UA115231C2 - Сполуки імідазопіролідинонів - Google Patents

Сполуки імідазопіролідинонів

Info

Publication number
UA115231C2
UA115231C2 UAA201407720A UAA201407720A UA115231C2 UA 115231 C2 UA115231 C2 UA 115231C2 UA A201407720 A UAA201407720 A UA A201407720A UA A201407720 A UAA201407720 A UA A201407720A UA 115231 C2 UA115231 C2 UA 115231C2
Authority
UA
Ukraine
Prior art keywords
compounds
imidazopyrolidine
mdm2
disorder
formula
Prior art date
Application number
UAA201407720A
Other languages
English (en)
Inventor
Паскаль Фуре
Віто Гуаньяно
Філіпп Хольцер
Йорг Каллен
Льв Ляо
Роберт Мах
Ліанг Мао
Кеіїчі Масуя
Ахім Шлапбах
Стефан Штутц
Андреа Фаупель
Original Assignee
Новартіс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA115231(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартіс Аг filed Critical Новартіс Аг
Publication of UA115231C2 publication Critical patent/UA115231C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Винахід стосується описаних тут сполук формули (І), фармацевтичних препаратів, що містять такі сполуки, застосування та способів застосування таких сполук при лікуванні розладу або захворювання, опосередкованого активністю MDM2 та/або MDM4, та комбінацій, що містять такі сполуки: EMBED ISISServer (І).
UAA201407720A 2012-01-26 2013-01-25 Сполуки імідазопіролідинонів UA115231C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261591001P 2012-01-26 2012-01-26
US201261669902P 2012-07-10 2012-07-10
CNPCT/CN2012/086703 2012-12-14
PCT/IB2013/050655 WO2013111105A1 (en) 2012-01-26 2013-01-25 Imidazopyrrolidinone compounds

Publications (1)

Publication Number Publication Date
UA115231C2 true UA115231C2 (uk) 2017-10-10

Family

ID=47997596

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201407720A UA115231C2 (uk) 2012-01-26 2013-01-25 Сполуки імідазопіролідинонів

Country Status (45)

Country Link
US (2) US8815926B2 (uk)
EP (3) EP2807164B1 (uk)
JP (3) JP5865519B2 (uk)
KR (2) KR101694383B1 (uk)
CN (1) CN104203952B (uk)
AP (1) AP2014007810A0 (uk)
AR (1) AR089807A1 (uk)
AU (1) AU2013213260B2 (uk)
BR (1) BR112014018475B1 (uk)
CA (1) CA2860951C (uk)
CL (1) CL2014001855A1 (uk)
CO (1) CO7010838A2 (uk)
CR (1) CR20140354A (uk)
CU (1) CU24336B1 (uk)
CY (1) CY1119058T1 (uk)
DK (1) DK2807164T3 (uk)
DO (1) DOP2014000170A (uk)
EA (2) EA201790134A3 (uk)
EC (1) ECSP14015553A (uk)
ES (2) ES2632430T3 (uk)
GE (1) GEP20166438B (uk)
GT (1) GT201400164A (uk)
HK (1) HK1245780B (uk)
HR (1) HRP20171005T1 (uk)
IL (1) IL233739A (uk)
JO (1) JO3357B1 (uk)
LT (1) LT2807164T (uk)
MA (1) MA35869B1 (uk)
MX (1) MX353315B (uk)
MY (1) MY177242A (uk)
NI (1) NI201400083A (uk)
NZ (1) NZ627277A (uk)
PE (1) PE20141655A1 (uk)
PH (1) PH12014501702B1 (uk)
PL (1) PL2807164T3 (uk)
PT (1) PT2807164T (uk)
RS (1) RS56197B1 (uk)
SG (1) SG11201403935VA (uk)
SI (1) SI2807164T1 (uk)
SM (1) SMT201700336T1 (uk)
TN (1) TN2014000319A1 (uk)
TW (2) TWI579284B (uk)
UA (1) UA115231C2 (uk)
UY (1) UY34591A (uk)
WO (1) WO2013111105A1 (uk)

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