UA71629C2 - Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction - Google Patents

Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction Download PDF

Info

Publication number: UA71629C2
Authority: UA; Ukraine
Prior art keywords: compound; particles; composition; particle size; variants
Prior art date: 1999-08-03

Application number

UA2002010773A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Lilli Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-03

Filing date

2000-01-08

Publication date

2004-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22520112&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA71629(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-01-08 Application filed by Lilli Icos Llc filed Critical Lilli Icos Llc

2004-12-15 Publication of UA71629C2 publication Critical patent/UA71629C2/uk

Links

239000000203 mixture Substances 0.000 title abstract description 76
239000003814 drug Substances 0.000 title abstract description 28
238000000034 method Methods 0.000 title abstract description 26
229940079593 drug Drugs 0.000 title abstract description 25
238000004519 manufacturing process Methods 0.000 title abstract description 8
201000001880 Sexual dysfunction Diseases 0.000 title abstract description 6
231100000872 sexual dysfunction Toxicity 0.000 title abstract description 6
150000001875 compounds Chemical class 0.000 description 106
239000002245 particle Substances 0.000 description 102
239000003826 tablet Substances 0.000 description 22
229940126601 medicinal product Drugs 0.000 description 18
239000008194 pharmaceutical composition Substances 0.000 description 18
239000003085 diluting agent Substances 0.000 description 17
239000000523 sample Substances 0.000 description 17
239000002244 precipitate Substances 0.000 description 14
239000000546 pharmaceutical excipient Substances 0.000 description 13
239000000725 suspension Substances 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
238000009826 distribution Methods 0.000 description 10
238000000227 grinding Methods 0.000 description 10
239000000843 powder Substances 0.000 description 10
239000007787 solid Substances 0.000 description 10
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239000008187 granular material Substances 0.000 description 7
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230000001186 cumulative effect Effects 0.000 description 6
238000004090 dissolution Methods 0.000 description 6
239000002552 dosage form Substances 0.000 description 6
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
229950008138 carmellose Drugs 0.000 description 5
239000002270 dispersing agent Substances 0.000 description 5
239000003937 drug carrier Substances 0.000 description 5
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238000002360 preparation method Methods 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
239000012453 solvate Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
239000008280 blood Substances 0.000 description 3
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239000002775 capsule Substances 0.000 description 3
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239000004615 ingredient Substances 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
239000006186 oral dosage form Substances 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
235000019333 sodium laurylsulphate Nutrition 0.000 description 3
239000007921 spray Substances 0.000 description 3
238000005550 wet granulation Methods 0.000 description 3
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 2
241000282472 Canis lupus familiaris Species 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
241000282412 Homo Species 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000000443 aerosol Substances 0.000 description 2
230000037007 arousal Effects 0.000 description 2
230000008901 benefit Effects 0.000 description 2
230000002902 bimodal effect Effects 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
238000000975 co-precipitation Methods 0.000 description 2
239000013068 control sample Substances 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
229960001021 lactose monohydrate Drugs 0.000 description 2
238000003801 milling Methods 0.000 description 2
238000002156 mixing Methods 0.000 description 2
229940124531 pharmaceutical excipient Drugs 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
238000003825 pressing Methods 0.000 description 2
238000012545 processing Methods 0.000 description 2
239000008213 purified water Substances 0.000 description 2
238000000926 separation method Methods 0.000 description 2
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238000007619 statistical method Methods 0.000 description 2
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GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241000700198 Cavia Species 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
208000010228 Erectile Dysfunction Diseases 0.000 description 1
241000402754 Erythranthe moschata Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241000269799 Perca fluviatilis Species 0.000 description 1
241000288906 Primates Species 0.000 description 1
241000700159 Rattus Species 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
238000005266 casting Methods 0.000 description 1
238000000451 chemical ionisation Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
238000004040 coloring Methods 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
238000007580 dry-mixing Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000006260 foam Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000000499 gel Substances 0.000 description 1
238000007429 general method Methods 0.000 description 1
235000021472 generally recognized as safe Nutrition 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000009478 high shear granulation Methods 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
201000001881 impotence Diseases 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000001788 irregular Effects 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229960001375 lactose Drugs 0.000 description 1
238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229940057948 magnesium stearate Drugs 0.000 description 1
239000012982 microporous membrane Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000007932 molded tablet Substances 0.000 description 1
238000002534 molecular mass spectrometry Methods 0.000 description 1
238000010905 molecular spectroscopy Methods 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
-1 phenylhexyl Chemical group 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000004033 plastic Substances 0.000 description 1
238000001492 polymer co-precipitation Methods 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000012439 solid excipient Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229960004274 stearic acid Drugs 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940033134 talc Drugs 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UA2002010773A 1999-08-03 2000-01-08 Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction UA71629C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14704899P	1999-08-03	1999-08-03
PCT/US2000/020981 WO2001008688A2 (en)	1999-08-03	2000-08-01	Beta-carboline drug products

Publications (1)

Publication Number	Publication Date
UA71629C2 true UA71629C2 (en)	2004-12-15

Family

ID=22520112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2002010773A UA71629C2 (en)	1999-08-03	2000-01-08	Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction

Country Status (33)

Country	Link
EP (1)	EP1200092B1 (de)
JP (1)	JP4456788B2 (de)
KR (1)	KR20020063842A (de)
CN (2)	CN1377270A (de)
AR (1)	AR033953A1 (de)
AT (1)	ATE264680T1 (de)
AU (1)	AU773666B2 (de)
BR (1)	BR0012901A (de)
CA (1)	CA2380087C (de)
CO (1)	CO5200849A1 (de)
CZ (1)	CZ300151B6 (de)
DE (1)	DE60010089T2 (de)
DK (1)	DK1200092T3 (de)
DZ (1)	DZ3180A1 (de)
EA (1)	EA004302B9 (de)
ES (1)	ES2220506T3 (de)
HK (1)	HK1044278B (de)
HR (1)	HRP20020091B1 (de)
HU (1)	HU229443B1 (de)
IL (1)	IL147642A0 (de)
MX (1)	MXPA02001197A (de)
MY (1)	MY125428A (de)
NO (1)	NO321602B1 (de)
NZ (1)	NZ516613A (de)
PE (1)	PE20010480A1 (de)
PL (1)	PL199469B1 (de)
PT (1)	PT1200092E (de)
SK (1)	SK286365B6 (de)
SV (1)	SV2002000137A (de)
TW (1)	TWI235658B (de)
UA (1)	UA71629C2 (de)
WO (1)	WO2001008688A2 (de)
ZA (1)	ZA200200825B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MD4009C2 (ro) *	2008-07-15	2010-08-31	Институт Химии Академии Наук Молдовы	Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos

Families Citing this family (24)

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Publication number	Priority date	Publication date	Assignee	Title
ATE399554T1 (de) *	1999-08-03	2008-07-15	Lilly Icos Llc	Pharmazeutische zusammensetzung enthaltend tadalafil
EP2216329A1 (de) *	2004-10-28	2010-08-11	Dr. Reddy's Laboratories Ltd.	Verfahren zur Herstellung von Tadalafil
DK1808164T3 (da)	2006-01-05	2009-04-20	Teva Pharma	Vådgranuleringsmetode til fremstilling af farmaceutiske sammensætninger af aripiprazol
DE102007028869A1 (de) *	2007-06-22	2008-12-24	Ratiopharm Gmbh	Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil
DE102009033396A1 (de)	2009-07-16	2011-01-20	Ratiopharm Gmbh	Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung
DE102009035211A1 (de)	2009-07-29	2011-02-17	Ratiopharm Gmbh	Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung
WO2012085927A2 (en) *	2010-12-02	2012-06-28	Mylan Laboratories, Limited	Tadalafil compositions
WO2012095151A1 (en)	2010-12-23	2012-07-19	Zaklady Farmaceutyczne Polpharma Sa	Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof
WO2012107090A1 (en)	2011-02-10	2012-08-16	Synthon Bv	Granulated composition comprising tadalafil and a disintegrant
WO2012107541A1 (en)	2011-02-10	2012-08-16	Synthon Bv	Pharmaceutical composition comprising tadalafil and a cyclodextrin
WO2012107092A1 (en)	2011-02-10	2012-08-16	Synthon Bv	Pharmaceutical composition comprising tadalafil and a cyclodextrin
JP5930686B2 (ja) *	2011-12-07	2016-06-08	株式会社トクヤマ	溶解性および安定性の向上した難溶性医薬品原体及びその製造方法
WO2013135352A1 (de)	2012-03-15	2013-09-19	Merck Patent Gmbh	Elektronische vorrichtungen
WO2014003677A1 (en) *	2012-06-28	2014-01-03	Xspray Microparticles Ab	Pharmaceutical compositions comprising solid dispersion particles containing tadalafil
WO2014003678A1 (en) *	2012-06-28	2014-01-03	Xspray Microparticles Ab	Pharmaceutical compositions comprising ambrisentan and solid dispersion particles containing tadalafil
CN105310984A (zh) *	2014-06-10	2016-02-10	合肥贝霓医药科技有限公司	一种pde5抑制剂的超微粉体及其制备方法
ES2699160T3 (es) *	2014-06-24	2019-02-07	Wooshin Labottach Co Ltd	Formulación de película de desintegración oral que contiene tadalafilo y procedimiento de preparación de la misma
EP3466951B1 (de)	2014-07-23	2022-01-19	KRKA, d.d., Novo mesto	Verfahren zur herstellung des cgmp-phosphodiesterasehemmers und orale pharmazeutische formulierung mit tadalafil-co-präzipitaten
JP2016106139A (ja) *	2016-03-07	2016-06-16	株式会社トクヤマ	溶解性および安定性の向上した難溶性医薬品原体及びその製造方法
JP2021509114A (ja)	2017-12-26	2021-03-18	エフティーエフファーマプライベートリミテッド	Ｐｄｅｖ阻害剤のための液体経口処方物
EP3510997B1 (de)	2018-01-10	2020-08-05	Gap S.A.	Weichgelatinekapseln mit einer suspension für tadalafil
CN110638770B (zh) *	2019-10-25	2022-04-05	株洲千金药业股份有限公司	他达拉非片剂的制备方法及以该方法制得的片剂
EP4531815A1 (de)	2022-05-27	2025-04-09	Rontis Hellas S.A.	Verbesserte pharmazeutische zusammensetzung mit tadalafil und nanomühlungsverfahren zur herstellung davon
CN119112817A (zh) *	2024-08-20	2024-12-13	武汉九珑人福药业有限责任公司	一种他达拉非片及其制备方法

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US5618845A (en) *	1994-10-06	1997-04-08	Cephalon, Inc.	Acetamide derivative having defined particle size
GB9511220D0 (en) *	1995-06-02	1995-07-26	Glaxo Group Ltd	Solid dispersions

2000
- 2000-01-08 UA UA2002010773A patent/UA71629C2/uk unknown
- 2000-08-01 NZ NZ516613A patent/NZ516613A/en not_active IP Right Cessation
- 2000-08-01 WO PCT/US2000/020981 patent/WO2001008688A2/en not_active Ceased
- 2000-08-01 DE DE60010089T patent/DE60010089T2/de not_active Expired - Lifetime
- 2000-08-01 PL PL353268A patent/PL199469B1/pl unknown
- 2000-08-01 HR HR20020091A patent/HRP20020091B1/xx not_active IP Right Cessation
- 2000-08-01 HK HK02104540.5A patent/HK1044278B/en not_active IP Right Cessation
- 2000-08-01 BR BR0012901-1A patent/BR0012901A/pt not_active Application Discontinuation
- 2000-08-01 PT PT00952371T patent/PT1200092E/pt unknown
- 2000-08-01 EP EP00952371A patent/EP1200092B1/de not_active Expired - Lifetime
- 2000-08-01 SK SK172-2002A patent/SK286365B6/sk not_active IP Right Cessation
- 2000-08-01 DZ DZ003180A patent/DZ3180A1/xx active
- 2000-08-01 ES ES00952371T patent/ES2220506T3/es not_active Expired - Lifetime
- 2000-08-01 MX MXPA02001197A patent/MXPA02001197A/es active IP Right Grant
- 2000-08-01 HU HU0202781A patent/HU229443B1/hu unknown
- 2000-08-01 AT AT00952371T patent/ATE264680T1/de active
- 2000-08-01 CN CN00813777A patent/CN1377270A/zh active Pending
- 2000-08-01 JP JP2001513418A patent/JP4456788B2/ja not_active Expired - Lifetime
- 2000-08-01 AU AU65084/00A patent/AU773666B2/en not_active Expired
- 2000-08-01 DK DK00952371T patent/DK1200092T3/da active
- 2000-08-01 CN CNA2007101408018A patent/CN101134019A/zh active Pending
- 2000-08-01 EA EA200200119A patent/EA004302B9/ru not_active IP Right Cessation
- 2000-08-01 KR KR1020027001407A patent/KR20020063842A/ko not_active Ceased
- 2000-08-01 CZ CZ20020387A patent/CZ300151B6/cs not_active IP Right Cessation
- 2000-08-01 IL IL14764200A patent/IL147642A0/xx active IP Right Grant
- 2000-08-01 CA CA002380087A patent/CA2380087C/en not_active Expired - Lifetime
- 2000-08-02 MY MYPI20003524 patent/MY125428A/en unknown
- 2000-08-02 CO CO00058156A patent/CO5200849A1/es not_active Application Discontinuation
- 2000-08-03 AR ARP000104015A patent/AR033953A1/es not_active Application Discontinuation
- 2000-08-03 PE PE2000000773A patent/PE20010480A1/es not_active IP Right Cessation
- 2000-08-03 TW TW089115586A patent/TWI235658B/zh not_active IP Right Cessation
- 2000-08-07 SV SV2000000137A patent/SV2002000137A/es unknown
2002
- 2002-01-30 ZA ZA200200825A patent/ZA200200825B/en unknown
- 2002-02-01 NO NO20020531A patent/NO321602B1/no unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MD4009C2 (ro) *	2008-07-15	2010-08-31	Институт Химии Академии Наук Молдовы	Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos

Also Published As

Publication number	Publication date
CZ300151B6 (cs)	2009-02-25
SK1722002A3 (en)	2002-05-09
CO5200849A1 (es)	2002-09-27
TWI235658B (en)	2005-07-11
ATE264680T1 (de)	2004-05-15
AU6508400A (en)	2001-02-19
EP1200092B1 (de)	2004-04-21
ES2220506T3 (es)	2004-12-16
DE60010089T2 (de)	2004-10-14
PL199469B1 (pl)	2008-09-30
HK1044278B (en)	2004-10-08
IL147642A0 (en)	2002-08-14
HRP20020091A2 (en)	2004-02-29
DK1200092T3 (da)	2004-08-16
HU229443B1 (en)	2013-12-30
PT1200092E (pt)	2004-07-30
NO20020531D0 (no)	2002-02-01
KR20020063842A (ko)	2002-08-05
CA2380087A1 (en)	2001-02-08
CN1377270A (zh)	2002-10-30
NZ516613A (en)	2003-08-29
JP4456788B2 (ja)	2010-04-28
HK1044278A1 (en)	2002-10-18
HRP20020091B1 (en)	2006-02-28
SK286365B6 (sk)	2008-08-05
SV2002000137A (es)	2002-06-07
EA004302B1 (ru)	2004-02-26
AR033953A1 (es)	2004-01-21
MXPA02001197A (es)	2003-02-12
HUP0202781A3 (en)	2003-10-28
EP1200092A2 (de)	2002-05-02
NO20020531L (no)	2002-04-03
JP2003505510A (ja)	2003-02-12
CN101134019A (zh)	2008-03-05
CZ2002387A3 (cs)	2002-10-16
DE60010089D1 (de)	2004-05-27
AU773666B2 (en)	2004-06-03
HUP0202781A2 (hu)	2002-12-28
ZA200200825B (en)	2003-04-30
NO321602B1 (no)	2006-06-12
WO2001008688A3 (en)	2001-08-16
PL353268A1 (en)	2003-11-03
DZ3180A1 (fr)	2001-02-08
MY125428A (en)	2006-07-31
PE20010480A1 (es)	2001-05-26
CA2380087C (en)	2007-05-01
EA200200119A1 (ru)	2002-06-27
WO2001008688A2 (en)	2001-02-08
BR0012901A (pt)	2002-04-16
EA004302B9 (ru)	2019-01-31

Publication	Publication Date	Title
US6821975B1 (en)	2004-11-23	Beta-carboline drug products
AU773666B2 (en)	2004-06-03	Beta-carboline drug products
JP6932746B2 (ja)	2021-09-08	エンザルタミドの製剤
RU2445092C2 (ru)	2012-03-20	Композиция, содержащая средство против деменции
MX2008011240A (es)	2009-01-27	Tabletas resistentes al rompimiento destinadas a prevenir un mal uso accidental y la alteracion ilegal en su uso.
UA72922C2 (uk)	2005-05-16	ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ З <font face="Symbol">b</font>-КАРБОЛІНОМ (ВАРІАНТИ) ТА СПОСІБ ЛІКУВАННЯ СЕКСУАЛЬНОЇ ДИСФУНКЦІЇ
Rahul et al.	2014	A review on immediate release drug delivery systems
EP3227299B1 (de)	2021-05-26	Formulierung zur hemmung der effekte einer schwach sauren umgebung
JP2009501694A (ja)	2009-01-22	メシル酸サキナビル経口投与剤型
Narwariya et al.	2021	Development And Evaluation Of Mouth Dissolving Antiinflammatory Tablet Containing Fenoprofen
Bhoyar et al.	2010	Formulation and characterization of patient-friendly dosage form of ondansetron hydrochloride
Vemula et al.	2015	Lovastatin fast dissolving tablets: Formulation and in vitro evaluation
Islam et al.	2016	Design and development of bi-layered sustained release azithromycin tablets
Vemula et al.	2014	Formulation and evaluation of meclizine hydrochloride fast dissolving tablets
HK1249732A1 (zh)	2018-11-09	口腔崩解片

UA71629C2 - Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction - Google Patents

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