UA78523C2 - 4,5-dihydro-1h-pyrazoie derivatives as cb1 antagonists - Google Patents
4,5-dihydro-1h-pyrazoie derivatives as cb1 antagonists Download PDFInfo
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- UA78523C2 UA78523C2 UA20040402982A UA20040402982A UA78523C2 UA 78523 C2 UA78523 C2 UA 78523C2 UA 20040402982 A UA20040402982 A UA 20040402982A UA 20040402982 A UA20040402982 A UA 20040402982A UA 78523 C2 UA78523 C2 UA 78523C2
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- group
- alkyl
- disorders
- phenyl
- dihydro
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- 229940124802 CB1 antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 51
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 8
- 201000010099 disease Diseases 0.000 claims abstract description 7
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- -1 trifluoromethoxy, nitro, amino Chemical group 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 125000001544 thienyl group Chemical group 0.000 claims description 9
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 4
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- QMHAHUAQAJVBIW-UHFFFAOYSA-N [methyl(sulfamoyl)amino]methane Chemical compound CN(C)S(N)(=O)=O QMHAHUAQAJVBIW-UHFFFAOYSA-N 0.000 claims description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203850 | 2001-09-21 | ||
| PCT/EP2002/010433 WO2003026647A1 (en) | 2001-09-21 | 2002-09-17 | Novel 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA78523C2 true UA78523C2 (en) | 2007-04-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| UA20040402982A UA78523C2 (en) | 2001-09-21 | 2002-09-17 | 4,5-dihydro-1h-pyrazoie derivatives as cb1 antagonists |
Country Status (25)
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|---|---|
| US (1) | US7528162B2 (de) |
| EP (1) | EP1429761B1 (de) |
| JP (1) | JP4313671B2 (de) |
| KR (1) | KR100903760B1 (de) |
| CN (2) | CN101659639A (de) |
| AR (1) | AR036596A1 (de) |
| AT (1) | ATE344663T1 (de) |
| AU (1) | AU2002333852B2 (de) |
| BR (1) | BR0212044A (de) |
| CA (1) | CA2456606C (de) |
| DE (1) | DE60215960T2 (de) |
| DK (1) | DK1429761T3 (de) |
| ES (1) | ES2272809T3 (de) |
| HR (1) | HRP20040085A2 (de) |
| HU (1) | HUP0401567A3 (de) |
| IL (2) | IL160081A0 (de) |
| MX (1) | MXPA04002583A (de) |
| NO (1) | NO20041176L (de) |
| PL (1) | PL368441A1 (de) |
| PT (1) | PT1429761E (de) |
| RU (1) | RU2299199C2 (de) |
| SI (1) | SI1429761T1 (de) |
| UA (1) | UA78523C2 (de) |
| WO (1) | WO2003026647A1 (de) |
| ZA (1) | ZA200402099B (de) |
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| JP3813152B2 (ja) | 2002-03-12 | 2006-08-23 | メルク エンド カムパニー インコーポレーテッド | 置換アミド類 |
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| US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
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| HRP20080549T3 (en) * | 2004-01-30 | 2008-11-30 | Solvay Pharmaceuticals B.V. | 1,3,5-trisubstituted 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity |
| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
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| AR047613A1 (es) * | 2004-02-19 | 2006-01-25 | Solvay Pharm Bv | Derivados de imidazolina que tienen actividad antagonista cb1 |
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| TW200602314A (en) | 2004-05-28 | 2006-01-16 | Tanabe Seiyaku Co | A novel pyrrolidine compound and a process for preparing the same |
| EP2343302A1 (de) | 2004-07-12 | 2011-07-13 | Cadila Healthcare Limited | Tricyclische pyrazolderivate als cannabinoid- rezeptor modulatoren |
| US20060025448A1 (en) | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
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| JP2008517976A (ja) | 2004-10-25 | 2008-05-29 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ１カンナビノイド受容体拮抗薬及びカリウムチャンネルオープナーから成る、真性糖尿病１型、肥満及び関連症状の治療用の医薬組成物 |
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| ES2326460B1 (es) * | 2005-07-15 | 2010-04-19 | Laboratorios Del Dr. Esteve, S.A. | Sales de amonio cuaternario de compuestos de pirazolina sustituidos, su preparacion y uso como medicamentos. |
| EP1743890A1 (de) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-Pyrazol-Derivative, Verfahren zur Herstellung und ihre Verwendung als Medikamente. |
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| EP1749821A1 (de) * | 2005-07-15 | 2007-02-07 | Laboratorios Del Dr. Esteve, S.A. | Salze von substituierten Pyrazolin Derivaten, ihre Herstellung und Anwendung als Arzneimittel |
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