UA74324C2 - Форми кристалічного ефавіренцу та способи лікування з їх допомогою - Google Patents

Форми кристалічного ефавіренцу та способи лікування з їх допомогою

Info

Publication number
UA74324C2
UA74324C2 UA2000127048A UA00127048A UA74324C2 UA 74324 C2 UA74324 C2 UA 74324C2 UA 2000127048 A UA2000127048 A UA 2000127048A UA 00127048 A UA00127048 A UA 00127048A UA 74324 C2 UA74324 C2 UA 74324C2
Authority
UA
Ukraine
Prior art keywords
crystalline
forms
treatment
methods
efavirentz
Prior art date
Application number
UA2000127048A
Other languages
English (en)
Russian (ru)
Inventor
Ліліан А. Радеска
Міхаель Б. Маурін
Шеллі Р. Рабель
Джеймс Р. Моор
Original Assignee
Брістол-Майєрс Сквібб Фарма Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22214647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA74324(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Брістол-Майєрс Сквібб Фарма Компані filed Critical Брістол-Майєрс Сквібб Фарма Компані
Publication of UA74324C2 publication Critical patent/UA74324C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Потенційний інгібітор реверсивної транскриптази - ефавіренц існує в декількох фізичних формах, які позначені як форми 1, 2, 3, 4 та 5 та які розрізняються картиною рентгенопроменевої порошкової дифракції та термограмою диференційної скануючої калориметрії. Описані також способи лікування від ВІЛ-інфекції з допомогою вказаних форм ефавіренцу.
UA2000127048A 1998-06-11 1999-06-10 Форми кристалічного ефавіренцу та способи лікування з їх допомогою UA74324C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8898198P 1998-06-11 1998-06-11
PCT/US1999/013199 WO1999064405A1 (en) 1998-06-11 1999-06-10 Crystalline efavirenz

Publications (1)

Publication Number Publication Date
UA74324C2 true UA74324C2 (uk) 2005-12-15

Family

ID=22214647

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2000127048A UA74324C2 (uk) 1998-06-11 1999-06-10 Форми кристалічного ефавіренцу та способи лікування з їх допомогою

Country Status (21)

Country Link
EP (1) EP1086087A1 (uk)
JP (1) JP2002517487A (uk)
CN (1) CN1307568A (uk)
AR (3) AR018670A1 (uk)
AU (1) AU758114C (uk)
BR (1) BR9911523A (uk)
CA (1) CA2333550A1 (uk)
EE (1) EE05547B1 (uk)
HR (1) HRP990182A2 (uk)
HU (1) HUP0103819A3 (uk)
IL (1) IL139793A (uk)
MY (1) MY126450A (uk)
NO (1) NO20006255L (uk)
NZ (1) NZ507713A (uk)
PL (1) PL198504B1 (uk)
SG (3) SG111980A1 (uk)
SK (1) SK18182000A3 (uk)
TW (1) TWI235152B (uk)
UA (1) UA74324C2 (uk)
WO (1) WO1999064405A1 (uk)
ZA (1) ZA200006173B (uk)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
WO2006018853A2 (en) 2004-08-19 2006-02-23 Hetero Drugs Limited Novel polymorphs of efavirenz
US7205402B2 (en) * 2004-09-02 2007-04-17 Bristol-Myers Squibb Company Synthesis of a benzoxazinone
WO2008108630A1 (en) * 2007-03-02 2008-09-12 Ultimorphix Technologies B.V. Polymorphic forms of efavirenz
WO2009011567A1 (en) * 2007-07-16 2009-01-22 Ultimorphix Technologies B.V. Crystalline forms of efavirenz
CA2712574C (en) 2008-02-04 2014-01-07 Pfizer Limited Polymorphic form of a [1,2,4]triazolo[4,3-a]pyridine derivative for treating inflammatory diseases
US8383811B2 (en) 2008-12-22 2013-02-26 Hetero Research Foundation Process for preparing efavirenz polymorph
DE102009041443A1 (de) 2009-09-16 2011-03-31 Archimica Gmbh Salze des 6-Chlor-4-(cyclopropylethinyl)-1,4-dihydro-4-(trifluormethyl)-2H-3,1-benzoxazin-2-ons und deren Synthese, Aufreinigung und Anwendung als Vorstufen für Efavirenz
EP2471783A1 (en) 2010-12-23 2012-07-04 Esteve Química, S.A. Novel polymorphic form of efavirenz
CN103508973B (zh) * 2012-06-25 2016-04-27 上海迪赛诺药业有限公司 制备依非韦伦i型结晶的方法
CN102924398B (zh) * 2012-11-22 2015-11-18 安徽贝克生物制药有限公司 用于除去依非韦伦对应异构体的方法
US9468646B2 (en) 2013-01-23 2016-10-18 Alienor Farma Increased dosage of efavirenz for the treatment of cancer
CN105037175B (zh) * 2014-07-18 2017-02-22 盐城迪赛诺制药有限公司 一种用于提高依非韦伦中间体光学纯度的方法
CN105001101B (zh) * 2015-05-28 2017-11-28 乐平市瑞盛制药有限公司 一种4‑氯‑2‑三氟乙酰基苯胺水合物盐酸盐的合成方法
CN108947855B (zh) * 2018-08-10 2021-10-22 江苏沙星化工有限公司 一种依非韦伦关键中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
CA2260922A1 (en) * 1996-07-26 1998-02-05 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
ES2203790T3 (es) * 1996-10-02 2004-04-16 Bristol-Myers Squibb Pharma Company 1,4-dihidro-2h-3,1-benzoxacin-2-onas 4,4-disustituidas utiles como inhibidores de la transcriptasa reversa del hiv e intermedios y procedimientos para su preparacion.
HU229087B1 (en) * 1997-02-05 2013-07-29 Merck Sharp & Dohme Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent

Also Published As

Publication number Publication date
AU758114C (en) 2003-10-30
AR018670A1 (es) 2001-11-28
EE200000743A (et) 2002-10-15
SG111980A1 (en) 2005-06-29
PL198504B1 (pl) 2008-06-30
TWI235152B (en) 2005-07-01
CA2333550A1 (en) 1999-12-16
NO20006255D0 (no) 2000-12-08
AU4436499A (en) 1999-12-30
PL345221A1 (en) 2001-12-03
EP1086087A1 (en) 2001-03-28
HUP0103819A2 (hu) 2002-02-28
SK18182000A3 (sk) 2001-08-06
IL139793A (en) 2006-10-31
MY126450A (en) 2006-10-31
NZ507713A (en) 2003-08-29
SG111981A1 (en) 2005-06-29
ZA200006173B (en) 2001-10-31
IL139793A0 (en) 2002-02-10
HRP990182A2 (en) 2000-02-29
NO20006255L (no) 2001-02-12
BR9911523A (pt) 2001-09-18
SG134977A1 (en) 2007-09-28
WO1999064405A1 (en) 1999-12-16
CN1307568A (zh) 2001-08-08
JP2002517487A (ja) 2002-06-18
HUP0103819A3 (en) 2003-05-28
AR077469A2 (es) 2011-08-31
EE05547B1 (et) 2012-06-15
AU758114B2 (en) 2003-03-13
AR077407A2 (es) 2011-08-24

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