DK0620214T3 - 1H-indol-3-eddikesyrehydrazid som sPLA2-inhibitorer - Google Patents

1H-indol-3-eddikesyrehydrazid som sPLA2-inhibitorer

Info

Publication number: DK0620214T3
Authority: DK; Denmark
Prior art keywords: indole; acetic acid; acid hydrazide; spla2 inhibitors; spla2
Prior art date: 1993-04-16

Application number

DK94302646T

Other languages

English (en)

Inventor

Nicholas James Bach

Robert Delane Dillard

Susan Elizabeth Draheim

Robert Bell Hermann

Richard Walter Schevitz

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-16

Filing date

1994-04-14

Publication date

1999-09-27

1994-04-14 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1999-09-27 Application granted granted Critical

1999-09-27 Publication of DK0620214T3 publication Critical patent/DK0620214T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Child & Adolescent Psychology (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)

DK94302646T 1993-04-16 1994-04-14 1H-indol-3-eddikesyrehydrazid som sPLA2-inhibitorer DK0620214T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4860893A	1993-04-16	1993-04-16

Publications (1)

Publication Number	Publication Date
DK0620214T3 true DK0620214T3 (da)	1999-09-27

Family

ID=21955471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94302646T DK0620214T3 (da)	1993-04-16	1994-04-14	1H-indol-3-eddikesyrehydrazid som sPLA2-inhibitorer

Country Status (27)

Country	Link
US (1)	US5578634A (da)
EP (1)	EP0620214B1 (da)
JP (1)	JP3621128B2 (da)
KR (1)	KR100330816B1 (da)
CN (1)	CN1067986C (da)
AT (1)	ATE177081T1 (da)
AU (1)	AU669782B2 (da)
BR (1)	BR9401484A (da)
CA (1)	CA2121321A1 (da)
CO (1)	CO4230091A1 (da)
CZ (1)	CZ289791B6 (da)
DE (1)	DE69416705T2 (da)
DK (1)	DK0620214T3 (da)
ES (1)	ES2128510T3 (da)
FI (1)	FI941766L (da)
GR (1)	GR3029689T3 (da)
HU (1)	HU220221B (da)
IL (1)	IL109309A (da)
NO (1)	NO300210B1 (da)
NZ (1)	NZ260299A (da)
PL (1)	PL179472B1 (da)
RU (1)	RU2127725C1 (da)
SI (1)	SI0620214T1 (da)
TW (1)	TW306914B (da)
UA (1)	UA40575C2 (da)
YU (1)	YU20094A (da)
ZA (1)	ZA942614B (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA952693B (en) *	1994-04-01	1996-09-30	Lilly Co Eli	1H-indole-3-Glyoxylamide sPLA2 inhibitors
US6214876B1 (en)	1994-07-21	2001-04-10	Eli Lilly And Company	Indene-1-acetamide sPLA2 inhibitors
US5641800A (en) *	1994-07-21	1997-06-24	Eli Lilly And Company	1H-indole-1-functional sPLA2 inhibitors
WO1998005637A1 (de) *	1996-08-01	1998-02-12	Merckle Gmbh	Acylpyrroldicarbonsäuren und acylindoldicarbonsäuren sowie ihre derivate als hemmstoffe der cytosolischen phospholipase a¿2?
US6630496B1 (en)	1996-08-26	2003-10-07	Genetics Institute Llc	Inhibitors of phospholipase enzymes
US6713645B1 (en) *	1996-10-30	2004-03-30	Eli Lilly And Company	Substituted tricyclics
US6177440B1 (en)	1996-10-30	2001-01-23	Eli Lilly And Company	Substituted tricyclics
PL332896A1 (en) *	1996-10-30	1999-10-25	Lilly Co Eli	Substituted tricyclic compounds
EP0987250A4 (en) *	1997-02-20	2000-12-06	Shionogi & Co	INDOLDICARBONIC ACID DERIVATIVES
US6828344B1 (en)	1998-02-25	2004-12-07	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
NZ506329A (en) *	1998-02-25	2004-01-30	Inst Genetics Llc	Inhibitors of phospholipase enzymes
US6916841B2 (en) *	1998-02-25	2005-07-12	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
US6500853B1 (en)	1998-02-28	2002-12-31	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
EP1066290A1 (en) *	1998-03-31	2001-01-10	Shionogi & Co., Ltd.	PYRROLO[1,2-a]PYRAZINE sPLA 2 INHIBITOR
ID23219A (id) *	1998-04-17	2000-03-30	Lilly Co Eli	Trisiklik tersubstitusi
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.
EP1085021A4 (en)	1998-05-21	2003-01-08	Shionogi & Co	DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2?
CA2338855A1 (en)	1998-08-03	2000-02-17	Eli Lilly And Company	Indole spla2 inhibitors
EP1100493A4 (en) *	1998-08-03	2001-10-24	Lilly Co Eli	SPLA 2 INHIBITORS? OF THE INDOLTYPS
AU6240099A (en)	1998-08-24	2000-03-14	Susan E Draheim	Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2
EP1157704B1 (en) *	1998-10-14	2006-06-14	Shionogi & Co., Ltd.	Spla2 inhibitors for the treatment of ischaemic reperfusion injury
CA2356162A1 (en) *	1998-12-22	2000-06-29	Eli Lilly And Company	Substituted tricyclics
AU2373600A (en) *	1998-12-22	2000-07-12	Eli Lilly And Company	Novel spla2 inhibitors
JP4636521B2 (ja)	1999-07-19	2011-02-23	塩野義製薬株式会社	ｓＰＬＡ２阻害作用を有する三環系化合物
WO2001012600A1 (en) *	1999-08-12	2001-02-22	Cor Therapeutics, Inc.	INHIBITORS OF FACTOR Xa
US6787545B1 (en)	1999-08-23	2004-09-07	Shiongi & Co., Ltd.	Pyrrolotriazine derivatives having spla2-inhibitory activities
AU7559600A (en) *	1999-10-15	2001-04-23	Shionogi & Co., Ltd.	V type and/or x type spla2 inhibitors
WO2001036420A1 (en)	1999-11-15	2001-05-25	Shionogi & Co., Ltd.	Tricyclic azaindolizine derivatives having an spla2- inhibiting effect
JPWO2002000621A1 (ja) *	2000-06-29	2004-04-22	塩野義製薬株式会社	Ｘ型ｓＰＬＡ２阻害作用を有する化合物
ES2294003T3 (es) *	2000-06-29	2008-04-01	Anthera Pharmaceuticals, Inc.	Remedios contra el cancer.
AU2001267825A1 (en)	2000-06-29	2002-01-08	Shionogi And Co., Ltd.	Remedies for cirrhosis
WO2002005796A2 (en) *	2000-07-14	2002-01-24	Eli Lilly And Company	Use of a spla2 inhibitor for the treatment of sepsis
CA2430808A1 (en) *	2000-12-18	2002-06-27	Eli Lilly And Company	Cycloalkylfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases
TWI314457B (da) *	2001-03-19	2009-09-11	Shionogi & Co
US7205329B2 (en)	2003-05-30	2007-04-17	Microbia, Inc.	Modulators of CRTH2 activity
US7348338B2 (en)	2003-07-17	2008-03-25	Plexxikon, Inc.	PPAR active compounds
WO2005009958A1 (en) *	2003-07-17	2005-02-03	Plexxikon, Inc.	Ppar active compounds
GB2407318A (en) *	2003-10-23	2005-04-27	Oxagen Ltd	Substituted Indol-3-yl acetic acid derivatives
EP1819673A2 (en)	2004-11-30	2007-08-22	Plexxikon, Inc.	Indole derivatives for use as ppar active compounds
WO2006102126A2 (en) *	2005-03-18	2006-09-28	Duke University	Inhibitors of isoprenylcysteine carboxyl methyltransferase
TW200718687A (en) *	2005-05-27	2007-05-16	Wyeth Corp	Inhibitors of cytosolic phospholipase A2
AU2006311767A1 (en)	2005-11-03	2007-05-18	Ilypsa, Inc.	Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors
WO2007056275A2 (en) *	2005-11-03	2007-05-18	Ilypsa, Inc.	Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en)	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en)	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
PE20090159A1 (es)	2007-03-08	2009-02-21	Plexxikon Inc	COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
US8048880B2 (en) *	2007-05-03	2011-11-01	Anthera Pharmaceuticals, Inc.	Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies
US7750027B2 (en)	2008-01-18	2010-07-06	Oxagen Limited	Compounds having CRTH2 antagonist activity
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
JP6139682B2 (ja) *	2012-08-30	2017-05-31	チョンクンダンファーマシューティカルコーポレーション	選択的ｔ細胞抑制剤および抗リンパ性悪性腫瘍薬のためのｎ−アシルヒドラゾン誘導体
GB201407807D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
GB201407820D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2825734A (en) *	1955-04-11	1958-03-04	Upjohn Co	Reduction of carbonylic radicals in indolyl-3 compounds
US2890223A (en) *	1956-03-22	1959-06-09	Research Corp	1-benzyl, 2-methyl, 5-methoxy tryptamine
US3242163A (en) *	1961-03-13	1966-03-22	Merck & Co Inc	Indolyl aliphatic acids
US3242193A (en) *	1961-03-13	1966-03-22	Merck & Co Inc	Indolyl aliphatic acids
US3196162A (en) *	1961-03-13	1965-07-20	Merck & Co Inc	Indolyl aliphatic acids
US3242162A (en) *	1961-03-13	1966-03-22	Merck & Co Inc	Indolyl aliphatic acids
US3271416A (en) *	1961-10-24	1966-09-06	Merck & Co Inc	Indolyl aliphatic acids
IT1036004B (it) *	1968-05-21	1979-10-30	Abc Ist Biolog Chem Spa	Acidt 3 indolil adetoidrossamici
US4012513A (en) *	1971-11-03	1977-03-15	Imperial Chemical Industries Limited	Indole derivatives for providing analgesic and anti-inflammatory effects
US4792555A (en) *	1987-03-20	1988-12-20	American Home Products Corporation	Phospholipase A2 inhibitors
IL109311A0 (en) *	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors

1994
- 1994-04-12 IL IL10930994A patent/IL109309A/xx not_active IP Right Cessation
- 1994-04-13 HU HU9401058A patent/HU220221B/hu not_active IP Right Cessation
- 1994-04-13 TW TW083103279A patent/TW306914B/zh active
- 1994-04-13 NZ NZ260299A patent/NZ260299A/en unknown
- 1994-04-14 AT AT94302646T patent/ATE177081T1/de not_active IP Right Cessation
- 1994-04-14 EP EP94302646A patent/EP0620214B1/en not_active Expired - Lifetime
- 1994-04-14 CO CO94014980A patent/CO4230091A1/es unknown
- 1994-04-14 DK DK94302646T patent/DK0620214T3/da active
- 1994-04-14 CZ CZ1994894A patent/CZ289791B6/cs not_active IP Right Cessation
- 1994-04-14 BR BR9401484A patent/BR9401484A/pt not_active Application Discontinuation
- 1994-04-14 DE DE69416705T patent/DE69416705T2/de not_active Expired - Fee Related
- 1994-04-14 CA CA002121321A patent/CA2121321A1/en not_active Abandoned
- 1994-04-14 ES ES94302646T patent/ES2128510T3/es not_active Expired - Lifetime
- 1994-04-14 SI SI9430246T patent/SI0620214T1/xx unknown
- 1994-04-15 AU AU59486/94A patent/AU669782B2/en not_active Ceased
- 1994-04-15 YU YU20094A patent/YU20094A/sh unknown
- 1994-04-15 ZA ZA942614A patent/ZA942614B/xx unknown
- 1994-04-15 UA UA94005182A patent/UA40575C2/uk unknown
- 1994-04-15 RU RU94012931A patent/RU2127725C1/ru active
- 1994-04-15 JP JP07764694A patent/JP3621128B2/ja not_active Expired - Fee Related
- 1994-04-15 PL PL94303027A patent/PL179472B1/pl unknown
- 1994-04-15 NO NO941360A patent/NO300210B1/no not_active IP Right Cessation
- 1994-04-15 CN CN94104433A patent/CN1067986C/zh not_active Expired - Fee Related
- 1994-04-15 KR KR1019940007934A patent/KR100330816B1/ko not_active Expired - Fee Related
- 1994-04-15 FI FI941766A patent/FI941766L/fi unknown
1995
- 1995-05-12 US US08/440,154 patent/US5578634A/en not_active Expired - Fee Related
1999
- 1999-03-12 GR GR990400773T patent/GR3029689T3/el unknown

Also Published As

Publication number	Publication date
FI941766A7 (fi)	1994-10-17
CA2121321A1 (en)	1994-10-17
AU5948694A (en)	1994-10-20
HU9401058D0 (en)	1994-08-29
TW306914B (da)	1997-06-01
PL179472B1 (en)	2000-09-29
CO4230091A1 (es)	1995-10-19
BR9401484A (pt)	1994-11-22
RU2127725C1 (ru)	1999-03-20
CZ89494A3 (en)	1994-11-16
HU220221B (hu)	2001-11-28
JPH0710838A (ja)	1995-01-13
NO941360D0 (no)	1994-04-15
NZ260299A (en)	1996-03-26
FI941766L (fi)	1994-10-17
YU20094A (sh)	1997-03-07
DE69416705D1 (de)	1999-04-08
ZA942614B (en)	1995-10-16
EP0620214A1 (en)	1994-10-19
CN1098714A (zh)	1995-02-15
DE69416705T2 (de)	1999-07-29
IL109309A0 (en)	1994-07-31
CN1067986C (zh)	2001-07-04
JP3621128B2 (ja)	2005-02-16
IL109309A (en)	2000-06-29
GR3029689T3 (en)	1999-06-30
NO300210B1 (no)	1997-04-28
US5578634A (en)	1996-11-26
ES2128510T3 (es)	1999-05-16
AU669782B2 (en)	1996-06-20
KR100330816B1 (ko)	2002-11-01
SI0620214T1 (en)	1999-08-31
ATE177081T1 (de)	1999-03-15
EP0620214B1 (en)	1999-03-03
HUT70205A (en)	1995-09-28
UA40575C2 (uk)	2001-08-15
CZ289791B6 (cs)	2002-04-17
FI941766A0 (fi)	1994-04-15
NO941360L (no)	1994-10-17

Publication	Publication Date	Title
DK0620214T3 (da)	1999-09-27	1H-indol-3-eddikesyrehydrazid som sPLA2-inhibitorer
FI941767A0 (fi)	1994-04-15	1H-indoli-3-asetamidi sPLA2 inhibiittoreita
RU94012931A (ru)	1995-12-20	Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2
DK0675110T3 (da)	2002-10-07	1H-indol-3-glyoxylamid-sPLA2-inhibitorer
ATE251158T1 (de)	2003-10-15	Indolizin spal2 inhibitoren
ATE203744T1 (de)	2001-08-15	Naphthyl-acetamide als spla2-inhibitoren