UA40575C2 - Гідразид 1н-індол-3-оцтової кислоти (варіанти) як інгібітор spla2 та фармацевтична композиція - Google Patents

Гідразид 1н-індол-3-оцтової кислоти (варіанти) як інгібітор spla2 та фармацевтична композиція

Info

Publication number
UA40575C2
UA40575C2 UA94005182A UA94005182A UA40575C2 UA 40575 C2 UA40575 C2 UA 40575C2 UA 94005182 A UA94005182 A UA 94005182A UA 94005182 A UA94005182 A UA 94005182A UA 40575 C2 UA40575 C2 UA 40575C2
Authority
UA
Ukraine
Prior art keywords
acetic acid
indol
options
pharmaceutical composition
acid hydrazide
Prior art date
Application number
UA94005182A
Other languages
English (en)
Russian (ru)
Inventor
Ніколас Джеймс Бах
Николас Джеймс Бах
Роберт Ділейн Діллард
Роберт Дилейн Диллард
Сюзан Елізабет Драхейм
Сюзан Элизабет Драхейм
Роберт Белл Германн
Ричард Вальтер Шевіц
Ричард Вальтер Шевиц
Original Assignee
Елі Ліллі Енд Компані
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані, Эли Лилли Энд Компани filed Critical Елі Ліллі Енд Компані
Publication of UA40575C2 publication Critical patent/UA40575C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

Цей винахід належить до нових гідразидів 1Н-індол-3-оцтової кислоти, які можуть бути використані з метою інгібування sРLА2-опосередкованого вивільнення арахідонової кислоти для лікування таких станів, як септичний шок. Гідразид 1Н-індол-3-оцтової кислоти, представлений формулою (I), і його фармацевтично прийнятні солі, де X є киснем або сіркою, R1 вибирають з груп (I), (II) і (III), де (I) являє собою С4-С20-алкіл, С4-С20-алкеніл, С4-С20-алкініл, С4-С20-галогеналкіл, С4-С12-циклоалкіл,(II) являє собою арил або арил, заміщений галогеном, -CN, -СНО, -ОН, -SH, С1-С10-алкілтіо, С,-С10-алкоксі, С1-С10-алкілом, карбоксілом, аміно або гідроксіаміно, (III) являє собою
UA94005182A 1993-04-16 1994-04-15 Гідразид 1н-індол-3-оцтової кислоти (варіанти) як інгібітор spla2 та фармацевтична композиція UA40575C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4860893A 1993-04-16 1993-04-16

Publications (1)

Publication Number Publication Date
UA40575C2 true UA40575C2 (uk) 2001-08-15

Family

ID=21955471

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94005182A UA40575C2 (uk) 1993-04-16 1994-04-15 Гідразид 1н-індол-3-оцтової кислоти (варіанти) як інгібітор spla2 та фармацевтична композиція

Country Status (27)

Country Link
US (1) US5578634A (uk)
EP (1) EP0620214B1 (uk)
JP (1) JP3621128B2 (uk)
KR (1) KR100330816B1 (uk)
CN (1) CN1067986C (uk)
AT (1) ATE177081T1 (uk)
AU (1) AU669782B2 (uk)
BR (1) BR9401484A (uk)
CA (1) CA2121321A1 (uk)
CO (1) CO4230091A1 (uk)
CZ (1) CZ289791B6 (uk)
DE (1) DE69416705T2 (uk)
DK (1) DK0620214T3 (uk)
ES (1) ES2128510T3 (uk)
FI (1) FI941766L (uk)
GR (1) GR3029689T3 (uk)
HU (1) HU220221B (uk)
IL (1) IL109309A (uk)
NO (1) NO300210B1 (uk)
NZ (1) NZ260299A (uk)
PL (1) PL179472B1 (uk)
RU (1) RU2127725C1 (uk)
SI (1) SI0620214T1 (uk)
TW (1) TW306914B (uk)
UA (1) UA40575C2 (uk)
YU (1) YU20094A (uk)
ZA (1) ZA942614B (uk)

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US6214876B1 (en) 1994-07-21 2001-04-10 Eli Lilly And Company Indene-1-acetamide sPLA2 inhibitors
US5641800A (en) * 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
CA2262847C (en) * 1996-08-01 2007-06-05 Merckle Gmbh Acylpyrroldicarboxylic acids and acylindoldicarboxylic acids and their derivatives and inhibitors of the cytosolic phospholipase a2
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
US6713645B1 (en) * 1996-10-30 2004-03-30 Eli Lilly And Company Substituted tricyclics
KR20000049210A (ko) * 1996-10-30 2000-07-25 피터 지. 스트링거 치환된 트리시클릭류
US6177440B1 (en) 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
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GEP20032920B (en) * 1998-02-25 2003-03-25 Genetics Inst Inhibitors of Phospholipase Enzymes
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
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Also Published As

Publication number Publication date
NO941360L (no) 1994-10-17
PL179472B1 (en) 2000-09-29
NO300210B1 (no) 1997-04-28
IL109309A (en) 2000-06-29
HU9401058D0 (en) 1994-08-29
HU220221B (hu) 2001-11-28
SI0620214T1 (en) 1999-08-31
CZ289791B6 (cs) 2002-04-17
EP0620214B1 (en) 1999-03-03
NZ260299A (en) 1996-03-26
EP0620214A1 (en) 1994-10-19
AU669782B2 (en) 1996-06-20
KR100330816B1 (ko) 2002-11-01
ATE177081T1 (de) 1999-03-15
FI941766A7 (fi) 1994-10-17
TW306914B (uk) 1997-06-01
NO941360D0 (no) 1994-04-15
ES2128510T3 (es) 1999-05-16
AU5948694A (en) 1994-10-20
YU20094A (sh) 1997-03-07
CN1067986C (zh) 2001-07-04
CN1098714A (zh) 1995-02-15
HUT70205A (en) 1995-09-28
ZA942614B (en) 1995-10-16
BR9401484A (pt) 1994-11-22
DK0620214T3 (da) 1999-09-27
RU2127725C1 (ru) 1999-03-20
CO4230091A1 (es) 1995-10-19
CA2121321A1 (en) 1994-10-17
CZ89494A3 (en) 1994-11-16
JPH0710838A (ja) 1995-01-13
GR3029689T3 (en) 1999-06-30
JP3621128B2 (ja) 2005-02-16
US5578634A (en) 1996-11-26
IL109309A0 (en) 1994-07-31
DE69416705T2 (de) 1999-07-29
FI941766A0 (fi) 1994-04-15
FI941766L (fi) 1994-10-17
DE69416705D1 (de) 1999-04-08

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