UA103340C2 - Терапевтическое, диетологическое или косметическое применение соединений со специфическим антиапоптозным дейсвием на каспазу-3 и композиция, которая содержит эти соединения - Google Patents
Терапевтическое, диетологическое или косметическое применение соединений со специфическим антиапоптозным дейсвием на каспазу-3 и композиция, которая содержит эти соединенияInfo
- Publication number
- UA103340C2 UA103340C2 UAA201106636A UAA201106636A UA103340C2 UA 103340 C2 UA103340 C2 UA 103340C2 UA A201106636 A UAA201106636 A UA A201106636A UA A201106636 A UAA201106636 A UA A201106636A UA 103340 C2 UA103340 C2 UA 103340C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- dietary
- therapeutic
- compositions containing
- specific anti
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 235000005911 diet Nutrition 0.000 title abstract 2
- 230000000378 dietary effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- 102000003952 Caspase 3 Human genes 0.000 title 1
- 108090000397 Caspase 3 Proteins 0.000 title 1
- 230000002424 anti-apoptotic effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 abstract 2
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 abstract 1
- 208000003024 Diffuse alopecia Diseases 0.000 abstract 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 abstract 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 abstract 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 abstract 1
- 208000004631 alopecia areata Diseases 0.000 abstract 1
- 206010068168 androgenetic alopecia Diseases 0.000 abstract 1
- 201000002996 androgenic alopecia Diseases 0.000 abstract 1
- 238000003782 apoptosis assay Methods 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 208000022605 chemotherapy-induced alopecia Diseases 0.000 abstract 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 abstract 1
- 230000005522 programmed cell death Effects 0.000 abstract 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 abstract 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 abstract 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 abstract 1
- 235000005493 rutin Nutrition 0.000 abstract 1
- 229960004555 rutoside Drugs 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 229940063673 spermidine Drugs 0.000 abstract 1
- 201000001297 telogen effluvium Diseases 0.000 abstract 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 abstract 1
- 230000007306 turnover Effects 0.000 abstract 1
- 229940043269 zeaxanthin Drugs 0.000 abstract 1
- 235000010930 zeaxanthin Nutrition 0.000 abstract 1
- 239000001775 zeaxanthin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение касается применения зеаксантина или отдельно, или в комбинации с рутином, или в комбинации с рутином и спермидином, в составе фармацевтической, диетологической или косметической композиции для лечения расстройств на волосистой части кожи головы, в том числе вызванной химиотерапией алопеции, очаговой алопеции, андрогенетической алопеции и телогенной алопеции.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08425704 | 2008-11-03 | ||
| PCT/EP2009/064368 WO2010060729A1 (en) | 2008-11-03 | 2009-10-30 | Therapeutic, dietary, or cosmetic use of compounds with specific anti-apoptotic activity toward caspase-3, and compositions containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA103340C2 true UA103340C2 (ru) | 2013-10-10 |
Family
ID=40386219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201106636A UA103340C2 (ru) | 2008-11-03 | 2009-10-30 | Терапевтическое, диетологическое или косметическое применение соединений со специфическим антиапоптозным дейсвием на каспазу-3 и композиция, которая содержит эти соединения |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8729033B2 (ru) |
| EP (1) | EP2352493B1 (ru) |
| JP (1) | JP5709217B2 (ru) |
| KR (1) | KR101747442B1 (ru) |
| CN (1) | CN102202659B (ru) |
| AU (1) | AU2009319185B2 (ru) |
| BR (1) | BRPI0921491A2 (ru) |
| CA (1) | CA2741746C (ru) |
| DK (1) | DK2352493T3 (ru) |
| ES (1) | ES2450390T3 (ru) |
| IL (1) | IL212567A (ru) |
| MX (1) | MX2011004482A (ru) |
| NZ (1) | NZ593180A (ru) |
| PL (1) | PL2352493T3 (ru) |
| PT (1) | PT2352493E (ru) |
| RU (1) | RU2504366C2 (ru) |
| UA (1) | UA103340C2 (ru) |
| WO (1) | WO2010060729A1 (ru) |
| ZA (1) | ZA201104079B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103153293B (zh) | 2010-08-04 | 2016-08-24 | 体恤医药公司 | 用于组织维护和修复的多阴离子聚合物和亚精胺的超分子复合物 |
| CH705756B1 (de) * | 2011-11-13 | 2016-03-31 | Compad Consulting Gmbh | Nachhaltige kosmetische und dermatologische Zubereitungen. |
| JP6092039B2 (ja) * | 2013-08-02 | 2017-03-08 | 富士フイルム株式会社 | 乳化組成物 |
| JP6092038B2 (ja) * | 2013-08-02 | 2017-03-08 | 富士フイルム株式会社 | 乳化組成物 |
| FR3009955B1 (fr) * | 2013-08-30 | 2016-11-25 | Laboratoires Inneov | Composition a base d'acide gras polyinsature et de vitamine d destinee a une administration par voie orale pour ameliorer la qualite de la chevelure |
| BR112018012757B1 (pt) | 2015-12-31 | 2021-12-07 | Colgate-Palmolive Company | Composições de higiene pessoal, método para aumentar a deposição de um aminoácido na superfície epitelial de um mamífero e método para a preparação de uma composição de higiene pessoal |
| CN105969725B (zh) * | 2016-06-12 | 2019-04-26 | 暨南大学 | 枸杞红素的用途 |
| RU2631642C1 (ru) * | 2016-11-29 | 2017-09-25 | Общество с ограниченной ответственностью "Научно-производственная компания Стемма" | Способ лечения нерубцовой алопеции |
| CN110882173B (zh) * | 2019-12-05 | 2022-06-17 | 西北农林科技大学 | 一种靶向毛囊干细胞防治脱发的外用型日化品配方 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH072677A (ja) * | 1993-06-18 | 1995-01-06 | Toyo Seito Kk | 経口育毛剤 |
| US6218436B1 (en) * | 1993-06-28 | 2001-04-17 | The Howard Foundation | Pharmaceutically active carotenoids |
| GB9419715D0 (en) | 1994-09-30 | 1994-11-16 | Boots Co Plc | Hair stimulant composition |
| US20060264357A1 (en) * | 1997-04-22 | 2006-11-23 | Zikria Bashir A | Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals |
| US6573299B1 (en) * | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
| AU4473101A (en) * | 2000-04-07 | 2001-10-23 | Taisho Pharmaceutical Co Ltd | Hair growth stimulant compositions |
| US6254898B1 (en) * | 2000-05-25 | 2001-07-03 | Protective Factors, Inc. | Nutraceutical composition for protection against solar radiation |
| JP2002029989A (ja) * | 2000-07-12 | 2002-01-29 | Mitsuyo Kamata | 鍼灸による脱毛治療の育毛を促進する経口剤 |
| FR2811569B1 (fr) * | 2000-07-13 | 2003-03-14 | Oreal | Composition, notamment cosmetique, renfermant la dhea et/ou ses precurseurs ou derives, et un carotenoide |
| FR2815541B1 (fr) * | 2000-10-24 | 2008-02-29 | Lipha | Utilisation d'inhibiteurs de l'apoptose des pericytes pour le traitement et/ou la prevention de la retinopathie diabetique |
| ITMI20020189A1 (it) * | 2002-02-01 | 2003-08-01 | Giuliani Spa | Composizione per uso farmaceutico o dietetico per contrastare la caduta dei capelli |
| US9138408B2 (en) * | 2002-06-21 | 2015-09-22 | L'oreal | Use of taurine for treating alopecia |
| US8088363B2 (en) * | 2002-10-28 | 2012-01-03 | Zeavision Llc | Protection against sunburn and skin problems with orally-ingested high-dosage zeaxanthin |
| CN1481804A (zh) * | 2002-12-17 | 2004-03-17 | 无锡杰西医药科技有限公司 | 防治白内障、黄斑变性等眼病的配方及其使用方法 |
| JP4535827B2 (ja) * | 2004-09-29 | 2010-09-01 | 株式会社マンダム | アポトーシス誘導阻害剤及びその評価方法 |
| CA2589633A1 (en) * | 2004-12-03 | 2006-06-08 | Nu-Tein Co., Inc. | Method for treating skin disorders with xanthophylls |
| MX2008004981A (es) * | 2005-10-16 | 2008-10-17 | Lycored Ltd | Composiciones para el tratamiento de enfermedades de los ojos. |
| JP2008007476A (ja) * | 2006-06-30 | 2008-01-17 | Lion Corp | 育毛養毛剤組成物 |
| JP2008127505A (ja) * | 2006-11-22 | 2008-06-05 | Q P Corp | 粉末状組成物およびその製造方法、ならびにこれを含有する食品組成物 |
| ITMI20070555A1 (it) * | 2007-03-21 | 2007-06-20 | Giuliani Spa | Composizione provvista di attivita' di inibizione sulla 5 alfa-reduttasi |
-
2009
- 2009-10-30 AU AU2009319185A patent/AU2009319185B2/en not_active Ceased
- 2009-10-30 NZ NZ593180A patent/NZ593180A/xx not_active IP Right Cessation
- 2009-10-30 EP EP09759916.1A patent/EP2352493B1/en active Active
- 2009-10-30 DK DK09759916.1T patent/DK2352493T3/da active
- 2009-10-30 US US13/127,446 patent/US8729033B2/en not_active Expired - Fee Related
- 2009-10-30 CN CN200980143229.8A patent/CN102202659B/zh not_active Expired - Fee Related
- 2009-10-30 MX MX2011004482A patent/MX2011004482A/es active IP Right Grant
- 2009-10-30 BR BRPI0921491A patent/BRPI0921491A2/pt not_active IP Right Cessation
- 2009-10-30 WO PCT/EP2009/064368 patent/WO2010060729A1/en not_active Ceased
- 2009-10-30 ES ES09759916.1T patent/ES2450390T3/es active Active
- 2009-10-30 RU RU2011122458/15A patent/RU2504366C2/ru not_active IP Right Cessation
- 2009-10-30 PT PT97599161T patent/PT2352493E/pt unknown
- 2009-10-30 PL PL09759916T patent/PL2352493T3/pl unknown
- 2009-10-30 KR KR1020117012264A patent/KR101747442B1/ko not_active Expired - Fee Related
- 2009-10-30 UA UAA201106636A patent/UA103340C2/ru unknown
- 2009-10-30 JP JP2011533740A patent/JP5709217B2/ja not_active Expired - Fee Related
- 2009-10-30 CA CA2741746A patent/CA2741746C/en not_active Expired - Fee Related
-
2011
- 2011-04-28 IL IL212567A patent/IL212567A/en not_active IP Right Cessation
- 2011-06-01 ZA ZA2011/04079A patent/ZA201104079B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ593180A (en) | 2012-09-28 |
| ES2450390T3 (es) | 2014-03-24 |
| EP2352493B1 (en) | 2013-12-11 |
| AU2009319185A1 (en) | 2011-06-23 |
| RU2504366C2 (ru) | 2014-01-20 |
| CN102202659A (zh) | 2011-09-28 |
| US8729033B2 (en) | 2014-05-20 |
| CA2741746C (en) | 2016-08-23 |
| CA2741746A1 (en) | 2010-06-03 |
| IL212567A (en) | 2015-08-31 |
| ZA201104079B (en) | 2012-02-29 |
| PL2352493T3 (pl) | 2014-05-30 |
| JP5709217B2 (ja) | 2015-04-30 |
| EP2352493A1 (en) | 2011-08-10 |
| IL212567A0 (en) | 2011-06-30 |
| MX2011004482A (es) | 2011-05-31 |
| DK2352493T3 (da) | 2014-02-10 |
| CN102202659B (zh) | 2014-04-16 |
| RU2011122458A (ru) | 2012-12-10 |
| US20110218164A1 (en) | 2011-09-08 |
| BRPI0921491A2 (pt) | 2016-07-19 |
| JP2012507489A (ja) | 2012-03-29 |
| KR101747442B1 (ko) | 2017-06-14 |
| AU2009319185B2 (en) | 2013-11-14 |
| KR20110086126A (ko) | 2011-07-27 |
| WO2010060729A1 (en) | 2010-06-03 |
| PT2352493E (pt) | 2014-03-20 |
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