UA61898C2 - Pharmaceutical composition based on 9-hydroxyrisperidone esters, method for its production and method for treatment - Google Patents

Pharmaceutical composition based on 9-hydroxyrisperidone esters, method for its production and method for treatment Download PDF

Info

Publication number: UA61898C2
Authority: UA; Ukraine
Prior art keywords: fact; composition according; active ingredient; mixture; agent
Prior art date: 1996-05-20

Application number

UA98052747A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-20

Filing date

1997-12-05

Publication date

2003-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8224016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA61898(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-12-05 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-12-15 Publication of UA61898C2 publication Critical patent/UA61898C2/uk

Links

238000000034 method Methods 0.000 title claims abstract description 14
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical class FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 title claims description 18
238000004519 manufacturing process Methods 0.000 title description 2
239000000203 mixture Substances 0.000 claims abstract description 48
239000003814 drug Substances 0.000 claims abstract description 41
239000004480 active ingredient Substances 0.000 claims abstract description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
230000003542 behavioural effect Effects 0.000 claims abstract description 15
239000003937 drug carrier Substances 0.000 claims abstract description 8
208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 8
201000000980 schizophrenia Diseases 0.000 claims abstract description 8
208000019901 Anxiety disease Diseases 0.000 claims abstract description 7
206010003805 Autism Diseases 0.000 claims abstract description 7
208000020706 Autistic disease Diseases 0.000 claims abstract description 7
206010012289 Dementia Diseases 0.000 claims abstract description 7
206010026749 Mania Diseases 0.000 claims abstract description 7
208000036626 Mental retardation Diseases 0.000 claims abstract description 7
230000036506 anxiety Effects 0.000 claims abstract description 7
150000003839 salts Chemical class 0.000 claims abstract description 6
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 4
239000000194 fatty acid Substances 0.000 claims abstract description 4
229930195729 fatty acid Natural products 0.000 claims abstract description 4
229940079593 drug Drugs 0.000 claims description 38
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical group OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
239000003755 preservative agent Substances 0.000 claims description 10
239000000375 suspending agent Substances 0.000 claims description 10
VOMKSBFLAZZBOW-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate Chemical group FC1=CC=C2C(C3CCN(CC3)CCC3=C(C)N=C4N(C3=O)CCCC4OC(=O)CCCCCCCCCCCCCCC)=NOC2=C1 VOMKSBFLAZZBOW-UHFFFAOYSA-N 0.000 claims description 9
239000000080 wetting agent Substances 0.000 claims description 8
229920001213 Polysorbate 20 Polymers 0.000 claims description 7
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
239000007951 isotonicity adjuster Substances 0.000 claims description 7
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 7
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 7
229940068977 polysorbate 20 Drugs 0.000 claims description 7
230000002335 preservative effect Effects 0.000 claims description 7
229940002612 prodrug Drugs 0.000 claims description 7
239000000651 prodrug Substances 0.000 claims description 7
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
208000011580 syndromic disease Diseases 0.000 claims description 7
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
229930195725 Mannitol Natural products 0.000 claims description 6
208000028017 Psychotic disease Diseases 0.000 claims description 6
235000019445 benzyl alcohol Nutrition 0.000 claims description 6
239000000594 mannitol Substances 0.000 claims description 6
235000010355 mannitol Nutrition 0.000 claims description 6
230000000698 schizophrenic effect Effects 0.000 claims description 6
238000007918 intramuscular administration Methods 0.000 claims description 5
238000007920 subcutaneous administration Methods 0.000 claims description 5
230000037396 body weight Effects 0.000 claims description 4
239000000872 buffer Substances 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 4
239000004615 ingredient Substances 0.000 claims description 4
150000004665 fatty acids Chemical class 0.000 claims description 2
125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
210000002966 serum Anatomy 0.000 claims description 2
239000008240 homogeneous mixture Substances 0.000 claims 1
239000008363 phosphate buffer Substances 0.000 claims 1
238000012876 topography Methods 0.000 claims 1
-1 9-hydroxyrisperidone fatty acid ester Chemical class 0.000 abstract description 8
238000009472 formulation Methods 0.000 abstract 1
238000010255 intramuscular injection Methods 0.000 abstract 1
239000007927 intramuscular injection Substances 0.000 abstract 1
238000010254 subcutaneous injection Methods 0.000 abstract 1
239000007929 subcutaneous injection Substances 0.000 abstract 1
RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 23
229960001534 risperidone Drugs 0.000 description 21
239000002245 particle Substances 0.000 description 12
238000002360 preparation method Methods 0.000 description 12
238000010521 absorption reaction Methods 0.000 description 11
230000004060 metabolic process Effects 0.000 description 11
230000000694 effects Effects 0.000 description 10
239000000725 suspension Substances 0.000 description 10
239000002253 acid Substances 0.000 description 9
208000035475 disorder Diseases 0.000 description 9
239000007900 aqueous suspension Substances 0.000 description 8
239000008159 sesame oil Substances 0.000 description 7
235000011803 sesame oil Nutrition 0.000 description 7
230000003111 delayed effect Effects 0.000 description 6
238000002156 mixing Methods 0.000 description 6
229960004217 benzyl alcohol Drugs 0.000 description 5
230000000144 pharmacologic effect Effects 0.000 description 5
239000000243 solution Substances 0.000 description 5
239000000126 substance Substances 0.000 description 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
150000007513 acids Chemical class 0.000 description 4
JWPGJSVJDAJRLW-UHFFFAOYSA-N debrisoquin Chemical compound C1=CC=C2CN(C(=N)N)CCC2=C1 JWPGJSVJDAJRLW-UHFFFAOYSA-N 0.000 description 4
229960004096 debrisoquine Drugs 0.000 description 4
229910052739 hydrogen Inorganic materials 0.000 description 4
239000001257 hydrogen Substances 0.000 description 4
239000003921 oil Substances 0.000 description 4
235000019198 oils Nutrition 0.000 description 4
229910052717 sulfur Inorganic materials 0.000 description 4
239000011593 sulfur Substances 0.000 description 4
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
238000005189 flocculation Methods 0.000 description 3
230000016615 flocculation Effects 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
230000002503 metabolic effect Effects 0.000 description 3
239000002207 metabolite Substances 0.000 description 3
IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 3
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical group [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
230000009885 systemic effect Effects 0.000 description 3
CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 description 2
206010071602 Genetic polymorphism Diseases 0.000 description 2
208000001953 Hypotension Diseases 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 2
239000003792 electrolyte Substances 0.000 description 2
239000000835 fiber Substances 0.000 description 2
LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 2
229940126601 medicinal product Drugs 0.000 description 2
239000002609 medium Substances 0.000 description 2
229920000609 methyl cellulose Polymers 0.000 description 2
239000001923 methylcellulose Substances 0.000 description 2
235000010981 methylcellulose Nutrition 0.000 description 2
239000012053 oil suspension Substances 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
238000007873 sieving Methods 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical compound O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 description 1
RGUKYNXWOWSRET-UHFFFAOYSA-N 4-pyrrolidin-1-ylpyridine Chemical compound C1CCCN1C1=CC=NC=C1 RGUKYNXWOWSRET-UHFFFAOYSA-N 0.000 description 1
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000004255 Butylated hydroxyanisole Substances 0.000 description 1
239000004322 Butylated hydroxytoluene Substances 0.000 description 1
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
208000027776 Extrapyramidal disease Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 description 1
229940072056 alginate Drugs 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
230000000561 anti-psychotic effect Effects 0.000 description 1
239000000935 antidepressant agent Substances 0.000 description 1
229940005513 antidepressants Drugs 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
208000018300 basal ganglia disease Diseases 0.000 description 1
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
229960001950 benzethonium chloride Drugs 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
150000001559 benzoic acids Chemical class 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
210000005013 brain tissue Anatomy 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
229940043253 butylated hydroxyanisole Drugs 0.000 description 1
235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
229940095259 butylated hydroxytoluene Drugs 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
229960002242 chlorocresol Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000013078 crystal Substances 0.000 description 1
GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
229960003964 deoxycholic acid Drugs 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000006196 drop Substances 0.000 description 1
238000002651 drug therapy Methods 0.000 description 1
230000029142 excretion Effects 0.000 description 1
LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
229960003878 haloperidol Drugs 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 1
239000002075 main ingredient Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
229940100630 metacresol Drugs 0.000 description 1
230000000116 mitigating effect Effects 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000012044 organic layer Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000008196 pharmacological composition Substances 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
229940049953 phenylacetate Drugs 0.000 description 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

UA98052747A 1996-05-20 1997-12-05 Pharmaceutical composition based on 9-hydroxyrisperidone esters, method for its production and method for treatment UA61898C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96201429		1996-05-20
PCT/EP1997/002504 WO1997044039A1 (fr)	1996-05-20	1997-05-12	Suspensions aqueuses d'esters d'acides gras de 9-hydroxyrisperidone

Publications (1)

Publication Number	Publication Date
UA61898C2 true UA61898C2 (en)	2003-12-15

Family

ID=8224016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA98052747A UA61898C2 (en)	1996-05-20	1997-12-05	Pharmaceutical composition based on 9-hydroxyrisperidone esters, method for its production and method for treatment

Country Status (37)

Country	Link
US (1)	US6077843A (fr)
EP (1)	EP0904081B1 (fr)
JP (1)	JP3274687B2 (fr)
KR (1)	KR100358373B1 (fr)
CN (1)	CN1093762C (fr)
AR (1)	AR007194A1 (fr)
AT (1)	ATE208619T1 (fr)
AU (1)	AU715572B2 (fr)
BG (1)	BG62684B1 (fr)
BR (1)	BR9706824B8 (fr)
CA (1)	CA2236691C (fr)
CY (2)	CY2270B1 (fr)
CZ (1)	CZ291284B6 (fr)
DE (2)	DE122011100027I1 (fr)
DK (1)	DK0904081T3 (fr)
EA (1)	EA000536B1 (fr)
EE (1)	EE03594B1 (fr)
ES (1)	ES2167745T3 (fr)
FR (1)	FR11C0035I2 (fr)
HR (1)	HRP970276B1 (fr)
HU (2)	HU224025B1 (fr)
ID (1)	ID16927A (fr)
IL (1)	IL124551A (fr)
LU (1)	LU91842I2 (fr)
MX (1)	MX9804816A (fr)
MY (1)	MY126302A (fr)
NO (2)	NO315931B1 (fr)
NZ (1)	NZ330369A (fr)
PL (1)	PL188309B1 (fr)
PT (1)	PT904081E (fr)
SI (1)	SI0904081T1 (fr)
SK (1)	SK284013B6 (fr)
TR (1)	TR199800923T2 (fr)
TW (1)	TW487572B (fr)
UA (1)	UA61898C2 (fr)
WO (1)	WO1997044039A1 (fr)
ZA (1)	ZA974331B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA72189C2 (uk) *	1997-11-17	2005-02-15	Янссен Фармацевтика Н.В.	Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
AU753278B2 (en) *	1998-02-25	2002-10-10	Abbott Laboratories	Butorphanol sustained release formulations
US6342488B1 (en) *	1998-08-18	2002-01-29	Sepracor, Inc.	Phosphonorisperidone and sulforisperidone compositions and methods
PL198797B1 (pl)	1999-03-31	2008-07-31	Janssen Pharmaceutica Nv	Zastosowanie wstępnie żelowanej skrobi
US6495164B1 (en) *	2000-05-25	2002-12-17	Alkermes Controlled Therapeutics, Inc. I	Preparation of injectable suspensions having improved injectability
MXPA03001337A (es) *	2000-08-14	2005-06-30	Teva Pharma	Preparacion de risperidona.
US7666445B2 (en) *	2000-10-20	2010-02-23	The Trustees Of The University Of Pennsylvania	Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
GB0216416D0 (en) *	2002-07-15	2002-08-21	Novartis Ag	Organic compounds
US20050232995A1 (en)	2002-07-29	2005-10-20	Yam Nyomi V	Methods and dosage forms for controlled delivery of paliperidone and risperidone
RU2321391C2 (ru) *	2002-07-29	2008-04-10	Алза Корпорейшн	Способы и лекарственные формы для контролируемой доставки палиперидона
GB0322994D0 (en) *	2003-10-01	2003-11-05	Novartis Ag	Organic compounds
BRPI0415531B8 (pt)	2003-10-23	2021-05-25	Otsuka Pharma Co Ltd	formulação de aripiprazol injetável estéril de liberação controlada e método para a sua preparação
US8221778B2 (en)	2005-01-12	2012-07-17	The Trustees Of The University Of Pennsylvania	Drug-containing implants and methods of use thereof
CA2553254C (fr) *	2004-01-12	2013-12-17	The Trustees Of The University Of Pennsylvania	Preparations a liberation a long terme et procedes d'utlisation de celles-ci
US8329203B2 (en) *	2004-01-12	2012-12-11	The Trustees Of The University Of Pennsylvania	Drug-containing implants and methods of use thereof
ES2245252B1 (es) *	2004-06-15	2007-03-01	Farmalider, S.A.	Solucion acuosa de risperidona para administracion oral.
US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
JP5249748B2 (ja)	2005-04-25	2013-07-31	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	無菌３−［２−［４−（６−フルオロ−１，２−ベンズイソオキサゾール−３−イル）−１−ピペリジニル］エチル］−６，７，８，９−テトラヒドロ−９−ヒドロキシ−２−メチル−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンパルミチン酸エステルの製造
PL116330U1 (en)	2005-10-31	2007-04-02	Alza Corp	Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
CA2670821C (fr)	2006-08-09	2012-05-15	Intarcia Therapeutics, Inc.	Systemes d'administration osmotiques et ensembles pistons
US8314110B2 (en) *	2007-04-19	2012-11-20	Youxin Li	Compounds for treating mental disorders, and preparation and uses thereof
CA2683610C (fr)	2007-04-23	2013-01-08	Intarcia Therapeutics, Inc.	Formulations en suspension de peptides insulinotropes et leurs utilisations
US20090076035A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched paliperidone
CN101932327A (zh) *	2007-12-19	2010-12-29	詹森药业有限公司	与长效注射用帕潘立酮酯相关的给药方案
WO2009089076A2 (fr) *	2008-01-10	2009-07-16	Teva Pharmaceutical Industries Ltd.	Procédés de préparation et de purification de palmitate de palipéridone
WO2009102467A2 (fr)	2008-02-13	2009-08-20	Intarcia Therapeutics, Inc.	Dispositifs, formulations et méthodes d’administration de plusieurs agents bénéfiques
SMT202000405T1 (it)	2008-09-04	2020-09-10	Amylin Pharmaceuticals Llc	Formulazioni a rilascio prolungato usando veicolanti non acquosi
MX378797B (es)	2009-09-28	2025-03-10	Intarcia Therapeutics Inc	Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
KR20120116401A (ko)	2009-10-30	2012-10-22	얀센 파마슈티카 엔.브이.	장기-작용성의 주사가능한 팔리페리돈 에스테르와 관련된 투약 요법
US20120259116A1 (en) *	2009-12-17	2012-10-11	Rajiv Kumar	Novel Process for the Preparation of Paliperidone
TWI577377B (zh)	2010-09-16	2017-04-11	Ｖｉｉｖ醫療保健公司	醫藥組合物
CN107595771A (zh)	2010-10-18	2018-01-19	大日本住友制药株式会社	注射用缓释制剂
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2012164582A1 (fr)	2011-05-31	2012-12-06	Ramamohan Rao Davuluri	Préparation de 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-pipéridinyl)-6, 7, 8, 9-tétrahydro-9-hydroxy-2-méthyl-4h-pyrido [ 1, 2-a]-pyrimidin-4-one (palepéridone) et de palmitate de palipéridone
WO2013046225A2 (fr) *	2011-08-10	2013-04-04	Glenmark Generics Limited	Procédé de préparation de palmitate de palipéridone
CN102993200B (zh) *	2011-09-10	2016-02-03	鲁翠涛	帕潘立酮氨基酸酯及其制备方法
WO2014078568A1 (fr)	2012-11-14	2014-05-22	The Johns Hopkins University	Méthodes et compositions pour le traitement de la schizophrénie
US10525057B2 (en)	2013-09-24	2020-01-07	Otsuka Pharmaceutical Co., Ltd.	Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
US9889085B1 (en)	2014-09-30	2018-02-13	Intarcia Therapeutics, Inc.	Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
FI3744326T3 (fi)	2015-04-07	2024-02-02	Janssen Pharmaceutica Nv	Annosteluohjelma pitkävaikutteisten injektoitavien paliperidoniestereiden ottamatta jääneille annoksille
CN113598842A (zh)	2015-06-03	2021-11-05	因塔西亚制药公司	植入物放置和移除系统
KR102574993B1 (ko)	2016-05-16	2023-09-06	인타르시아 세라퓨틱스 인코포레이티드	글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD840030S1 (en)	2016-06-02	2019-02-05	Intarcia Therapeutics, Inc.	Implant placement guide
USD860451S1 (en)	2016-06-02	2019-09-17	Intarcia Therapeutics, Inc.	Implant removal tool
WO2018129058A1 (fr)	2017-01-03	2018-07-12	Intarcia Therapeutics, Inc.	Méthodes comprenant l'administration continue d'un agoniste du récepteur glp-1 et la co-adminstration d'un médicament
CA3203015A1 (fr)	2020-11-30	2022-06-02	Janssen Pharmaceutica Nv	Schemas posologiques associes a des formulations injectables de paliperidone a liberation prolongee
CN116528837B (zh)	2020-11-30	2025-03-14	詹森药业有限公司	用于确保棕榈酸帕潘立酮制剂再悬浮的方法
SMT202400077T1 (it)	2020-11-30	2024-03-13	Janssen Pharmaceutica Nv	Regimi di dosaggio associati con formulazioni iniettabili di paliperidone a rilascio prolungato
MX2023006370A (es)	2020-11-30	2023-08-07	Janssen Pharmaceutica Nv	Regimenes de dosificacion asociados con formulaciones inyectables de paliperidona de liberacion prolongada.
HUP2100259A1 (hu)	2021-07-07	2023-01-28	Richter Gedeon Nyrt	Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
MX2024002215A (es)	2021-08-20	2024-05-10	Janssen Pharmaceutica Nv	Regímenes de dosificación asociados con formulaciones inyectables de paliperidona de liberación prolongada.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5254556A (en) *	1988-11-07	1993-10-19	Janssen Pharmaceutica N.V.	3-piperidinyl-1,2-benzisoxazoles
US5158952A (en) *	1988-11-07	1992-10-27	Janssen Pharmaceutica N.V.	3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
CA2000786C (fr) *	1988-11-07	1999-01-26	Janssen Pharmaceutica, Naamloze Vennootschap	3-piperidinyl-1,2-benzisoxazoles
TW376319B (en) *	1993-04-28	1999-12-11	Janssen Pharmaceutica Nv	Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
ATE288270T1 (de) *	1993-11-19	2005-02-15	Janssen Pharmaceutica Nv	Mikroverkapselte 1,2-benzazole
US5650173A (en) *	1993-11-19	1997-07-22	Alkermes Controlled Therapeutics Inc. Ii	Preparation of biodegradable microparticles containing a biologically active agent
EP2283821A1 (fr) *	1993-11-19	2011-02-16	Alkermes, Inc.	Préparation des microparticules biodégradables contenant un agent biologiquement actif
JP3057763B2 (ja) *	1995-06-06	2000-07-04	ヘキスト・マリオン・ルセル・インコーポレイテツド	抗精神病薬としてのベンゾイソオキサゾール及びインダゾール誘導体
US5792477A (en) *	1996-05-07	1998-08-11	Alkermes Controlled Therapeutics, Inc. Ii	Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

1997
- 1997-05-01 TW TW086105768A patent/TW487572B/zh not_active IP Right Cessation
- 1997-05-12 CN CN97191494A patent/CN1093762C/zh not_active Expired - Lifetime
- 1997-05-12 ES ES97923912T patent/ES2167745T3/es not_active Expired - Lifetime
- 1997-05-12 SK SK620-98A patent/SK284013B6/sk not_active IP Right Cessation
- 1997-05-12 DE DE201112100027 patent/DE122011100027I1/de active Pending
- 1997-05-12 CA CA002236691A patent/CA2236691C/fr not_active Expired - Lifetime
- 1997-05-12 US US09/180,659 patent/US6077843A/en not_active Expired - Lifetime
- 1997-05-12 DK DK97923912T patent/DK0904081T3/da active
- 1997-05-12 AU AU29559/97A patent/AU715572B2/en not_active Expired
- 1997-05-12 EA EA199800531A patent/EA000536B1/ru not_active IP Right Cessation
- 1997-05-12 CZ CZ19981401A patent/CZ291284B6/cs not_active IP Right Cessation
- 1997-05-12 DE DE69708284T patent/DE69708284T2/de not_active Expired - Lifetime
- 1997-05-12 EP EP97923912A patent/EP0904081B1/fr not_active Expired - Lifetime
- 1997-05-12 EE EE9800136A patent/EE03594B1/xx active Protection Beyond IP Right Term
- 1997-05-12 IL IL12455197A patent/IL124551A/xx not_active IP Right Cessation
- 1997-05-12 NZ NZ330369A patent/NZ330369A/xx not_active IP Right Cessation
- 1997-05-12 WO PCT/EP1997/002504 patent/WO1997044039A1/fr not_active Ceased
- 1997-05-12 HU HU9901319A patent/HU224025B1/hu active Protection Beyond IP Right Term
- 1997-05-12 SI SI9730272T patent/SI0904081T1/xx unknown
- 1997-05-12 PL PL97327995A patent/PL188309B1/pl unknown
- 1997-05-12 JP JP54150097A patent/JP3274687B2/ja not_active Expired - Lifetime
- 1997-05-12 AT AT97923912T patent/ATE208619T1/de active
- 1997-05-12 BR BRPI9706824-1B8A patent/BR9706824B8/pt not_active IP Right Cessation
- 1997-05-12 KR KR10-1998-0703629A patent/KR100358373B1/ko not_active Expired - Lifetime
- 1997-05-12 PT PT97923912T patent/PT904081E/pt unknown
- 1997-05-12 TR TR1998/00923T patent/TR199800923T2/xx unknown
- 1997-05-19 MY MYPI97002172A patent/MY126302A/en unknown
- 1997-05-19 AR ARP970102112A patent/AR007194A1/es active IP Right Grant
- 1997-05-19 ZA ZA974331A patent/ZA974331B/xx unknown
- 1997-05-19 ID IDP971649A patent/ID16927A/id unknown
- 1997-05-20 HR HR970276A patent/HRP970276B1/xx not_active IP Right Cessation
- 1997-12-05 UA UA98052747A patent/UA61898C2/uk unknown
1998
- 1998-04-30 NO NO19981984A patent/NO315931B1/no not_active IP Right Cessation
- 1998-05-12 BG BG102443A patent/BG62684B1/bg unknown
- 1998-06-15 MX MX9804816A patent/MX9804816A/es unknown
2002
- 2002-04-25 CY CY0200021A patent/CY2270B1/xx unknown
2011
- 2011-07-20 LU LU91842C patent/LU91842I2/fr unknown
- 2011-08-18 CY CY2011011C patent/CY2011011I1/el unknown
- 2011-08-18 HU HUS1100013C patent/HUS1100013I1/hu unknown
- 2011-08-29 NO NO2011015C patent/NO2011015I2/no unknown
- 2011-09-02 FR FR11C0035C patent/FR11C0035I2/fr active Active

Also Published As

Publication number	Publication date
TW487572B (en)	2002-05-21
CN1093762C (zh)	2002-11-06
NO981984L (no)	1998-11-19
SK62098A3 (en)	2000-04-10
NO2011015I2 (no)	2013-03-11
JP3274687B2 (ja)	2002-04-15
PL188309B1 (pl)	2005-01-31
PL327995A1 (en)	1999-01-04
HRP970276B1 (en)	2002-04-30
FR11C0035I2 (fr)	2013-08-16
CY2011011I2 (el)	2016-12-14
IL124551A0 (en)	1998-12-06
SI0904081T1 (en)	2002-04-30
IL124551A (en)	2001-08-26
US6077843A (en)	2000-06-20
NO981984D0 (no)	1998-04-30
ZA974331B (en)	1998-11-19
BG102443A (en)	1999-06-30
HU224025B1 (hu)	2005-05-30
NO315931B1 (no)	2003-11-17
DK0904081T3 (da)	2002-02-25
HRP970276A2 (en)	1998-04-30
CN1206347A (zh)	1999-01-27
CA2236691C (fr)	2007-01-02
JP2000513718A (ja)	2000-10-17
EP0904081A1 (fr)	1999-03-31
DE69708284T2 (de)	2002-07-25
CZ140198A3 (cs)	1999-04-14
BG62684B1 (bg)	2000-05-31
AU2955997A (en)	1997-12-09
AR007194A1 (es)	1999-10-13
PT904081E (pt)	2002-04-29
AU715572B2 (en)	2000-02-03
MY126302A (en)	2006-09-29
EA000536B1 (ru)	1999-10-28
MX9804816A (es)	1998-10-31
SK284013B6 (sk)	2004-08-03
FR11C0035I1 (fr)	2011-07-10
KR19990067603A (ko)	1999-08-25
DE69708284D1 (de)	2001-12-20
CY2270B1 (en)	2003-07-04
NZ330369A (en)	2000-04-28
EP0904081B1 (fr)	2001-11-14
BR9706824A (pt)	1999-03-23
CY2011011I1 (el)	2016-12-14
KR100358373B1 (ko)	2003-02-11
ID16927A (id)	1997-11-20
CZ291284B6 (cs)	2003-01-15
HK1017852A1 (en)	1999-12-03
BR9706824B8 (pt)	2015-02-18
NO2011015I1 (no)	2011-09-19
EE03594B1 (et)	2002-02-15
DE122011100027I1 (de)	2011-11-17
HUP9901319A3 (en)	1999-11-29
WO1997044039A1 (fr)	1997-11-27
HUS1100013I1 (hu)	2017-03-28
HUP9901319A2 (hu)	1999-08-30
TR199800923T2 (xx)	1999-09-21
ATE208619T1 (de)	2001-11-15
EE9800136A (et)	1998-10-15
EA199800531A1 (ru)	1998-12-24
ES2167745T3 (es)	2002-05-16
LU91842I2 (fr)	2011-09-20
CA2236691A1 (fr)	1997-11-27

Publication	Publication Date	Title
EA000536B1 (ru)	1999-10-28	Водные суспензии сложных эфиров жирной кислоты 9-гидроксирисперидона
CN108743952B (zh)	2021-08-31	局部麻醉药的磷脂-混溶剂-油缓释递药系统组方与制备方法
CN102133171A (zh)	2011-07-27	延缓释放阿立哌唑的可注射组合物
US10154968B2 (en)	2018-12-18	Buprenorphine nanoparticle composition and methods thereof
KR20150041794A (ko)	2015-04-17	오피오이드 제형
EP2910242B1 (fr)	2019-04-10	Formulation à libération contrôlée d'ester de dinalbuphine de sébacoyle-plga analgésique durable
KR20120030561A (ko)	2012-03-28	아세나핀을 함유하는 주사가능한 제제 및 그를 사용한 치료 방법
US20150283077A1 (en)	2015-10-08	Controlled release hydrogels
CN111603439B (zh)	2024-12-17	一种长效依匹哌唑原位相变凝胶注射剂及其制备方法
TWI448287B (zh)	2014-08-11	長效止痛藥癸二醯雙那布扶林酯－ｐｌｇａ控釋劑型
US12409153B2 (en)	2025-09-09	Liquid injectable composition
CN111481559B (zh)	2021-10-08	一种高浓度的氟维司群组合物及其制备方法
EP1694242B1 (fr)	2014-04-16	Procede permettant d'obtenir des preparations pharmaceutiques de 7-(2-trimethylsilylethyl) camptothecin
WO2012029076A2 (fr)	2012-03-08	Composition pharmaceutique stable
TWI819756B (zh)	2023-10-21	包含塞納布啡的藥物組合物
CN111388418A (zh)	2020-07-10	一种含有罗哌卡因或其药用盐的药物组合物
CN121588032A (zh)	2026-03-03	一种储库型局麻药缓释组合物及其制备方法和应用
CN121588035A (zh)	2026-03-03	一种含酸的缓释组合物及其制备方法和应用
HK1017852B (en)	2002-03-08	Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
CN121243086A (zh)	2026-01-02	一种依匹哌唑可注射缓释微粒制剂及其制备方法
CN120004750A (zh)	2025-05-16	一种无菌的双他喷他多癸二酸酯及其制备方法与用途
NZ232627A (en)	1992-02-25	Antibacterial composition comprising 2,4-diamino-5-(8-dimethyl-amino-7-methyl-5-quinolylmethyl) pyrimidine and sulphadimethoxine
NZ762767B2 (en)	2024-01-04	Aripiprazole formulations having increased injection speeds
CA2231732A1 (fr)	1997-12-31	Compositions de sufentanil a liberation prolongee
HK1206595B (en)	2023-10-13	Pharmaceutical compositions comprising benzyl alcohol