UA103844C2 - Фармацевтический состав, который содержит в матрице, которая подвергается эрозии, один или более эфиров фумаровой кислоты - Google Patents

Фармацевтический состав, который содержит в матрице, которая подвергается эрозии, один или более эфиров фумаровой кислоты

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Publication number
UA103844C2
UA103844C2 UAA201209635A UAA201209635A UA103844C2 UA 103844 C2 UA103844 C2 UA 103844C2 UA A201209635 A UAA201209635 A UA A201209635A UA A201209635 A UAA201209635 A UA A201209635A UA 103844 C2 UA103844 C2 UA 103844C2
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UA
Ukraine
Prior art keywords
fumaric acid
pharmaceutical formulation
acid esters
erosion matrix
erosion
Prior art date
Application number
UAA201209635A
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English (en)
Ukrainian (uk)
Inventor
Генрик Нильссон
Роналд Рупп
Original Assignee
Форвард Фарма А/С
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42026676&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA103844(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Форвард Фарма А/С filed Critical Форвард Фарма А/С
Publication of UA103844C2 publication Critical patent/UA103844C2/ru

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract

Изобретение касается фармацевтического состава в форме таблетки с матрицей, которая подвергается эрозии, который содержит: i) от 10 масс. % до 80 масс. % одного или больше эфиров фумаровой кислоты, выбранных из ди-(С-С)алкилэфиров фумаровой кислоты и моно-(С-С)алкилэфиров фумаровой кислоты, или их фармацевтически приемлемой соли как активного вещества; ii) 1-50 масс. % одного или больше агентов, которые контролируют скорость; и энтеросолюбильное покрытие, при этом указанное энтеросолюбильное покрытие наносят в количестве, которое составляет 1,5-3,5 масс. % от массы ядра, при этом эрозия указанной матрицы, которая подвергается эрозии, обеспечивает контролируемое или замедленное высвобождение указанного активного вещества.
UAA201209635A 2009-01-09 2010-01-08 Фармацевтический состав, который содержит в матрице, которая подвергается эрозии, один или более эфиров фумаровой кислоты UA103844C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200900034 2009-01-09
PCT/EP2010/050172 WO2010079222A1 (en) 2009-01-09 2010-01-08 Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix

Publications (1)

Publication Number Publication Date
UA103844C2 true UA103844C2 (ru) 2013-11-25

Family

ID=42026676

Family Applications (3)

Application Number Title Priority Date Filing Date
UAA201307178A UA112975C2 (uk) 2009-01-09 2010-01-08 Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти
UAA201707740A UA125896C2 (uk) 2009-01-09 2010-01-08 Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти
UAA201209635A UA103844C2 (ru) 2009-01-09 2010-01-08 Фармацевтический состав, который содержит в матрице, которая подвергается эрозии, один или более эфиров фумаровой кислоты

Family Applications Before (2)

Application Number Title Priority Date Filing Date
UAA201307178A UA112975C2 (uk) 2009-01-09 2010-01-08 Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти
UAA201707740A UA125896C2 (uk) 2009-01-09 2010-01-08 Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти

Country Status (18)

Country Link
US (5) US8906420B2 (ru)
EP (4) EP2379063B2 (ru)
JP (3) JP5788331B2 (ru)
KR (1) KR101699912B1 (ru)
CN (2) CN102369001A (ru)
CY (2) CY1114010T1 (ru)
DK (2) DK2379063T4 (ru)
EA (1) EA201290596A1 (ru)
ES (2) ES2411972T5 (ru)
HR (2) HRP20130480T4 (ru)
HU (1) HUE030169T2 (ru)
PL (2) PL2379063T5 (ru)
PT (2) PT2379063E (ru)
RU (2) RU2743637C2 (ru)
SI (2) SI2564839T1 (ru)
SM (1) SMT201300065B (ru)
UA (3) UA112975C2 (ru)
WO (1) WO2010079222A1 (ru)

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PL2316430T3 (pl) 2004-10-08 2012-11-30 Forward Pharma As Kompozycje farmaceutyczne o kontrolowanym uwalnianiu, zawierające ester kwasu fumarowego
ES2599227T3 (es) * 2007-02-08 2017-01-31 Biogen Ma Inc. Neuroprotección en enfermedades desmielinizantes
RU2554347C2 (ru) 2008-08-19 2015-06-27 Ксенопорт, Инк. Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения
CN102369001A (zh) 2009-01-09 2012-03-07 前进制药公司 包含溶蚀骨架中的一种或多种富马酸酯的药物制剂
JP2012525385A (ja) * 2009-04-29 2012-10-22 バイオジェン・アイデック・エムエイ・インコーポレイテッド 神経変性および神経炎症の治療
KR20150080037A (ko) * 2011-06-08 2015-07-08 바이오젠 엠에이 인코포레이티드 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법
CN114146081A (zh) * 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
EP2692343A1 (en) * 2012-08-03 2014-02-05 Forward Pharma A/S Combination therapy for treatment of multiple sclerosis
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US20200000758A1 (en) * 2012-08-22 2020-01-02 Xenoport, Inc. Oral Dosage Forms Of Methyl Hydrogen Fumarate And Prodrugs Thereof
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KR102085557B1 (ko) 2013-03-14 2020-03-06 엘커메스 파마 아일랜드 리미티드 푸마레이트의 프로드럭 및 다양한 질환을 치료하는데 있어서의 이들의 용도
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US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
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