UA72002C2 - Inhibitors crystals of sodium-hydrogen exchange of 1 type, a method for the preparation thereof (variants), a pharmaceuticalcomposition based thereon and a method for the reduction of tissue damage - Google Patents

Inhibitors crystals of sodium-hydrogen exchange of 1 type, a method for the preparation thereof (variants), a pharmaceuticalcomposition based thereon and a method for the reduction of tissue damage Download PDF

Info

Publication number: UA72002C2
Authority: UA; Ukraine
Prior art keywords: tissue; intensity; relative; distance; crystalline compound
Prior art date: 1999-10-29

Application number

UA2002043503A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-29

Filing date

2000-09-10

Publication date

2005-01-17

2000-09-10 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2005-01-17 Publication of UA72002C2 publication Critical patent/UA72002C2/uk

Links

238000000034 method Methods 0.000 title claims abstract description 81
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239000013078 crystal Substances 0.000 title abstract description 23
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238000002360 preparation method Methods 0.000 title description 4
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239000007929 subcutaneous injection Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229910052722 tritium Inorganic materials 0.000 description 1
238000005406 washing Methods 0.000 description 1
MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
229960000537 xipamide Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Toxicology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Treatment Of Water By Ion Exchange (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

UA2002043503A 1999-10-29 2000-09-10 Inhibitors crystals of sodium-hydrogen exchange of 1 type, a method for the preparation thereof (variants), a pharmaceuticalcomposition based thereon and a method for the reduction of tissue damage UA72002C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16237499P	1999-10-29	1999-10-29
PCT/IB2000/001460 WO2001030759A2 (en)	1999-10-29	2000-10-09	Sodium-hydrogen exchanger type 1 inhibitor crystals

Publications (1)

Publication Number	Publication Date
UA72002C2 true UA72002C2 (en)	2005-01-17

Family

ID=22585355

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2002043503A UA72002C2 (en)	1999-10-29	2000-09-10	Inhibitors crystals of sodium-hydrogen exchange of 1 type, a method for the preparation thereof (variants), a pharmaceuticalcomposition based thereon and a method for the reduction of tissue damage

Country Status (44)

Country	Link
EP (1)	EP1224179B1 (cs)
JP (1)	JP2003512455A (cs)
KR (1)	KR100464526B1 (cs)
CN (2)	CN1205205C (cs)
AP (1)	AP2002002493A0 (cs)
AR (1)	AR029402A1 (cs)
AT (1)	ATE271047T1 (cs)
AU (1)	AU778573B2 (cs)
BG (1)	BG106729A (cs)
BR (1)	BR0015275A (cs)
CA (1)	CA2389020A1 (cs)
CO (1)	CO5271714A1 (cs)
CZ (1)	CZ20021332A3 (cs)
DE (1)	DE60012208T2 (cs)
DK (1)	DK1224179T3 (cs)
DZ (1)	DZ3463A1 (cs)
EA (1)	EA004937B1 (cs)
EE (1)	EE200200227A (cs)
ES (1)	ES2222923T3 (cs)
GE (1)	GEP20043222B (cs)
GT (1)	GT200000180A (cs)
HK (1)	HK1048472B (cs)
HR (1)	HRP20020366B1 (cs)
HU (1)	HUP0204009A3 (cs)
IL (1)	IL148581A0 (cs)
IS (1)	IS6302A (cs)
MA (1)	MA26840A1 (cs)
MX (1)	MXPA02004358A (cs)
NO (1)	NO20021821L (cs)
NZ (1)	NZ517738A (cs)
OA (1)	OA12080A (cs)
PA (1)	PA8505501A1 (cs)
PE (1)	PE20010764A1 (cs)
PL (1)	PL354869A1 (cs)
PT (1)	PT1224179E (cs)
SI (1)	SI1224179T1 (cs)
SK (1)	SK5312002A3 (cs)
SV (1)	SV2002000209A (cs)
TN (1)	TNSN00210A1 (cs)
TR (1)	TR200201167T2 (cs)
UA (1)	UA72002C2 (cs)
WO (1)	WO2001030759A2 (cs)
YU (1)	YU31502A (cs)
ZA (1)	ZA200203295B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6441176B1 (en)	1999-10-29	2002-08-27	Pfizer Inc.	Method for preparing sodium-hydrogen exchanger type 1 inhibitor
CA2436539A1 (en) *	2001-01-31	2002-08-08	Pfizer Products Inc.	Ethanolates of sodium-hydrogen exchanger type-1 inhibitor
EP1472242A1 (en) *	2002-01-30	2004-11-03	Pfizer Products Inc.	Zoniporide mesylate pharmaceutical compositions and processes for improving solubility of zoniporide
EP1499317A1 (en) *	2002-05-02	2005-01-26	Pfizer Products Inc.	Treatment of diabetes and diabetic complications with nhe-1 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002504546A (ja) *	1998-02-27	2002-02-12	ファイザー・プロダクツ・インク	虚血の治療のためのｎ−［（置換５員ジもしくはトリアザ二不飽和環）カルボニル］グアニジン誘導体

2000
- 2000-09-10 UA UA2002043503A patent/UA72002C2/uk unknown
- 2000-10-09 TR TR2002/01167T patent/TR200201167T2/xx unknown
- 2000-10-09 SK SK531-2002A patent/SK5312002A3/sk unknown
- 2000-10-09 HU HU0204009A patent/HUP0204009A3/hu unknown
- 2000-10-09 BR BR0015275-7A patent/BR0015275A/pt not_active IP Right Cessation
- 2000-10-09 SI SI200030449T patent/SI1224179T1/xx unknown
- 2000-10-09 EP EP00962776A patent/EP1224179B1/en not_active Expired - Lifetime
- 2000-10-09 CN CNB008146748A patent/CN1205205C/zh not_active Expired - Fee Related
- 2000-10-09 EE EEP200200227A patent/EE200200227A/xx unknown
- 2000-10-09 NZ NZ517738A patent/NZ517738A/en unknown
- 2000-10-09 PT PT00962776T patent/PT1224179E/pt unknown
- 2000-10-09 AU AU74415/00A patent/AU778573B2/en not_active Ceased
- 2000-10-09 OA OA1200200128A patent/OA12080A/en unknown
- 2000-10-09 HK HK03100504.6A patent/HK1048472B/zh not_active IP Right Cessation
- 2000-10-09 PL PL00354869A patent/PL354869A1/xx not_active Application Discontinuation
- 2000-10-09 DZ DZ003463A patent/DZ3463A1/fr active
- 2000-10-09 CA CA002389020A patent/CA2389020A1/en not_active Abandoned
- 2000-10-09 DE DE60012208T patent/DE60012208T2/de not_active Expired - Fee Related
- 2000-10-09 ES ES00962776T patent/ES2222923T3/es not_active Expired - Lifetime
- 2000-10-09 GE GEAP20006430A patent/GEP20043222B/en unknown
- 2000-10-09 YU YU31502A patent/YU31502A/sh unknown
- 2000-10-09 KR KR10-2002-7005366A patent/KR100464526B1/ko not_active Expired - Fee Related
- 2000-10-09 MX MXPA02004358A patent/MXPA02004358A/es active IP Right Grant
- 2000-10-09 JP JP2001533113A patent/JP2003512455A/ja active Pending
- 2000-10-09 WO PCT/IB2000/001460 patent/WO2001030759A2/en not_active Ceased
- 2000-10-09 AT AT00962776T patent/ATE271047T1/de not_active IP Right Cessation
- 2000-10-09 CN CNA200410094665XA patent/CN1636991A/zh active Pending
- 2000-10-09 EA EA200200416A patent/EA004937B1/ru not_active IP Right Cessation
- 2000-10-09 CZ CZ20021332A patent/CZ20021332A3/cs unknown
- 2000-10-09 IL IL14858100A patent/IL148581A0/xx unknown
- 2000-10-09 AP APAP/P/2002/002493A patent/AP2002002493A0/en unknown
- 2000-10-09 DK DK00962776T patent/DK1224179T3/da active
- 2000-10-09 HR HR20020366A patent/HRP20020366B1/xx not_active IP Right Cessation
- 2000-10-18 GT GT200000180A patent/GT200000180A/es unknown
- 2000-10-20 PA PA20008505501A patent/PA8505501A1/es unknown
- 2000-10-25 CO CO00081375A patent/CO5271714A1/es not_active Application Discontinuation
- 2000-10-26 PE PE2000001145A patent/PE20010764A1/es not_active Application Discontinuation
- 2000-10-27 TN TNTNSN00210A patent/TNSN00210A1/fr unknown
- 2000-10-27 SV SV2000000209A patent/SV2002000209A/es unknown
- 2000-10-27 AR ARP000105700A patent/AR029402A1/es unknown
2002
- 2002-03-15 IS IS6302A patent/IS6302A/is unknown
- 2002-04-18 NO NO20021821A patent/NO20021821L/no not_active Application Discontinuation
- 2002-04-22 MA MA26615A patent/MA26840A1/fr unknown
- 2002-04-25 ZA ZA200203295A patent/ZA200203295B/xx unknown
- 2002-05-20 BG BG106729A patent/BG106729A/bg unknown

Also Published As

Publication number	Publication date
HK1048472B (zh)	2005-09-16
SV2002000209A (es)	2002-07-16
EA200200416A1 (ru)	2002-10-31
ATE271047T1 (de)	2004-07-15
SK5312002A3 (en)	2003-01-09
NO20021821D0 (no)	2002-04-18
GT200000180A (es)	2002-04-11
TNSN00210A1 (fr)	2005-11-10
ES2222923T3 (es)	2005-02-16
HUP0204009A3 (en)	2004-07-28
EE200200227A (et)	2003-06-16
JP2003512455A (ja)	2003-04-02
AR029402A1 (es)	2003-06-25
AP2002002493A0 (en)	2002-06-30
PL354869A1 (en)	2004-03-08
DE60012208D1 (de)	2004-08-19
NZ517738A (en)	2005-06-24
CA2389020A1 (en)	2001-05-03
HK1048472A1 (en)	2003-04-04
MXPA02004358A (es)	2002-11-07
IL148581A0 (en)	2002-09-12
HRP20020366B1 (en)	2005-04-30
ZA200203295B (en)	2003-06-25
SI1224179T1 (en)	2004-10-31
OA12080A (en)	2003-08-25
DZ3463A1 (fr)	2001-05-03
EP1224179B1 (en)	2004-07-14
EA004937B1 (ru)	2004-10-28
BG106729A (bg)	2002-12-29
CN1636991A (zh)	2005-07-13
HRP20020366A2 (en)	2004-02-29
AU7441500A (en)	2001-05-08
CN1205205C (zh)	2005-06-08
CZ20021332A3 (cs)	2002-10-16
PE20010764A1 (es)	2001-07-23
BR0015275A (pt)	2002-07-16
TR200201167T2 (tr)	2002-08-21
KR100464526B1 (ko)	2005-01-03
DK1224179T3 (da)	2004-10-25
DE60012208T2 (de)	2005-07-21
EP1224179A2 (en)	2002-07-24
PA8505501A1 (es)	2003-09-05
NO20021821L (no)	2002-04-18
WO2001030759A3 (en)	2001-09-13
WO2001030759A2 (en)	2001-05-03
KR20020040918A (ko)	2002-05-30
HUP0204009A2 (hu)	2003-03-28
IS6302A (is)	2002-03-15
AU778573B2 (en)	2004-12-09
CN1384829A (zh)	2002-12-11
GEP20043222B (en)	2004-04-26
PT1224179E (pt)	2004-10-29
YU31502A (sh)	2004-12-31
CO5271714A1 (es)	2003-04-30
MA26840A1 (fr)	2004-12-20

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EA004882B1 (ru)	2004-08-26	Ингибитор натрий-водородного обмена типа 1(nhe-1)
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HK1036057B (en)	2004-09-30	Method for preparing sodium-hydrogen exchanger type 1 inhibitor
AU2005201428A1 (en)	2005-04-28	Method for preparing sodium-hydrogen exchanger type 1 inhibitor
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