UA66945C2 - ПОХІДНІ ПУРИНУ З ВЛАСТИВОСТЯМИ АГОНІСТА ЛЮДСЬКОГО А2<sub>А</sub> РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ - Google Patents

ПОХІДНІ ПУРИНУ З ВЛАСТИВОСТЯМИ АГОНІСТА ЛЮДСЬКОГО А2<sub>А</sub> РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ

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Publication number
UA66945C2
UA66945C2 UA2002042943A UA200242943A UA66945C2 UA 66945 C2 UA66945 C2 UA 66945C2 UA 2002042943 A UA2002042943 A UA 2002042943A UA 200242943 A UA200242943 A UA 200242943A UA 66945 C2 UA66945 C2 UA 66945C2
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UA
Ukraine
Prior art keywords
preparation
sub
human
treatment
pharmaceutical composition
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Application number
UA2002042943A
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English (en)
Russian (ru)
Inventor
Сандра Маріна Монеган
Original Assignee
Пфайзер Інк.
Пфайзер Инк.
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Publication date
Application filed by Пфайзер Інк., Пфайзер Инк. filed Critical Пфайзер Інк.
Publication of UA66945C2 publication Critical patent/UA66945C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)

Abstract

Представлений винахід стосується сполук формули (І) і їх фармацевтично прийнятних солей і сольватів, способу їх одержання, проміжних сполук, що використовуються при їх одержанні, композицій, що їх містять, і використання таких сполук як агоністів А2а рецептора аденозину.
UA2002042943A 1999-10-14 2000-10-06 ПОХІДНІ ПУРИНУ З ВЛАСТИВОСТЯМИ АГОНІСТА ЛЮДСЬКОГО А2<sub>А</sub> РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ UA66945C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9924363.6A GB9924363D0 (en) 1999-10-14 1999-10-14 Purine derivatives
PCT/IB2000/001444 WO2001027130A1 (en) 1999-10-14 2000-10-06 Purine derivatives

Publications (1)

Publication Number Publication Date
UA66945C2 true UA66945C2 (uk) 2004-06-15

Family

ID=10862760

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002042943A UA66945C2 (uk) 1999-10-14 2000-10-06 ПОХІДНІ ПУРИНУ З ВЛАСТИВОСТЯМИ АГОНІСТА ЛЮДСЬКОГО А2<sub>А</sub> РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ

Country Status (50)

Country Link
US (1) US6350735B1 (uk)
EP (1) EP1220863B1 (uk)
JP (1) JP3994007B2 (uk)
KR (1) KR20020037774A (uk)
CN (1) CN1151167C (uk)
AP (1) AP1442A (uk)
AR (1) AR023275A1 (uk)
AT (1) ATE238336T1 (uk)
AU (1) AU768308B2 (uk)
BG (1) BG106569A (uk)
BR (1) BR0011776A (uk)
CA (1) CA2387531C (uk)
CO (1) CO5251399A1 (uk)
CR (1) CR6584A (uk)
CZ (1) CZ20021223A3 (uk)
DE (1) DE60002356T2 (uk)
DK (1) DK1220863T3 (uk)
DZ (1) DZ3159A1 (uk)
EA (1) EA004655B1 (uk)
EC (1) ECSP003712A (uk)
EE (1) EE200200193A (uk)
ES (1) ES2193990T3 (uk)
GB (1) GB9924363D0 (uk)
GE (1) GEP20043269B (uk)
GT (1) GT200000172A (uk)
HK (1) HK1047110B (uk)
HN (1) HN2000000204A (uk)
HU (1) HUP0203483A2 (uk)
IL (1) IL146342A0 (uk)
IS (1) IS6165A (uk)
MA (1) MA26828A1 (uk)
MX (1) MXPA02003812A (uk)
MY (1) MY136242A (uk)
NO (1) NO20021692D0 (uk)
NZ (1) NZ515323A (uk)
OA (1) OA12059A (uk)
PA (1) PA8503501A1 (uk)
PE (1) PE20010755A1 (uk)
PL (1) PL354932A1 (uk)
PT (1) PT1220863E (uk)
SI (1) SI1220863T1 (uk)
SK (1) SK4842002A3 (uk)
SV (1) SV2002000198A (uk)
TN (1) TNSN00202A1 (uk)
TR (1) TR200200985T2 (uk)
UA (1) UA66945C2 (uk)
UY (1) UY26397A1 (uk)
WO (1) WO2001027130A1 (uk)
YU (1) YU88901A (uk)
ZA (1) ZA200202849B (uk)

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YU88901A (sh) 2004-09-03
AP1442A (en) 2005-06-29
BG106569A (en) 2002-12-29
CO5251399A1 (es) 2003-02-28
SV2002000198A (es) 2002-02-05
AR023275A1 (es) 2002-09-04
SI1220863T1 (en) 2003-10-31
ES2193990T3 (es) 2003-11-16
TR200200985T2 (tr) 2002-10-21
HK1047110A1 (en) 2003-02-07
US6350735B1 (en) 2002-02-26
IS6165A (is) 2001-11-16
DE60002356D1 (de) 2003-05-28
PL354932A1 (en) 2004-03-22
ECSP003712A (es) 2002-05-23
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CZ20021223A3 (cs) 2003-05-14
CA2387531A1 (en) 2001-04-19
HK1047110B (zh) 2005-03-04
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AP2002002478A0 (en) 2002-06-30
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TNSN00202A1 (fr) 2005-11-10
CN1358192A (zh) 2002-07-10
CR6584A (es) 2004-01-14
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MXPA02003812A (es) 2002-09-30
EA200101107A1 (ru) 2002-10-31
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IL146342A0 (en) 2002-07-25
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CA2387531C (en) 2006-12-05
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BR0011776A (pt) 2002-03-12
JP2003511459A (ja) 2003-03-25
DE60002356T2 (de) 2004-02-19
EA004655B1 (ru) 2004-06-24
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EP1220863B1 (en) 2003-04-23
MA26828A1 (fr) 2004-12-20
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PT1220863E (pt) 2003-07-31
EE200200193A (et) 2003-06-16
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AU768308B2 (en) 2003-12-04
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