UA73270C2 - Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted - Google Patents

Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted Download PDF

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Publication number: UA73270C2
Authority: UA; Ukraine
Prior art keywords: cells; gene; host; cell; rejection
Prior art date: 1996-11-29

Application number

UA99063590A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-29

Filing date

1996-11-29

Publication date

2005-07-15

1996-11-29 Application filed filed Critical

2005-07-15 Publication of UA73270C2 publication Critical patent/UA73270C2/uk

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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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General Health & Medical Sciences (AREA)
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Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
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Plant Pathology (AREA)
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Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

UA99063590A 1996-11-29 1996-11-29 Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted UA73270C2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP1996/005280 WO1998023748A1 (en)	1996-11-29	1996-11-29	Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3)

Publications (1)

Publication Number	Publication Date
UA73270C2 true UA73270C2 (en)	2005-07-15

Family

ID=8166413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA99063590A UA73270C2 (en)	1996-11-29	1996-11-29	Application of genetically structured cells expressing lymphocytes activation gene (lag-3) on the surface for protection of transplant against rejection and a method for induction of specific protection against rejection of material being tranplanted

Country Status (19)

Country	Link
US (1)	US6500422B2 (da)
EP (1)	EP0941329B1 (da)
JP (1)	JP3920928B2 (da)
KR (1)	KR100481230B1 (da)
AR (1)	AR018489A1 (da)
AT (1)	ATE271607T1 (da)
AU (1)	AU733825B2 (da)
BR (1)	BR9612821A (da)
CA (1)	CA2272130C (da)
DE (1)	DE69632967T2 (da)
DK (1)	DK0941329T3 (da)
EA (1)	EA003772B1 (da)
ES (1)	ES2225901T3 (da)
IL (1)	IL130168A (da)
NO (1)	NO324378B1 (da)
PT (1)	PT941329E (da)
UA (1)	UA73270C2 (da)
WO (1)	WO1998023748A1 (da)
ZA (1)	ZA9710737B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0941329B1 (en) *	1996-11-29	2004-07-21	Applied Research Systems ARS Holding N.V.	Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3)
US20060240024A1 (en)	2003-02-28	2006-10-26	The Johns Hopkins University	T cell regulation
KR20050082389A (ko) *	2004-02-18	2005-08-23	메덱스젠 주식회사	직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물
EP2044949A1 (en) *	2007-10-05	2009-04-08	Immutep	Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
AR072999A1 (es) *	2008-08-11	2010-10-06	Medarex Inc	Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
UY34887A (es)	2012-07-02	2013-12-31	Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware	Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
AU2014323523B2 (en)	2013-09-20	2020-02-20	Bristol-Myers Squibb Company	Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
GB201322626D0 (en)	2013-12-19	2014-02-05	Immutep S A	Combined preparations for the treatment of cancer
JO3663B1 (ar)	2014-08-19	2020-08-27	Merck Sharp & Dohme	الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
GB201500374D0 (en)	2015-01-09	2015-02-25	Immutep S A	Combined preparations for the treatment of cancer
DK3356411T3 (da)	2015-10-02	2021-09-06	Hoffmann La Roche	Bispecifikke antistoffer, der er specifikke for PD1 og TIM3
JP7000322B2 (ja)	2015-12-16	2022-02-04	メルク・シャープ・アンド・ドーム・コーポレーション	抗ｌａｇ３抗体および抗原結合性フラグメント
EP4201953A1 (en)	2017-04-03	2023-06-28	F. Hoffmann-La Roche AG	Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
SG11201909154SA (en)	2017-04-05	2019-10-30	Hoffmann La Roche	Bispecific antibodies specifically binding to pd1 and lag3
KR102721137B1 (ko)	2017-05-30	2024-10-25	브리스톨-마이어스 스큅 컴퍼니	항-lag-3 항체 또는 항-lag-3 항체 및 항-pd-1 또는 항-pd-l1 항체를 포함하는 조성물
CA3060984A1 (en)	2017-05-30	2018-12-06	Bristol-Myers Squibb Company	Treatment of lag-3 positive tumors
KR102559149B1 (ko)	2018-10-26	2023-07-24	에프. 호프만-라 로슈 아게	재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법
US20240101666A1 (en)	2020-10-23	2024-03-28	Bristol-Myers Squibb Company	Lag-3 antagonist therapy for lung cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2656800B1 (fr) *	1990-01-08	1992-05-15	Roussy Inst Gustave	Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5876708A (en) *	1992-02-19	1999-03-02	The General Hospital Corporation	Allogeneic and xenogeneic transplantation
DK0758383T3 (da)	1994-05-06	2007-05-29	Roussy Inst Gustave	Oplöselige polypeptidfraktioner af LAG-3-proteinet; fremgangsmåde til fremstilling; terapeutisk sammensætning; antiidiotypisk antistof
EP0941329B1 (en) *	1996-11-29	2004-07-21	Applied Research Systems ARS Holding N.V.	Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3)

1996
- 1996-11-29 EP EP96940658A patent/EP0941329B1/en not_active Expired - Lifetime
- 1996-11-29 IL IL130168A patent/IL130168A/en not_active IP Right Cessation
- 1996-11-29 AU AU10667/97A patent/AU733825B2/en not_active Ceased
- 1996-11-29 JP JP52611398A patent/JP3920928B2/ja not_active Expired - Fee Related
- 1996-11-29 UA UA99063590A patent/UA73270C2/uk unknown
- 1996-11-29 KR KR10-1999-7004274A patent/KR100481230B1/ko not_active Expired - Fee Related
- 1996-11-29 DK DK96940658T patent/DK0941329T3/da active
- 1996-11-29 CA CA002272130A patent/CA2272130C/en not_active Expired - Fee Related
- 1996-11-29 ES ES96940658T patent/ES2225901T3/es not_active Expired - Lifetime
- 1996-11-29 DE DE69632967T patent/DE69632967T2/de not_active Expired - Fee Related
- 1996-11-29 US US09/319,147 patent/US6500422B2/en not_active Expired - Fee Related
- 1996-11-29 BR BR9612821-6A patent/BR9612821A/pt not_active Application Discontinuation
- 1996-11-29 WO PCT/EP1996/005280 patent/WO1998023748A1/en not_active Ceased
- 1996-11-29 EA EA199900507A patent/EA003772B1/ru not_active IP Right Cessation
- 1996-11-29 AT AT96940658T patent/ATE271607T1/de not_active IP Right Cessation
- 1996-11-29 PT PT96940658T patent/PT941329E/pt unknown
1997
- 1997-11-28 ZA ZA9710737A patent/ZA9710737B/xx unknown
- 1997-11-28 AR ARP970105619A patent/AR018489A1/es not_active Application Discontinuation
1999
- 1999-05-27 NO NO19992569A patent/NO324378B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1998023748A1 (en)	1998-06-04
NO992569D0 (no)	1999-05-27
IL130168A0 (en)	2000-06-01
JP2001505770A (ja)	2001-05-08
JP3920928B2 (ja)	2007-05-30
EP0941329A1 (en)	1999-09-15
US6500422B2 (en)	2002-12-31
AR018489A1 (es)	2001-11-28
EA199900507A1 (ru)	2000-02-28
CA2272130C (en)	2007-10-23
AU733825B2 (en)	2001-05-24
DK0941329T3 (da)	2004-11-29
AU1066797A (en)	1998-06-22
KR20000053291A (ko)	2000-08-25
ZA9710737B (en)	1998-07-30
IL130168A (en)	2006-09-05
KR100481230B1 (ko)	2005-04-07
US20020081282A1 (en)	2002-06-27
EP0941329B1 (en)	2004-07-21
HK1023599A1 (en)	2000-09-15
ATE271607T1 (de)	2004-08-15
CA2272130A1 (en)	1998-06-04
BR9612821A (pt)	2000-04-11
DE69632967T2 (de)	2005-08-11
PT941329E (pt)	2004-11-30
EA003772B1 (ru)	2003-08-28
NO992569L (no)	1999-05-27
DE69632967D1 (de)	2004-08-26
ES2225901T3 (es)	2005-03-16
NO324378B1 (no)	2007-10-01

Publication	Publication Date	Title
AU733825B2 (en)	2001-05-24	Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (LAG-3)
US8071085B2 (en)	2011-12-06	Primary cultured adipocytes for gene therapy
Yasuda et al.	1998	Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.
JP6018081B2 (ja)	2016-11-02	自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞
US20140242037A1 (en)	2014-08-28	Apc-mediated tolerance induction for therapy of multiple sclerosis
Andreoletti et al.	2001	Engraftment of autologous retrovirally transduced hepatocytes after intraportal transplantation into nonhuman primates: implication for ex vivo gene therapy
WO2023003826A2 (en)	2023-01-26	Single- and multi-epitope peptide and mrna vaccines to generate tolerogenic effects for allergic and autoimmune disease by targeting liver sinusoidal endothelial cells
Tamura et al.	1997	Targeted killing of migrating glioma cells by injection of HTK-modified glioma cells
US6677311B1 (en)	2004-01-13	Inducible HSV-TK in transformed cell populations
JP4879867B2 (ja)	2012-02-22	遺伝子治療用初代培養脂肪細胞
MXPA99004550A (en)	2000-02-02	Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3)
Rahim et al.	2014	Gene therapy modalities in lung transplantation
Whartenby et al.	1995	Gene therapy: clinical potential and relationships to drug treatment
Pichard et al.	2006	Mixed hematopoietic molecular chimerism results in permanent transgene expression from retrovirally transduced hepatocytes in mice
Tremblay	2000	Immune Reaction Following Cell and Gene Therapy
Ma et al.	2006	984. Liver Restricted Expression of Canine Iduronidase Does Not Prevent a CTL Response in Adult MPS I Mice after Retroviral Vector-Mediated Gene Therapy, but Transient Immunomodulation with CTLA4-Ig Combined with Anti-CD4 or Anti-CD40 Ligand Does
HK1023599B (en)	2005-08-05	Cells for preventing graft rejection in transplantation and their uses
Magee et al.	2011	GENE THERAPY IN ORGAN TRANSPLANTATION: APPLICABILITIES AND
Wei	1996	Establishment and application of an embryonic yolk sac cell-derived mini-organ gene delivery system for gene therapy
KR20050024341A (ko)	2005-03-10	유전자 치료용 초대 배양 지방세포