ATE492530T1 - Derivate einer arylsulfonamidosubstituierten hydroxamsäure als matrixmetalloproteinaseinhibitoren - Google Patents

Derivate einer arylsulfonamidosubstituierten hydroxamsäure als matrixmetalloproteinaseinhibitoren

Info

Publication number
ATE492530T1
ATE492530T1 AT05769876T AT05769876T ATE492530T1 AT E492530 T1 ATE492530 T1 AT E492530T1 AT 05769876 T AT05769876 T AT 05769876T AT 05769876 T AT05769876 T AT 05769876T AT E492530 T1 ATE492530 T1 AT E492530T1
Authority
AT
Austria
Prior art keywords
arylsulfonamido
derivatives
hydroxamic acid
matrix metalloproteinase
substituted hydroxamic
Prior art date
Application number
AT05769876T
Other languages
English (en)
Inventor
Ivano Bertini
Marco Fragai
Conte Mauro Lo
Claudio Luchinat
Cristina Nativi
Chiara Venturi
Original Assignee
Protera S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protera S R L filed Critical Protera S R L
Application granted granted Critical
Publication of ATE492530T1 publication Critical patent/ATE492530T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Lubricants (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05769876T 2004-08-03 2005-07-29 Derivate einer arylsulfonamidosubstituierten hydroxamsäure als matrixmetalloproteinaseinhibitoren ATE492530T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000174A ITFI20040174A1 (it) 2004-08-03 2004-08-03 Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
PCT/EP2005/053722 WO2006013193A2 (en) 2004-08-03 2005-07-29 Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors

Publications (1)

Publication Number Publication Date
ATE492530T1 true ATE492530T1 (de) 2011-01-15

Family

ID=35787488

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05769876T ATE492530T1 (de) 2004-08-03 2005-07-29 Derivate einer arylsulfonamidosubstituierten hydroxamsäure als matrixmetalloproteinaseinhibitoren

Country Status (14)

Country Link
US (2) US7772430B2 (de)
EP (2) EP2308837A3 (de)
JP (1) JP2008509108A (de)
CN (1) CN101076514A (de)
AT (1) ATE492530T1 (de)
AU (1) AU2005268765B2 (de)
BR (1) BRPI0514030A (de)
CA (1) CA2580235A1 (de)
DE (1) DE602005025495D1 (de)
IT (1) ITFI20040174A1 (de)
MX (1) MX2007001269A (de)
RU (2) RU2406721C2 (de)
WO (1) WO2006013193A2 (de)
ZA (1) ZA200701798B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011000512A (es) 2008-07-14 2011-02-24 Novartis Ag Inhibidores selectivos de mmp-12 y mmp-13 basados en acido hidroxamico.
DE102011088926A1 (de) * 2011-12-19 2013-06-20 Beiersdorf Ag Haarstylingformulierung zur Erstellung eines flexiblen Haltes durch Einsatz von Octanohydroxamsäure
AU2012363033B2 (en) * 2011-12-28 2016-06-02 Galectin Therapeutics, Inc. Composition of novel carbohydrate drug for treatment of human diseases
EP2907512A1 (de) 2014-02-14 2015-08-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Hemmer von MMP-12 als antivirale Wirkstoffe
CN105728047B (zh) * 2016-03-24 2017-12-26 万华化学集团股份有限公司 一种氢甲酰化催化剂及其制备方法和应用
JP2017210442A (ja) * 2016-05-26 2017-11-30 イノレックス インベストメント コーポレイション マトリックスメタロプロテイナーゼを阻害して皮膚の老化を軽減する方法及び関連の相乗的組成物
IT201600083975A1 (it) * 2016-08-09 2018-02-09 Consorzio Interuniversitario Naz Per La Scienza E Tecnologia Dei Materiali Acido ialuronico funzionalizzato
JP6541118B1 (ja) * 2018-04-27 2019-07-10 株式会社成和化成 化粧品基材および該化粧品基材を含有する毛髪用化粧品、美白剤
LV15485B (lv) * 2018-09-13 2020-06-20 Latvijas Organiskās Sintēzes Institūts Selenofēnhromenonu hidroksāmskābes, to izgatavošana un izmantošana angioģenēzes inhibīcijā

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LU68901A1 (de) 1973-11-30 1975-08-20
US5506242A (en) 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
EP0950656B1 (de) * 1996-01-23 2007-04-11 Shionogi & Co., Ltd. Sulfonierte aminosäurederivate und metalloproteinase-inhibitoren, die diese enthalten
JPH10265452A (ja) * 1996-05-24 1998-10-06 Ono Pharmaceut Co Ltd フェニルスルホンアミド誘導体
WO1998003166A1 (en) * 1996-07-22 1998-01-29 Monsanto Company Thiol sulfonamide metalloprotease inhibitors
JP2001503400A (ja) * 1996-10-22 2001-03-13 ファルマシア・アンド・アップジョン・カンパニー マトリックス・メタロプロテイナーゼ阻害剤としてのα―アミノスルホニルヒドロキサム酸類
AU721748B2 (en) * 1997-02-03 2000-07-13 Pfizer Products Inc. Arylsulfonylamino hydroxamic acid derivatives
WO1998050348A1 (en) * 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
JP2001513484A (ja) * 1997-07-31 2001-09-04 ザ プロクター アンド ギャンブル カンパニー 非環式メタロプロテアーゼ阻害剤
JPH11199512A (ja) * 1997-10-24 1999-07-27 Pfizer Prod Inc 変形性関節症および他のｍｍｐ媒介疾患の治療のためのｍｍｐ−１３選択的阻害剤の使用
PA8469601A1 (es) * 1998-04-10 2000-09-29 Pfizer Prod Inc Procedimiento para alquilar sulfonamidas impedidas estericamente
HRP20010443A2 (en) * 1998-12-22 2002-06-30 Hoffmann La Roche Sulfonamide hydroxamates
US6616935B1 (en) 1998-12-28 2003-09-09 Celanese Ventures Gmbh Method of filtering UV- light
FR2799964B1 (fr) 1999-10-22 2002-07-26 Oreal Emulsions contenant au moins un filtre uv organique insoluble et un polymere associatif
ES2264985T3 (es) 2000-05-10 2007-02-01 Ciba Specialty Chemicals Holding Inc. Compuestos sililados como precursores para composiciones de autobronceado.
GB0028161D0 (en) 2000-11-17 2001-01-03 Natural Environment Res Personal care compositions
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
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ATE429909T1 (de) * 2002-05-29 2009-05-15 Merck & Co Inc Nützliche verbindungen für die behandlung von anthrax und hemmung des letalen faktors

Also Published As

Publication number Publication date
EP2308837A2 (de) 2011-04-13
EP2308837A3 (de) 2011-04-20
WO2006013193A3 (en) 2006-08-31
CA2580235A1 (en) 2006-02-09
WO2006013193A8 (en) 2010-07-29
RU2406721C2 (ru) 2010-12-20
ZA200701798B (en) 2008-08-27
US20080249032A1 (en) 2008-10-09
BRPI0514030A (pt) 2008-05-27
RU2007107872A (ru) 2008-09-10
JP2008509108A (ja) 2008-03-27
US7772430B2 (en) 2010-08-10
CN101076514A (zh) 2007-11-21
ITFI20040174A1 (it) 2004-11-03
AU2005268765B2 (en) 2011-08-04
AU2005268765A1 (en) 2006-02-09
EP1781601A2 (de) 2007-05-09
RU2010136061A (ru) 2012-03-10
WO2006013193A2 (en) 2006-02-09
MX2007001269A (es) 2007-07-16
US20100298439A1 (en) 2010-11-25
DE602005025495D1 (de) 2011-02-03
EP1781601B1 (de) 2010-12-22

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