UA79276C2 - 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof - Google Patents

1-oxa-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof Download PDF

Info

Publication number: UA79276C2
Authority: UA; Ukraine
Prior art keywords: azadibenzo; formula; compounds; oxa; thia
Prior art date: 2002-04-10

Application number

UA20041008545A

Other languages

English (en)

Ukrainian (uk)

Inventor

Mladen Mercep

Milan Mesic

Dijana Pesic

Iva Benko

Original Assignee

Pliva Istrazivacki Inst D O O

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-10

Filing date

2003-09-04

Publication date

2007-06-11

2003-09-04 Application filed by Pliva Istrazivacki Inst D O O filed Critical Pliva Istrazivacki Inst D O O

2007-06-11 Publication of UA79276C2 publication Critical patent/UA79276C2/uk

Links

238000004519 manufacturing process Methods 0.000 title claims abstract description 20
239000003112 inhibitor Substances 0.000 title claims description 8
239000000543 intermediate Substances 0.000 title abstract description 5
TYGCUCNYUAIZNG-UHFFFAOYSA-N 5-oxa-3-azatetracyclo[12.4.0.02,6.08,13]octadeca-1(18),2,6,8,10,12,14,16-octaene Chemical class O1CN=C2C3=C(C4=C(C=C12)C=CC=C4)C=CC=C3 TYGCUCNYUAIZNG-UHFFFAOYSA-N 0.000 title abstract 2
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230000003637 steroidlike Effects 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
125000005017 substituted alkenyl group Chemical group 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
229960002317 succinimide Drugs 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 description 1
229960003676 tenidap Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000007970 thio esters Chemical class 0.000 description 1
230000009466 transformation Effects 0.000 description 1
125000004306 triazinyl group Chemical group 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Toxicology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

UA20041008545A 2002-04-10 2003-09-04 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof UA79276C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HR20020304A HRP20020304B1 (en)	2002-04-10	2002-04-10	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
PCT/HR2003/000015 WO2003084964A1 (en)	2002-04-10	2003-04-09	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof

Publications (1)

Publication Number	Publication Date
UA79276C2 true UA79276C2 (en)	2007-06-11

Family

ID=28686902

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20041008545A UA79276C2 (en)	2002-04-10	2003-09-04	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof

Country Status (23)

Country	Link
US (1)	US7232815B2 (pl)
EP (1)	EP1492797B1 (pl)
JP (1)	JP2005529867A (pl)
CN (1)	CN1649878A (pl)
AT (1)	ATE320434T1 (pl)
AU (1)	AU2003259960A1 (pl)
BR (1)	BR0309101A (pl)
CA (1)	CA2481463A1 (pl)
DE (1)	DE60304047T2 (pl)
DK (1)	DK1492797T3 (pl)
ES (1)	ES2260636T3 (pl)
HR (1)	HRP20020304B1 (pl)
IL (1)	IL164397A0 (pl)
IS (1)	IS7473A (pl)
MX (1)	MXPA04009944A (pl)
NO (1)	NO20044507L (pl)
NZ (1)	NZ535621A (pl)
PL (1)	PL372456A1 (pl)
PT (1)	PT1492797E (pl)
RU (1)	RU2323222C2 (pl)
UA (1)	UA79276C2 (pl)
WO (1)	WO2003084964A1 (pl)
YU (1)	YU88204A (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020304B1 (en) *	2002-04-10	2008-04-30	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
DE10256416A1 (de) *	2002-12-02	2004-06-09	Basf Ag	Feste Pigmentzubereitungen, enthaltend Pigmentderivate und oberflächenaktive Additive
HRP20030959A2 (pl) *	2003-11-21	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.
EP1844053A2 (en) *	2005-01-13	2007-10-17	GlaxoSmithKline istrazivacki centar Zagreb d.o.o.	Anti-inflammatory macrolide conjugates

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3745167A (en) *	1968-03-19	1973-07-10	Hoffmann La Roche	3a,12b-dihydro-8h-dibenzo(3,4,6,7)cyclohept(1,2,-)oxazol-8-ones and processes for their preparation
JPS458611Y1 (pl)	1969-08-18	1970-04-22
GB1340637A (en) *	1971-02-05	1973-12-12	Richardson Merrell Spa	Dibenzocycloheptadioxolan derivatives
US3711489A (en) *	1971-03-31	1973-01-16	Pfizer	Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
CA967573A (en)	1972-12-22	1975-05-13	Joseph G. Lombardino	Tetracyclic anti-inflammatory agents
US4198421A (en) *	1978-11-30	1980-04-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
RU2161159C2 (ru) *	1994-11-02	2000-12-27	Жансен Фармасетика Н.В.	Замещенные тетрациклические производные оксазепина и тиазепина, способ их получения, композиция, обладающая антипсихотической активностью, и способ ее получения
HRP20000310A2 (en)	2000-05-17	2002-02-28	Pliva Farmaceutska Ind Dioniko	New dibenzoazulene compounds as tumor necrosis factor inhibitors
HRP20020304B1 (en) *	2002-04-10	2008-04-30	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
HRP20020305A8 (en) *	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
US20050131056A1 (en) *	2002-04-10	2005-06-16	Pliva-Istrazivacki Institut D.O.O.	2- thia-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HRP20020303B8 (en) *	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) *	2002-05-21	2003-12-31	Pliva D D	1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020440B1 (en) *	2002-05-21	2008-02-29	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HRP20020451A2 (en) *	2002-05-23	2003-12-31	Pliva D D	1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20020453A2 (en) *	2002-05-23	2003-12-31	Pliva D D	1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) *	2003-03-06	2005-04-30	Pliva-Istra�iva�ki institut d.o.o.	1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS

2002
- 2002-04-10 HR HR20020304A patent/HRP20020304B1/xx not_active IP Right Cessation
2003
- 2003-04-09 BR BR0309101-5A patent/BR0309101A/pt not_active IP Right Cessation
- 2003-04-09 RU RU2004132867/04A patent/RU2323222C2/ru not_active IP Right Cessation
- 2003-04-09 AT AT03745848T patent/ATE320434T1/de not_active IP Right Cessation
- 2003-04-09 JP JP2003582161A patent/JP2005529867A/ja active Pending
- 2003-04-09 PT PT03745848T patent/PT1492797E/pt unknown
- 2003-04-09 DK DK03745848T patent/DK1492797T3/da active
- 2003-04-09 CN CNA038096382A patent/CN1649878A/zh active Pending
- 2003-04-09 AU AU2003259960A patent/AU2003259960A1/en not_active Abandoned
- 2003-04-09 US US10/510,620 patent/US7232815B2/en not_active Expired - Fee Related
- 2003-04-09 YU YU88204A patent/YU88204A/sh unknown
- 2003-04-09 ES ES03745848T patent/ES2260636T3/es not_active Expired - Lifetime
- 2003-04-09 DE DE60304047T patent/DE60304047T2/de not_active Expired - Fee Related
- 2003-04-09 WO PCT/HR2003/000015 patent/WO2003084964A1/en not_active Ceased
- 2003-04-09 PL PL03372456A patent/PL372456A1/pl not_active Application Discontinuation
- 2003-04-09 NZ NZ535621A patent/NZ535621A/xx unknown
- 2003-04-09 IL IL16439703A patent/IL164397A0/xx unknown
- 2003-04-09 MX MXPA04009944A patent/MXPA04009944A/es active IP Right Grant
- 2003-04-09 EP EP03745848A patent/EP1492797B1/en not_active Expired - Lifetime
- 2003-04-09 CA CA002481463A patent/CA2481463A1/en not_active Abandoned
- 2003-09-04 UA UA20041008545A patent/UA79276C2/uk unknown
2004
- 2004-09-27 IS IS7473A patent/IS7473A/is unknown
- 2004-10-21 NO NO20044507A patent/NO20044507L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR0309101A (pt)	2005-02-09
EP1492797A1 (en)	2005-01-05
NZ535621A (en)	2006-03-31
DE60304047T2 (de)	2006-11-09
DK1492797T3 (da)	2006-07-17
WO2003084964A1 (en)	2003-10-16
US7232815B2 (en)	2007-06-19
CA2481463A1 (en)	2003-10-16
HRP20020304B1 (en)	2008-04-30
PL372456A1 (pl)	2005-07-25
PT1492797E (pt)	2006-07-31
ATE320434T1 (de)	2006-04-15
CN1649878A (zh)	2005-08-03
DE60304047D1 (de)	2006-05-11
ES2260636T3 (es)	2006-11-01
US20050148576A1 (en)	2005-07-07
RU2323222C2 (ru)	2008-04-27
EP1492797B1 (en)	2006-03-15
NO20044507L (no)	2004-11-09
AU2003259960A1 (en)	2003-10-20
JP2005529867A (ja)	2005-10-06
HRP20020304A2 (en)	2004-06-30
MXPA04009944A (es)	2005-09-30
IL164397A0 (en)	2005-12-18
IS7473A (is)	2004-09-27
YU88204A (sh)	2006-08-17
RU2004132867A (ru)	2005-05-10

Publication	Publication Date	Title
UA79276C2 (en)	2007-06-11	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof
JP2005534637A (ja)	2005-11-17	腫瘍壊死因子産生の阻害剤として１−アザ−ジベンゾアズレン及びその製造用中間体
EP1492795B1 (en)	2005-11-16	1- or 3-thia-benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
CN1315838C (zh)	2007-05-16	作为肿瘤坏死因子产生的抑制剂的1－氧杂－二苯并薁类和制备该类化合物的中间体
JP2005531586A (ja)	2005-10-20	腫瘍壊死因子産生の阻害剤としての１，３−ジアザ−ジベンゾアズレン類及びその製造用中間体
EP1509530B1 (en)	2006-03-15	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
RS100004A (sr)	2006-10-27	1-tia-3-aza-dibenzoazuleni kao inhibitori stvaranja faktora tumorske nekroze i međuproizvodi za njihovo pripremanje
US7550498B2 (en)	2009-06-23	1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
US20060069149A1 (en)	2006-03-30	Thiadibenzoazulene derivatives for the treatment of inflammatory diseases
US20050131056A1 (en)	2005-06-16	2- thia-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HK1081950B (en)	2007-11-23	1-oxa-dibenzoazulenes as inhibitors of thmour necrosis factor production and intermediates for the preparation thereof
KR20050020774A (ko)	2005-03-04	종양괴사인자 생성의 억제제로서의1-옥사-3-아자-디벤조아줄렌 및 그의 제조를 위한 중간체
US20050130956A1 (en)	2005-06-16	1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
KR20050016336A (ko)	2005-02-21	종양괴사인자 생성 억제제로서의 2-티아-디벤조아줄렌 및그의 제조를 위한 중간체
ZA200408060B (en)	2006-08-30	1-oxa-3-aza-deibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof