UA76535C2 - Process for reacting alkaloids by adding phosphorus derivative, reaction products suitable for drug subnstances - Google Patents

Process for reacting alkaloids by adding phosphorus derivative, reaction products suitable for drug subnstances Download PDF

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Publication number
UA76535C2
UA76535C2 UA20040604558A UA20040604558A UA76535C2 UA 76535 C2 UA76535 C2 UA 76535C2 UA 20040604558 A UA20040604558 A UA 20040604558A UA 20040604558 A UA20040604558 A UA 20040604558A UA 76535 C2 UA76535 C2 UA 76535C2
Authority
UA
Ukraine
Prior art keywords
alkaloid
product
interaction
alkaloids
water
Prior art date
Application number
UA20040604558A
Other languages
English (en)
Ukrainian (uk)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UA76535C2 publication Critical patent/UA76535C2/uk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G5/00—Alkaloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
UA20040604558A 2001-11-15 2002-10-28 Process for reacting alkaloids by adding phosphorus derivative, reaction products suitable for drug subnstances UA76535C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH02094/01A CH695417A5 (de) 2001-11-15 2001-11-15 Verfahren zur Umsetzung von Alkaloiden.
PCT/EP2002/012003 WO2003041721A1 (fr) 2001-11-15 2002-10-28 Processus de reaction d'alcaloides et utilisation des produits de reaction dans la preparation de medicaments

Publications (1)

Publication Number Publication Date
UA76535C2 true UA76535C2 (en) 2006-08-15

Family

ID=4567486

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20040604558A UA76535C2 (en) 2001-11-15 2002-10-28 Process for reacting alkaloids by adding phosphorus derivative, reaction products suitable for drug subnstances

Country Status (38)

Country Link
US (1) US20050043340A1 (fr)
EP (1) EP1443943B1 (fr)
JP (1) JP2005509006A (fr)
KR (1) KR100849488B1 (fr)
CN (1) CN100436462C (fr)
AR (1) AR037527A1 (fr)
AT (1) ATE485826T1 (fr)
AU (1) AU2002346888B2 (fr)
BR (1) BR0214173A (fr)
CA (1) CA2465723C (fr)
CH (1) CH695417A5 (fr)
CO (1) CO5580784A2 (fr)
CR (1) CR7340A (fr)
CU (1) CU23451B7 (fr)
CY (1) CY1111139T1 (fr)
DE (1) DE60238134D1 (fr)
DK (1) DK1443943T3 (fr)
EA (1) EA007097B1 (fr)
EC (1) ECSP045107A (fr)
ES (1) ES2353207T3 (fr)
GE (1) GEP20053701B (fr)
HR (1) HRP20040430A2 (fr)
HU (1) HU229688B1 (fr)
IL (2) IL161766A0 (fr)
IS (1) IS2812B (fr)
MA (1) MA26232A1 (fr)
MX (1) MXPA04004643A (fr)
NO (1) NO334701B1 (fr)
NZ (1) NZ532941A (fr)
PL (1) PL212111B1 (fr)
PT (1) PT1443943E (fr)
RS (1) RS51219B (fr)
SA (1) SA02230496B1 (fr)
TN (1) TNSN04084A1 (fr)
TW (1) TWI262080B (fr)
UA (1) UA76535C2 (fr)
WO (1) WO2003041721A1 (fr)
ZA (1) ZA200403371B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1459753A1 (fr) 2003-03-18 2004-09-22 Nowicky, Wassyl, Dipl.-Ing. DDr. Dérivés quaternaires de chelidonine et d'alkaloides, procédé pour leur préparation et leur utilisation dans la préparation de médicaments
WO2006053649A1 (fr) * 2004-11-19 2006-05-26 Nowicky Wassili Procede de detection du cancer
WO2006053680A1 (fr) * 2004-11-19 2006-05-26 Nowicky Wassili Procede permettant de diagnostiquer un cancer ex vivo
WO2007073919A2 (fr) 2005-12-28 2007-07-05 Nowicky Wassili Procede de detection du cancer
ITMI20080284A1 (it) * 2008-02-22 2009-08-23 Indena Spa Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono
CA2941315C (fr) * 2016-08-12 2018-03-06 Api Labs Inc. Pavot a teneur elevee en thebaine et procede de fabrication associe

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865830A (en) * 1969-06-16 1975-02-11 Nikolai Mikhailovich Turkevich Thiophosphamide derivatives of isoquinoline alkaloids, method of producing and application thereof
SU368254A1 (ru) * 1969-06-16 1973-01-26 А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт Способ получения соединений тиофосфамида с алкалоидами чистотела большого
AT354644B (de) * 1975-12-19 1980-01-25 Nowicky Wassili Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure
AT377988B (de) * 1976-06-28 1985-05-28 Nowicky Wassili Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden
DE3128018A1 (de) * 1981-07-13 1983-04-07 Wassyl 1060 Wien Nowicky "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze"
US4970212A (en) * 1982-05-18 1990-11-13 Nowicky Wassili Method of treating human illnesses which compromise the ability to mount an effective immunological response
AT407608B (de) * 1994-03-18 2001-05-25 Nowicky Wassili Mittel zur behandlung von osteoporose
AT407833B (de) * 1995-06-01 2001-06-25 Nowicky Wassyl Dr Mittel zur behandlung von strahlenschäden
AT408719B (de) * 2000-03-22 2002-02-25 Nowicky Wassili Mittel zur behandlung von hepatitis c

Also Published As

Publication number Publication date
ZA200403371B (en) 2005-05-04
MA26232A1 (fr) 2004-07-01
HUP0402365A2 (hu) 2005-02-28
HU229688B1 (en) 2014-04-28
DK1443943T3 (da) 2011-02-14
CO5580784A2 (es) 2005-11-30
EA007097B1 (ru) 2006-06-30
KR100849488B1 (ko) 2008-07-31
ES2353207T3 (es) 2011-02-28
NO20041845D0 (no) 2004-05-05
EA200400679A1 (ru) 2004-10-28
EP1443943B1 (fr) 2010-10-27
CN100436462C (zh) 2008-11-26
RS51219B (sr) 2010-12-31
TNSN04084A1 (en) 2006-06-01
ECSP045107A (es) 2004-06-28
IL161766A0 (en) 2005-11-20
AR037527A1 (es) 2004-11-17
TWI262080B (en) 2006-09-21
MXPA04004643A (es) 2005-03-14
SA02230496B1 (ar) 2008-09-10
CY1111139T1 (el) 2015-06-11
NO20041845L (no) 2004-06-25
CR7340A (es) 2004-12-06
JP2005509006A (ja) 2005-04-07
HRP20040430A2 (en) 2004-08-31
BR0214173A (pt) 2004-09-28
GEP20053701B (en) 2005-12-12
KR20050040859A (ko) 2005-05-03
DE60238134D1 (de) 2010-12-09
AU2002346888B2 (en) 2007-03-22
US20050043340A1 (en) 2005-02-24
WO2003041721A1 (fr) 2003-05-22
ATE485826T1 (de) 2010-11-15
CU23451B7 (es) 2009-10-16
PT1443943E (pt) 2010-12-03
IL161766A (en) 2009-11-18
IS2812B (is) 2012-11-15
IS7245A (is) 2004-04-30
RS40804A (sr) 2006-12-15
NZ532941A (en) 2006-08-31
PL212111B1 (pl) 2012-08-31
CN1422859A (zh) 2003-06-11
CH695417A5 (de) 2006-05-15
CA2465723C (fr) 2010-01-05
HK1054041A1 (zh) 2003-11-14
AU2002346888C1 (en) 2003-05-26
PL368879A1 (en) 2005-04-04
HRP20040430B1 (fr) 2012-11-30
NO334701B1 (no) 2014-05-12
CA2465723A1 (fr) 2003-05-22
EP1443943A1 (fr) 2004-08-11

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