UA105580C2 - Спосіб одержання діалкілпеметрекседу високої чистоти - Google Patents
Спосіб одержання діалкілпеметрекседу високої чистотиInfo
- Publication number
- UA105580C2 UA105580C2 UAA201302744A UAA201302744A UA105580C2 UA 105580 C2 UA105580 C2 UA 105580C2 UA A201302744 A UAA201302744 A UA A201302744A UA A201302744 A UAA201302744 A UA A201302744A UA 105580 C2 UA105580 C2 UA 105580C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pemetrexed
- dialkyl
- preparation
- highly pure
- pure dialkyl
- Prior art date
Links
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 title abstract 5
- 229960005079 pemetrexed Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- YQKJOPVLOSCCQQ-UHFFFAOYSA-N C1=NC2=NC(N)=CC2=C(O)N1CCC1=CC=CC=C1C(O)=O Chemical compound C1=NC2=NC(N)=CC2=C(O)N1CCC1=CC=CC=C1C(O)=O YQKJOPVLOSCCQQ-UHFFFAOYSA-N 0.000 abstract 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XZZNDPSIHUTMOC-UHFFFAOYSA-N triphenyl phosphate Chemical class C=1C=CC=CC=1OP(OC=1C=CC=CC=1)(=O)OC1=CC=CC=C1 XZZNDPSIHUTMOC-UHFFFAOYSA-N 0.000 abstract 1
- 238000001665 trituration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2194MU2010 | 2010-08-02 | ||
| PCT/IN2010/000700 WO2012017443A1 (fr) | 2010-08-02 | 2010-10-27 | Procédé pour la préparation de pemetrexed dialkylé de haute pureté |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA105580C2 true UA105580C2 (uk) | 2014-05-26 |
Family
ID=43858427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201302744A UA105580C2 (uk) | 2010-08-02 | 2010-10-27 | Спосіб одержання діалкілпеметрекседу високої чистоти |
Country Status (3)
| Country | Link |
|---|---|
| RU (1) | RU2552519C2 (fr) |
| UA (1) | UA105580C2 (fr) |
| WO (1) | WO2012017443A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9051322B2 (en) * | 2011-03-23 | 2015-06-09 | Scinopharm Taiwan, Ltd. | Process for the production of a pemetrexed salt |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO169490C (no) | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
| KR0162654B1 (ko) | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| WO1999016742A1 (fr) | 1997-09-26 | 1999-04-08 | Eli Lilly And Company | Procedes et intermediaires pour la production d'antifoliques |
| US6066732A (en) * | 1998-08-21 | 2000-05-23 | The Trustees Of Princeton University | Process for the preparation of pyrrolo[2,3-d]pyrimidines |
| AU6890800A (en) * | 1999-08-23 | 2001-03-19 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
-
2010
- 2010-10-27 WO PCT/IN2010/000700 patent/WO2012017443A1/fr not_active Ceased
- 2010-10-27 RU RU2013109299/04A patent/RU2552519C2/ru active
- 2010-10-27 UA UAA201302744A patent/UA105580C2/uk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012017443A1 (fr) | 2012-02-09 |
| RU2552519C2 (ru) | 2015-06-10 |
| RU2013109299A (ru) | 2014-09-10 |
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