UA101385C2 - Иммунологическая композиция, которая в качестве адъюванты содержит сульфолипо-циклодекстрин (sl-cd) и сапонин - Google Patents
Иммунологическая композиция, которая в качестве адъюванты содержит сульфолипо-циклодекстрин (sl-cd) и сапонинInfo
- Publication number
- UA101385C2 UA101385C2 UAA201101661A UAA201101661A UA101385C2 UA 101385 C2 UA101385 C2 UA 101385C2 UA A201101661 A UAA201101661 A UA A201101661A UA A201101661 A UAA201101661 A UA A201101661A UA 101385 C2 UA101385 C2 UA 101385C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cyclodextrin
- antigen
- immunological compositions
- methods
- sulpholipo
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 230000001900 immune effect Effects 0.000 title abstract 6
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 title abstract 2
- 229930182490 saponin Natural products 0.000 title abstract 2
- 150000007949 saponins Chemical class 0.000 title abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title 2
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 241000120506 Bluetongue virus Species 0.000 abstract 3
- 241000712462 Bovine ephemeral fever virus Species 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000701083 Bovine alphaherpesvirus 1 Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Заявленное изобретение касается иммунологических композиций, которые содержат сульфолипо-циклодекстрин (SL-CD) и сапонин, который является Quil А, и необязательно по крайней мере один антиген. Изобретение касается способов и иммунологических композиций, которые содержат по крайней мере один антиген, который может быть ветеринарным антигеном. Ветеринарный антиген в способах и иммунологических композициях изобретения может быть антигеном коров. Изобретение касается способов и иммунологических композиций, которые содержат рабдовирус коров (BEFV), вирус герпеса 1 коров (IBR) или вирус африканской катаральной лихорадки (BTV). Изобретение касается способа выявления иммунного ответа против BEFV, IBR или BTV у животного, которое заключается во введении животному композиции изобретения. В изобретении, в частности, иммунный ответ является защитным иммунным ответом. Изобретение касается способа приготовления иммунологической композиции, который заключается в добавлении Quil А к вирусу.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008904261A AU2008904261A0 (en) | 2008-08-19 | Immunological Composition | |
| PCT/US2009/054285 WO2010022135A1 (en) | 2008-08-19 | 2009-08-19 | Immunological composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA101385C2 true UA101385C2 (ru) | 2013-03-25 |
Family
ID=41696586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201101661A UA101385C2 (ru) | 2008-08-19 | 2009-08-19 | Иммунологическая композиция, которая в качестве адъюванты содержит сульфолипо-циклодекстрин (sl-cd) и сапонин |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100047279A1 (ru) |
| EP (1) | EP2331126A1 (ru) |
| JP (1) | JP2012500282A (ru) |
| KR (1) | KR101320141B1 (ru) |
| CN (1) | CN102186502B (ru) |
| AR (1) | AR076437A1 (ru) |
| AU (1) | AU2009282581B2 (ru) |
| BR (1) | BRPI0917290A8 (ru) |
| CA (1) | CA2734654C (ru) |
| CO (1) | CO6341568A2 (ru) |
| MX (1) | MX2011001910A (ru) |
| RU (1) | RU2506094C2 (ru) |
| TW (1) | TW201010719A (ru) |
| UA (1) | UA101385C2 (ru) |
| WO (1) | WO2010022135A1 (ru) |
| ZA (1) | ZA201102082B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2485725A2 (en) * | 2009-10-07 | 2012-08-15 | Wyeth LLC | Compositions comprising adjuvant, macrolide and proteinaceous antigen and methods of use thereof |
| ES2617743T3 (es) * | 2010-03-12 | 2017-06-19 | Merial, Inc. | Vacunas recombinantes del virus de la lengua azul y sus utilizaciones |
| WO2012154739A1 (en) * | 2011-05-09 | 2012-11-15 | Uwm Research Foundation, Inc. | The use of cyclodextrins in diets, water or vaccine adjuvants to boost the immune system of fish |
| CN103083658B (zh) * | 2011-10-27 | 2015-09-02 | 普莱柯生物工程股份有限公司 | 一种用于治疗或预防猪感染性疾病的疫苗佐剂组合物 |
| MX2016004961A (es) | 2013-10-17 | 2016-06-28 | Zoetis Services Llc | Procedimientos y composiciones para el tratamiento de infecciones por s. equi. |
| AU2015263877B2 (en) * | 2014-05-23 | 2021-01-21 | Desert King International Llc | Combination, composition, and method of administering the combination or composition to animals |
| BR102021012953A2 (pt) * | 2021-06-29 | 2023-01-10 | Fabp Biotech Desenvolvimento Em Biotecnologia Ltda. | Composição de vacina veterinária contra helmintos, método para tratamento e prevenção de infecção causada por helmintos e uso |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0295749A1 (en) * | 1987-06-15 | 1988-12-21 | Duphar International Research B.V | Sulpholipopolysaccharides as stimulators of the non-specific defence mechanism |
| GB9622159D0 (en) * | 1996-10-24 | 1996-12-18 | Solvay Sociutu Anonyme | Polyanionic polymers as adjuvants for mucosal immunization |
| CA2302522C (en) * | 1997-08-29 | 2010-08-17 | Antigenics Llc | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
| PT1104306E (pt) * | 1998-08-10 | 2006-05-31 | Antigenics Inc | Composicoes de cpg e adjuvantes de saponina e seus metodos |
| EP1104767A1 (en) * | 1999-11-30 | 2001-06-06 | Stichting Dienst Landbouwkundig Onderzoek | Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups |
| EP1434859A2 (en) * | 2001-07-25 | 2004-07-07 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
| CN1909925B (zh) * | 2004-02-20 | 2010-10-13 | 中国农业大学 | 一种免疫佐剂 |
| WO2005123120A1 (en) * | 2004-06-16 | 2005-12-29 | Smart Drug Systems Inc. | Sustained release vaccine composition |
| RU2288007C2 (ru) * | 2005-02-17 | 2006-11-27 | ГНУ ВНИИ ветеринарной вирусологии и микробиологии | Способ изготовления ассоциированной инактивированной культуральной вакцины против инфекционного ринотрахеита и парагриппа-3 крупного рогатого скота |
-
2009
- 2009-08-18 TW TW098127794A patent/TW201010719A/zh unknown
- 2009-08-19 JP JP2011523956A patent/JP2012500282A/ja not_active Ceased
- 2009-08-19 RU RU2011105863/10A patent/RU2506094C2/ru not_active IP Right Cessation
- 2009-08-19 WO PCT/US2009/054285 patent/WO2010022135A1/en not_active Ceased
- 2009-08-19 EP EP09791663A patent/EP2331126A1/en not_active Withdrawn
- 2009-08-19 BR BRPI0917290A patent/BRPI0917290A8/pt not_active IP Right Cessation
- 2009-08-19 US US12/543,536 patent/US20100047279A1/en not_active Abandoned
- 2009-08-19 KR KR1020117006189A patent/KR101320141B1/ko not_active Expired - Fee Related
- 2009-08-19 AR ARP090103175A patent/AR076437A1/es not_active Application Discontinuation
- 2009-08-19 CA CA2734654A patent/CA2734654C/en not_active Expired - Fee Related
- 2009-08-19 AU AU2009282581A patent/AU2009282581B2/en not_active Ceased
- 2009-08-19 MX MX2011001910A patent/MX2011001910A/es active IP Right Grant
- 2009-08-19 UA UAA201101661A patent/UA101385C2/ru unknown
- 2009-08-19 CN CN200980141319.3A patent/CN102186502B/zh not_active Expired - Fee Related
-
2011
- 2011-02-23 CO CO11022016A patent/CO6341568A2/es not_active Application Discontinuation
- 2011-03-18 ZA ZA2011/02082A patent/ZA201102082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102186502A (zh) | 2011-09-14 |
| ZA201102082B (en) | 2011-11-30 |
| TW201010719A (en) | 2010-03-16 |
| MX2011001910A (es) | 2011-06-20 |
| KR20110044791A (ko) | 2011-04-29 |
| JP2012500282A (ja) | 2012-01-05 |
| BRPI0917290A8 (pt) | 2016-11-01 |
| AR076437A1 (es) | 2011-06-15 |
| CN102186502B (zh) | 2014-07-16 |
| CA2734654A1 (en) | 2010-02-25 |
| KR101320141B1 (ko) | 2013-11-13 |
| CO6341568A2 (es) | 2011-11-21 |
| HK1157182A1 (en) | 2012-06-29 |
| RU2011105863A (ru) | 2012-09-27 |
| EP2331126A1 (en) | 2011-06-15 |
| AU2009282581A1 (en) | 2010-02-25 |
| BRPI0917290A2 (pt) | 2015-11-10 |
| CA2734654C (en) | 2015-02-10 |
| RU2506094C2 (ru) | 2014-02-10 |
| WO2010022135A1 (en) | 2010-02-25 |
| US20100047279A1 (en) | 2010-02-25 |
| AU2009282581B2 (en) | 2013-12-19 |
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