UA117809C2 - Похідні бендамустину, споріднені сполуки та їхнє медичне застосування для лікування раку - Google Patents

Похідні бендамустину, споріднені сполуки та їхнє медичне застосування для лікування раку

Info

Publication number
UA117809C2
UA117809C2 UAA201413290A UAA201413290A UA117809C2 UA 117809 C2 UA117809 C2 UA 117809C2 UA A201413290 A UAA201413290 A UA A201413290A UA A201413290 A UAA201413290 A UA A201413290A UA 117809 C2 UA117809 C2 UA 117809C2
Authority
UA
Ukraine
Prior art keywords
derivatives
related compounds
bendamoustine
cancer treatment
medical application
Prior art date
Application number
UAA201413290A
Other languages
English (en)
Inventor
Хельмут Шикканедер
Крістіан Шикканедер
Армін Бушауер
Гюнтер БЕРНХАРДТ
Штефан ХУБЕР
Міхаель Ліммерт
Матіас Луббе
Гаральд ХОФМАЙЕР
Original Assignee
Хельмут Шикканедер
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хельмут Шикканедер filed Critical Хельмут Шикканедер
Publication of UA117809C2 publication Critical patent/UA117809C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Даний винахід стосується похідних бендамустину і споріднених сполук формули (VII), (VIII) і (IX) і їхнього медичного застосування, зокрема, для лікування раку.
UAA201413290A 2012-06-19 2013-06-14 Похідні бендамустину, споріднені сполуки та їхнє медичне застосування для лікування раку UA117809C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661374P 2012-06-19 2012-06-19
US201261670158P 2012-07-11 2012-07-11
PCT/EP2013/062347 WO2013189847A1 (en) 2012-06-19 2013-06-14 Bendamustine derivatives and related compounds, and medical use thereof cancer therapy

Publications (1)

Publication Number Publication Date
UA117809C2 true UA117809C2 (uk) 2018-10-10

Family

ID=48628661

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201413290A UA117809C2 (uk) 2012-06-19 2013-06-14 Похідні бендамустину, споріднені сполуки та їхнє медичне застосування для лікування раку

Country Status (12)

Country Link
US (2) US10526290B2 (uk)
EP (1) EP2861564B1 (uk)
JP (1) JP6153606B2 (uk)
KR (1) KR101955065B1 (uk)
CN (1) CN104395296A (uk)
BR (1) BR112014031556B1 (uk)
CA (1) CA2875455C (uk)
ES (1) ES2694757T3 (uk)
MX (1) MX365192B (uk)
RU (1) RU2695383C2 (uk)
UA (1) UA117809C2 (uk)
WO (1) WO2013189847A1 (uk)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015010501A2 (pt) 2012-11-12 2017-07-11 Ignyta Inc composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada
EP2886536A1 (en) * 2013-12-19 2015-06-24 Helmut Schickaneder Bendamustine derivatives as anti-proliferative agents
WO2017162661A1 (en) 2016-03-22 2017-09-28 Bayer Pharma Aktiengesellschaft 1h-benzo[de]isoquinoline-1,3(2h)-diones
KR102653426B1 (ko) 2017-11-13 2024-03-29 에코랍 유에스에이 인코퍼레이티드 2-치환된 벤즈이미다졸의 대규모 생산을 위한 신규한 단일반응기 균질 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD34727A1 (de) * 1963-12-21 1964-12-28 Dietrich Krebs Verfahren zur Herstellung von 1-Stellung substituierten [5-Bis-(chloräthyl)-amino-benzimidazolyl-(2)]-alkancarbonsäuren
WO1994027954A1 (en) * 1993-05-25 1994-12-08 Auckland Uniservices Limited Nitrobenzyl mustard quaternary salts and their use as hypoxia-selective cytotoxic agents
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
WO2007029847A1 (ja) * 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. 二環性芳香族置換ピリドン誘導体
EP2346836B1 (en) 2008-10-08 2018-03-07 Cephalon, Inc. Processes for the preparation of bendamustine
US20130217888A1 (en) * 2010-11-01 2013-08-22 Shailpa Medicare Limited Process for preparing bendamus tine hydrochloride monohydrate
PT2656843E (pt) * 2012-04-26 2015-04-14 Helmut Schickaneder Ésteres de bendamustina e compostos relacionados e a sua utilização médica

Also Published As

Publication number Publication date
EP2861564B1 (en) 2018-08-08
US10526290B2 (en) 2020-01-07
US20170313663A1 (en) 2017-11-02
CN104395296A (zh) 2015-03-04
ES2694757T3 (es) 2018-12-27
US10294208B2 (en) 2019-05-21
JP6153606B2 (ja) 2017-06-28
MX365192B (es) 2019-05-23
CA2875455C (en) 2020-03-10
HK1209725A1 (en) 2016-04-08
MX2014014895A (es) 2015-06-17
CA2875455A1 (en) 2013-12-27
EP2861564A1 (en) 2015-04-22
RU2695383C2 (ru) 2019-07-23
JP2015520200A (ja) 2015-07-16
KR20150020581A (ko) 2015-02-26
BR112014031556B1 (pt) 2019-10-29
RU2014146896A (ru) 2016-08-10
WO2013189847A1 (en) 2013-12-27
BR112014031556A2 (pt) 2015-12-22
KR101955065B1 (ko) 2019-03-06
US20150152066A1 (en) 2015-06-04

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