UA66840C2 - 6,9-дизамещенные 2-[транс-(4-аминоциклогексил)амино]пурины - Google Patents

6,9-дизамещенные 2-[транс-(4-аминоциклогексил)амино]пурины

Info

Publication number
UA66840C2
UA66840C2 UA2000095501A UA00095501A UA66840C2 UA 66840 C2 UA66840 C2 UA 66840C2 UA 2000095501 A UA2000095501 A UA 2000095501A UA 00095501 A UA00095501 A UA 00095501A UA 66840 C2 UA66840 C2 UA 66840C2
Authority
UA
Ukraine
Prior art keywords
formula
inhibiting
admixture
association
pharmaceutically acceptable
Prior art date
Application number
UA2000095501A
Other languages
English (en)
Ukrainian (uk)
Inventor
Дженніфєр А. Дюмон
Алан Дж. Бітонті
Алан Дж. Битонти
Девід Р. Борчердінг
Нортон П. Піт
Х. Ренделл Мансон
Патрік В.К. Шам
Original Assignee
Авентіс Фармасьютікалз Інк.
Авентис Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентіс Фармасьютікалз Інк., Авентис Фармасьютикалз Инк. filed Critical Авентіс Фармасьютікалз Інк.
Priority claimed from PCT/US1999/003450 external-priority patent/WO1999043675A1/en
Publication of UA66840C2 publication Critical patent/UA66840C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описаны соединения формулы (І), где R выбирают из группы, которая включает R2, R2NH- или R3R4N-R5- и R1 выбирают из группы, которая включает циклопентил, циклопентенил и изопропил, и их фармацевтически приемлемые соли, оптические изомеры и гидраты, предложен способ ингибирования развития клеточного цикла, способ ингибирования циклинзависимых киназ, в частности сdк-2, способ предупреждения апоптоза нервных клеток и способ торможения развития неоплазм, композиция, которая включает определенную исследовательским путем определенное количество соединения формулы (І) в смеси, или объединенную с инертным носителем другим способом, и фармацевтическую композицию, которая включает эффективную ингибирующее количество соединения формулы (І) в смеси, или объединенную с одним или больше фармацевтически приемлемыми инертными носителями и эксципиентами другим способом (І).
UA2000095501A 1998-02-26 1999-02-18 6,9-дизамещенные 2-[транс-(4-аминоциклогексил)амино]пурины UA66840C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3097598A 1998-02-26 1998-02-26
PCT/US1999/003450 WO1999043675A1 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number Publication Date
UA66840C2 true UA66840C2 (ru) 2004-06-15

Family

ID=21856977

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2000095501A UA66840C2 (ru) 1998-02-26 1999-02-18 6,9-дизамещенные 2-[транс-(4-аминоциклогексил)амино]пурины

Country Status (13)

Country Link
KR (1) KR100568657B1 (ru)
AR (1) AR018121A1 (ru)
AT (1) ATE252583T1 (ru)
DE (1) DE69912248T2 (ru)
DK (1) DK1056744T3 (ru)
ES (1) ES2207182T3 (ru)
ID (1) ID25444A (ru)
NZ (1) NZ506235A (ru)
OA (1) OA11455A (ru)
PT (1) PT1056744E (ru)
RU (1) RU2200162C2 (ru)
TW (1) TWI225060B (ru)
UA (1) UA66840C2 (ru)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232155A (en) * 1979-09-13 1980-11-04 Bristol-Myers Company Purine compounds
PT874846E (pt) * 1995-11-01 2003-08-29 Novartis Ag Derivados de purina e processos para a sua preparacao
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

Also Published As

Publication number Publication date
ES2207182T3 (es) 2004-05-16
KR100568657B1 (ko) 2006-04-07
DE69912248T2 (de) 2004-04-22
OA11455A (en) 2003-12-05
KR20010041318A (ko) 2001-05-15
DE69912248D1 (de) 2003-11-27
PT1056744E (pt) 2004-03-31
ATE252583T1 (de) 2003-11-15
RU2200162C2 (ru) 2003-03-10
NZ506235A (en) 2003-02-28
AR018121A1 (es) 2001-10-31
DK1056744T3 (da) 2004-02-23
TWI225060B (en) 2004-12-11
HK1030949A1 (en) 2001-05-25
ID25444A (id) 2000-10-05

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