UA116132C2 - Заміщені 7-азабіцикли і їхнє застосування як модуляторів рецептора орексину - Google Patents

Заміщені 7-азабіцикли і їхнє застосування як модуляторів рецептора орексину

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Publication number
UA116132C2
UA116132C2 UAA201510021A UAA201510021A UA116132C2 UA 116132 C2 UA116132 C2 UA 116132C2 UA A201510021 A UAA201510021 A UA A201510021A UA A201510021 A UAA201510021 A UA A201510021A UA 116132 C2 UA116132 C2 UA 116132C2
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UA
Ukraine
Prior art keywords
alkyl
compounds
aikoxy
pyrazolyl
pyridyl
Prior art date
Application number
UAA201510021A
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English (en)
Inventor
Хітер Р. Коут
Курт А. Дворак
Енн Е. Фітцджералд
Террі П. Лєболд
Кеті Превілл
Брок Т. Шайрман
Original Assignee
Янссен Фармацевтика Нв
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Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of UA116132C2 publication Critical patent/UA116132C2/uk

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Цей винахід стосується сполук формули І: , I де кільце А являє собою феніл, нафталініл, піридил, хінолініл, ізохінолініл, імідазопіридил, фураніл, тіазоліл, ізоксазоліл, піразоліл, імідазотіазоліл, бензімідазоліл або індазоліл; R1 являє собою Н, алкіл, алкокси, гідроксіалкілен, ОН, галоген, феніл, триазоліл, оксазоліл, ізоксазоліл, піридил, піримідил, піразиніл, піридазиніл, піперазиніл, піразоліл, оксадіазоліл, піролідиніл, тіофеніл, морфолініл або діалкіламіно; R2 являє собою Н, алкіл, алкокси, гідроксіалкілен або галоген; Z являє собою NH, N-алкіл або О; R5 являє собою піридил, піримідиніл, піразиніл, піридазиніл, хіназолініл, хіноксалініл, піразоліл, бензоксазоліл, імідазопіразиніл, триазолопіразиніл, необов'язково заміщений одним або двома замісниками, незалежно вибраними з групи, що складається з алкілу, алкокси або галогену; і n дорівнює 0 або 1. Також описані способи отримання сполук формули І. Цей винахід також стосується фармацевтичних композицій, що містять сполуки формули І. Способи застосування сполук згідно з цим винаходом також входять в обсяг цього винаходу.
UAA201510021A 2013-03-13 2014-03-12 Заміщені 7-азабіцикли і їхнє застосування як модуляторів рецептора орексину UA116132C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361780428P 2013-03-13 2013-03-13
PCT/US2014/024322 WO2014159591A1 (en) 2013-03-13 2014-03-12 Substituted 7-azabicycles and their use as orexin receptor modulators

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