TWI801378B - 作為tnf活性調節劑之稠合五環咪唑衍生物 - Google Patents

作為tnf活性調節劑之稠合五環咪唑衍生物 Download PDF

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Publication number: TWI801378B
Authority: TW; Taiwan
Prior art keywords: methyl; mmol; compound; difluoromethoxy; formula
Prior art date: 2017-04-25

Application number

TW107113777A

Other languages

English (en)

Chinese (zh)

Other versions

TW201841918A (zh

Inventor

丹尼爾克里斯多夫布魯金斯

海羅葛爾莎泰瑞莎迪

揚恩佛瑞切

海倫崔西霍斯萊

馬丁克里夫亨琴斯

詹姆士安德魯強森

馬爾康馬寇斯

宣孟陽

曉寧徐

Original Assignee

比利時商Ｕｃｂ生物製藥公司

法商賽諾菲公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-04-25

Filing date

2018-04-24

Publication date

2023-05-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58632834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI801378(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2018-04-24 Application filed by 比利時商Ｕｃｂ生物製藥公司, 法商賽諾菲公司 filed Critical 比利時商Ｕｃｂ生物製藥公司

2018-12-01 Publication of TW201841918A publication Critical patent/TW201841918A/zh

2023-05-11 Application granted granted Critical

2023-05-11 Publication of TWI801378B publication Critical patent/TWI801378B/zh

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- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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TW107113777A 2017-04-25 2018-04-24 作為tnf活性調節劑之稠合五環咪唑衍生物 TWI801378B (zh)

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US (4)	US10980814B2 (fr)
EP (2)	EP3939980B1 (fr)
JP (2)	JP7083358B2 (fr)
KR (1)	KR102565132B1 (fr)
CN (1)	CN110582495B (fr)
AR (1)	AR111426A1 (fr)
AU (1)	AU2018259040B2 (fr)
CA (1)	CA3058980A1 (fr)
CL (1)	CL2019002875A1 (fr)
CO (1)	CO2019012856A2 (fr)
CR (1)	CR20190526A (fr)
DK (1)	DK3615534T3 (fr)
EA (1)	EA039049B1 (fr)
ES (2)	ES2956555T3 (fr)
HR (1)	HRP20211927T1 (fr)
HU (1)	HUE056593T2 (fr)
IL (1)	IL269890B (fr)
LT (1)	LT3615534T (fr)
MA (2)	MA49055B1 (fr)
MX (1)	MX2019012443A (fr)
MY (1)	MY197212A (fr)
PE (1)	PE20200662A1 (fr)
PH (1)	PH12019502182B1 (fr)
PL (2)	PL3939980T3 (fr)
PT (2)	PT3939980T (fr)
PY (1)	PY1829804A (fr)
RS (1)	RS62596B1 (fr)
SG (1)	SG11201908871SA (fr)
SI (1)	SI3615534T1 (fr)
TW (1)	TWI801378B (fr)
UY (1)	UY37700A (fr)
WO (1)	WO2018197503A1 (fr)
ZA (1)	ZA201906255B (fr)

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TW202519231A (zh)	2023-07-04	2025-05-16	法商賽諾菲公司	結晶形式
WO2025038927A1 (fr)	2023-08-16	2025-02-20	Raythera, Inc.	Modulateurs de l'activité du tnf alpha et leurs utilisations
WO2025068505A1 (fr)	2023-09-29	2025-04-03	Sanofi	Préparation de dérivés d'imidazole pentacycliques pontés en tant que modulateurs de l'activité du tnf, intermédiaires et leur préparation
WO2025201449A1 (fr) *	2024-03-27	2025-10-02	海思科医药集团股份有限公司	Dérivés hétérocycliques et leur utilisation en médecine
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WO2025218735A1 (fr) *	2024-04-17	2025-10-23	上海翰森生物医药科技有限公司	Inhibiteur de dérivé pentacyclique, son procédé de préparation et son utilisation
WO2025247401A1 (fr) *	2024-05-31	2025-12-04	海思科医药集团股份有限公司	Dérivé hétérocyclique fusionné et son utilisation pharmaceutique
WO2025252251A1 (fr) *	2024-06-07	2025-12-11	上海翰森生物医药科技有限公司	Inhibiteur de dérivé hétérocyclique contenant de l'oxygène, son procédé de préparation et son utilisation
WO2026012303A1 (fr) *	2024-07-09	2026-01-15	Hangzhou Highlightll Pharmaceutical Co., Ltd	NOUVEAUX COMPOSÉS BENZO[4,5]IMIDAZO EN TANT QUE MODULATEURS DE TNFα
WO2026022134A1 (fr)	2024-07-23	2026-01-29	Sanofi	Nouveaux procédés d'aminocarbonylation
WO2026021586A1 (fr) *	2024-07-26	2026-01-29	上海瀚辰星泰医药科技有限公司	Composé polycyclique, son procédé de préparation et son utilisation
WO2026027449A1 (fr)	2024-07-29	2026-02-05	Sanofi	Dérivés d'imidazole pentacycliques fusionnés
WO2026051930A1 (fr) *	2024-09-04	2026-03-12	苏州湃玥生物科技有限公司	Dérivé de benzimidazole pentacyclique fusionné utilisé en tant que modulateur d'activité de tnf, son procédé de préparation et son utilisation
WO2026055519A1 (fr)	2024-09-06	2026-03-12	Rapt Therapeutics, Inc.	Composés imidazole à cycle fusionné
WO2026064602A1 (fr) *	2024-09-23	2026-03-26	Synnovation Therapeutics, Inc.	COMPOSÉS HÉTÉROCYCLIQUES EN TANT QUE MODULATEURS DE L'ACTIVITÉ DU TNFα
WO2026068677A1 (fr)	2024-09-27	2026-04-02	Sanofi	Procédés de préparation d'imidazoles pentacycliques fusionnés et d'intermédiaires

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2018
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2019
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2021
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US20210252012A1 (en)	2021-08-19
JP7299382B2 (ja)	2023-06-27
NZ758198A (en)	2024-01-26
JP2020517637A (ja)	2020-06-18
HRP20211927T1 (hr)	2022-03-18
CO2019012856A2 (es)	2020-01-17
BR112019020314A2 (pt)	2020-04-28
MX2019012443A (es)	2020-01-13
AU2018259040A1 (en)	2019-10-31
EP3615534B1 (fr)	2021-09-15
EP3939980B1 (fr)	2023-07-26
CN110582495A (zh)	2019-12-17
MY197212A (en)	2023-06-01
ES2956555T3 (es)	2023-12-22
PY1829804A (es)	2019-03-01
UY37700A (es)	2018-11-30
SG11201908871SA (en)	2019-10-30
MA49055B1 (fr)	2021-12-31
AU2018259040B2 (en)	2022-04-28
WO2018197503A1 (fr)	2018-11-01
LT3615534T (lt)	2021-11-25
JP2022116233A (ja)	2022-08-09
EP3615534A1 (fr)	2020-03-04
PH12019502182A1 (en)	2020-06-08
PL3615534T3 (pl)	2022-01-31
KR102565132B1 (ko)	2023-08-08
PL3939980T3 (pl)	2024-02-05
MA57699B1 (fr)	2023-11-30
US20230250105A1 (en)	2023-08-10
EP3939980A1 (fr)	2022-01-19
IL269890B (en)	2022-03-01
US20200046723A1 (en)	2020-02-13
EA201992407A1 (ru)	2020-04-06
ES2893807T3 (es)	2022-02-10
US10980814B2 (en)	2021-04-20
TW201841918A (zh)	2018-12-01
DK3615534T3 (da)	2021-10-18
RS62596B1 (sr)	2021-12-31
PT3939980T (pt)	2023-08-07
KR20190141200A (ko)	2019-12-23
JP7083358B2 (ja)	2022-06-10
CN110582495B (zh)	2022-04-01
PT3615534T (pt)	2021-10-21
CR20190526A (es)	2020-01-07
CA3058980A1 (fr)	2018-11-01
AR111426A1 (es)	2019-07-10
HUE056593T2 (hu)	2022-02-28
ZA201906255B (en)	2021-01-27
PE20200662A1 (es)	2020-06-11
MA49055A (fr)	2021-05-05
EA039049B1 (ru)	2021-11-26
SI3615534T1 (sl)	2022-01-31
CL2019002875A1 (es)	2020-03-06
PH12019502182B1 (en)	2024-01-31
US20250127795A1 (en)	2025-04-24

Publication	Publication Date	Title
TWI801378B (zh)	2023-05-11	作為tnf活性調節劑之稠合五環咪唑衍生物
KR102442235B1 (ko)	2022-09-08	융합된 펜타시클릭 이미다졸 유도체
US11554122B2 (en)	2023-01-17	Fused pentacyclic imidazole derivatives as modulators of TNF activity
AU2024227155A1 (en)	2024-10-31	Carboxy-benzimidazole GLP-1R modulating compounds.
EP3596078B1 (fr)	2023-04-12	Dérivés d'imidazoles pentacycliques condensés en tant que modulateurs de l'activité de tnf
HK40058586B (en)	2023-09-15	Process for preparing fused pentacyclic imidazole derivatives and uses thereof as modulators of tnf activity
HK40058586A (en)	2022-04-29	Process for preparing fused pentacyclic imidazole derivatives and uses thereof as modulators of tnf activity
HK40024466A (en)	2020-12-11	Fused pentacyclic imidazole derivatives as modulators of tnf activity
HK40024466B (en)	2022-01-14	Fused pentacyclic imidazole derivatives as modulators of tnf activity
BR112019020314B1 (pt)	2025-02-18	Derivados de imidazol pentacíclico fundido como moduladores da atividade de tnf, composição farmacêutica compreendendo os mesmos e uso dos mesmos