UA101385C2 - Иммунологическая композиция, которая в качестве адъюванты содержит сульфолипо-циклодекстрин (sl-cd) и сапонин - Google Patents
Иммунологическая композиция, которая в качестве адъюванты содержит сульфолипо-циклодекстрин (sl-cd) и сапонинInfo
- Publication number
- UA101385C2 UA101385C2 UAA201101661A UAA201101661A UA101385C2 UA 101385 C2 UA101385 C2 UA 101385C2 UA A201101661 A UAA201101661 A UA A201101661A UA A201101661 A UAA201101661 A UA A201101661A UA 101385 C2 UA101385 C2 UA 101385C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cyclodextrin
- antigen
- immunological compositions
- methods
- sulpholipo
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 230000001900 immune effect Effects 0.000 title abstract 6
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 title abstract 2
- 229930182490 saponin Natural products 0.000 title abstract 2
- 150000007949 saponins Chemical class 0.000 title abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title 2
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 241000120506 Bluetongue virus Species 0.000 abstract 3
- 241000712462 Bovine ephemeral fever virus Species 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000701083 Bovine alphaherpesvirus 1 Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Заявленное изобретение касается иммунологических композиций, которые содержат сульфолипо-циклодекстрин (SL-CD) и сапонин, который является Quil А, и необязательно по крайней мере один антиген. Изобретение касается способов и иммунологических композиций, которые содержат по крайней мере один антиген, который может быть ветеринарным антигеном. Ветеринарный антиген в способах и иммунологических композициях изобретения может быть антигеном коров. Изобретение касается способов и иммунологических композиций, которые содержат рабдовирус коров (BEFV), вирус герпеса 1 коров (IBR) или вирус африканской катаральной лихорадки (BTV). Изобретение касается способа выявления иммунного ответа против BEFV, IBR или BTV у животного, которое заключается во введении животному композиции изобретения. В изобретении, в частности, иммунный ответ является защитным иммунным ответом. Изобретение касается способа приготовления иммунологической композиции, который заключается в добавлении Quil А к вирусу.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008904261A AU2008904261A0 (en) | 2008-08-19 | Immunological Composition | |
| PCT/US2009/054285 WO2010022135A1 (en) | 2008-08-19 | 2009-08-19 | Immunological composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA101385C2 true UA101385C2 (ru) | 2013-03-25 |
Family
ID=41696586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201101661A UA101385C2 (ru) | 2008-08-19 | 2009-08-19 | Иммунологическая композиция, которая в качестве адъюванты содержит сульфолипо-циклодекстрин (sl-cd) и сапонин |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100047279A1 (ru) |
| EP (1) | EP2331126A1 (ru) |
| JP (1) | JP2012500282A (ru) |
| KR (1) | KR101320141B1 (ru) |
| CN (1) | CN102186502B (ru) |
| AR (1) | AR076437A1 (ru) |
| AU (1) | AU2009282581B2 (ru) |
| BR (1) | BRPI0917290A8 (ru) |
| CA (1) | CA2734654C (ru) |
| CO (1) | CO6341568A2 (ru) |
| MX (1) | MX2011001910A (ru) |
| RU (1) | RU2506094C2 (ru) |
| TW (1) | TW201010719A (ru) |
| UA (1) | UA101385C2 (ru) |
| WO (1) | WO2010022135A1 (ru) |
| ZA (1) | ZA201102082B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012004133A (es) * | 2009-10-07 | 2012-05-08 | Wyeth Llc | Composiciones que comprenden adyuvante, macrolido y antigeno proteico y procedimientos de uso de las mismas. |
| NZ602278A (en) * | 2010-03-12 | 2014-12-24 | Biolex Therapeutics Inc | Bluetongue virus recombinant vaccines and uses thereof |
| WO2012154739A1 (en) * | 2011-05-09 | 2012-11-15 | Uwm Research Foundation, Inc. | The use of cyclodextrins in diets, water or vaccine adjuvants to boost the immune system of fish |
| CN103083658B (zh) * | 2011-10-27 | 2015-09-02 | 普莱柯生物工程股份有限公司 | 一种用于治疗或预防猪感染性疾病的疫苗佐剂组合物 |
| CA2927224A1 (en) | 2013-10-17 | 2015-04-23 | Zoetis Services Llc | Methods and compositions for treatment of s. equi infection |
| KR20170008850A (ko) * | 2014-05-23 | 2017-01-24 | 피브로-애니멀 헬스 코포레이션 | 배합물, 조성물, 및 배합물 또는 조성물의 동물로의 투여 방법 |
| BR102021012953A2 (pt) * | 2021-06-29 | 2023-01-10 | Fabp Biotech Desenvolvimento Em Biotecnologia Ltda. | Composição de vacina veterinária contra helmintos, método para tratamento e prevenção de infecção causada por helmintos e uso |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK316188A (da) * | 1987-06-15 | 1988-12-16 | Duphar Int Res | Sulfolipopolysaccharider som stimolatorer for den ikke specifikke forsvarsmekanisme |
| GB9622159D0 (en) * | 1996-10-24 | 1996-12-18 | Solvay Sociutu Anonyme | Polyanionic polymers as adjuvants for mucosal immunization |
| CA2654522C (en) * | 1997-08-29 | 2014-01-28 | Antigenics Inc. | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as exipient |
| EP1104306B1 (en) * | 1998-08-10 | 2006-01-11 | Antigenics Inc. | Compositions of cpg and saponin adjuvants and methods of use thereof |
| EP1104767A1 (en) * | 1999-11-30 | 2001-06-06 | Stichting Dienst Landbouwkundig Onderzoek | Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups |
| JP2005500336A (ja) * | 2001-07-25 | 2005-01-06 | ニューヨーク・ユニバーシティ | 感染および癌に対するワクチンのためのアジュバントとしてのグリコシルセラミドの使用 |
| WO2005079842A1 (fr) * | 2004-02-20 | 2005-09-01 | China Agricultural University | Adjuvant immunologique |
| EP1765385A4 (en) * | 2004-06-16 | 2008-08-27 | Smart Drug Systems Inc | IMPORTS COMPOSITION WITH DELAYED RELEASE |
| RU2288007C2 (ru) * | 2005-02-17 | 2006-11-27 | ГНУ ВНИИ ветеринарной вирусологии и микробиологии | Способ изготовления ассоциированной инактивированной культуральной вакцины против инфекционного ринотрахеита и парагриппа-3 крупного рогатого скота |
-
2009
- 2009-08-18 TW TW098127794A patent/TW201010719A/zh unknown
- 2009-08-19 CN CN200980141319.3A patent/CN102186502B/zh not_active Expired - Fee Related
- 2009-08-19 WO PCT/US2009/054285 patent/WO2010022135A1/en not_active Ceased
- 2009-08-19 UA UAA201101661A patent/UA101385C2/ru unknown
- 2009-08-19 AR ARP090103175A patent/AR076437A1/es not_active Application Discontinuation
- 2009-08-19 US US12/543,536 patent/US20100047279A1/en not_active Abandoned
- 2009-08-19 AU AU2009282581A patent/AU2009282581B2/en not_active Ceased
- 2009-08-19 RU RU2011105863/10A patent/RU2506094C2/ru not_active IP Right Cessation
- 2009-08-19 EP EP09791663A patent/EP2331126A1/en not_active Withdrawn
- 2009-08-19 CA CA2734654A patent/CA2734654C/en not_active Expired - Fee Related
- 2009-08-19 KR KR1020117006189A patent/KR101320141B1/ko not_active Expired - Fee Related
- 2009-08-19 BR BRPI0917290A patent/BRPI0917290A8/pt not_active IP Right Cessation
- 2009-08-19 MX MX2011001910A patent/MX2011001910A/es active IP Right Grant
- 2009-08-19 JP JP2011523956A patent/JP2012500282A/ja not_active Ceased
-
2011
- 2011-02-23 CO CO11022016A patent/CO6341568A2/es not_active Application Discontinuation
- 2011-03-18 ZA ZA2011/02082A patent/ZA201102082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201102082B (en) | 2011-11-30 |
| WO2010022135A1 (en) | 2010-02-25 |
| RU2011105863A (ru) | 2012-09-27 |
| CA2734654A1 (en) | 2010-02-25 |
| BRPI0917290A2 (pt) | 2015-11-10 |
| MX2011001910A (es) | 2011-06-20 |
| KR101320141B1 (ko) | 2013-11-13 |
| CA2734654C (en) | 2015-02-10 |
| HK1157182A1 (en) | 2012-06-29 |
| KR20110044791A (ko) | 2011-04-29 |
| RU2506094C2 (ru) | 2014-02-10 |
| CN102186502A (zh) | 2011-09-14 |
| AU2009282581A1 (en) | 2010-02-25 |
| CO6341568A2 (es) | 2011-11-21 |
| US20100047279A1 (en) | 2010-02-25 |
| AR076437A1 (es) | 2011-06-15 |
| BRPI0917290A8 (pt) | 2016-11-01 |
| TW201010719A (en) | 2010-03-16 |
| CN102186502B (zh) | 2014-07-16 |
| JP2012500282A (ja) | 2012-01-05 |
| AU2009282581B2 (en) | 2013-12-19 |
| EP2331126A1 (en) | 2011-06-15 |
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