UA77402C2 - Use of saratin for inhibition platelet adhesion - Google Patents

Use of saratin for inhibition platelet adhesion Download PDF

Info

Publication number: UA77402C2
Authority: UA; Ukraine
Prior art keywords: saratin; collagen; platelets; platelet; endarterectomy
Prior art date: 2000-08-25

Application number

UA2003032476A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-25

Filing date

2001-08-23

Publication date

2006-12-15

2001-08-23 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2006-12-15 Publication of UA77402C2 publication Critical patent/UA77402C2/uk

Links

108010011655 saratin Proteins 0.000 title claims abstract description 135
230000005764 inhibitory process Effects 0.000 title abstract description 21
238000000576 coating method Methods 0.000 claims abstract description 35
238000013171 endarterectomy Methods 0.000 claims abstract description 23
239000011248 coating agent Substances 0.000 claims abstract description 21
238000004519 manufacturing process Methods 0.000 claims abstract description 5
238000000034 method Methods 0.000 claims description 49
229920000642 polymer Polymers 0.000 claims description 28
238000013172 carotid endarterectomy Methods 0.000 claims description 23
230000006378 damage Effects 0.000 claims description 19
238000002399 angioplasty Methods 0.000 claims description 12
230000002401 inhibitory effect Effects 0.000 claims description 10
238000009825 accumulation Methods 0.000 claims description 8
238000000502 dialysis Methods 0.000 claims description 3
206010000891 acute myocardial infarction Diseases 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
206010002388 Angina unstable Diseases 0.000 claims 1
201000001320 Atherosclerosis Diseases 0.000 claims 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
201000000054 Coronary Restenosis Diseases 0.000 claims 1
206010056489 Coronary artery restenosis Diseases 0.000 claims 1
206010020880 Hypertrophy Diseases 0.000 claims 1
208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
208000006011 Stroke Diseases 0.000 claims 1
208000007814 Unstable Angina Diseases 0.000 claims 1
230000003872 anastomosis Effects 0.000 claims 1
201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
230000007774 longterm Effects 0.000 claims 1
201000004240 prostatic hypertrophy Diseases 0.000 claims 1
206010020718 hyperplasia Diseases 0.000 abstract description 40
208000007536 Thrombosis Diseases 0.000 abstract description 33
239000003814 drug Substances 0.000 abstract description 14
239000003112 inhibitor Substances 0.000 abstract description 6
208000024248 Vascular System injury Diseases 0.000 abstract description 4
208000012339 Vascular injury Diseases 0.000 abstract description 4
239000003860 topical agent Substances 0.000 abstract description 3
229920001184 polypeptide Polymers 0.000 abstract description 2
102000004196 processed proteins & peptides Human genes 0.000 abstract description 2
108090000765 processed proteins & peptides Proteins 0.000 abstract description 2
230000009805 platelet accumulation Effects 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 description 122
229920001436 collagen Polymers 0.000 description 77
102000008186 Collagen Human genes 0.000 description 75
108010035532 Collagen Proteins 0.000 description 75
241000700159 Rattus Species 0.000 description 45
210000001715 carotid artery Anatomy 0.000 description 30
210000001367 artery Anatomy 0.000 description 27
230000000694 effects Effects 0.000 description 21
238000011161 development Methods 0.000 description 20
241000282414 Homo sapiens Species 0.000 description 19
208000032843 Hemorrhage Diseases 0.000 description 18
208000034158 bleeding Diseases 0.000 description 18
230000000740 bleeding effect Effects 0.000 description 18
239000000017 hydrogel Substances 0.000 description 18
230000015572 biosynthetic process Effects 0.000 description 17
238000004220 aggregation Methods 0.000 description 16
230000002776 aggregation Effects 0.000 description 15
238000006073 displacement reaction Methods 0.000 description 14
239000000243 solution Substances 0.000 description 13
238000001356 surgical procedure Methods 0.000 description 13
230000009885 systemic effect Effects 0.000 description 13
230000004913 activation Effects 0.000 description 11
244000309466 calf Species 0.000 description 11
208000031481 Pathologic Constriction Diseases 0.000 description 10
210000004369 blood Anatomy 0.000 description 10
239000008280 blood Substances 0.000 description 10
238000006116 polymerization reaction Methods 0.000 description 10
208000037803 restenosis Diseases 0.000 description 10
230000036262 stenosis Effects 0.000 description 10
208000037804 stenosis Diseases 0.000 description 10
208000027418 Wounds and injury Diseases 0.000 description 9
208000014674 injury Diseases 0.000 description 9
239000000178 monomer Substances 0.000 description 9
230000002980 postoperative effect Effects 0.000 description 9
230000000699 topical effect Effects 0.000 description 9
210000002381 plasma Anatomy 0.000 description 8
208000010110 spontaneous platelet aggregation Diseases 0.000 description 8
102000012422 Collagen Type I Human genes 0.000 description 7
108010022452 Collagen Type I Proteins 0.000 description 7
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 7
241001465754 Metazoa Species 0.000 description 7
239000003795 chemical substances by application Substances 0.000 description 7
230000001419 dependent effect Effects 0.000 description 7
229940079593 drug Drugs 0.000 description 7
230000003993 interaction Effects 0.000 description 7
239000010410 layer Substances 0.000 description 7
239000011159 matrix material Substances 0.000 description 7
230000008569 process Effects 0.000 description 7
101150059172 AOR gene Proteins 0.000 description 6
238000004458 analytical method Methods 0.000 description 6
231100000673 dose–response relationship Toxicity 0.000 description 6
230000006870 function Effects 0.000 description 6
239000003999 initiator Substances 0.000 description 6
239000000126 substance Substances 0.000 description 6
230000001225 therapeutic effect Effects 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
102000009123 Fibrin Human genes 0.000 description 5
108010073385 Fibrin Proteins 0.000 description 5
239000000556 agonist Substances 0.000 description 5
230000003143 atherosclerotic effect Effects 0.000 description 5
230000001413 cellular effect Effects 0.000 description 5
239000000203 mixture Substances 0.000 description 5
230000010118 platelet activation Effects 0.000 description 5
230000002829 reductive effect Effects 0.000 description 5
238000002560 therapeutic procedure Methods 0.000 description 5
108010014258 Elastin Proteins 0.000 description 4
102000016942 Elastin Human genes 0.000 description 4
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 4
102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 4
108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 4
108090000190 Thrombin Proteins 0.000 description 4
239000003146 anticoagulant agent Substances 0.000 description 4
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 4
230000017531 blood circulation Effects 0.000 description 4
210000004027 cell Anatomy 0.000 description 4
230000015271 coagulation Effects 0.000 description 4
238000005345 coagulation Methods 0.000 description 4
229920002549 elastin Polymers 0.000 description 4
210000003743 erythrocyte Anatomy 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
229950003499 fibrin Drugs 0.000 description 4
230000023597 hemostasis Effects 0.000 description 4
239000000463 material Substances 0.000 description 4
230000007246 mechanism Effects 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
230000009467 reduction Effects 0.000 description 4
230000003068 static effect Effects 0.000 description 4
238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 4
229940124597 therapeutic agent Drugs 0.000 description 4
229960004072 thrombin Drugs 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
241000699800 Cricetinae Species 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
108010049003 Fibrinogen Proteins 0.000 description 3
102000008946 Fibrinogen Human genes 0.000 description 3
241000545744 Hirudinea Species 0.000 description 3
241000282898 Sus scrofa Species 0.000 description 3
229960004676 antithrombotic agent Drugs 0.000 description 3
230000008901 benefit Effects 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
229940096422 collagen type i Drugs 0.000 description 3
230000008021 deposition Effects 0.000 description 3
238000000635 electron micrograph Methods 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
239000000835 fiber Substances 0.000 description 3
229940012952 fibrinogen Drugs 0.000 description 3
239000008187 granular material Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
238000005259 measurement Methods 0.000 description 3
230000010412 perfusion Effects 0.000 description 3
239000002861 polymer material Substances 0.000 description 3
210000000329 smooth muscle myocyte Anatomy 0.000 description 3
238000007920 subcutaneous administration Methods 0.000 description 3
230000001732 thrombotic effect Effects 0.000 description 3
238000007631 vascular surgery Methods 0.000 description 3
IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
206010007688 Carotid artery thrombosis Diseases 0.000 description 2
102000000503 Collagen Type II Human genes 0.000 description 2
108010041390 Collagen Type II Proteins 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
239000004677 Nylon Substances 0.000 description 2
108010081391 Ristocetin Proteins 0.000 description 2
241000220317 Rosa Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
239000013543 active substance Substances 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
229940114079 arachidonic acid Drugs 0.000 description 2
235000021342 arachidonic acid Nutrition 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
239000000872 buffer Substances 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
108010051489 calin Proteins 0.000 description 2
230000036755 cellular response Effects 0.000 description 2
BGTFCAQCKWKTRL-YDEUACAXSA-N chembl1095986 Chemical compound C1[C@@H](N)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]([C@H]1C(N[C@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(C(=C(O)C=4)C)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@@H](C(=O)N3)[C@H](O)C=3C=CC(O4)=CC=3)C(=O)N1)C(O)=O)=O)C(C=C1)=CC=C1OC1=C(O[C@@H]3[C@H]([C@H](O)[C@@H](O)[C@H](CO[C@@H]5[C@H]([C@@H](O)[C@H](O)[C@@H](C)O5)O)O3)O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@@H]3[C@H]([C@H](O)[C@@H](CO)O3)O)C4=CC2=C1 BGTFCAQCKWKTRL-YDEUACAXSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
230000002596 correlated effect Effects 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000010494 dissociation reaction Methods 0.000 description 2
230000005593 dissociations Effects 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000004520 electroporation Methods 0.000 description 2
230000010102 embolization Effects 0.000 description 2
210000002889 endothelial cell Anatomy 0.000 description 2
239000012467 final product Substances 0.000 description 2
239000012530 fluid Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
230000009931 harmful effect Effects 0.000 description 2
235000012907 honey Nutrition 0.000 description 2
238000002513 implantation Methods 0.000 description 2
230000006872 improvement Effects 0.000 description 2
230000006698 induction Effects 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
238000001802 infusion Methods 0.000 description 2
230000003902 lesion Effects 0.000 description 2
230000001404 mediated effect Effects 0.000 description 2
230000002297 mitogenic effect Effects 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
230000001453 nonthrombogenic effect Effects 0.000 description 2
229920001778 nylon Polymers 0.000 description 2
239000002674 ointment Substances 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
210000004623 platelet-rich plasma Anatomy 0.000 description 2
239000003505 polymerization initiator Substances 0.000 description 2
239000011148 porous material Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
230000035755 proliferation Effects 0.000 description 2
150000003254 radicals Chemical class 0.000 description 2
102000005962 receptors Human genes 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
230000004044 response Effects 0.000 description 2
229950004257 ristocetin Drugs 0.000 description 2
238000004626 scanning electron microscopy Methods 0.000 description 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
239000002356 single layer Substances 0.000 description 2
239000007787 solid Substances 0.000 description 2
230000003637 steroidlike Effects 0.000 description 2
238000011477 surgical intervention Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
230000000451 tissue damage Effects 0.000 description 2
231100000827 tissue damage Toxicity 0.000 description 2
229960000187 tissue plasminogen activator Drugs 0.000 description 2
238000004448 titration Methods 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
230000002792 vascular Effects 0.000 description 2
230000003966 vascular damage Effects 0.000 description 2
238000012800 visualization Methods 0.000 description 2
QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 1
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
JPWITCRJVNDZOC-UHFFFAOYSA-N 2-cyano-5-methylhex-2-enoic acid Chemical class CC(C)CC=C(C#N)C(O)=O JPWITCRJVNDZOC-UHFFFAOYSA-N 0.000 description 1
OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 description 1
GWZMWHWAWHPNHN-UHFFFAOYSA-N 2-hydroxypropyl prop-2-enoate Chemical compound CC(O)COC(=O)C=C GWZMWHWAWHPNHN-UHFFFAOYSA-N 0.000 description 1
FQRHOOHLUYHMGG-BTJKTKAUSA-N 3-(2-acetylphenothiazin-10-yl)propyl-dimethylazanium;(z)-4-hydroxy-4-oxobut-2-enoate Chemical compound OC(=O)\C=C/C(O)=O.C1=C(C(C)=O)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 FQRHOOHLUYHMGG-BTJKTKAUSA-N 0.000 description 1
YCIGYTFKOXGYTA-UHFFFAOYSA-N 4-(3-cyanopropyldiazenyl)butanenitrile Chemical compound N#CCCCN=NCCCC#N YCIGYTFKOXGYTA-UHFFFAOYSA-N 0.000 description 1
DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
208000004476 Acute Coronary Syndrome Diseases 0.000 description 1
208000000230 African Trypanosomiasis Diseases 0.000 description 1
240000006054 Agastache cana Species 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
108010058207 Anistreplase Proteins 0.000 description 1
101710185725 Anti-platelet protein Proteins 0.000 description 1
206010003178 Arterial thrombosis Diseases 0.000 description 1
206010003210 Arteriosclerosis Diseases 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229940127291 Calcium channel antagonist Drugs 0.000 description 1
208000032544 Cicatrix Diseases 0.000 description 1
102100032392 Circadian-associated transcriptional repressor Human genes 0.000 description 1
101710130150 Circadian-associated transcriptional repressor Proteins 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
102000009268 Collagen Receptors Human genes 0.000 description 1
108010048623 Collagen Receptors Proteins 0.000 description 1
241000573484 Copsychus Species 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
229920001651 Cyanoacrylate Polymers 0.000 description 1
102000004127 Cytokines Human genes 0.000 description 1
108090000695 Cytokines Proteins 0.000 description 1
208000005189 Embolism Diseases 0.000 description 1
101800003838 Epidermal growth factor Proteins 0.000 description 1
102400001368 Epidermal growth factor Human genes 0.000 description 1
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
235000010650 Hyssopus officinalis Nutrition 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
208000005168 Intussusception Diseases 0.000 description 1
PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 description 1
JRLGPAXAGHMNOL-LURJTMIESA-N N(2)-acetyl-L-ornithine Chemical compound CC(=O)N[C@H](C([O-])=O)CCC[NH3+] JRLGPAXAGHMNOL-LURJTMIESA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241000282520 Papio Species 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920000954 Polyglycolide Polymers 0.000 description 1
229920001710 Polyorthoester Polymers 0.000 description 1
206010050902 Postoperative thrombosis Diseases 0.000 description 1
102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
206010037742 Rabies Diseases 0.000 description 1
230000010799 Receptor Interactions Effects 0.000 description 1
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
108010023197 Streptokinase Proteins 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
206010072810 Vascular wall hypertrophy Diseases 0.000 description 1
206010047249 Venous thrombosis Diseases 0.000 description 1
JUIBLDFFVYKUAC-UHFFFAOYSA-N [5-(2-ethylhexanoylperoxy)-2,5-dimethylhexan-2-yl] 2-ethylhexaneperoxoate Chemical compound CCCCC(CC)C(=O)OOC(C)(C)CCC(C)(C)OOC(=O)C(CC)CCCC JUIBLDFFVYKUAC-UHFFFAOYSA-N 0.000 description 1
210000000683 abdominal cavity Anatomy 0.000 description 1
229960001946 acepromazine maleate Drugs 0.000 description 1
239000008351 acetate buffer Substances 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
230000009471 action Effects 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000005250 alkyl acrylate group Chemical group 0.000 description 1
239000002168 alkylating agent Substances 0.000 description 1
229940100198 alkylating agent Drugs 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000002744 anti-aggregatory effect Effects 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
230000001028 anti-proliverative effect Effects 0.000 description 1
230000002965 anti-thrombogenic effect Effects 0.000 description 1
230000002785 anti-thrombosis Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
229940127218 antiplatelet drug Drugs 0.000 description 1
229940127217 antithrombotic drug Drugs 0.000 description 1
210000000709 aorta Anatomy 0.000 description 1
208000011775 arteriosclerosis disease Diseases 0.000 description 1
230000001588 bifunctional effect Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
229920000249 biocompatible polymer Polymers 0.000 description 1
229920002988 biodegradable polymer Polymers 0.000 description 1
239000004621 biodegradable polymer Substances 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
208000015294 blood coagulation disease Diseases 0.000 description 1
238000006664 bond formation reaction Methods 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
DTGWMJJKPLJKQD-UHFFFAOYSA-N butyl 2,2-dimethylpropaneperoxoate Chemical group CCCCOOC(=O)C(C)(C)C DTGWMJJKPLJKQD-UHFFFAOYSA-N 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
239000000480 calcium channel blocker Substances 0.000 description 1
150000007942 carboxylates Chemical class 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
210000000748 cardiovascular system Anatomy 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
230000010307 cell transformation Effects 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
238000012412 chemical coupling Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
230000035605 chemotaxis Effects 0.000 description 1
238000000546 chi-square test Methods 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
229960001338 colchicine Drugs 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
210000004351 coronary vessel Anatomy 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical class C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 description 1
OIWOHHBRDFKZNC-UHFFFAOYSA-N cyclohexyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1CCCCC1 OIWOHHBRDFKZNC-UHFFFAOYSA-N 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
229920006237 degradable polymer Polymers 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
230000010339 dilation Effects 0.000 description 1
238000002224 dissection Methods 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
238000009556 duplex ultrasonography Methods 0.000 description 1
238000013156 embolectomy Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000003511 endothelial effect Effects 0.000 description 1
229940116977 epidermal growth factor Drugs 0.000 description 1
229960001123 epoprostenol Drugs 0.000 description 1
KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 1
STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
210000002744 extracellular matrix Anatomy 0.000 description 1
239000004744 fabric Substances 0.000 description 1
108010078346 fibrin destabilase Proteins 0.000 description 1
239000003527 fibrinolytic agent Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
BBKFSSMUWOMYPI-UHFFFAOYSA-N gold palladium Chemical compound [Pd].[Au] BBKFSSMUWOMYPI-UHFFFAOYSA-N 0.000 description 1
230000035876 healing Effects 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
UMGLBHQOFQXXSI-UHFFFAOYSA-N hepta-2,5-dienedioic acid Chemical compound OC(=O)C=CCC=CC(O)=O UMGLBHQOFQXXSI-UHFFFAOYSA-N 0.000 description 1
210000000548 hind-foot Anatomy 0.000 description 1
208000029080 human African trypanosomiasis Diseases 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
-1 hydroxyalkyl acrylate Chemical compound 0.000 description 1
238000010191 image analysis Methods 0.000 description 1
238000007654 immersion Methods 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
239000000138 intercalating agent Substances 0.000 description 1
229940047122 interleukins Drugs 0.000 description 1
230000007794 irritation Effects 0.000 description 1
229960002725 isoflurane Drugs 0.000 description 1
108010076401 isopeptidase Proteins 0.000 description 1
210000004731 jugular vein Anatomy 0.000 description 1
229960003299 ketamine Drugs 0.000 description 1
230000031700 light absorption Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000003055 low molecular weight heparin Substances 0.000 description 1
229940127215 low-molecular weight heparin Drugs 0.000 description 1
239000012528 membrane Substances 0.000 description 1
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
125000005395 methacrylic acid group Chemical group 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
238000007491 morphometric analysis Methods 0.000 description 1
210000000651 myofibroblast Anatomy 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
238000000399 optical microscopy Methods 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000008816 organ damage Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229910000489 osmium tetroxide Inorganic materials 0.000 description 1
239000012285 osmium tetroxide Substances 0.000 description 1
238000010979 pH adjustment Methods 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
238000002161 passivation Methods 0.000 description 1
230000001991 pathophysiological effect Effects 0.000 description 1
230000007310 pathophysiology Effects 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000008055 phosphate buffer solution Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000000106 platelet aggregation inhibitor Substances 0.000 description 1
229920002721 polycyanoacrylate Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
238000010837 poor prognosis Methods 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000006916 protein interaction Effects 0.000 description 1
238000004445 quantitative analysis Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000011552 rat model Methods 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000004153 renaturation Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
150000003873 salicylate salts Chemical class 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000037387 scars Effects 0.000 description 1
238000013391 scatchard analysis Methods 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
201000002612 sleeping sickness Diseases 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
230000015590 smooth muscle cell migration Effects 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
241000894007 species Species 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
238000010025 steaming Methods 0.000 description 1
229960005202 streptokinase Drugs 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229920003051 synthetic elastomer Polymers 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000002885 thrombogenetic effect Effects 0.000 description 1
229960000103 thrombolytic agent Drugs 0.000 description 1
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
150000003595 thromboxanes Chemical class 0.000 description 1
238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1
230000006442 vascular tone Effects 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
230000003313 weakening effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Peptides Or Proteins (AREA)
Media Introduction/Drainage Providing Device (AREA)

UA2003032476A 2000-08-25 2001-08-23 Use of saratin for inhibition platelet adhesion UA77402C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00118542		2000-08-25
PCT/EP2001/009746 WO2002015919A2 (en)	2000-08-25	2001-08-23	Saratin for inhibiting platelet adhesion to collagen

Publications (1)

Publication Number	Publication Date
UA77402C2 true UA77402C2 (en)	2006-12-15

Family

ID=8169664

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003032476A UA77402C2 (en)	2000-08-25	2001-08-23	Use of saratin for inhibition platelet adhesion

Country Status (26)

Country	Link
US (2)	US6881722B2 (de)
EP (1)	EP1311284B1 (de)
JP (1)	JP4988131B2 (de)
KR (1)	KR100794277B1 (de)
CN (1)	CN1224421C (de)
AR (1)	AR030492A1 (de)
AT (1)	ATE285246T1 (de)
AU (2)	AU9550601A (de)
BR (1)	BR0113478A (de)
CA (1)	CA2419385C (de)
CZ (1)	CZ302353B6 (de)
DE (1)	DE60107962T2 (de)
DK (1)	DK1311284T3 (de)
EC (1)	ECSP034485A (de)
ES (1)	ES2234896T3 (de)
HU (1)	HU229367B1 (de)
MX (1)	MXPA03001604A (de)
MY (1)	MY128992A (de)
NO (1)	NO331326B1 (de)
PT (1)	PT1311284E (de)
RU (1)	RU2302880C2 (de)
SI (1)	SI1311284T1 (de)
SK (1)	SK287829B6 (de)
UA (1)	UA77402C2 (de)
WO (1)	WO2002015919A2 (de)
ZA (1)	ZA200302296B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA01009363A (es) *	1999-03-18	2002-06-04	Merck Patent Gmbh	Proteina para bloquear la adhesion de plaquetas.
NZ540194A (en)	2002-11-08	2008-07-31	Ablynx Nv	Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
JP2009510105A (ja) *	2005-09-28	2009-03-12	バイオバスキュラーインコーポレーティッド	血小板および細胞の接着、細胞移動、および炎症を阻止するための方法および組成物
US20110034396A1 (en) *	2005-09-28	2011-02-10	Biovascular, Inc.	Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20080069774A1 (en) *	2005-11-17	2008-03-20	Lance Liotta	Proteomic antisense molecular shield and targeting
EP3846867B1 (de) *	2018-09-06	2025-02-19	Biomodics APS	Medizinische rohrförmige vorrichtung
CN117229423B (zh) *	2023-11-10	2024-02-06	北京科技大学	一种用于结合胶原的多肽纳米材料及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3947401A (en) *	1971-10-05	1976-03-30	Union Optics Corporation	Hydrogels of unsaturated ester copolymers
US5705355A (en)	1984-03-27	1998-01-06	Transgene, S.A.	Hirudin, pharmaceutical compositions comprising it and their use
US4879135A (en) *	1984-07-23	1989-11-07	University Of Medicine And Dentistry Of New Jersey	Drug bonded prosthesis and process for producing same
US4898734A (en) *	1988-02-29	1990-02-06	Massachusetts Institute Of Technology	Polymer composite for controlled release or membrane formation
IL86857A (en) *	1988-06-24	1994-04-12	Yissum Res Dev Co	Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5304121A (en) *	1990-12-28	1994-04-19	Boston Scientific Corporation	Drug delivery system making use of a hydrogel polymer coating
CA2052486A1 (en) *	1990-10-09	1992-04-10	Thomas M. Connolly	Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) *	1990-10-10	1990-11-21	Biopharm Ltd	Platelet adhesion inhibitor
US5179082A (en) *	1990-11-13	1993-01-12	Merck & Co., Inc.	Method for blocking platelet adhesion to collagen
CA2117174A1 (en) *	1991-09-05	1993-03-18	Schering Aktiengesellschaft	Collagen-induced platelet aggregation inhibitor
DE4136513A1 (de)	1991-11-06	1993-05-13	Basf Ag	Neues thrombininhibitorisches protein aus raubwanzen
HU214580B (hu) *	1993-07-01	1998-04-28	Merck Patent Gmbh	Kollagén által stimulált vérlemezke-aggregációt gátló protein, eljárás ennek előállítására, és ezt tartalmazó gyógyászati készítmény
AU7476894A (en) *	1993-07-29	1995-02-28	Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The	Method of treating atherosclerosis or restenosis using microtubule stabilizing agent
US5532287A (en) *	1994-05-04	1996-07-02	Ciba-Geigy Corporation	Radiation cured drug release controlling membrane
US5767108A (en) *	1995-08-22	1998-06-16	Medtronic, Inc.	Method for making improved heparinized biomaterials
US6246715B1 (en) *	1998-06-26	2001-06-12	Samsung Electronics Co., Ltd.	Data transmitter and receiver of a DS-CDMA communication system
US5843172A (en) *	1997-04-15	1998-12-01	Advanced Cardiovascular Systems, Inc.	Porous medicated stent
IL142539A0 (en) *	1998-10-16	2002-03-10	Immunex Corp	Inhibitors of platelet activation and recruitment
IT1304135B1 (it) *	1998-11-26	2001-03-07	Magneti Marelli Spa	Metodo di controllo dell' iniezione e dell' accensione in un motoreendotermico ad iniezione diretta per accelerare il riscaldamento del
AU772103B2 (en) *	1999-02-19	2004-04-08	Zymogenetics Inc.	Inhibitors for use in hemostasis and immune function
MXPA01009363A (es)	1999-03-18	2002-06-04	Merck Patent Gmbh	Proteina para bloquear la adhesion de plaquetas.

2001
- 2001-08-22 MY MYPI20013935A patent/MY128992A/en unknown
- 2001-08-23 AU AU9550601A patent/AU9550601A/xx active Pending
- 2001-08-23 AT AT01976139T patent/ATE285246T1/de active
- 2001-08-23 BR BR0113478-7A patent/BR0113478A/pt not_active Application Discontinuation
- 2001-08-23 PT PT01976139T patent/PT1311284E/pt unknown
- 2001-08-23 US US10/362,476 patent/US6881722B2/en not_active Expired - Fee Related
- 2001-08-23 JP JP2002520840A patent/JP4988131B2/ja not_active Expired - Fee Related
- 2001-08-23 SI SI200130310T patent/SI1311284T1/xx unknown
- 2001-08-23 ES ES01976139T patent/ES2234896T3/es not_active Expired - Lifetime
- 2001-08-23 DE DE60107962T patent/DE60107962T2/de not_active Expired - Lifetime
- 2001-08-23 DK DK01976139T patent/DK1311284T3/da active
- 2001-08-23 WO PCT/EP2001/009746 patent/WO2002015919A2/en not_active Ceased
- 2001-08-23 CN CNB018146600A patent/CN1224421C/zh not_active Expired - Fee Related
- 2001-08-23 UA UA2003032476A patent/UA77402C2/uk unknown
- 2001-08-23 SK SK313-2003A patent/SK287829B6/sk not_active IP Right Cessation
- 2001-08-23 CZ CZ20030720A patent/CZ302353B6/cs not_active IP Right Cessation
- 2001-08-23 AU AU2001295506A patent/AU2001295506B2/en not_active Ceased
- 2001-08-23 HU HU0303747A patent/HU229367B1/hu not_active IP Right Cessation
- 2001-08-23 RU RU2003107919/15A patent/RU2302880C2/ru not_active IP Right Cessation
- 2001-08-23 KR KR1020037002188A patent/KR100794277B1/ko not_active Expired - Fee Related
- 2001-08-23 EP EP01976139A patent/EP1311284B1/de not_active Expired - Lifetime
- 2001-08-23 MX MXPA03001604A patent/MXPA03001604A/es active IP Right Grant
- 2001-08-23 CA CA2419385A patent/CA2419385C/en not_active Expired - Fee Related
- 2001-08-27 AR ARP010104073A patent/AR030492A1/es not_active Application Discontinuation
2003
- 2003-02-21 EC EC2003004485A patent/ECSP034485A/es unknown
- 2003-02-24 NO NO20030841A patent/NO331326B1/no not_active IP Right Cessation
- 2003-03-24 ZA ZA200302296A patent/ZA200302296B/en unknown
2004
- 2004-12-21 US US11/016,854 patent/US7459438B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ZA200302296B (en)	2004-06-30
ATE285246T1 (de)	2005-01-15
RU2302880C2 (ru)	2007-07-20
AR030492A1 (es)	2003-08-20
SK287829B6 (sk)	2011-11-04
PT1311284E (pt)	2005-05-31
SI1311284T1 (de)	2005-08-31
NO20030841D0 (no)	2003-02-24
SK3132003A3 (en)	2003-08-05
ES2234896T3 (es)	2005-07-01
DK1311284T3 (da)	2005-04-18
DE60107962D1 (de)	2005-01-27
ECSP034485A (es)	2003-03-31
DE60107962T2 (de)	2005-12-15
US20030190342A1 (en)	2003-10-09
CN1449291A (zh)	2003-10-15
AU2001295506B2 (en)	2007-02-15
HK1059736A1 (en)	2004-07-16
HU229367B1 (en)	2013-11-28
JP4988131B2 (ja)	2012-08-01
WO2002015919A3 (en)	2002-05-30
PL359246A1 (en)	2004-08-23
US7459438B2 (en)	2008-12-02
BR0113478A (pt)	2003-07-15
JP2004506690A (ja)	2004-03-04
EP1311284A2 (de)	2003-05-21
CA2419385C (en)	2011-05-10
CZ302353B6 (cs)	2011-03-30
CA2419385A1 (en)	2002-02-28
NO20030841L (no)	2003-02-24
NO331326B1 (no)	2011-11-28
WO2002015919A2 (en)	2002-02-28
CN1224421C (zh)	2005-10-26
US20050143305A1 (en)	2005-06-30
KR100794277B1 (ko)	2008-01-11
US6881722B2 (en)	2005-04-19
MY128992A (en)	2007-03-30
CZ2003720A3 (cs)	2003-06-18
HUP0303747A3 (en)	2006-01-30
MXPA03001604A (es)	2003-06-04
HUP0303747A2 (hu)	2004-03-01
EP1311284B1 (de)	2004-12-22
KR20030034141A (ko)	2003-05-01
AU9550601A (en)	2002-03-04

Publication	Publication Date	Title
US11938250B2 (en)	2024-03-26	Article coatings including oligomerized polyphenol layer and biological methods of use
JP2007532197A (ja)	2007-11-15	生物活性物質のための被覆組成物
US20120277852A1 (en)	2012-11-01	Coating compositions, methods and coated devices
JP2005036007A (ja)	2005-02-10	トロンビン由来ペプチドを使用した治療法
JP2018198954A (ja)	2018-12-20	改良医療デバイス
KR19980703832A (ko)	1998-12-05	혈류내 또는 사람 체조직내로 삽입가능한 생체물질용 피복물
Weisel et al.	2025	Exploring the thrombus niche: lessons learned and potential therapeutic opportunities
Natesan et al.	2019	PEGylated platelet-free blood plasma-based hydrogels for full-thickness wound regeneration
JP2019511468A (ja)	2019-04-25	慢性創傷を治療するための組成物及び方法
RU2302880C2 (ru)	2007-07-20	Новый специфический механизм ингибирования адгезии тромбоцитов к коллагену
Bonatti et al.	2005	Neointimal hyperplasia in coronary vein grafts: pathophysiology and prevention of a significant clinical problem
Applewhite et al.	2023	Periadventitial β-aminopropionitrile-loaded nanofibers reduce fibrosis and improve arteriovenous fistula remodeling in rats
AU2001295506A1 (en)	2002-05-30	Saratin for inhibiting platelet adhesion to collagen
RU2702239C1 (ru)	2019-10-07	Технология изготовления функционально активных биодеградируемых сосудистых протезов малого диаметра с лекарственным покрытием
JP2004506690A5 (de)	2008-10-09
RU2835436C1 (ru)	2025-02-25	Способ изготовления функционально активной полимерной заплаты для артериальной реконструкции, устойчивой к аневризмообразованию
HK1059736B (en)	2006-07-21	A new specific mechanism for inhibiting platelet adhesion to collagen
JP2002501789A (ja)	2002-01-22	医療用インプラントのための生体適合性を増強したコーティング
Herbert	1996	Neurite growth from chick dorsal root ganglia entrapped within three-dimensional fibrin gels mixed with copolymers of poly (acrylic acid) and bioactive peptides