UA100248C2 - Heterocyclic compound and pharmaceutical composition thereof - Google Patents

Heterocyclic compound and pharmaceutical composition thereof

Info

Publication number
UA100248C2
UA100248C2 UAA201006444A UA100248C2 UA 100248 C2 UA100248 C2 UA 100248C2 UA A201006444 A UAA201006444 A UA A201006444A UA 100248 C2 UA100248 C2 UA 100248C2
Authority
UA
Ukraine
Prior art keywords
group
heterocyclic ring
heterocyclic compound
hydrogen atom
pharmaceutical composition
Prior art date
Application number
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Такумі Суміда
Фудзіо Табуса
Казуо Секігуті
Такесі Кодама
Коіті Ясумура
Ютака Кодзіма
Масаакі Мотояма
Кеісуке Міядзіма
Кендзі Йосіда
Кеізо Кан
Макото САКАМОТО
Хідекі Такасу
Такасі Накагава
Наото Охі
Ясуо Харада
Норіказу Хасімото
Хіронорі Мацуяма
Масатосі Ііда
Сігеказу Фудзіта
Тає Фукусіма
Original Assignee
Оцука Фармасьютікал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оцука Фармасьютікал Ко., Лтд. filed Critical Оцука Фармасьютікал Ко., Лтд.
Publication of UA100248C2 publication Critical patent/UA100248C2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UAA201006444 2007-10-30 2008-10-29 Heterocyclic compound and pharmaceutical composition thereof UA100248C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007281601 2007-10-30
JP2007336157 2007-12-27
PCT/JP2008/070153 WO2009057811A2 (en) 2007-10-30 2008-10-29 Heterocyclic compound and pharmaceutical composition thereof

Publications (1)

Publication Number Publication Date
UA100248C2 true UA100248C2 (en) 2012-12-10

Family

ID=40474791

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201006444 UA100248C2 (en) 2007-10-30 2008-10-29 Heterocyclic compound and pharmaceutical composition thereof

Country Status (28)

Country Link
US (1) US8551999B2 (da)
EP (1) EP2207773B1 (da)
JP (1) JP5236002B2 (da)
KR (1) KR20100092469A (da)
CN (2) CN103224488A (da)
AR (1) AR069065A1 (da)
AU (1) AU2008319719B2 (da)
BR (1) BRPI0819232A2 (da)
CA (1) CA2703240A1 (da)
CL (1) CL2008003265A1 (da)
CO (1) CO6210724A2 (da)
CY (1) CY1113812T1 (da)
DK (1) DK2207773T3 (da)
ES (1) ES2390710T3 (da)
HR (1) HRP20120748T1 (da)
IL (1) IL204942A0 (da)
MX (1) MX2010004893A (da)
MY (1) MY148482A (da)
NZ (1) NZ584573A (da)
PE (1) PE20090949A1 (da)
PL (1) PL2207773T3 (da)
PT (1) PT2207773E (da)
RU (1) RU2010121857A (da)
SI (1) SI2207773T1 (da)
TW (1) TWI440638B (da)
UA (1) UA100248C2 (da)
WO (1) WO2009057811A2 (da)
ZA (1) ZA201002547B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200700811B (en) 2004-08-06 2008-10-29 Otsuka Pharma Co Ltd Aromatic compound
CN101321529B (zh) * 2005-12-05 2012-09-05 大塚制药株式会社 作为抗肿瘤剂的二芳基醚衍生物
UA95978C2 (ru) * 2006-10-02 2011-09-26 Оцука Фармас'Ютікел Ко., Лтд. Ингибитор активации stat3/5
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
JP5688918B2 (ja) * 2009-04-28 2015-03-25 大塚製薬株式会社 医薬組成物
CN102574843B (zh) 2009-10-22 2015-06-17 法博太科制药有限公司 抗纤维化剂的稠环类似物
HRP20141190T1 (hr) * 2010-01-29 2015-01-30 Otsuka Pharmaceutical Co., Ltd. Disupstituirani derivati piridina kao antikancerogena sredstva
US9040555B2 (en) * 2012-01-26 2015-05-26 Angion Biomedica Corp. Antifibrotic compounds and uses thereof
HUE038700T2 (hu) 2012-03-01 2018-11-28 Allergan Inc Benzofuran-2-szulfonamid származékok, mint kemokinreceptor-modulációk
CN105102448B (zh) 2013-02-28 2018-03-06 百时美施贵宝公司 作为rock1和rock2抑制剂的苯基吡唑衍生物
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
JP7185631B2 (ja) 2017-02-03 2022-12-07 サータ セラピューティクス プロプライエタリー リミテッド 抗線維化化合物
CN108721621B (zh) * 2017-04-14 2022-03-01 中国科学院上海高等研究院 抑制肝纤维化的小分子化合物及应用
CN108033918B (zh) * 2017-12-28 2020-12-25 西安欧得光电材料有限公司 一种光电材料中间体2-氯-4-苯基苯并[h]喹唑啉的合成方法
CN112300145B (zh) * 2019-07-31 2023-07-21 上海宇耀生物科技有限公司 一类靶向stat3双功能磷酸化位点的三芳香环类化合物及其应用
JP2023175057A (ja) * 2020-10-29 2023-12-12 クミアイ化学工業株式会社 縮合ヘテロ環誘導体及びそれを有効成分として含有する除草剤
CN120981455A (zh) * 2023-03-27 2025-11-18 上海宇耀生物科技有限公司 三芳香环类衍生物的盐、其晶型、制备方法和用途
CN116715657B (zh) * 2023-04-19 2025-07-11 河南省锐达医药科技有限公司 一种二芳基乙炔类化合物、其制备方法及应用
CN116768864B (zh) * 2023-06-25 2025-08-01 河南省锐达医药科技有限公司 一种哌嗪吲哚酰胺类化合物、其制备方法及应用
CN118772123B (zh) * 2024-06-14 2025-09-16 河南省锐达医药科技有限公司 一种哌嗪-1-甲基吲哚-2-甲酰胺衍生物、其制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR015733A1 (es) 1998-03-25 2001-05-16 Otsuka Pharma Co Ltd DERIVADO DE PIRIDINA, EL PRODUCTO Y LA COMPOSICIoN FARMACEUTICA QUE CONTIENE DICHO DERIVADO.
JP2001089412A (ja) * 1999-09-22 2001-04-03 Otsuka Pharmaceut Co Ltd ベンゼン誘導体またはその医薬的に許容される塩
JP2001089450A (ja) * 1999-09-22 2001-04-03 Otsuka Pharmaceut Co Ltd ピリジン誘導体含有医薬製剤
AU9598601A (en) * 2000-10-20 2002-04-29 Eisai Co Ltd Nitrogenous aromatic ring compounds

Also Published As

Publication number Publication date
CL2008003265A1 (es) 2010-02-05
TWI440638B (zh) 2014-06-11
MX2010004893A (es) 2010-05-19
DK2207773T3 (da) 2012-09-10
US8551999B2 (en) 2013-10-08
CN101842367A (zh) 2010-09-22
JP2011502115A (ja) 2011-01-20
WO2009057811A3 (en) 2009-07-09
CN103224488A (zh) 2013-07-31
BRPI0819232A2 (pt) 2016-11-01
EP2207773B1 (en) 2012-07-11
CA2703240A1 (en) 2009-05-07
TW200922932A (en) 2009-06-01
ZA201002547B (en) 2011-08-31
IL204942A0 (en) 2010-11-30
PE20090949A1 (es) 2009-07-13
ES2390710T3 (es) 2012-11-15
SI2207773T1 (sl) 2012-09-28
PT2207773E (pt) 2012-10-09
JP5236002B2 (ja) 2013-07-17
MY148482A (en) 2013-04-30
US20100261720A1 (en) 2010-10-14
RU2010121857A (ru) 2011-12-10
HRP20120748T1 (hr) 2012-10-31
AU2008319719A1 (en) 2009-05-07
AR069065A1 (es) 2009-12-23
CO6210724A2 (es) 2010-10-20
CY1113812T1 (el) 2016-07-27
NZ584573A (en) 2012-05-25
PL2207773T3 (pl) 2012-11-30
WO2009057811A2 (en) 2009-05-07
KR20100092469A (ko) 2010-08-20
EP2207773A2 (en) 2010-07-21
AU2008319719B2 (en) 2013-12-12

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