UA76224C2 - Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists - Google Patents

Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists Download PDF

Info

Publication number: UA76224C2
Authority: UA; Ukraine
Prior art keywords: group; compounds; phenyl; reaction; compound
Prior art date: 2001-10-15

Application number

UA20040503667A

Other languages

English (en)

Ukrainian (uk)

Inventor

Frans Eduard Janssens

Joseph Elisabeth Leenaerts

Francisco Javi Fernandez-Gadea

Theo Frans Meert

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-15

Filing date

2002-10-10

Publication date

2006-07-17

2002-10-10 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2006-07-17 Publication of UA76224C2 publication Critical patent/UA76224C2/uk

Links

229940127450 Opioid Agonists Drugs 0.000 title abstract description 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract description 4
GBANLFWFVPIRMO-UHFFFAOYSA-N 4-(1h-imidazol-2-yl)-4-phenylpiperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NC=CN1 GBANLFWFVPIRMO-UHFFFAOYSA-N 0.000 title abstract 2
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Classifications

- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

UA20040503667A 2001-10-15 2002-10-10 Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists UA76224C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01203926		2001-10-15
PCT/EP2002/011372 WO2003033486A1 (en)	2001-10-15	2002-10-10	Novel substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists

Publications (1)

Publication Number	Publication Date
UA76224C2 true UA76224C2 (en)	2006-07-17

Family

ID=8181080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040503667A UA76224C2 (en)	2001-10-15	2002-10-10	Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists

Country Status (26)

Country	Link
US (2)	US7282508B2 (pl)
EP (1)	EP1438304B1 (pl)
JP (1)	JP4417108B2 (pl)
KR (1)	KR100898562B1 (pl)
CN (1)	CN100354273C (pl)
AR (1)	AR037506A1 (pl)
AT (1)	ATE347549T1 (pl)
AU (1)	AU2002346994B2 (pl)
BR (1)	BR0213327A (pl)
CA (1)	CA2462953C (pl)
CY (1)	CY1106356T1 (pl)
DE (1)	DE60216627T2 (pl)
EA (1)	EA006507B1 (pl)
ES (1)	ES2278065T3 (pl)
HR (1)	HRP20040324A2 (pl)
HU (1)	HUP0600447A3 (pl)
IL (2)	IL161348A0 (pl)
MX (1)	MXPA04003479A (pl)
MY (1)	MY137356A (pl)
NO (1)	NO327602B1 (pl)
NZ (1)	NZ531679A (pl)
PL (1)	PL367967A1 (pl)
PT (1)	PT1438304E (pl)
UA (1)	UA76224C2 (pl)
WO (1)	WO2003033486A1 (pl)
ZA (1)	ZA200402818B (pl)

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BR0213325A (pt) *	2001-10-15	2004-10-13	Janssen Pharmaceutica Nv	Derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina substituìda para a redução de dano isquêmico
TW200403058A (en) *	2002-04-19	2004-03-01	Bristol Myers Squibb Co	Heterocyclo inhibitors of potassium channel function
JP2006515278A (ja)	2002-05-08	2006-05-25	ニューロジェンコーポレイション	置換イミダゾリルメチルピリジン及びピラジン誘導体並びにそれらのｇａｂａａ受容体リガンドとしての使用
DE60330794D1 (de) *	2002-07-03	2010-02-11	Glaxo Group Ltd	Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer
AR044010A1 (es) *	2003-04-11	2005-08-24	Janssen Pharmaceutica Nv	Uso de derivados de 4-fenil-4- [1h-imidazol-2-il]- piperidina sustituidos como agonistas delta opioideos no peptidos selectivos, con actividad antidepresiva y ansiolitica
KR20140015122A (ko)	2003-10-01	2014-02-06	아돌로 코포레이션	스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
ME02540B (me) *	2004-03-15	2017-02-20	Janssen Pharmaceutica Nv	Modulatori optoidnih receptora
AU2013205089B2 (en) *	2004-03-15	2013-12-19	Janssen Pharmaceutica, N.V.	Novel compounds as opioid receptor modulators
US7598261B2 (en)	2005-03-31	2009-10-06	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en)	2006-04-06	2009-08-18	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
MX2009002715A (es)	2006-09-12	2009-08-12	Adolor Corp	Metodos para mejorar la funcion cognoscitiva.
IT1396951B1 (it) *	2009-12-18	2012-12-20	Neuroscienze Pharmaness S C A R L	Composti farmaceutici
US20170119786A1 (en)	2011-03-08	2017-05-04	3-V Biosciences, Inc.	Heterocyclic modulators of lipid synthesis
US9675587B2 (en)	2013-03-14	2017-06-13	Allergan Holdings Unlimited Company	Opioid receptor modulator dosage formulations
TWI652264B (zh) *	2013-09-26	2019-03-01	東麗股份有限公司	Cyclic amine derivatives and their medical uses
JP7450534B2 (ja)	2017-10-19	2024-03-15	帝人ファーマ株式会社	ベンズイミダゾール誘導体及びその用途
MX2023013975A (es) *	2021-05-26	2023-12-11	Sumitomo Pharma Co Ltd	Derivado de fenil urea.

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JP2985322B2 (ja)	1991-03-01	1999-11-29	東レ株式会社	イソキノリン誘導体およびその医薬用途
US5354863A (en) *	1992-01-21	1994-10-11	G. D. Searle & Co.	Opioid agonist compounds
GB9202238D0 (en)	1992-02-03	1992-03-18	Wellcome Found	Compounds
EP0712402B1 (en)	1993-08-06	2002-04-10	Smithkline Beecham S.p.A.	Hydroisoquinoline derivatives
US5618934A (en)	1994-05-17	1997-04-08	Merck & Co., Inc.	Boronic acid compound
WO1996022276A1 (en)	1995-01-20	1996-07-25	Nippon Shinyaku Co., Ltd.	Ethylamine derivatives and drugs
IT1307327B1 (it)	1995-09-12	2001-10-30	Smithkline Beecham Spa	Derivati idroisochinolinici sostituiti
SE9604786D0 (sv)	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
DE19805370A1 (de)	1997-03-14	1998-09-17	Gruenenthal Gmbh	Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
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JP2005231995A (ja)	1999-12-22	2005-09-02	Meiji Seika Kaisha Ltd	オピオイドδ受容体アゴニスト／アンタゴニストとして有用なスピロ化合物

2002
- 2002-10-10 IL IL16134802A patent/IL161348A0/xx unknown
- 2002-10-10 PT PT02782881T patent/PT1438304E/pt unknown
- 2002-10-10 HR HR20040324A patent/HRP20040324A2/xx not_active Application Discontinuation
- 2002-10-10 BR BR0213327-0A patent/BR0213327A/pt not_active IP Right Cessation
- 2002-10-10 JP JP2003536226A patent/JP4417108B2/ja not_active Expired - Fee Related
- 2002-10-10 HU HU0600447A patent/HUP0600447A3/hu unknown
- 2002-10-10 MX MXPA04003479A patent/MXPA04003479A/es active IP Right Grant
- 2002-10-10 WO PCT/EP2002/011372 patent/WO2003033486A1/en not_active Ceased
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- 2002-10-10 DE DE60216627T patent/DE60216627T2/de not_active Expired - Lifetime
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- 2002-10-10 PL PL02367967A patent/PL367967A1/pl unknown
- 2002-10-10 NZ NZ531679A patent/NZ531679A/en not_active IP Right Cessation
- 2002-10-10 AT AT02782881T patent/ATE347549T1/de active
- 2002-10-10 EP EP02782881A patent/EP1438304B1/en not_active Expired - Lifetime
- 2002-10-10 CN CNB028203275A patent/CN100354273C/zh not_active Expired - Fee Related
- 2002-10-10 EA EA200400545A patent/EA006507B1/ru not_active IP Right Cessation
- 2002-10-10 UA UA20040503667A patent/UA76224C2/uk unknown
- 2002-10-10 CA CA2462953A patent/CA2462953C/en not_active Expired - Lifetime
- 2002-10-10 US US10/491,379 patent/US7282508B2/en not_active Expired - Fee Related
- 2002-10-11 AR ARP020103837A patent/AR037506A1/es unknown
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2004
- 2004-04-13 ZA ZA2004/02818A patent/ZA200402818B/en unknown
- 2004-04-13 IL IL161348A patent/IL161348A/en not_active IP Right Cessation
- 2004-04-22 NO NO20041666A patent/NO327602B1/no not_active IP Right Cessation
2007
- 2007-03-06 CY CY20071100311T patent/CY1106356T1/el unknown
- 2007-05-25 US US11/753,830 patent/US20080096925A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20041666L (no)	2004-04-22
DE60216627T2 (de)	2007-09-20
US20080096925A1 (en)	2008-04-24
IL161348A (en)	2010-11-30
DE60216627D1 (de)	2007-01-18
PT1438304E (pt)	2007-03-30
MY137356A (en)	2009-01-30
AU2002346994B2 (en)	2007-09-06
JP2005505625A (ja)	2005-02-24
WO2003033486A1 (en)	2003-04-24
EA200400545A1 (ru)	2004-08-26
KR100898562B1 (ko)	2009-05-20
KR20050035121A (ko)	2005-04-15
CA2462953A1 (en)	2003-04-24
ATE347549T1 (de)	2006-12-15
HUP0600447A2 (en)	2006-09-28
EP1438304B1 (en)	2006-12-06
JP4417108B2 (ja)	2010-02-17
ES2278065T3 (es)	2007-08-01
IL161348A0 (en)	2004-09-27
CY1106356T1 (el)	2011-10-12
EA006507B1 (ru)	2005-12-29
ZA200402818B (en)	2005-06-29
AR037506A1 (es)	2004-11-17
NZ531679A (en)	2005-02-25
PL367967A1 (pl)	2005-03-07
CN1568321A (zh)	2005-01-19
US7282508B2 (en)	2007-10-16
EP1438304A1 (en)	2004-07-21
US20040260096A1 (en)	2004-12-23
CN100354273C (zh)	2007-12-12
BR0213327A (pt)	2004-10-13
NO327602B1 (no)	2009-08-31
HRP20040324A2 (en)	2005-04-30
MXPA04003479A (es)	2004-07-30
CA2462953C (en)	2011-01-04
HUP0600447A3 (en)	2008-03-28

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