (1) | AR079701A1 (pt) |
| AU (1) | AU2010334974A1 (pt) |
| BR (1) | BR112012017164A2 (pt) |
| CA (1) | CA2785139A1 (pt) |
| MX (1) | MX2012007318A (pt) |
| TW (1) | TW201130511A (pt) |
| UY (1) | UY33132A (pt) |
| WO (1) | WO2011076781A1 (pt) |
Families Citing this family (88)
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-
2010
- 2010-12-21 BR BR112012017164A patent/BR112012017164A2/pt not_active IP Right Cessation
- 2010-12-21 JP JP2012545290A patent/JP2013514795A/ja active Pending
- 2010-12-21 CN CN2010800644263A patent/CN102939303A/zh active Pending
- 2010-12-21 TW TW099145049A patent/TW201130511A/zh unknown
- 2010-12-21 EP EP10795387A patent/EP2516458A1/en not_active Withdrawn
- 2010-12-21 AU AU2010334974A patent/AU2010334974A1/en not_active Abandoned
- 2010-12-21 WO PCT/EP2010/070355 patent/WO2011076781A1/en not_active Ceased
- 2010-12-21 KR KR1020127019187A patent/KR20120107122A/ko not_active Withdrawn
- 2010-12-21 MX MX2012007318A patent/MX2012007318A/es not_active Application Discontinuation
- 2010-12-21 US US13/517,989 patent/US20130011401A1/en not_active Abandoned
- 2010-12-21 CA CA2785139A patent/CA2785139A1/en not_active Abandoned
- 2010-12-22 AR ARP100104886A patent/AR079701A1/es unknown
- 2010-12-22 UY UY33132A patent/UY33132A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN102939303A (zh) | 2013-02-20 |
| AR079701A1 (es) | 2012-02-15 |
| MX2012007318A (es) | 2012-07-20 |
| CA2785139A1 (en) | 2011-06-30 |
| EP2516458A1 (en) | 2012-10-31 |
| KR20120107122A (ko) | 2012-09-28 |
| TW201130511A (en) | 2011-09-16 |
| UY33132A (es) | 2011-07-29 |
| AU2010334974A1 (en) | 2012-07-12 |
| JP2013514795A (ja) | 2013-05-02 |
| WO2011076781A1 (en) | 2011-06-30 |
| US20130011401A1 (en) | 2013-01-10 |
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