UA118549C2 - 2,3-дизаміщені похідні 1-ацил-4-аміно-1,2,3,4-тетрагідрохіноліну та їх застосування як інгібіторів бромодомену - Google Patents

2,3-дизаміщені похідні 1-ацил-4-аміно-1,2,3,4-тетрагідрохіноліну та їх застосування як інгібіторів бромодомену

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Publication number
UA118549C2
UA118549C2 UAA201507943A UAA201507943A UA118549C2 UA 118549 C2 UA118549 C2 UA 118549C2 UA A201507943 A UAA201507943 A UA A201507943A UA A201507943 A UAA201507943 A UA A201507943A UA 118549 C2 UA118549 C2 UA 118549C2
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UA
Ukraine
Prior art keywords
4аlkуl
disubstituted
acyl
amino
bromodomain inhibitors
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UAA201507943A
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English (en)
Inventor
Домінік Ейманз
Стівен Джон Еткінсон
Лі Ендрю Гаррісон
Дейвід Джонатан Герст
Роберт Пітер Ло
Меттью Ліндон
Елікзендер Престон
Джонатан Томас Сіл
Крістофер Роланд Веллавей
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Ґлаксосмітклайн Інтеллекчуал Проперті (№ 2) Лімітед
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Application filed by Ґлаксосмітклайн Інтеллекчуал Проперті (№ 2) Лімітед filed Critical Ґлаксосмітклайн Інтеллекчуал Проперті (№ 2) Лімітед
Publication of UA118549C2 publication Critical patent/UA118549C2/uk

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Винахід стосується нових сполук, таких як (2S,3R,4R)-1-ацетил-2-циклопропіл-3-метил-4-((4-метилпіримідин-2-іл)аміно)-1,2,3,4-тетрагідрохінолін-6-карбоксамід, що має структурну формулу (І): , фармацевтичних композицій, які містять такі сполуки, та їх застосування в лікуванні гострого або хронічного аутоімунного та/або запального стану.
UAA201507943A 2013-03-14 2014-03-12 2,3-дизаміщені похідні 1-ацил-4-аміно-1,2,3,4-тетрагідрохіноліну та їх застосування як інгібіторів бромодомену UA118549C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781583P 2013-03-14 2013-03-14
US201361882798P 2013-09-26 2013-09-26
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